Details for: ADCY7

Gene ID: 113

Symbol: ADCY7

Ensembl ID: ENSG00000121281

Description: adenylate cyclase 7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.55
    Marker Score: 768
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.25
    Marker Score: 402
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.06
    Marker Score: 2635
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71756
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47980
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.98
    Marker Score: 589
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.97
    Marker Score: 1109
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.92
    Marker Score: 399
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2721
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.89
    Marker Score: 323
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 358
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.89
    Marker Score: 3719.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.89
    Marker Score: 1073
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.88
    Marker Score: 7587
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.88
    Marker Score: 722
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4975
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5256
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.84
    Marker Score: 464
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.82
    Marker Score: 824
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.81
    Marker Score: 8378
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.81
    Marker Score: 548
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.78
    Marker Score: 19993
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.77
    Marker Score: 2132
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.77
    Marker Score: 4624
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 583
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1227
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 379
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.72
    Marker Score: 8385
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.72
    Marker Score: 11246
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2965
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.71
    Marker Score: 467
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.7
    Marker Score: 1680
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 623
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.67
    Marker Score: 1068
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.66
    Marker Score: 1930
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.66
    Marker Score: 209
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.65
    Marker Score: 215
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.65
    Marker Score: 447
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.65
    Marker Score: 356
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.63
    Marker Score: 263
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.61
    Marker Score: 1590.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.61
    Marker Score: 1115
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.61
    Marker Score: 1183
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.61
    Marker Score: 455
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.6
    Marker Score: 613
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.59
    Marker Score: 428
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.59
    Marker Score: 480
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.58
    Marker Score: 850
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 351
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.55
    Marker Score: 223
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.54
    Marker Score: 584
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.54
    Marker Score: 602
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.54
    Marker Score: 225
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.54
    Marker Score: 277
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.53
    Marker Score: 468
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.53
    Marker Score: 1491
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.52
    Marker Score: 379
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.52
    Marker Score: 179
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.52
    Marker Score: 301
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.51
    Marker Score: 3109
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.51
    Marker Score: 361
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.51
    Marker Score: 5054
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.51
    Marker Score: 3250
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5
    Marker Score: 337
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.49
    Marker Score: 1191
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.49
    Marker Score: 2025
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.48
    Marker Score: 626
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.48
    Marker Score: 298
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.47
    Marker Score: 7543
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.46
    Marker Score: 91
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.46
    Marker Score: 28084
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.45
    Marker Score: 120
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.45
    Marker Score: 384
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.45
    Marker Score: 221
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.45
    Marker Score: 113
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.45
    Marker Score: 102
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.45
    Marker Score: 4261
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.44
    Marker Score: 94
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.44
    Marker Score: 411
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.44
    Marker Score: 290
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.43
    Marker Score: 473
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.43
    Marker Score: 1367
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.43
    Marker Score: 94
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.43
    Marker Score: 589
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.43
    Marker Score: 112
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.42
    Marker Score: 414
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.42
    Marker Score: 355
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.42
    Marker Score: 85
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.41
    Marker Score: 205
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.41
    Marker Score: 4191
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.41
    Marker Score: 532
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.41
    Marker Score: 95
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.41
    Marker Score: 92

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Other Information

**Key characteristics:** * ADCY7 is a transmembrane protein that is expressed in the plasma membrane. * It is a member of the ADP-ribosyl cyclase family of enzymes. * It is responsible for the hydrolysis of ATP to ADP, which can then bind to and activate downstream targets. * It is involved in a variety of cellular processes, including water and electrolyte homeostasis, calcium signaling, and inflammation. **Pathways and functions:** * ADCY7 is involved in the regulation of water and electrolyte homeostasis through its interaction with aquaporins. * It is a key regulator of water transport in the brain and other tissues. * It is involved in the regulation of blood pressure and heart rate. * It is also involved in the regulation of inflammation and pain. **Clinical significance:** * Mutations in ADCY7 have been linked to a number of human diseases, including hypertension, heart failure, and stroke. * ADCY7 inhibitors are being investigated as a treatment for these diseases. **Additional information:** * ADCY7 is a highly conserved protein that is found in mammals. * It is expressed in high levels in the brain and other tissues that are involved in water and electrolyte transport. * It is a key regulator of water balance in the body.

Genular Protein ID: 2012471018

Symbol: ADCY7_HUMAN

Name: ATP pyrophosphate-lyase 7

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7584026

Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.

PubMed ID: 7584026

DOI: 10.1093/dnares/1.1.27

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12454008

Title: Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C delta.

PubMed ID: 12454008

DOI: 10.1074/jbc.m210386200

PubMed ID: 15581358

Title: A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase.

PubMed ID: 15581358

DOI: 10.1021/bi049088+

PubMed ID: 18541530

Title: Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII.

PubMed ID: 18541530

DOI: 10.1074/jbc.m803281200

PubMed ID: 23229509

Title: Regions on adenylyl cyclase VII required for selective regulation by the G13 pathway.

PubMed ID: 23229509

DOI: 10.1124/mol.112.082446

PubMed ID: 23842570

Title: Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(betagamma) subunits in human embryonic kidney 293T cells.

PubMed ID: 23842570

DOI: 10.1124/mol.113.087288

Sequence Information:

  • Length: 1080
  • Mass: 120308
  • Checksum: E33951621E281242
  • Sequence:
  • MPAKGRYFLN EGEEGPDQDA LYEKYQLTSQ HGPLLLTLLL VAATACVALI IIAFSQGDPS 
    RHQAILGMAF LVLAVFAALS VLMYVECLLR RWLRALALLT WACLVALGYV LVFDAWTKAA 
    CAWEQVPFFL FIVFVVYTLL PFSMRGAVAV GAVSTASHLL VLGSLMGGFT TPSVRVGLQL 
    LANAVIFLCG NLTGAFHKHQ MQDASRDLFT YTVKCIQIRR KLRIEKRQQE NLLLSVLPAH 
    ISMGMKLAII ERLKEHGDRR CMPDNNFHSL YVKRHQNVSI LYADIVGFTQ LASDCSPKEL 
    VVVLNELFGK FDQIAKANEC MRIKILGDCY YCVSGLPVSL PTHARNCVKM GLDMCQAIKQ 
    VREATGVDIN MRVGIHSGNV LCGVIGLRKW QYDVWSHDVS LANRMEAAGV PGRVHITEAT 
    LKHLDKAYEV EDGHGQQRDP YLKEMNIRTY LVIDPRSQQP PPPSQHLPRP KGDAALKMRA 
    SVRMTRYLES WGAARPFAHL NHRESVSSGE THVPNGRRPK SVPQRHRRTP DRSMSPKGRS 
    EDDSYDDEML SAIEGLSSTR PCCSKSDDFY TFGSIFLEKG FEREYRLAPI PRARHDFACA 
    SLIFVCILLV HVLLMPRTAA LGVSFGLVAC VLGLVLGLCF ATKFSRCCPA RGTLCTISER 
    VETQPLLRLT LAVLTIGSLL TVAIINLPLM PFQVPELPVG NETGLLAASS KTRALCEPLP 
    YYTCSCVLGF IACSVFLRMS LEPKVVLLTV ALVAYLVLFN LSPCWQWDCC GQGLGNLTKP 
    NGTTSGTPSC SWKDLKTMTN FYLVLFYITL LTLSRQIDYY CRLDCLWKKK FKKEHEEFET 
    MENVNRLLLE NVLPAHVAAH FIGDKLNEDW YHQSYDCVCV MFASVPDFKV FYTECDVNKE 
    GLECLRLLNE IIADFDELLL KPKFSGVEKI KTIGSTYMAA AGLSVASGHE NQELERQHAH 
    IGVMVEFSIA LMSKLDGINR HSFNSFRLRV GINHGPVIAG VIGARKPQYD IWGNTVNVAS 
    RMESTGELGK IQVTEETCTI LQGLGYSCEC RGLINVKGKG ELRTYFVCTD TAKFQGLGLN

Genular Protein ID: 1310842098

Symbol: Q86YI0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 433
  • Mass: 48088
  • Checksum: 575A9150E376F013
  • Sequence:
  • MPAKGRYFLN EGEEGPDQDA LYEKYQLTSQ HGPLLLTLLL VAATACVALI IIAFSQGDPS 
    RHQAILGMAF LVLAVFAALS VLMYVECLLR RWLRALALLT WACLVALGYV LVFDAWTKAA 
    CAWEQVPFFL FIVFVVYTLL PFSMRGAVAV GAVSTASHLL VLGSLMGGFT TPSVRVGLQL 
    LANAVIFLCG NLTGAFHKHQ MQDASRDLFT YTVKCIQIRR KLRIEKRQQE NLLLSVLPAH 
    ISMGMKLAII ERLKEHGDRR CMPDNNFHSL YVKRHQNVSI LYADIVGFTQ LASDCSPKEL 
    VVVLNELFGK FDQIAKANEC MRIKILGDCY YCVSGLPVSL PTHARNCVKM GLDMCQAIKQ 
    VREATGVDIN MRVGIHSGNV LCGVIGLRKW QYDVWSHDVS LANRMEAAGV PGRVHITEAT 
    LKHLDEALLL QVR

Genular Protein ID: 389711575

Symbol: F5H4D1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

  • Length: 734
  • Mass: 81478
  • Checksum: F2FA68E3C5F2E504
  • Sequence:
  • MPAKGRYFLN EGEEGPDQDA LYEKYQLTSQ HGPLLLTLLL VAATACVALI IIAFSQGDPS 
    RHQAILGMAF LVLAVFAALS VLMYVECLLR RWLRALALLT WACLVALGYV LVFDAWTKAA 
    CAWEQVPFFL FIVFVVYTLL PFSMRGAVAV GAVSTASHLL VLGSLMGGFT TPSVRVGLQL 
    LANAVIFLCG NLTGAFHKHQ MQDASRDLFT YTVKCIQIRR KLRIEKRQQE NLLLSVLPAH 
    ISMGMKLAII ERLKEHGDRR CMPDNNFHSL YVKRHQNVSI LYADIVGFTQ LASDCSPKEL 
    VVVLNELFGK FDQIAKANEC MRIKILGDCY YCVSGLPVSL PTHARNCVKM GLDMCQAIKQ 
    VREATGVDIN MRVGIHSGNV LCGVIGLRKW QYDVWSHDVS LANRMEAAGV PGRVHITEAT 
    LKHLDKAYEV EDGHGQQRDP YLKEMNIRTY LVIDPRSQQP PPPSQHLPRP KGDAALKMRA 
    SVRMTRYLES WGAARPFAHL NHRESVSSGE THVPNGRRPK SVPQRHRRTP DRSMSPKGRS 
    EDDSYDDEML SAIEGLSSTR PCCSKSDDFY TFGSIFLEKG FEREYRLAPI PRARHDFACA 
    SLIFVCILLV HVLLMPRTAA LGVSFGLVAC VLGLVLGLCF ATKFSRCCPA RGTLCTISER 
    VETQPLLRLT LAVLTIGSLL TVAIINLPLM PFQVPELPVG NETGLLAASS KTRALCEPLP 
    HLHTVFSRLN ELTS

Genular Protein ID: 175877627

Symbol: B3KSJ0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 734
  • Mass: 81497
  • Checksum: ECD6B385B8D416CC
  • Sequence:
  • MPAKGRYFLN EGEEGPDQDA LYEKYQLTSQ HGPLLLTLLL VAATACVALI IIAFSQGDPS 
    RHQAILGMAF LVLAVFAALS VLMYVECLLR RWLRALALLT WACLVALGYV LVFDAWTKAA 
    CAWEQVPFFL FIVFVVYTLL PFSMRGAVAV GAVSTASHLL VLGSLMGGFT TPSVRVGLQL 
    LANAVIFLCG NLTGAFHKHQ MQDASRDLFT YTVKCIQIRR KLRIEKRQQE NLLLSVLPAH 
    ISMGMKLAII ERLKEHGDRR CMPDNNFHSL YVKRHQNVSI LYADIVGFTQ LASDCSPKEL 
    VVVLNELFGK FDQIAKANEC MRIKILGDCY YCVSGLPVSL PTHARNCVKM GLDMCQAIKQ 
    VREATGVDIN MRVGIHSGNV LCGVIGLRKW QYDVWSHDVS LANRMEAAGV PGRVHITEAT 
    LKHLDKAYEV EDGRGQQRDP YLKEMNIRTY LVIDPRSQQP PPPSQHLPRP KGDAALKMRA 
    SVRMTRYLES WGAARPFAHL NHRESVSSGE THVPNGRRPK SVPQRHRRTP DRSMSPKGRS 
    EDDSYDDEML SAIEGLSSTR PCCSKSDDFY TFGSIFLEKG FEREYRLAPI PRARHDFACA 
    SLIFVCILLV HVLLMPRTAA LGVSFGLVAC VLGLVLGLCF ATKFSRCCPA RGTLCTISER 
    VETQPLLRLT LAVLTIGSLL TVAIINLPLM PFQVPELPVG NETGLLAASS KTRALCEPLP 
    HLHTVFSRLN ELTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.