Details for: USP18

Gene ID: 11274

Symbol: USP18

Ensembl ID: ENSG00000184979

Description: ubiquitin specific peptidase 18

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.88
    Marker Score: 3,885
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.38
    Marker Score: 5,092
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.05
    Marker Score: 1,031
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,794
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,019
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 494
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 448
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,728
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.91
    Marker Score: 615
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,081
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,271
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.83
    Marker Score: 360
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.76
    Marker Score: 6,463
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1,240
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 566
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 296
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 658
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.69
    Marker Score: 258
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,837
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.66
    Marker Score: 163
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 425
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.61
    Marker Score: 814
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.59
    Marker Score: 970
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.58
    Marker Score: 126
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.56
    Marker Score: 128
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.55
    Marker Score: 1,509
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 346
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.5
    Marker Score: 398
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.49
    Marker Score: 370
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.48
    Marker Score: 112
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.45
    Marker Score: 1,065
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.45
    Marker Score: 307
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.44
    Marker Score: 115
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.43
    Marker Score: 4,239
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.43
    Marker Score: 813
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.42
    Marker Score: 584
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.42
    Marker Score: 177
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.42
    Marker Score: 171
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.41
    Marker Score: 974
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.41
    Marker Score: 199
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.41
    Marker Score: 6,370
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.41
    Marker Score: 296
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.4
    Marker Score: 1,051
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.39
    Marker Score: 3,416
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.39
    Marker Score: 136
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.38
    Marker Score: 98
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.38
    Marker Score: 1,812
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.37
    Marker Score: 2,238
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.37
    Marker Score: 592
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.35
    Marker Score: 148
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 90
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.33
    Marker Score: 341
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.33
    Marker Score: 3,870
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.33
    Marker Score: 227
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.33
    Marker Score: 898
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.33
    Marker Score: 332
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.33
    Marker Score: 216
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.33
    Marker Score: 667
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.33
    Marker Score: 73
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.33
    Marker Score: 75
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.32
    Marker Score: 168
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.32
    Marker Score: 311
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.32
    Marker Score: 465
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.32
    Marker Score: 308
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.31
    Marker Score: 333
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.31
    Marker Score: 88
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.31
    Marker Score: 274
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.31
    Marker Score: 1,054
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.31
    Marker Score: 1,955
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.31
    Marker Score: 204
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3
    Marker Score: 16,983
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.29
    Marker Score: 186
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.29
    Marker Score: 166
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.29
    Marker Score: 15,356
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.29
    Marker Score: 313
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.29
    Marker Score: 1,167
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.28
    Marker Score: 161
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.28
    Marker Score: 2,800
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.27
    Marker Score: 86
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.27
    Marker Score: 142
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.27
    Marker Score: 240
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.27
    Marker Score: 163
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.27
    Marker Score: 692
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.26
    Marker Score: 57
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.26
    Marker Score: 129
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.25
    Marker Score: 156
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.25
    Marker Score: 490
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.25
    Marker Score: 65
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.25
    Marker Score: 783
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.24
    Marker Score: 317
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.24
    Marker Score: 594
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.24
    Marker Score: 55
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.24
    Marker Score: 271
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.24
    Marker Score: 683

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Deubiquitination Activity**: USP18 possesses a ubiquitin-specific peptidase activity, allowing it to remove ubiquitin molecules from target proteins, thus regulating protein stability and function. 2. **Multifunctional Role**: USP18 is involved in multiple immune-related pathways, including antiviral innate immune response, cytokine signaling, and regulation of inflammatory responses. 3. **Cell Type-Specific Expression**: USP18 is expressed in various cell types, including immune cells, epithelial cells, stem cells, and cancer cells, indicating its broad impact on immune homeostasis and disease progression. 4. **Antiviral Mechanism**: USP18 has been implicated in the regulation of antiviral mechanisms, including the deubiquitination of interferon-stimulated genes (ISGs) and the inhibition of viral replication. **Pathways and Functions:** 1. **Antiviral Innate Immune Response**: USP18 regulates the antiviral innate immune response by deubiquitinating ISGs, which are critical for the induction of antiviral genes and the inhibition of viral replication. 2. **Cytokine Signaling**: USP18 modulates cytokine signaling by deubiquitinating key cytokines, such as IFN-α/β, thus regulating the inflammatory response. 3. **Inflammation Regulation**: USP18 regulates the inflammatory response by deubiquitinating proteins involved in the NF-κB signaling pathway, which is a key regulator of inflammation. 4. **Toll-like Receptor Signaling**: USP18 is involved in the regulation of Toll-like receptor (TLR) signaling, which is critical for the recognition of pathogens and the activation of the innate immune response. **Clinical Significance:** USP18 has been implicated in various diseases, including: 1. **Cancer**: USP18 has been linked to cancer progression, where its overexpression can contribute to tumorigenesis and metastasis. 2. **Autoimmune Diseases**: USP18 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where its dysregulation can contribute to disease pathology. 3. **Viral Infections**: USP18 has been shown to play a critical role in antiviral mechanisms, making it a potential therapeutic target for viral infections. 4. **Neurological Disorders**: USP18 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where its dysregulation can contribute to disease pathology. In conclusion, USP18 is a multifaceted enzyme that plays a critical role in regulating various immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its mechanisms and potential therapeutic applications.

Genular Protein ID: 922462178

Symbol: UBP18_HUMAN

Name: Ubl carboxyl-terminal hydrolase 18

UniProtKB Accession Codes:

Q9UMW8 Q53Y90 Q6IAD9 Q9NY71

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTC 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 8 Ensembl 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10777664

Title: Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18).

PubMed ID: 10777664

DOI: 10.1006/geno.2000.6148

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11313150

Title: Cloning and characterization of human ubiquitin-processing protease-43 from terminally differentiated human melanoma cells using a rapid subtraction hybridization protocol RaSH.

PubMed ID: 11313150

DOI: 10.1016/s0378-1119(01)00384-5

PubMed ID: 11788588

Title: UBP43 (USP18) specifically removes ISG15 from conjugated proteins.

PubMed ID: 11788588

DOI: 10.1074/jbc.m109078200

PubMed ID: 22170061

Title: Two independent mechanisms promote expression of an N-terminal truncated USP18 isoform with higher DeISGylation activity in the nucleus.

PubMed ID: 22170061

DOI: 10.1074/jbc.m111.255570

PubMed ID: 23825189

Title: USP18 inhibits NF-kappaB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex.

PubMed ID: 23825189

DOI: 10.1084/jem.20122327

PubMed ID: 27325888

Title: Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome.

PubMed ID: 27325888

DOI: 10.1084/jem.20151529

PubMed ID: 27801882

Title: USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA.

PubMed ID: 27801882

DOI: 10.1038/cr.2016.125

PubMed ID: 28165510

Title: STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling.

PubMed ID: 28165510

DOI: 10.1038/nsmb.3378

PubMed ID: 31836668

Title: Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2.

PubMed ID: 31836668

DOI: 10.1126/sciimmunol.aav7501

PubMed ID: 32092142

Title: Homozygous STAT2 gain-of-function mutation by loss of USP18 activity in a patient with type I interferonopathy.

PubMed ID: 32092142

DOI: 10.1084/jem.20192319

Sequence Information:

  • Length: 372
  • Mass: 43011
  • Checksum: 60248E8D4CC42BF0
  • Sequence:
    • MSKAFGLLRQ ICQSILAESS QSPADLEEKK EEDSNMKREQ PRERPRAWDY PHGLVGLHNI 
GQTCCLNSLI QVFVMNVDFT RILKRITVPR GADEQRRSVP FQMLLLLEKM QDSRQKAVRP 
LELAYCLQKC NVPLFVQHDA AQLYLKLWNL IKDQITDVHL VERLQALYTI RVKDSLICVD 
CAMESSRNSS MLTLPLSLFD VDSKPLKTLE DALHCFFQPR ELSSKSKCFC ENCGKKTRGK 
QVLKLTHLPQ TLTIHLMRFS IRNSQTRKIC HSLYFPQSLD FSQILPMKRE SCDAEEQSGG 
QYELFAVIAH VGMADSGHYC VYIRNAVDGK WFCFNDSNIC LVSWEDIQCT YGNPNYHWQE 
TAYLLVYMKM EC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.