Details for: SCN11A
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2
Marker Score: 1,996 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1,171 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.53
Marker Score: 2,904 - Cell Name: mural cell (CL0008034)
Fold Change: 1.48
Marker Score: 169,568 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 857 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4,818 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.05
Marker Score: 2,133 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,829 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,054 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 510 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,408 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 463 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.97
Marker Score: 1,998 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,413 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.94
Marker Score: 389 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,331 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 374 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,741 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 326 - Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.88
Marker Score: 314 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,289 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.86
Marker Score: 397 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.83
Marker Score: 13,037 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.82
Marker Score: 166 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.82
Marker Score: 625 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,263 - Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.78
Marker Score: 2,232 - Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 709 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.69
Marker Score: 14,686 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.63
Marker Score: 379 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.59
Marker Score: 377 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.58
Marker Score: 504 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 447 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 173 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.52
Marker Score: 701 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.5
Marker Score: 779 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.46
Marker Score: 123 - Cell Name: goblet cell (CL0000160)
Fold Change: 0.45
Marker Score: 3,020 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.42
Marker Score: 201 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.41
Marker Score: 129 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.39
Marker Score: 173 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.39
Marker Score: 23,717 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.38
Marker Score: 225 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.37
Marker Score: 3,553 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.37
Marker Score: 340 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.37
Marker Score: 3,138 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.35
Marker Score: 157 - Cell Name: germ cell (CL0000586)
Fold Change: 0.34
Marker Score: 594 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.29
Marker Score: 2,698 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.28
Marker Score: 162 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.26
Marker Score: 312 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.26
Marker Score: 1,078 - Cell Name: oogonial cell (CL0000024)
Fold Change: 0.25
Marker Score: 356 - Cell Name: neuron (CL0000540)
Fold Change: 0.24
Marker Score: 983 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.23
Marker Score: 74 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.22
Marker Score: 8,248 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 73 - Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.21
Marker Score: 63 - Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.21
Marker Score: 237 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.21
Marker Score: 495 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.21
Marker Score: 54 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.2
Marker Score: 2,097 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.2
Marker Score: 126 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.19
Marker Score: 744 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.18
Marker Score: 648 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.18
Marker Score: 3,569 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.17
Marker Score: 6,542 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.17
Marker Score: 113 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 42 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.17
Marker Score: 403 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.16
Marker Score: 178 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.16
Marker Score: 65 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.16
Marker Score: 122 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.15
Marker Score: 228 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.15
Marker Score: 575 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.14
Marker Score: 593 - Cell Name: dendritic cell (CL0000451)
Fold Change: 0.14
Marker Score: 95 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.14
Marker Score: 146 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.14
Marker Score: 40 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.13
Marker Score: 1,996 - Cell Name: ganglion interneuron (CL0000397)
Fold Change: 0.13
Marker Score: 39 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.13
Marker Score: 121 - Cell Name: male germ cell (CL0000015)
Fold Change: 0.13
Marker Score: 37 - Cell Name: ciliated cell (CL0000064)
Fold Change: 0.13
Marker Score: 440 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.13
Marker Score: 980 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.13
Marker Score: 40 - Cell Name: Schwann cell (CL0002573)
Fold Change: 0.13
Marker Score: 44 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.12
Marker Score: 128 - Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 0.12
Marker Score: 90 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.12
Marker Score: 56 - Cell Name: mast cell (CL0000097)
Fold Change: 0.12
Marker Score: 68 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.12
Marker Score: 49 - Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.11
Marker Score: 30 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.11
Marker Score: 68 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.11
Marker Score: 99 - Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.11
Marker Score: 53 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.11
Marker Score: 71
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 696292269
Symbol: SCNBA_HUMAN
Name: Peripheral nerve sodium channel 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10580103
Title: Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons.
PubMed ID: 10580103
PubMed ID: 10623608
Title: Identification of a novel human voltage-gated sodium channel alpha subunit gene, SCN12A.
PubMed ID: 10623608
PubMed ID: 12384689
Title: Neurotrophin-evoked depolarization requires the sodium channel Nav1.9.
PubMed ID: 12384689
DOI: 10.1038/nature01085
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15302875
Title: Expression of alternatively spliced sodium channel alpha-subunit genes: unique splicing patterns are observed in dorsal root ganglia.
PubMed ID: 15302875
PubMed ID: 24207120
Title: Gain-of-function mutations in SCN11A cause familial episodic pain.
PubMed ID: 24207120
PubMed ID: 24036948
Title: A de novo gain-of-function mutation in SCN11A causes loss of pain perception.
PubMed ID: 24036948
DOI: 10.1038/ng.2767
PubMed ID: 24776970
Title: Gain-of-function mutations in sodium channel Na(v)1.9 in painful neuropathy.
PubMed ID: 24776970
DOI: 10.1093/brain/awu079
PubMed ID: 26645915
Title: Cold-aggravated pain in humans caused by a hyperactive NaV1.9 channel mutant.
PubMed ID: 26645915
DOI: 10.1038/ncomms10049
PubMed ID: 25791876
Title: The domain II S4-S5 linker in Nav1.9: a missense mutation enhances activation, impairs fast inactivation, and produces human painful neuropathy.
PubMed ID: 25791876
PubMed ID: 27224030
Title: Infantile pain episodes associated with novel Nav1.9 mutations in familial episodic pain syndrome in japanese families.
PubMed ID: 27224030
Sequence Information:
- Length: 1791
- Mass: 204922
- Checksum: DE38680BFB639ED1
- Sequence:
MDDRCYPVIF PDERNFRPFT SDSLAAIEKR IAIQKEKKKS KDQTGEVPQP RPQLDLKASR KLPKLYGDIP RELIGKPLED LDPFYRNHKT FMVLNRKRTI YRFSAKHALF IFGPFNSIRS LAIRVSVHSL FSMFIIGTVI INCVFMATGP AKNSNSNNTD IAECVFTGIY IFEALIKILA RGFILDEFSF LRDPWNWLDS IVIGIAIVSY IPGITIKLLP LRTFRVFRAL KAISVVSRLK VIVGALLRSV KKLVNVIILT FFCLSIFALV GQQLFMGSLN LKCISRDCKN ISNPEAYDHC FEKKENSPEF KMCGIWMGNS ACSIQYECKH TKINPDYNYT NFDNFGWSFL AMFRLMTQDS WEKLYQQTLR TTGLYSVFFF IVVIFLGSFY LINLTLAVVT MAYEEQNKNV AAEIEAKEKM FQEAQQLLKE EKEALVAMGI DRSSLTSLET SYFTPKKRKL FGNKKRKSFF LRESGKDQPP GSDSDEDCQK KPQLLEQTKR LSQNLSLDHF DEHGDPLQRQ RALSAVSILT ITMKEQEKSQ EPCLPCGENL ASKYLVWNCC PQWLCVKKVL RTVMTDPFTE LAITICIIIN TVFLAMEHHK MEASFEKMLN IGNLVFTSIF IAEMCLKIIA LDPYHYFRRG WNIFDSIVAL LSFADVMNCV LQKRSWPFLR SFRVLRVFKL AKSWPTLNTL IKIIGNSVGA LGSLTVVLVI VIFIFSVVGM QLFGRSFNSQ KSPKLCNPTG PTVSCLRHWH MGDFWHSFLV VFRILCGEWI ENMWECMQEA NASSSLCVIV FILITVIGKL VVLNLFIALL LNSFSNEERN GNLEGEARKT KVQLALDRFR RAFCFVRHTL EHFCHKWCRK QNLPQQKEVA GGCAAQSKDI IPLVMEMKRG SETQEELGIL TSVPKTLGVR HDWTWLAPLA EEEDDVEFSG EDNAQRITQP EPEQQAYELH QENKKPTSQR VQSVEIDMFS EDEPHLTIQD PRKKSDVTSI LSECSTIDLQ DGFGWLPEMV PKKQPERCLP KGFGCCFPCC SVDKRKPPWV IWWNLRKTCY QIVKHSWFES FIIFVILLSS GALIFEDVHL ENQPKIQELL NCTDIIFTHI FILEMVLKWV AFGFGKYFTS AWCCLDFIIV IVSVTTLINL MELKSFRTLR ALRPLRALSQ FEGMKVVVNA LIGAIPAILN VLLVCLIFWL VFCILGVYFF SGKFGKCING TDSVINYTII TNKSQCESGN FSWINQKVNF DNVGNAYLAL LQVATFKGWM DIIYAAVDST EKEQQPEFES NSLGYIYFVV FIIFGSFFTL NLFIGVIIDN FNQQQKKLGG QDIFMTEEQK KYYNAMKKLG SKKPQKPIPR PLNKCQGLVF DIVTSQIFDI IIISLIILNM ISMMAESYNQ PKAMKSILDH LNWVFVVIFT LECLIKIFAL RQYYFTNGWN LFDCVVVLLS IVSTMISTLE NQEHIPFPPT LFRIVRLARI GRILRLVRAA RGIRTLLFAL MMSLPSLFNI GLLLFLIMFI YAILGMNWFS KVNPESGIDD IFNFKTFASS MLCLFQISTS AGWDSLLSPM LRSKESCNSS SENCHLPGIA TSYFVSYIII SFLIVVNMYI AVILENFNTA TEESEDPLGE DDFDIFYEVW EKFDPEATQF IKYSALSDFA DALPEPLRVA KPNKYQFLVM DLPMVSEDRL HCMDILFAFT ARVLGGSDGL DSMKAMMEEK FMEANPLKKL YEPIVTTTKR KEEERGAAII QKAFRKYMMK VTKGDQGDQN DLENGPHSPL QTLCNGDLSS FGVAKGKVHC D
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.