Details for: KLF8

Gene ID: 11279

Symbol: KLF8

Ensembl ID: ENSG00000102349

Description: KLF transcription factor 8

Associated with

  • Aggresome
    (GO:0016235)
  • Chromatin
    (GO:0000785)
  • Cytosol
    (GO:0005829)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.58
    Marker Score: 1,747
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.29
    Marker Score: 10,928
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.23
    Marker Score: 1,126
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,791
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.08
    Marker Score: 9,349
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.02
    Marker Score: 781
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.01
    Marker Score: 9,612
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,800
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,024
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.98
    Marker Score: 3,979
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.97
    Marker Score: 616
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,735
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 365
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,165
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.89
    Marker Score: 605
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.88
    Marker Score: 363
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,279
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 685
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.74
    Marker Score: 7,645
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.72
    Marker Score: 760
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.64
    Marker Score: 989
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.64
    Marker Score: 6,007
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.63
    Marker Score: 5,435
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.63
    Marker Score: 1,283
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.63
    Marker Score: 1,092
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.61
    Marker Score: 4,768
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.57
    Marker Score: 1,346
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.56
    Marker Score: 134
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.55
    Marker Score: 2,112
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 341
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.53
    Marker Score: 2,199
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 314
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.51
    Marker Score: 197
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.51
    Marker Score: 348
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.5
    Marker Score: 1,422
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.5
    Marker Score: 9,987
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.49
    Marker Score: 30,340
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.46
    Marker Score: 2,769
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.46
    Marker Score: 7,195
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.46
    Marker Score: 15,512
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.46
    Marker Score: 255
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.45
    Marker Score: 216
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.45
    Marker Score: 584
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.45
    Marker Score: 132
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.45
    Marker Score: 508
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.45
    Marker Score: 374
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.43
    Marker Score: 231
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.42
    Marker Score: 621
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.4
    Marker Score: 465
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.4
    Marker Score: 231
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.39
    Marker Score: 488
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.39
    Marker Score: 102
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.38
    Marker Score: 365
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.38
    Marker Score: 121
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.38
    Marker Score: 1,348
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.37
    Marker Score: 172
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.37
    Marker Score: 396
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.36
    Marker Score: 326
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.36
    Marker Score: 173
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.35
    Marker Score: 255
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.35
    Marker Score: 74
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.35
    Marker Score: 92
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.34
    Marker Score: 231
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.34
    Marker Score: 122
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.34
    Marker Score: 303
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.33
    Marker Score: 361
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.33
    Marker Score: 114
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.33
    Marker Score: 111
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.33
    Marker Score: 132
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.32
    Marker Score: 74
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.32
    Marker Score: 209
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.32
    Marker Score: 99
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.31
    Marker Score: 127
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.31
    Marker Score: 185
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.31
    Marker Score: 107
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.3
    Marker Score: 377
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.3
    Marker Score: 110
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3
    Marker Score: 146
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.29
    Marker Score: 1,213
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.29
    Marker Score: 634
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.29
    Marker Score: 2,504
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.28
    Marker Score: 7,199
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.28
    Marker Score: 101
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.27
    Marker Score: 1,134
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.27
    Marker Score: 179
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.27
    Marker Score: 119
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.27
    Marker Score: 483
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.27
    Marker Score: 151
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.27
    Marker Score: 2,724
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.27
    Marker Score: 237
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.26
    Marker Score: 245

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional regulation:** KLF8 possesses DNA-binding properties, allowing it to regulate gene expression by interacting with specific DNA sequences, particularly those containing the CACCC motif. 2. **Negative regulation of transcription:** KLF8 has been shown to inhibit the transcriptional activity of RNA polymerase II, suggesting a role in the regulation of gene expression in response to cellular stress or inflammation. 3. **Metal ion binding:** KLF8 contains a metal ion-binding domain, which may contribute to its stability and function. 4. **Cell-type specificity:** KLF8 expression is highly specific to various cell types, including immune cells, suggesting a specialized role in immune regulation. **Pathways and Functions:** 1. **Aggresome formation:** KLF8 has been implicated in the regulation of aggresome formation, a process involved in the degradation of misfolded proteins. 2. **Chromatin remodeling:** KLF8 may participate in chromatin remodeling, influencing gene expression and cellular differentiation. 3. **RNA polymerase II regulation:** KLF8's negative regulation of RNA polymerase II activity suggests a role in the modulation of gene expression in response to cellular stress or inflammation. 4. **Inflammation and immune response:** KLF8's expression in immune cells and its involvement in inflammatory processes suggest a role in modulating the immune response. **Clinical Significance:** 1. **Autoimmune diseases:** Dysregulation of KLF8 has been implicated in various autoimmune diseases, including rheumatoid arthritis and lupus, suggesting a potential therapeutic target. 2. **Cancer:** KLF8's role in promoting cell proliferation and survival in certain cancer types, such as colorectal cancer, highlights its potential as a prognostic marker or therapeutic target. 3. **Inflammatory disorders:** KLF8's involvement in inflammatory processes suggests its potential as a therapeutic target in diseases characterized by chronic inflammation, such as asthma and inflammatory bowel disease. 4. **Neurological disorders:** KLF8's expression in neural cells and its involvement in neuroinflammation suggest its potential as a therapeutic target in neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, KLF8 is a multifaceted transcription factor that plays a critical role in regulating gene expression, immune homeostasis, and cellular differentiation. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target. Further research is necessary to fully elucidate the mechanisms by which KLF8 regulates gene expression and to explore its therapeutic potential in different disease contexts.

Genular Protein ID: 1558277889

Symbol: KLF8_HUMAN

Name: Krueppel-like factor 8

UniProtKB Accession Codes:

O95600 B4DJN3 E7EQQ8 L0R3U8 L0R4U2 Q2M246 Q59GV5 Q5HYQ5 Q5JXP7 Q6MZJ7 Q9UGC4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 11 Ensembl 3 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 8 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 23134681

Title: Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors.

PubMed ID: 23134681

DOI: 10.1096/fj.12-220319

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10756197

Title: Human Kruppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription.

PubMed ID: 10756197

DOI: 10.1093/nar/28.9.1955

PubMed ID: 12820964

Title: Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression.

PubMed ID: 12820964

DOI: 10.1016/s1097-2765(03)00179-5

PubMed ID: 16617055

Title: Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation.

PubMed ID: 16617055

DOI: 10.1074/jbc.m513135200

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

Sequence Information:

  • Length: 359
  • Mass: 39314
  • Checksum: F8FDCC1FD477C04F
  • Sequence:
    • MVDMDKLINN LEVQLNSEGG SMQVFKQVTA SVRNRDPPEI EYRSNMTSPT LLDANPMENP 
ALFNDIKIEP PEELLASDFS LPQVEPVDLS FHKPKAPLQP ASMLQAPIRP PKPQSSPQTL 
VVSTSTSDMS TSANIPTVLT PGSVLTSSQS TGSQQILHVI HTIPSVSLPN KMGGLKTIPV 
VVQSLPMVYT TLPADGGPAA ITVPLIGGDG KNAGSVKVDP TSMSPLEIPS DSEESTIESG 
SSALQSLQGL QQEPAAMAQM QGEESLDLKR RRIHQCDFAG CSKVYTKSSH LKAHRRIHTG 
EKPYKCTWDG CSWKFARSDE LTRHFRKHTG IKPFRCTDCN RSFSRSDHLS LHRRRHDTM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.