Details for: CHRM1

Gene ID: 1128

Symbol: CHRM1

Ensembl ID: ENSG00000168539

Description: cholinergic receptor muscarinic 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.6398
    Cell Significance Index: 90.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.1388
    Cell Significance Index: 192.4400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.1673
    Cell Significance Index: 46.9600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9091
    Cell Significance Index: 22.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9081
    Cell Significance Index: 172.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5096
    Cell Significance Index: 460.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4438
    Cell Significance Index: 159.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4412
    Cell Significance Index: 88.5000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4317
    Cell Significance Index: 12.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4181
    Cell Significance Index: 8.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3240
    Cell Significance Index: 35.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3199
    Cell Significance Index: 52.0300
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: 0.2362
    Cell Significance Index: 2.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2255
    Cell Significance Index: 13.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1935
    Cell Significance Index: 19.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1930
    Cell Significance Index: 9.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1515
    Cell Significance Index: 10.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1459
    Cell Significance Index: 9.8100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.1176
    Cell Significance Index: 2.0100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: 0.0757
    Cell Significance Index: 0.8300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0371
    Cell Significance Index: 25.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0280
    Cell Significance Index: 1.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0261
    Cell Significance Index: 0.9900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0075
    Cell Significance Index: 0.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0036
    Cell Significance Index: 1.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0031
    Cell Significance Index: 0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0018
    Cell Significance Index: -3.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0033
    Cell Significance Index: -5.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0037
    Cell Significance Index: -5.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0082
    Cell Significance Index: -0.3700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0106
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0117
    Cell Significance Index: -8.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0118
    Cell Significance Index: -0.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0119
    Cell Significance Index: -7.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0143
    Cell Significance Index: -7.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0154
    Cell Significance Index: -8.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0165
    Cell Significance Index: -4.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0176
    Cell Significance Index: -8.0000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0227
    Cell Significance Index: -0.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0305
    Cell Significance Index: -0.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0310
    Cell Significance Index: -4.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0347
    Cell Significance Index: -2.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0393
    Cell Significance Index: -7.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0407
    Cell Significance Index: -8.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0415
    Cell Significance Index: -8.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0419
    Cell Significance Index: -7.1500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0423
    Cell Significance Index: -0.8500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0426
    Cell Significance Index: -0.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0458
    Cell Significance Index: -3.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0532
    Cell Significance Index: -6.1000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0554
    Cell Significance Index: -1.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0561
    Cell Significance Index: -8.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0569
    Cell Significance Index: -7.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0590
    Cell Significance Index: -1.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0600
    Cell Significance Index: -6.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0665
    Cell Significance Index: -8.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0698
    Cell Significance Index: -5.2000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0716
    Cell Significance Index: -0.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0736
    Cell Significance Index: -7.6700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0742
    Cell Significance Index: -1.7800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0760
    Cell Significance Index: -0.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0764
    Cell Significance Index: -2.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0792
    Cell Significance Index: -1.6800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0849
    Cell Significance Index: -1.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0992
    Cell Significance Index: -2.5500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0994
    Cell Significance Index: -1.6100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1017
    Cell Significance Index: -2.0100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1133
    Cell Significance Index: -3.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1185
    Cell Significance Index: -3.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1202
    Cell Significance Index: -6.3100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1211
    Cell Significance Index: -3.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1243
    Cell Significance Index: -3.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1247
    Cell Significance Index: -7.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1293
    Cell Significance Index: -6.0800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1328
    Cell Significance Index: -2.7700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1450
    Cell Significance Index: -1.5800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1471
    Cell Significance Index: -3.0700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1475
    Cell Significance Index: -1.9900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1476
    Cell Significance Index: -5.4200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1496
    Cell Significance Index: -1.9400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1498
    Cell Significance Index: -1.8900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1515
    Cell Significance Index: -3.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1603
    Cell Significance Index: -8.3500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1704
    Cell Significance Index: -5.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1847
    Cell Significance Index: -5.3000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1880
    Cell Significance Index: -3.7000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1944
    Cell Significance Index: -1.8500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1978
    Cell Significance Index: -2.5600
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.1998
    Cell Significance Index: -2.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2013
    Cell Significance Index: -5.4800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2217
    Cell Significance Index: -4.4200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2238
    Cell Significance Index: -5.4600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2266
    Cell Significance Index: -5.6500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.2443
    Cell Significance Index: -2.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2464
    Cell Significance Index: -6.4800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2500
    Cell Significance Index: -2.9900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.2589
    Cell Significance Index: -3.5800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2686
    Cell Significance Index: -4.0800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2691
    Cell Significance Index: -6.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CHRM1, also known as Muscarinic acetylcholine receptor M1, is a subtype of muscarinic acetylcholine receptors that is predominantly expressed in the immune system. It is characterized by its ability to bind to acetylcholine, a neurotransmitter involved in cholinergic signaling, and activate G protein-coupled receptor signaling pathways. The M1 receptor is primarily found in cardiac endothelial cells, plasma cells, megakaryocytes, and various epithelial cells, where it regulates immune responses, inflammation, and tissue homeostasis. **Pathways and Functions** CHRM1-mediated signaling involves the activation of G protein-coupled receptor kinases (GRKs) and G protein-coupled receptor phosphatases (GRPs), which in turn regulate downstream signaling events. The M1 receptor is involved in several key pathways, including: 1. **Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway**: CHRM1 modulates adenylate cyclase activity, leading to changes in intracellular cAMP levels and influencing immune response and inflammation. 2. **G alpha (q) signaling events**: The M1 receptor activates Gq proteins, which trigger phospholipase C activation, resulting in the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). 3. **Phosphatidylinositol phospholipase C activity**: CHRM1 regulates phospholipase C activity, influencing phospholipid metabolism and immune response. 4. **Regulation of glial cell proliferation**: The M1 receptor modulates glial cell proliferation, which is essential for tissue homeostasis and immune system function. **Clinical Significance** Dysregulation of CHRM1-mediated signaling has been implicated in various immune-related disorders, including: 1. **Asthma**: CHRM1 expression is altered in asthma, leading to impaired airway function and inflammation. 2. **Rheumatoid arthritis**: CHRM1 is involved in the regulation of immune responses and inflammation in rheumatoid arthritis. 3. **Allergic diseases**: CHRM1 plays a role in the development and severity of allergic diseases, such as allergic rhinitis and atopic dermatitis. 4. **Neurodegenerative diseases**: CHRM1 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In conclusion, CHRM1 is a critical component of the immune system, and its dysregulation has significant implications for our understanding of immune-related disorders. Further research is necessary to elucidate the complex mechanisms underlying CHRM1-mediated signaling and to explore its therapeutic potential in the treatment of immune-related diseases.

Genular Protein ID: 2477357518

Symbol: ACM1_HUMAN

Name: Muscarinic acetylcholine receptor M1

UniProtKB Accession Codes:

P11229 Q96RH1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EMBL 8 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3697105

Title: Sequence of the gene encoding the human M1 muscarinic acetylcholine receptor.

PubMed ID: 3697105

DOI: 10.1093/nar/15.24.10604

PubMed ID: 2336407

Title: Isolation of the human ml (Hml) muscarinic acetylcholine receptor gene by PCR amplification.

PubMed ID: 2336407

DOI: 10.1093/nar/18.8.2191

PubMed ID: 3443095

Title: Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

PubMed ID: 3443095

DOI: 10.1002/j.1460-2075.1987.tb02733.x

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1445347

Title: Mutational analysis of third cytoplasmic loop domains in G-protein coupling of the HM1 muscarinic receptor.

PubMed ID: 1445347

DOI: 10.1016/0006-291x(92)91346-r

PubMed ID: 15086532

Title: Identification of a novel family of G protein-coupled receptor associated sorting proteins.

PubMed ID: 15086532

DOI: 10.1111/j.1471-4159.2004.02411.x

PubMed ID: 21056967

Title: Regulation of M(3) muscarinic receptor expression and function by transmembrane protein 147.

PubMed ID: 21056967

DOI: 10.1124/mol.110.067363

PubMed ID: 32646996

Title: Structure and selectivity engineering of the M1 muscarinic receptor toxin complex.

PubMed ID: 32646996

DOI: 10.1126/science.aax2517

Sequence Information:

  • Length: 460
  • Mass: 51421
  • Checksum: 567C20F63541C8D0
  • Sequence:
    • MNTSAPPAVS PNITVLAPGK GPWQVAFIGI TTGLLSLATV TGNLLVLISF KVNTELKTVN 
NYFLLSLACA DLIIGTFSMN LYTTYLLMGH WALGTLACDL WLALDYVASN ASVMNLLLIS 
FDRYFSVTRP LSYRAKRTPR RAALMIGLAW LVSFVLWAPA ILFWQYLVGE RTVLAGQCYI 
QFLSQPIITF GTAMAAFYLP VTVMCTLYWR IYRETENRAR ELAALQGSET PGKGGGSSSS 
SERSQPGAEG SPETPPGRCC RCCRAPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV 
VIKMPMVDPE AQAPTKQPPR SSPNTVKRPT KKGRDRAGKG QKPRGKEQLA KRKTFSLVKE 
KKAARTLSAI LLAFILTWTP YNIMVLVSTF CKDCVPETLW ELGYWLCYVN STINPMCYAL 
CNKAFRDTFR LLLLCRWDKR RWRKIPKRPG SVHRTPSRQC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.