Details for: CYP4F8

Gene ID: 11283

Symbol: CYP4F8

Ensembl ID: ENSG00000186526

Description: cytochrome P450 family 4 subfamily F member 8

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.51
    Marker Score: 2,529
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1,179
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 863
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 493
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,694
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,826
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 515
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,839
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,063
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 468
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.96
    Marker Score: 442
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.95
    Marker Score: 379
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,352
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 330
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,744
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.86
    Marker Score: 2,093
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1,368
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.79
    Marker Score: 1,493
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 468
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.73
    Marker Score: 1,513
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.67
    Marker Score: 1,357
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.63
    Marker Score: 505
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.61
    Marker Score: 9,531
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.55
    Marker Score: 328
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.32
    Marker Score: 155
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.27
    Marker Score: 285
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.22
    Marker Score: 329
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.15
    Marker Score: 346
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.14
    Marker Score: 64
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.11
    Marker Score: 60
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1
    Marker Score: 5,458
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.1
    Marker Score: 139
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.09
    Marker Score: 172
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.09
    Marker Score: 96
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.09
    Marker Score: 58
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.08
    Marker Score: 56
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.08
    Marker Score: 62
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.07
    Marker Score: 3,825
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.07
    Marker Score: 45
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.06
    Marker Score: 12
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.05
    Marker Score: 52
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.05
    Marker Score: 86
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.05
    Marker Score: 77
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.05
    Marker Score: 54
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.04
    Marker Score: 58
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.04
    Marker Score: 134
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.04
    Marker Score: 151
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.03
    Marker Score: 298
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.03
    Marker Score: 45
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.03
    Marker Score: 36
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.03
    Marker Score: 47
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.02
    Marker Score: 50
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.02
    Marker Score: 39
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.02
    Marker Score: 12

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The CYP4F8 gene is a member of the cytochrome P450 superfamily, which consists of enzymes that catalyze the oxidation of lipids and other organic molecules. The CYP4F8 enzyme is a monooxygenase that exhibits specificity for arachidonic acid and other fatty acids. Its expression is restricted to cells involved in immune regulation and lipid metabolism, including endothelial cells, goblet cells, and intestinal epithelial cells. The CYP4F8 enzyme has been shown to be involved in the synthesis of eicosanoids, which are signaling molecules that play a crucial role in immune responses and inflammation. **Pathways and Functions:** The CYP4F8 enzyme is involved in several metabolic pathways, including: 1. **Arachidonic acid metabolism:** The CYP4F8 enzyme catalyzes the oxidation of arachidonic acid, leading to the production of eicosanoids, such as prostaglandins and leukotrienes. 2. **Fatty acid metabolism:** The CYP4F8 enzyme is involved in the metabolism of various fatty acids, including arachidonic acid, linoleic acid, and oleic acid. 3. **Aromatase activity:** The CYP4F8 enzyme has been shown to exhibit aromatase activity, which is involved in the conversion of androgens to estrogens. 4. **Cytochrome p450 - arranged by substrate type:** The CYP4F8 enzyme is a member of the cytochrome P450 superfamily, which is involved in the metabolism of a wide range of substrates, including lipids, steroids, and other organic molecules. **Clinical Significance:** Dysregulation of the CYP4F8 gene has been implicated in several diseases, including: 1. **Inflammatory disorders:** The CYP4F8 enzyme has been shown to play a role in the synthesis of eicosanoids, which are involved in inflammatory responses. 2. **Cancer:** The CYP4F8 enzyme has been implicated in the metabolism of arachidonic acid, which is involved in cancer progression and metastasis. 3. **Immunological disorders:** The CYP4F8 enzyme has been shown to play a role in the regulation of immune responses, including the synthesis of eicosanoids and the modulation of inflammatory responses. In conclusion, the CYP4F8 gene plays a crucial role in the metabolism of lipids and the regulation of immune responses. Its dysregulation has been implicated in several diseases, highlighting the importance of this gene in human health and disease. Further studies are needed to fully elucidate the role of the CYP4F8 enzyme in human disease and to develop therapeutic strategies for the treatment of related disorders.

Genular Protein ID: 3300261523

Symbol: CP4F8_HUMAN

Name: CYPIVF8

UniProtKB Accession Codes:

P98187

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 100 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 56 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10405341

Title: Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles.

PubMed ID: 10405341

DOI: 10.1006/bbrc.1999.1011

PubMed ID: 10791960

Title: Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides.

PubMed ID: 10791960

DOI: 10.1074/jbc.m001712200

PubMed ID: 12464258

Title: Expression of CYP4F8 (prostaglandin H 19-hydroxylase) in human epithelia and prominent induction in epidermis of psoriatic lesions.

PubMed ID: 12464258

DOI: 10.1016/s0003-9861(02)00511-8

PubMed ID: 16112640

Title: Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8.

PubMed ID: 16112640

DOI: 10.1016/j.abb.2005.07.003

PubMed ID: 15789615

Title: On the mechanism of biosynthesis of 19-hydroxyprostaglandins of human seminal fluid and expression of cyclooxygenase-2, PGH 19-hydroxylase (CYP4F8) and microsomal PGE synthase-1 in seminal vesicles and vas deferens.

PubMed ID: 15789615

DOI: 10.1016/j.prostaglandins.2004.09.014

Sequence Information:

  • Length: 520
  • Mass: 59995
  • Checksum: 6839640CF4E9EB86
  • Sequence:
    • MSLLSLSWLG LRPVAASPWL LLLVVGASWL LARILAWTYA FYHNGRRLRC FPQPRKQNWF 
LGHLGLVTPT EEGLRVLTQL VATYPQGFVR WLGPITPIIN LCHPDIVRSV INTSDAITDK 
DIVFYKTLKP WLGDGLLLSV GDKWRHHRRL LTPAFHFNIL KPYIKIFSKS ANIMHAKWQR 
LAMEGSTCLD VFEHISLMTL DSLQKCIFSF DSNCQEKPSE YITAIMELSA LVVKRNNQFF 
RYKDFLYFLT PCGRRFHRAC RLVHDFTDAV IQERRRTLTS QGVDDFLQAK AKSKTLDFID 
VLLLSEDKNG KELSDEDIRA EADTFMFGGH DTTASGLSWV LYNLARHPEY QERCRQEVQE 
LLKDREPKEI EWDDLAQLPF LTMCLKESLR LHPPIPTFAR GCTQDVVLPD SRVIPKGNVC 
NINIFAIHHN PSVWPDPEVY DPFRFDPENA QKRSPMAFIP FSAGPRNCIG QKFAMAEMKV 
VLALTLLRFR ILPDHREPRR TPEIVLRAED GLWLRVEPLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.