Details for: POU6F2

Gene ID: 11281

Symbol: POU6F2

Ensembl ID: ENSG00000106536

Description: POU class 6 homeobox 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 3.1
    Marker Score: 1,808
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.72
    Marker Score: 3,392
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.3
    Marker Score: 8,905
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.16
    Marker Score: 907
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.03
    Marker Score: 125,025
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.02
    Marker Score: 905
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.98
    Marker Score: 601
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.92
    Marker Score: 3,981
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.9
    Marker Score: 28,467
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.86
    Marker Score: 15,946
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.77
    Marker Score: 484
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.75
    Marker Score: 16,627
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.64
    Marker Score: 3,761
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,169
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,554
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.47
    Marker Score: 1,812
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.45
    Marker Score: 5,156
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.45
    Marker Score: 2,742
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.42
    Marker Score: 30,345
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.4
    Marker Score: 2,851
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.35
    Marker Score: 618
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.29
    Marker Score: 410
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 854
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.2
    Marker Score: 1,036
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.19
    Marker Score: 9,127
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 487
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,810
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.14
    Marker Score: 684
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 503
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.09
    Marker Score: 715
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16,412
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,040
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.96
    Marker Score: 1,109
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.95
    Marker Score: 2,243
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,332
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.91
    Marker Score: 444
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.9
    Marker Score: 33,326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 633
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.82
    Marker Score: 1,425
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.8
    Marker Score: 1,237
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.79
    Marker Score: 172
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.78
    Marker Score: 401
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.75
    Marker Score: 360
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.74
    Marker Score: 232
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.73
    Marker Score: 806
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.72
    Marker Score: 292
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.71
    Marker Score: 185
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.69
    Marker Score: 251
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.68
    Marker Score: 379
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.65
    Marker Score: 6,742
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.63
    Marker Score: 179
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.62
    Marker Score: 240
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.62
    Marker Score: 228
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.61
    Marker Score: 393
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.59
    Marker Score: 2,393
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 455
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.56
    Marker Score: 1,221
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.54
    Marker Score: 584
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.54
    Marker Score: 379
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.52
    Marker Score: 211
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.52
    Marker Score: 163
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.48
    Marker Score: 214
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.47
    Marker Score: 488
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.45
    Marker Score: 8,987
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.41
    Marker Score: 517
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.4
    Marker Score: 216
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.39
    Marker Score: 137
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.39
    Marker Score: 1,060
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.39
    Marker Score: 216
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.37
    Marker Score: 215
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.36
    Marker Score: 395
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.36
    Marker Score: 269
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.36
    Marker Score: 149
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.35
    Marker Score: 123
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.35
    Marker Score: 506
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.34
    Marker Score: 303
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.34
    Marker Score: 97
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.33
    Marker Score: 219
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.33
    Marker Score: 553
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.33
    Marker Score: 96
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.32
    Marker Score: 325
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.31
    Marker Score: 6,818
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.3
    Marker Score: 176
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.3
    Marker Score: 179
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 0.29
    Marker Score: 99

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** POU6F2 is a transcription factor that exhibits a characteristic POU domain, a conserved DNA-binding motif essential for its function. The gene is primarily expressed in cells of the CNS, including neurons, glial cells, and progenitor cells. Its expression is also observed in other cell types, such as epithelial cells, ganglion cells, and kidney proximal convoluted tubule epithelial cells. POU6F2 is involved in regulating transcriptional activity, particularly in the context of RNA polymerase II-dependent gene expression. **Pathways and Functions:** POU6F2 is implicated in various signaling pathways, including: 1. **Central Nervous System Development:** POU6F2 is essential for the proper development and differentiation of neurons, particularly in the retina and CNS. It regulates the expression of genes involved in neural development, cell fate specification, and axon guidance. 2. **Chromatin and DNA-Binding Transcription Factor Activity:** POU6F2 binds to specific DNA sequences, influencing chromatin structure and transcriptional regulation. Its activity is mediated by its POU domain, which interacts with other transcription factors and co-regulators. 3. **RNA Polymerase II-Dependent Transcription:** POU6F2 regulates the expression of genes involved in RNA polymerase II-dependent transcription, including those involved in neuronal development and function. 4. **Visual Perception:** POU6F2 is specifically expressed in retinal ganglion cells, where it plays a role in regulating the expression of genes involved in visual perception. **Clinical Significance:** Dysregulation of POU6F2 has been implicated in various neurological and immunological disorders, including: 1. **Neurodevelopmental Disorders:** Mutations in POU6F2 have been associated with neurodevelopmental disorders, such as autism spectrum disorder and intellectual disability. 2. **Visual Impairment:** Alterations in POU6F2 expression have been linked to visual impairment and blindness. 3. **Immune System Dysregulation:** POU6F2 may play a role in regulating the immune response, particularly in the context of autoimmune diseases. In conclusion, POU6F2 is a multifunctional transcription factor that plays a critical role in regulating cellular processes, including development, differentiation, and maintenance of the CNS, as well as immune responses. Further research is necessary to fully elucidate the mechanisms by which POU6F2 regulates these processes and to explore its therapeutic potential in the treatment of neurological and immunological disorders.

Genular Protein ID: 1598585097

Symbol: PO6F2_HUMAN

Name: POU domain, class 6, transcription factor 2

UniProtKB Accession Codes:

P78424 A4D1W2 C4AMB9 P78425 Q75ME8 Q86UM6 Q9UDS7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8601806

Title: Retina-derived POU-domain factor-1: a complex POU-domain gene implicated in the development of retinal ganglion and amacrine cells.

PubMed ID: 8601806

DOI: 10.1523/jneurosci.16-07-02261.1996

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 11284034

Title: Refinement within single yeast artificial chromosome clones of a minimal region commonly deleted on the short arm of chromosome 7 in Wilms tumours.

PubMed ID: 11284034

DOI: 10.1002/gcc.1116

Sequence Information:

  • Length: 691
  • Mass: 73265
  • Checksum: 3460C858ECBB5535
  • Sequence:
    • MSALLQDPMI AGQVSKPLLS VRSEMNAELR GEDKAATSDS ELNEPLLAPV ESNDSEDTPS 
KLFGARGNPA LSDPGTPDQH QASQTHPPFP VGPQPLLTAQ QLASAVAGVM PGGPPALNQP 
ILIPFNMAGQ LGGQQGLVLT LPTANLTNIQ GLVAAAAAGG IMTLPLQNLQ ATSSLNSQLQ 
QLQLQLQQQQ QQQQQQPPPS TNQHPQPAPQ APSQSQQQPL QPTPPQQPPP ASQQPPAPTS 
QLQQAPQPQQ HQPHSHSQNQ NQPSPTQQSS SPPQKPSQSP GHGLPSPLTP PNPLQLVNNP 
LASQAAAAAA AMSSIASSQA FGNALSSLQG VTGQLVTNAQ GQIIGTIPLM PNPGPSSQAA 
SGTQGLQVQP ITPQLLTNAQ GQIIATVIGN QILPVINTQG ITLSPIKPGQ QLHQPSQTSV 
GQAASQGNLL HLAHSQASMS QSPVRQASSS SSSSSSSSAL SVGQLVSNPQ TAAGEVDGVN 
LEEIREFAKA FKIRRLSLGL TQTQVGQALS ATEGPAYSQS AICRHTILRS HFFLPQEAQE 
NTIASSLTAK LNPGLLYPAR FEKLDITPKS AQKIKPVLER WMAEAEARHR AGMQNLTEFI 
GSEPSKKRKR RTSFTPQALE ILNAHFEKNT HPSGQEMTEI AEKLNYDREV VRVWFCNKRQ 
ALKNTIKRLK QHEPATAVPL EPLTDSLEEN S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.