Details for: CHRM1

Gene ID: 1128

Symbol: CHRM1

Ensembl ID: ENSG00000168539

Description: cholinergic receptor muscarinic 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.21
    Marker Score: 4195
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.98
    Marker Score: 2217
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.68
    Marker Score: 953
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.62
    Marker Score: 3351
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.57
    Marker Score: 1568.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 857
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.2
    Marker Score: 2437
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4815
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.07
    Marker Score: 623
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.04
    Marker Score: 430
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.01
    Marker Score: 15738
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5336
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.81
    Marker Score: 484
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.76
    Marker Score: 241
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.73
    Marker Score: 6904
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.72
    Marker Score: 6173
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.69
    Marker Score: 402
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.66
    Marker Score: 388
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.65
    Marker Score: 39807
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.61
    Marker Score: 945
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 483
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.6
    Marker Score: 286
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.55
    Marker Score: 2127
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.54
    Marker Score: 747
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.52
    Marker Score: 19689
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.52
    Marker Score: 7717
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.49
    Marker Score: 226
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.48
    Marker Score: 268
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.48
    Marker Score: 3652
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.47
    Marker Score: 1932
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.44
    Marker Score: 2048
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.4
    Marker Score: 126
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.4
    Marker Score: 176
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.39
    Marker Score: 3703
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.39
    Marker Score: 203
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.37
    Marker Score: 402
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.35
    Marker Score: 186
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.35
    Marker Score: 162
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.35
    Marker Score: 554
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.34
    Marker Score: 12477
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.33
    Marker Score: 774
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.31
    Marker Score: 111
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.3
    Marker Score: 5941
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.29
    Marker Score: 343
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.27
    Marker Score: 1129
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.23
    Marker Score: 149
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.22
    Marker Score: 132
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.2
    Marker Score: 129
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.19
    Marker Score: 76
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.19
    Marker Score: 144
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.18
    Marker Score: 163
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.17
    Marker Score: 44
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.17
    Marker Score: 63
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.17
    Marker Score: 68
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.17
    Marker Score: 387
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.17
    Marker Score: 71
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.16
    Marker Score: 145
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.15
    Marker Score: 74
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.15
    Marker Score: 74
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.14
    Marker Score: 37
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.14
    Marker Score: 133
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.14
    Marker Score: 349
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.13
    Marker Score: 1327
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.13
    Marker Score: 143
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.12
    Marker Score: 117
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 37
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.11
    Marker Score: 46
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.11
    Marker Score: 157
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.11
    Marker Score: 131
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.1
    Marker Score: 195
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.1
    Marker Score: 43
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.1
    Marker Score: 66
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.09
    Marker Score: 106
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.09
    Marker Score: 375
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.09
    Marker Score: 129
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.09
    Marker Score: 78
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.09
    Marker Score: 40

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Other Information

**Key characteristics:** - M1 is a transmembrane protein with seven transmembrane domains. - It is a G protein-coupled receptor, meaning it binds to G proteins and activates them. - M1 is a member of the muscarinic acetylcholine receptor family of receptors. **Pathways and functions:** - M1 is a key receptor for acetylcholine in the central nervous system. - It is involved in a variety of physiological processes, including cardiac function, blood pressure regulation, and gastric motility. - In the cardiovascular system, M1 is expressed on cardiac endothelial cells and smooth muscle cells. - In the central nervous system, M1 is expressed on neurons, astrocytes, and smooth muscle cells. - M1 is also involved in the regulation of blood pressure and fluid balance. **Clinical significance:** - Mutations in the CHRM1 gene have been linked to a number of human diseases, including hypertension, heart failure, and diabetes. - M1 agonists are used as antihypertensive drugs. - M1 antagonists are used as bronchodilators in asthma and other respiratory conditions.

Genular Protein ID: 2477357518

Symbol: ACM1_HUMAN

Name: Muscarinic acetylcholine receptor M1

UniProtKB Accession Codes:

P11229 Q96RH1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EMBL 8 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 6 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3697105

Title: Sequence of the gene encoding the human M1 muscarinic acetylcholine receptor.

PubMed ID: 3697105

DOI: 10.1093/nar/15.24.10604

PubMed ID: 2336407

Title: Isolation of the human ml (Hml) muscarinic acetylcholine receptor gene by PCR amplification.

PubMed ID: 2336407

DOI: 10.1093/nar/18.8.2191

PubMed ID: 3443095

Title: Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

PubMed ID: 3443095

DOI: 10.1002/j.1460-2075.1987.tb02733.x

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1445347

Title: Mutational analysis of third cytoplasmic loop domains in G-protein coupling of the HM1 muscarinic receptor.

PubMed ID: 1445347

DOI: 10.1016/0006-291x(92)91346-r

PubMed ID: 15086532

Title: Identification of a novel family of G protein-coupled receptor associated sorting proteins.

PubMed ID: 15086532

DOI: 10.1111/j.1471-4159.2004.02411.x

PubMed ID: 21056967

Title: Regulation of M(3) muscarinic receptor expression and function by transmembrane protein 147.

PubMed ID: 21056967

DOI: 10.1124/mol.110.067363

PubMed ID: 32646996

Title: Structure and selectivity engineering of the M1 muscarinic receptor toxin complex.

PubMed ID: 32646996

DOI: 10.1126/science.aax2517

Sequence Information:

  • Length: 460
  • Mass: 51421
  • Checksum: 567C20F63541C8D0
  • Sequence:
    • MNTSAPPAVS PNITVLAPGK GPWQVAFIGI TTGLLSLATV TGNLLVLISF KVNTELKTVN 
NYFLLSLACA DLIIGTFSMN LYTTYLLMGH WALGTLACDL WLALDYVASN ASVMNLLLIS 
FDRYFSVTRP LSYRAKRTPR RAALMIGLAW LVSFVLWAPA ILFWQYLVGE RTVLAGQCYI 
QFLSQPIITF GTAMAAFYLP VTVMCTLYWR IYRETENRAR ELAALQGSET PGKGGGSSSS 
SERSQPGAEG SPETPPGRCC RCCRAPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV 
VIKMPMVDPE AQAPTKQPPR SSPNTVKRPT KKGRDRAGKG QKPRGKEQLA KRKTFSLVKE 
KKAARTLSAI LLAFILTWTP YNIMVLVSTF CKDCVPETLW ELGYWLCYVN STINPMCYAL 
CNKAFRDTFR LLLLCRWDKR RWRKIPKRPG SVHRTPSRQC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.