CHRM1 | ENSG00000168539 | NCBI 1128

Details for: CHRM1

Gene ID: 1128

Symbol: CHRM1

Ensembl ID: ENSG00000168539

Description: cholinergic receptor muscarinic 1

Associated with

Amine ligand-binding receptors
(R-HSA-375280)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Muscarinic acetylcholine receptors
(R-HSA-390648)
Signaling by gpcr
(R-HSA-372790)
Adenylate cyclase-inhibiting g protein-coupled acetylcholine receptor signaling pathway
(GO:0007197)
Axon terminus
(GO:0043679)
Chemical synaptic transmission
(GO:0007268)
Cholinergic synapse
(GO:0098981)
Cognition
(GO:0050890)
Dendrite
(GO:0030425)
Glutamatergic synapse
(GO:0098978)
G protein-coupled acetylcholine receptor activity
(GO:0016907)
G protein-coupled acetylcholine receptor signaling pathway
(GO:0007213)
G protein-coupled receptor signaling pathway
(GO:0007186)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
(GO:0007187)
G protein-coupled serotonin receptor activity
(GO:0004993)
G protein-coupled serotonin receptor signaling pathway
(GO:0098664)
Membrane
(GO:0016020)
Nervous system development
(GO:0007399)
Neuromuscular synaptic transmission
(GO:0007274)
Phosphatidylinositol phospholipase c activity
(GO:0004435)
Phospholipase c-activating g protein-coupled acetylcholine receptor signaling pathway
(GO:0007207)
Plasma membrane
(GO:0005886)
Positive regulation of intracellular protein transport
(GO:0090316)
Positive regulation of monoatomic ion transport
(GO:0043270)
Postsynaptic density membrane
(GO:0098839)
Postsynaptic modulation of chemical synaptic transmission
(GO:0099170)
Presynaptic membrane
(GO:0042734)
Protein binding
(GO:0005515)
Protein kinase c-activating g protein-coupled receptor signaling pathway
(GO:0007205)
Regulation of glial cell proliferation
(GO:0060251)
Regulation of locomotion
(GO:0040012)
Regulation of postsynaptic membrane potential
(GO:0060078)
Saliva secretion
(GO:0046541)
Schaffer collateral - ca1 synapse
(GO:0098685)
Signal transduction
(GO:0007165)
Synapse
(GO:0045202)

Other Information

Proteins

Muscarinic acetylcholine receptor M1

Genular Protein ID: 2477357518

Symbol: ACM1_HUMAN

Name: Muscarinic acetylcholine receptor M1

UniProtKB Accession Codes:

P11229 Q96RH1

Database IDs:

Citations:

PubMed ID: 3697105

Title: Sequence of the gene encoding the human M1 muscarinic acetylcholine receptor.

PubMed ID: 3697105

DOI: 10.1093/nar/15.24.10604

PubMed ID: 2336407

Title: Isolation of the human ml (Hml) muscarinic acetylcholine receptor gene by PCR amplification.

PubMed ID: 2336407

DOI: 10.1093/nar/18.8.2191

PubMed ID: 3443095

Title: Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

PubMed ID: 3443095

DOI: 10.1002/j.1460-2075.1987.tb02733.x

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1445347

Title: Mutational analysis of third cytoplasmic loop domains in G-protein coupling of the HM1 muscarinic receptor.

PubMed ID: 1445347

DOI: 10.1016/0006-291x(92)91346-r

PubMed ID: 15086532

Title: Identification of a novel family of G protein-coupled receptor associated sorting proteins.

PubMed ID: 15086532

DOI: 10.1111/j.1471-4159.2004.02411.x

PubMed ID: 21056967

Title: Regulation of M(3) muscarinic receptor expression and function by transmembrane protein 147.

PubMed ID: 21056967

DOI: 10.1124/mol.110.067363

PubMed ID: 32646996

Title: Structure and selectivity engineering of the M1 muscarinic receptor toxin complex.

PubMed ID: 32646996

DOI: 10.1126/science.aax2517

Sequence Information:

Length: 460
Mass: 51421
Checksum: 567C20F63541C8D0
Sequence:

MNTSAPPAVS PNITVLAPGK GPWQVAFIGI TTGLLSLATV TGNLLVLISF KVNTELKTVN 
NYFLLSLACA DLIIGTFSMN LYTTYLLMGH WALGTLACDL WLALDYVASN ASVMNLLLIS 
FDRYFSVTRP LSYRAKRTPR RAALMIGLAW LVSFVLWAPA ILFWQYLVGE RTVLAGQCYI 
QFLSQPIITF GTAMAAFYLP VTVMCTLYWR IYRETENRAR ELAALQGSET PGKGGGSSSS 
SERSQPGAEG SPETPPGRCC RCCRAPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV 
VIKMPMVDPE AQAPTKQPPR SSPNTVKRPT KKGRDRAGKG QKPRGKEQLA KRKTFSLVKE 
KKAARTLSAI LLAFILTWTP YNIMVLVSTF CKDCVPETLW ELGYWLCYVN STINPMCYAL 
CNKAFRDTFR LLLLCRWDKR RWRKIPKRPG SVHRTPSRQC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CHRM1

Associated with

Other Information

Sequence of the gene encoding the human M1 muscarinic acetylcholine receptor. PubMed ID: 3697105

Isolation of the human ml (Hml) muscarinic acetylcholine receptor gene by PCR amplification. PubMed ID: 2336407

Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. PubMed ID: 3443095

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mutational analysis of third cytoplasmic loop domains in G-protein coupling of the HM1 muscarinic receptor. PubMed ID: 1445347

Identification of a novel family of G protein-coupled receptor associated sorting proteins. PubMed ID: 15086532

Regulation of M(3) muscarinic receptor expression and function by transmembrane protein 147. PubMed ID: 21056967

Structure and selectivity engineering of the M1 muscarinic receptor toxin complex. PubMed ID: 32646996