Details for: CHRM2

Gene ID: 1129

Symbol: CHRM2

Ensembl ID: ENSG00000181072

Description: cholinergic receptor muscarinic 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 4.16
    Marker Score: 92977
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.52
    Marker Score: 12529
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.37
    Marker Score: 2385.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1509
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.09
    Marker Score: 19641
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.77
    Marker Score: 6838
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.76
    Marker Score: 1020
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.68
    Marker Score: 2029
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170171
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.46
    Marker Score: 4185
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.3
    Marker Score: 17232
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19657
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.17
    Marker Score: 523
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.16
    Marker Score: 23112
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.16
    Marker Score: 4709
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.1
    Marker Score: 41762.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.07
    Marker Score: 2205
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.03
    Marker Score: 396.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.02
    Marker Score: 1930
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1
    Marker Score: 456.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71814
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48037
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.99
    Marker Score: 7565
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.95
    Marker Score: 58216.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5346
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.93
    Marker Score: 34336.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.92
    Marker Score: 704
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.92
    Marker Score: 7892
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.91
    Marker Score: 4220
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.83
    Marker Score: 314.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.78
    Marker Score: 1581
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1191
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.74
    Marker Score: 233
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.7
    Marker Score: 418
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.68
    Marker Score: 395
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 443
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 485
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.59
    Marker Score: 6084
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.58
    Marker Score: 308
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.56
    Marker Score: 164
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.56
    Marker Score: 282
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5
    Marker Score: 2988
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 473
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.48
    Marker Score: 1137
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.48
    Marker Score: 182
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.44
    Marker Score: 1267
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.44
    Marker Score: 232
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 388
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.41
    Marker Score: 388
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.39
    Marker Score: 226
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.38
    Marker Score: 185
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.38
    Marker Score: 157
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.37
    Marker Score: 678
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.37
    Marker Score: 746
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.36
    Marker Score: 5385
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.35
    Marker Score: 114
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.35
    Marker Score: 303
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.34
    Marker Score: 1430
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.31
    Marker Score: 447
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.3
    Marker Score: 145
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.3
    Marker Score: 725
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.3
    Marker Score: 377
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.29
    Marker Score: 364
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.29
    Marker Score: 171.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.28
    Marker Score: 217.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.28
    Marker Score: 159.5
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.28
    Marker Score: 78
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.27
    Marker Score: 386
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.27
    Marker Score: 70
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.27
    Marker Score: 84
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.26
    Marker Score: 619.5
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.26
    Marker Score: 320
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.26
    Marker Score: 113
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.25
    Marker Score: 99
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.24
    Marker Score: 137
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.24
    Marker Score: 62
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.24
    Marker Score: 264
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.23
    Marker Score: 113.5
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.23
    Marker Score: 244
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.22
    Marker Score: 58
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.22
    Marker Score: 378
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.22
    Marker Score: 91
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.21
    Marker Score: 70
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.21
    Marker Score: 121
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.21
    Marker Score: 42
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 61

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Other Information

**Key characteristics** * CHRM2 is a single-pass transmembrane protein with a molecular weight of approximately 140 kDa. * It is expressed in a variety of cell types, including cardiac myocytes, endothelial cells, and neurons. * It is a ligand for the G protein-coupled acetylcholine receptor. **Pathways and functions** * CHRM2 is a key component of the adenylate cyclase-modulating g protein-coupled receptor signaling pathway. This pathway is involved in a variety of cellular processes, including smooth muscle contraction, mucus secretion, and vascular tone regulation. * It is also a ligand for the G protein-coupled serotonin receptor. * It is involved in the regulation of smooth muscle contraction. **Clinical significance** * Mutations in the CHRM2 gene have been linked to a number of human diseases, including hypertension, heart failure, and vascular smooth muscle diseases. * Gene therapy approaches targeting CHRM2 are being investigated as a potential treatment for these diseases. **Additional information** * The CHRM2 gene is located on chromosome 17q21.1. * It is a member of the muscarinic acetylcholine receptor family of G protein-coupled receptors. * It is expressed in a variety of cell types, including cardiac myocytes, endothelial cells, and neurons. * It is a key component of the adenylate cyclase-modulating g protein-coupled receptor signaling pathway. * It is also a ligand for the G protein-coupled serotonin receptor.

Genular Protein ID: 3053406946

Symbol: ACM2_HUMAN

Name: Muscarinic acetylcholine receptor M2

UniProtKB Accession Codes:

P08172 Q4VBK6 Q9P1X9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 91 DrugCentral 1 EMBL 7 EMDB 6 Ensembl 5 ExpressionAtlas 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 14 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 9 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3037705

Title: Identification of a family of muscarinic acetylcholine receptor genes.

PubMed ID: 3037705

DOI: 10.1126/science.3037705

PubMed ID: 3443095

Title: Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

PubMed ID: 3443095

DOI: 10.1002/j.1460-2075.1987.tb02733.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15014171

Title: Human-specific amino acid changes found in 103 protein-coding genes.

PubMed ID: 15014171

DOI: 10.1093/molbev/msh100

PubMed ID: 7822302

Title: Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, beta 2-adrenergic, and m2 muscarinic cholinergic receptors.

PubMed ID: 7822302

DOI: 10.1074/jbc.270.2.720

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 15229186

Title: Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome.

PubMed ID: 15229186

DOI: 10.1093/hmg/ddh194

PubMed ID: 20976005

Title: RACK1 associates with muscarinic receptors and regulates M(2) receptor trafficking.

PubMed ID: 20976005

DOI: 10.1371/journal.pone.0013517

PubMed ID: 22278061

Title: Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist.

PubMed ID: 22278061

DOI: 10.1038/nature10753

PubMed ID: 24256733

Title: Activation and allosteric modulation of a muscarinic acetylcholine receptor.

PubMed ID: 24256733

DOI: 10.1038/nature12735

Sequence Information:

  • Length: 466
  • Mass: 51715
  • Checksum: 2FC2FD7748C22BEC
  • Sequence:
    • MNNSTNSSNN SLALTSPYKT FEVVFIVLVA GSLSLVTIIG NILVMVSIKV NRHLQTVNNY 
FLFSLACADL IIGVFSMNLY TLYTVIGYWP LGPVVCDLWL ALDYVVSNAS VMNLLIISFD 
RYFCVTKPLT YPVKRTTKMA GMMIAAAWVL SFILWAPAIL FWQFIVGVRT VEDGECYIQF 
FSNAAVTFGT AIAAFYLPVI IMTVLYWHIS RASKSRIKKD KKEPVANQDP VSPSLVQGRI 
VKPNNNNMPS SDDGLEHNKI QNGKAPRDPV TENCVQGEEK ESSNDSTSVS AVASNMRDDE 
ITQDENTVST SLGHSKDENS KQTCIRIGTK TPKSDSCTPT NTTVEVVGSS GQNGDEKQNI 
VARKIVKMTK QPAKKKPPPS REKKVTRTIL AILLAFIITW APYNVMVLIN TFCAPCIPNT 
VWTIGYWLCY INSTINPACY ALCNATFKKT FKHLLMCHYK NIGATR

Genular Protein ID: 3740387020

Symbol: Q6SL59_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6SL59

Database IDs:

BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 GenomeRNAi 1 NCBI Taxonomy 1 RefSeq 2

Citations:

PubMed ID: 15379890

Title: Multiple promoters drive tissue-specific expression of the human M muscarinic acetylcholine receptor gene.

PubMed ID: 15379890

DOI: 10.1111/j.1471-4159.2004.02694.x

Sequence Information:

  • Length: 13
  • Mass: 1353
  • Checksum: 1B95B61EED6CA5B4
  • Sequence:
    • MNNSTNSSNN SLA

Genular Protein ID: 2831036633

Symbol: Q86SJ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86SJ1

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 7 GenomeRNAi 1 KEGG 1 NCBI Taxonomy 1 PharmGKB 1 RefSeq 6

Citations:

PubMed ID: 14512373

Title: Novel polymorphisms influencing transcription of the human CHRM2 gene in airway smooth muscle.

PubMed ID: 14512373

DOI: 10.1165/rcmb.2003-0011OC

Sequence Information:

  • Length: 30
  • Mass: 3262
  • Checksum: 238EDC76DE52EB1F
  • Sequence:
    • MNNSTNSSNN SLALTSPYKT FEVVFIVLVA

Genular Protein ID: 3569902233

Symbol: Q6SL56_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6SL56

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 2 Pfam 1 PharmGKB 1 RefSeq 8 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15379890

Title: Multiple promoters drive tissue-specific expression of the human M muscarinic acetylcholine receptor gene.

PubMed ID: 15379890

DOI: 10.1111/j.1471-4159.2004.02694.x

Sequence Information:

  • Length: 72
  • Mass: 8269
  • Checksum: 8A833B2696817373
  • Sequence:
    • AFIITWAPYN VMVLINTFCA PCIPNTVWTI GYWLCYINST INPACYALCN ATFKKTFKHL 
LMCHYKNIGA TR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.