CYP4F8 | ENSG00000186526 | NCBI 11283

Details for: CYP4F8

Gene ID: 11283

Symbol: CYP4F8

Ensembl ID: ENSG00000186526

Description: cytochrome P450 family 4 subfamily F member 8

Associated with

Arachidonic acid metabolism
(R-HSA-2142753)
Biological oxidations
(R-HSA-211859)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Eicosanoids
(R-HSA-211979)
Fatty acid metabolism
(R-HSA-8978868)
Fatty acids
(R-HSA-211935)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Phase i - functionalization of compounds
(R-HSA-211945)
Synthesis of leukotrienes (lt) and eoxins (ex)
(R-HSA-2142691)
Alkane 1-monooxygenase activity
(GO:0018685)
Aromatase activity
(GO:0070330)
Endoplasmic reticulum membrane
(GO:0005789)
Heme binding
(GO:0020037)
Icosanoid metabolic process
(GO:0006690)
Iron ion binding
(GO:0005506)
Monooxygenase activity
(GO:0004497)
Prostaglandin metabolic process
(GO:0006693)

Other Information

Proteins

CYPIVF8

Genular Protein ID: 3300261523

Symbol: CP4F8_HUMAN

Name: CYPIVF8

UniProtKB Accession Codes:

P98187

Database IDs:

Citations:

PubMed ID: 10405341

Title: Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles.

PubMed ID: 10405341

DOI: 10.1006/bbrc.1999.1011

PubMed ID: 10791960

Title: Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides.

PubMed ID: 10791960

DOI: 10.1074/jbc.m001712200

PubMed ID: 12464258

Title: Expression of CYP4F8 (prostaglandin H 19-hydroxylase) in human epithelia and prominent induction in epidermis of psoriatic lesions.

PubMed ID: 12464258

DOI: 10.1016/s0003-9861(02)00511-8

PubMed ID: 16112640

Title: Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8.

PubMed ID: 16112640

DOI: 10.1016/j.abb.2005.07.003

PubMed ID: 15789615

Title: On the mechanism of biosynthesis of 19-hydroxyprostaglandins of human seminal fluid and expression of cyclooxygenase-2, PGH 19-hydroxylase (CYP4F8) and microsomal PGE synthase-1 in seminal vesicles and vas deferens.

PubMed ID: 15789615

DOI: 10.1016/j.prostaglandins.2004.09.014

Sequence Information:

Length: 520
Mass: 59995
Checksum: 6839640CF4E9EB86
Sequence:

MSLLSLSWLG LRPVAASPWL LLLVVGASWL LARILAWTYA FYHNGRRLRC FPQPRKQNWF 
LGHLGLVTPT EEGLRVLTQL VATYPQGFVR WLGPITPIIN LCHPDIVRSV INTSDAITDK 
DIVFYKTLKP WLGDGLLLSV GDKWRHHRRL LTPAFHFNIL KPYIKIFSKS ANIMHAKWQR 
LAMEGSTCLD VFEHISLMTL DSLQKCIFSF DSNCQEKPSE YITAIMELSA LVVKRNNQFF 
RYKDFLYFLT PCGRRFHRAC RLVHDFTDAV IQERRRTLTS QGVDDFLQAK AKSKTLDFID 
VLLLSEDKNG KELSDEDIRA EADTFMFGGH DTTASGLSWV LYNLARHPEY QERCRQEVQE 
LLKDREPKEI EWDDLAQLPF LTMCLKESLR LHPPIPTFAR GCTQDVVLPD SRVIPKGNVC 
NINIFAIHHN PSVWPDPEVY DPFRFDPENA QKRSPMAFIP FSAGPRNCIG QKFAMAEMKV 
VLALTLLRFR ILPDHREPRR TPEIVLRAED GLWLRVEPLG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CYP4F8

Associated with

Other Information

Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles. PubMed ID: 10405341

Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides. PubMed ID: 10791960

Expression of CYP4F8 (prostaglandin H 19-hydroxylase) in human epithelia and prominent induction in epidermis of psoriatic lesions. PubMed ID: 12464258