PNKP | ENSG00000039650 | NCBI 11284

Details for: PNKP

Gene ID: 11284

Symbol: PNKP

Ensembl ID: ENSG00000039650

Description: polynucleotide kinase 3'-phosphatase

Associated with

Apex1-independent resolution of ap sites via the single nucleotide replacement pathway
(R-HSA-5649702)
Base excision repair
(R-HSA-73884)
Resolution of abasic sites (ap sites)
(R-HSA-73933)
Atp-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
(GO:0046404)
Atp binding
(GO:0005524)
Base-excision repair, gap-filling
(GO:0006287)
Damaged dna binding
(GO:0003684)
Dna-templated dna replication
(GO:0006261)
Dna ligation involved in dna repair
(GO:0051103)
Dna repair
(GO:0006281)
Double-strand break repair via nonhomologous end joining
(GO:0006303)
Double-stranded dna binding
(GO:0003690)
Endonuclease activity
(GO:0004519)
Membrane
(GO:0016020)
Negative regulation of protein adp-ribosylation
(GO:0010836)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleotide-excision repair
(GO:0006289)
Nucleus
(GO:0005634)
Phosphorylation
(GO:0016310)
Polynucleotide 3'-phosphatase activity
(GO:0046403)
Positive regulation of double-strand break repair via nonhomologous end joining
(GO:2001034)
Positive regulation of telomerase activity
(GO:0051973)
Positive regulation of telomere capping
(GO:1904355)
Positive regulation of telomere maintenance via telomerase
(GO:0032212)
Protein binding
(GO:0005515)
Purine nucleotide binding
(GO:0017076)
Response to oxidative stress
(GO:0006979)
Response to radiation
(GO:0009314)
Site of double-strand break
(GO:0035861)

Other Information

Proteins

Bifunctional polynucleotide phosphatase/kinase

Genular Protein ID: 3299470044

Symbol: PNKP_HUMAN

Name: Bifunctional polynucleotide phosphatase/kinase

UniProtKB Accession Codes:

Q96T60 Q9BUL2 Q9P1V2 Q9UKU8 Q9UNF8 Q9UNI0

Database IDs:

Citations:

PubMed ID: 10446192

Title: Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage.

PubMed ID: 10446192

DOI: 10.1074/jbc.274.34.24176

PubMed ID: 10446193

Title: Molecular characterization of a human DNA kinase.

PubMed ID: 10446193

DOI: 10.1074/jbc.274.34.24187

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15385968

Title: Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.

PubMed ID: 15385968

DOI: 10.1038/sj.emboj.7600375

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20852255

Title: Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining.

PubMed ID: 20852255

DOI: 10.1074/jbc.m109.058719

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28453785

Title: Structural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex.

PubMed ID: 28453785

DOI: 10.1093/nar/gkx275

PubMed ID: 25728773

Title: Mutations in PNKP cause recessive ataxia with oculomotor apraxia type 4.

PubMed ID: 25728773

DOI: 10.1016/j.ajhg.2015.01.005

PubMed ID: 19155274

Title: Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK.

PubMed ID: 19155274

DOI: 10.1093/nar/gkn1086

PubMed ID: 20118933

Title: Mutations in PNKP cause microcephaly, seizures and defects in DNA repair.

PubMed ID: 20118933

DOI: 10.1038/ng.526

PubMed ID: 27232581

Title: Microcephalic primordial dwarfism in an Emirati patient with PNKP mutation.

PubMed ID: 27232581

DOI: 10.1002/ajmg.a.37766

Sequence Information:

Length: 521
Mass: 57076
Checksum: 22B5C94D41E62516
Sequence:

MGEVEAPGRL WLESPPGGAP PIFLPSDGQA LVLGRGPLTQ VTDRKCSRTQ VELVADPETR 
TVAVKQLGVN PSTTGTQELK PGLEGSLGVG DTLYLVNGLH PLTLRWEETR TPESQPDTPP 
GTPLVSQDEK RDAELPKKRM RKSNPGWENL EKLLVFTAAG VKPQGKVAGF DLDGTLITTR 
SGKVFPTGPS DWRILYPEIP RKLRELEAEG YKLVIFTNQM SIGRGKLPAE EFKAKVEAVV 
EKLGVPFQVL VATHAGLYRK PVTGMWDHLQ EQANDGTPIS IGDSIFVGDA AGRPANWAPG 
RKKKDFSCAD RLFALNLGLP FATPEEFFLK WPAAGFELPA FDPRTVSRSG PLCLPESRAL 
LSASPEVVVA VGFPGAGKST FLKKHLVSAG YVHVNRDTLG SWQRCVTTCE TALKQGKRVA 
IDNTNPDAAS RARYVQCARA AGVPCRCFLF TATLEQARHN NRFREMTDSS HIPVSDMVMY 
GYRKQFEAPT LAEGFSAILE IPFRLWVEPR LGRLYCQFSE G

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PNKP

Associated with

Other Information

Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage. PubMed ID: 10446192

Molecular characterization of a human DNA kinase. PubMed ID: 10446193

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV. PubMed ID: 15385968

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining. PubMed ID: 20852255

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Structural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex. PubMed ID: 28453785

Mutations in PNKP cause recessive ataxia with oculomotor apraxia type 4. PubMed ID: 25728773

Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK. PubMed ID: 19155274

Mutations in PNKP cause microcephaly, seizures and defects in DNA repair. PubMed ID: 20118933

Microcephalic primordial dwarfism in an Emirati patient with PNKP mutation. PubMed ID: 27232581