USP18 | ENSG00000184979 | NCBI 11274

Details for: USP18

Gene ID: 11274

Symbol: USP18

Ensembl ID: ENSG00000184979

Description: ubiquitin specific peptidase 18

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Cytokine signaling in immune system
(R-HSA-1280215)
Deubiquitination
(R-HSA-5688426)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interferon alpha/beta signaling
(R-HSA-909733)
Interferon signaling
(R-HSA-913531)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Isg15 antiviral mechanism
(R-HSA-1169408)
Metabolism of proteins
(R-HSA-392499)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Post-translational protein modification
(R-HSA-597592)
Regulation of ifna/ifnb signaling
(R-HSA-912694)
Regulation of nf-kappa b signaling
(R-HSA-9758274)
Signaling by interleukins
(R-HSA-449147)
Tak1-dependent ikk and nf-kappa-b activation
(R-HSA-445989)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Ub-specific processing proteases
(R-HSA-5689880)
Antiviral innate immune response
(GO:0140374)
Cysteine-type deubiquitinase activity
(GO:0004843)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Intracellular membrane-bounded organelle
(GO:0043231)
Isg15-specific peptidase activity
(GO:0019785)
Molecular adaptor activity
(GO:0060090)
Negative regulation of type i interferon-mediated signaling pathway
(GO:0060339)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein deubiquitination
(GO:0016579)
Proteolysis
(GO:0006508)
Regulation of inflammatory response
(GO:0050727)
Response to bacterium
(GO:0009617)
Response to stilbenoid
(GO:0035634)

Other Information

Proteins

Ubl carboxyl-terminal hydrolase 18

Genular Protein ID: 922462178

Symbol: UBP18_HUMAN

Name: Ubl carboxyl-terminal hydrolase 18

UniProtKB Accession Codes:

Q9UMW8 Q53Y90 Q6IAD9 Q9NY71

Database IDs:

Citations:

PubMed ID: 10777664

Title: Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18).

PubMed ID: 10777664

DOI: 10.1006/geno.2000.6148

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11313150

Title: Cloning and characterization of human ubiquitin-processing protease-43 from terminally differentiated human melanoma cells using a rapid subtraction hybridization protocol RaSH.

PubMed ID: 11313150

DOI: 10.1016/s0378-1119(01)00384-5

PubMed ID: 11788588

Title: UBP43 (USP18) specifically removes ISG15 from conjugated proteins.

PubMed ID: 11788588

DOI: 10.1074/jbc.m109078200

PubMed ID: 22170061

Title: Two independent mechanisms promote expression of an N-terminal truncated USP18 isoform with higher DeISGylation activity in the nucleus.

PubMed ID: 22170061

DOI: 10.1074/jbc.m111.255570

PubMed ID: 23825189

Title: USP18 inhibits NF-kappaB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex.

PubMed ID: 23825189

DOI: 10.1084/jem.20122327

PubMed ID: 27325888

Title: Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome.

PubMed ID: 27325888

DOI: 10.1084/jem.20151529

PubMed ID: 27801882

Title: USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA.

PubMed ID: 27801882

DOI: 10.1038/cr.2016.125

PubMed ID: 28165510

Title: STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling.

PubMed ID: 28165510

DOI: 10.1038/nsmb.3378

PubMed ID: 31836668

Title: Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2.

PubMed ID: 31836668

DOI: 10.1126/sciimmunol.aav7501

PubMed ID: 32092142

Title: Homozygous STAT2 gain-of-function mutation by loss of USP18 activity in a patient with type I interferonopathy.

PubMed ID: 32092142

DOI: 10.1084/jem.20192319

Sequence Information:

Length: 372
Mass: 43011
Checksum: 60248E8D4CC42BF0
Sequence:

MSKAFGLLRQ ICQSILAESS QSPADLEEKK EEDSNMKREQ PRERPRAWDY PHGLVGLHNI 
GQTCCLNSLI QVFVMNVDFT RILKRITVPR GADEQRRSVP FQMLLLLEKM QDSRQKAVRP 
LELAYCLQKC NVPLFVQHDA AQLYLKLWNL IKDQITDVHL VERLQALYTI RVKDSLICVD 
CAMESSRNSS MLTLPLSLFD VDSKPLKTLE DALHCFFQPR ELSSKSKCFC ENCGKKTRGK 
QVLKLTHLPQ TLTIHLMRFS IRNSQTRKIC HSLYFPQSLD FSQILPMKRE SCDAEEQSGG 
QYELFAVIAH VGMADSGHYC VYIRNAVDGK WFCFNDSNIC LVSWEDIQCT YGNPNYHWQE 
TAYLLVYMKM EC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: USP18

Associated with

Other Information

Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18). PubMed ID: 10777664

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

A genome annotation-driven approach to cloning the human ORFeome. PubMed ID: 15461802

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning and characterization of human ubiquitin-processing protease-43 from terminally differentiated human melanoma cells using a rapid subtraction hybridization protocol RaSH. PubMed ID: 11313150

UBP43 (USP18) specifically removes ISG15 from conjugated proteins. PubMed ID: 11788588

Two independent mechanisms promote expression of an N-terminal truncated USP18 isoform with higher DeISGylation activity in the nucleus. PubMed ID: 22170061

USP18 inhibits NF-kappaB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. PubMed ID: 23825189

Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome. PubMed ID: 27325888

USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA. PubMed ID: 27801882

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling. PubMed ID: 28165510

Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2. PubMed ID: 31836668

Homozygous STAT2 gain-of-function mutation by loss of USP18 activity in a patient with type I interferonopathy. PubMed ID: 32092142