Details for: SYNRG

Gene ID: 11276

Symbol: SYNRG

Ensembl ID: ENSG00000275066

Description: synergin gamma

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 4.01
    Marker Score: 53,294
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 3.64
    Marker Score: 10,265
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.98
    Marker Score: 6,176
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.41
    Marker Score: 1,171
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.17
    Marker Score: 3,791
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.17
    Marker Score: 2,298
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.02
    Marker Score: 3,345
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.96
    Marker Score: 1,571
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.94
    Marker Score: 2,087
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.89
    Marker Score: 5,293
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.86
    Marker Score: 3,583
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.8
    Marker Score: 901
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.76
    Marker Score: 759
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.68
    Marker Score: 7,028
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.67
    Marker Score: 35,692
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.65
    Marker Score: 4,171
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.65
    Marker Score: 2,942
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.64
    Marker Score: 508
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.59
    Marker Score: 644
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.58
    Marker Score: 2,230
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.56
    Marker Score: 6,016
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.54
    Marker Score: 1,311
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.53
    Marker Score: 56,536
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.53
    Marker Score: 14,381
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.51
    Marker Score: 884
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.51
    Marker Score: 477
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.51
    Marker Score: 57,232
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.47
    Marker Score: 90,199
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.46
    Marker Score: 507
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.45
    Marker Score: 3,181
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.42
    Marker Score: 3,472
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.42
    Marker Score: 13,515
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.42
    Marker Score: 1,569
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.41
    Marker Score: 21,151
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.41
    Marker Score: 843
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.39
    Marker Score: 1,600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.39
    Marker Score: 27,632
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.38
    Marker Score: 11,892
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.38
    Marker Score: 3,820
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.38
    Marker Score: 631
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.37
    Marker Score: 1,203
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.35
    Marker Score: 5,579
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.34
    Marker Score: 750
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.34
    Marker Score: 2,071
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.33
    Marker Score: 389
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.33
    Marker Score: 1,605
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.32
    Marker Score: 656
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.31
    Marker Score: 2,254
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.31
    Marker Score: 894
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.31
    Marker Score: 691
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.31
    Marker Score: 10,020
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.3
    Marker Score: 4,092
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.29
    Marker Score: 778
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.28
    Marker Score: 1,721
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.28
    Marker Score: 745
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.27
    Marker Score: 533
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.27
    Marker Score: 2,215
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.24
    Marker Score: 27,751
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.23
    Marker Score: 4,367
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.21
    Marker Score: 918
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.2
    Marker Score: 982
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.2
    Marker Score: 1,765
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.2
    Marker Score: 418
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.2
    Marker Score: 63,214
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.19
    Marker Score: 664
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 1.18
    Marker Score: 348
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.17
    Marker Score: 1,218
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.16
    Marker Score: 880
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.15
    Marker Score: 349
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.15
    Marker Score: 378
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.14
    Marker Score: 420
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.13
    Marker Score: 271
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.12
    Marker Score: 1,057
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.11
    Marker Score: 1,633
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.11
    Marker Score: 807
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.1
    Marker Score: 763
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.1
    Marker Score: 795
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.08
    Marker Score: 4,000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.07
    Marker Score: 1,167
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.07
    Marker Score: 337
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.07
    Marker Score: 234
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.07
    Marker Score: 238
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.06
    Marker Score: 400
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.06
    Marker Score: 433
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.05
    Marker Score: 1,515
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.05
    Marker Score: 531
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.05
    Marker Score: 378
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.04
    Marker Score: 978
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.04
    Marker Score: 959
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.03
    Marker Score: 225
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.03
    Marker Score: 254
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.03
    Marker Score: 249
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.03
    Marker Score: 1,284
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.03
    Marker Score: 507
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.03
    Marker Score: 281
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.03
    Marker Score: 1,101
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.03
    Marker Score: 770
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.02
    Marker Score: 1,223
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.02
    Marker Score: 355
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.02
    Marker Score: 3,019

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: SYNRG is a cytoplasmic protein composed of two tandem coiled-coil domains, which enable it to interact with other proteins and regulate cellular processes. 2. **Localization**: SYNRG is primarily localized to the cytoplasm and Golgi apparatus, where it is involved in endocytosis, protein transport, and apoptosis. 3. **Interactions**: SYNRG interacts with various proteins, including the Ap-1 adaptor complex, clathrin, and other cytoskeletal proteins, to regulate cellular processes. 4. **Expression**: SYNRG is highly expressed in multiple cell types, including cardiac muscle cells, immune cells, and epithelial cells. **Pathways and Functions** 1. **Apoptosis**: SYNRG is involved in regulating apoptosis, particularly in immune cells, where it interacts with Bcl-2 family proteins to modulate cell death. 2. **Endocytosis**: SYNRG is a component of the clathrin-coated vesicle formation, regulating the internalization of proteins and lipids. 3. **Intracellular protein transport**: SYNRG interacts with cytoskeletal proteins to regulate the transport of proteins within the cell. 4. **Golgi apparatus**: SYNRG is involved in regulating the function of the Golgi apparatus, including protein modification and secretion. **Clinical Significance** 1. **Immune-related disorders**: Variants in the SYNRG gene have been associated with autoimmune diseases, such as rheumatoid arthritis and lupus, suggesting its role in regulating immune cell function. 2. **Cancer**: Alterations in SYNRG expression have been observed in various cancers, including breast and colon cancer, where it may contribute to tumor progression and metastasis. 3. **Cardiac disease**: SYNRG has been implicated in cardiac development and function, and alterations in its expression have been associated with cardiac arrhythmias and cardiomyopathy. 4. **Neurological disorders**: SYNRG has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease, where it may contribute to neurodegeneration and synaptic dysfunction. In conclusion, SYNRG is a multifunctional protein involved in various cellular processes, including apoptosis, endocytosis, and protein transport. Its unique structure and interactions with other molecules make it an attractive target for further investigation into its role in human diseases. Further studies are necessary to fully elucidate the mechanisms by which SYNRG regulates cellular processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1515479715

Symbol: SYNRG_HUMAN

Name: Synergin gamma

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10477754

Title: Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin.

PubMed ID: 10477754

DOI: 10.1083/jcb.146.5.993

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10814529

Title: Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin.

PubMed ID: 10814529

DOI: 10.1006/bbrc.2000.2700

PubMed ID: 12538641

Title: EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking.

PubMed ID: 12538641

DOI: 10.1083/jcb.200208023

PubMed ID: 14665628

Title: Definition of the consensus motif recognized by gamma-adaptin ear domains.

PubMed ID: 14665628

DOI: 10.1074/jbc.m311873200

PubMed ID: 15758025

Title: The aftiphilin/p200/gamma-synergin complex.

PubMed ID: 15758025

DOI: 10.1091/mbc.e04-12-1077

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28397838

Title: Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families.

PubMed ID: 28397838

DOI: 10.1038/mp.2017.60

Sequence Information:

  • Length: 1314
  • Mass: 140654
  • Checksum: 70C105203EF0BBBF
  • Sequence:
  • MALRPGAGSG GGGAAGAGAG SAGGGGFMFP VAGGIRPPQA GLMPMQQQGF PMVSVMQPNM 
    QGIMGMNYSS QMSQGPIAMQ AGIPMGPMPA AGMPYLGQAP FLGMRPPGPQ YTPDMQKQFA 
    EEQQKRFEQQ QKLLEEERKR RQFEEQKQKL RLLSSVKPKT GEKSRDDALE AIKGNLDGFS 
    RDAKMHPTPA SHPKKPGPSL EEKFLVSCDI STSGQEQIKL NTSEVGHKAL GPGSSKKYPS 
    LMASNGVAVD GCVSGTTTAE AENTSDQNLS IEESGVGVFP SQDPAQPRMP PWIYNESLVP 
    DAYKKILETT MTPTGIDTAK LYPILMSSGL PRETLGQIWA LANRTTPGKL TKEELYTVLA 
    MIAVTQRGVP AMSPDALNQF PAAPIPTLSG FSMTLPTPVS QPTVIPSGPA GSMPLSLGQP 
    VMGINLVGPV GGAAAQASSG FIPTYPANQV VKPEEDDFQD FQDASKSGSL DDSFSDFQEL 
    PASSKTSNSQ HGNSAPSLLM PLPGTKALPS MDKYAVFKGI AADKSSENTV PPGDPGDKYS 
    AFRELEQTAE NKPLGESFAE FRSAGTDDGF TDFKTADSVS PLEPPTKDKT FPPSFPSGTI 
    QQKQQTQVKN PLNLADLDMF SSVNCSSEKP LSFSAVFSTS KSVSTPQSTG SAATMTALAA 
    TKTSSLADDF GEFSLFGEYS GLAPVGEQDD FADFMAFSNS SISSEQKPDD KYDALKEEAS 
    PVPLTSNVGS TVKGGQNSTA ASTKYDVFRQ LSLEGSGLGV EDLKDNTPSG KSDDDFADFH 
    SSKFSSINSD KSLGEKAVAF RHTKEDSASV KSLDLPSIGG SSVGKEDSED ALSVQFDMKL 
    ADVGGDLKHV MSDSSLDLPT VSGQHPPAAD IEDLKYAAFG SYSSNFAVST LTSYDWSDRD 
    DATQGRKLSP FVLSAGSGSP SATSILQKKE TSFGSSENIT MTSLSKVTTF VSEDALPETT 
    FPALASFKDT IPQTSEQKEY ENRDYKDFTK QDLPTAERSQ EATCPSPASS GASQETPNEC 
    SDDFGEFQSE KPKISKFDFL VATSQSKMKS SEEMIKSELA TFDLSVQGSH KRSLSLGDKE 
    ISRSSPSPAL EQPFRDRSNT LNEKPALPVI RDKYKDLTGE VEENERYAYE WQRCLGSALN 
    VIKKANDTLN GISSSSVCTE VIQSAQGMEY LLGVVEVYRV TKRVELGIKA TAVCSEKLQQ 
    LLKDIDKVWN NLIGFMSLAT LTPDENSLDF SSCMLRPGIK NAQELACGVC LLNVDSRSRK 
    EEKPAEEHPK KAFNSETDSF KLAYGGHQYH ASCANFWINC VEPKPPGLVL PDLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.