Details for: LYST

Gene ID: 1130

Symbol: LYST

Ensembl ID: ENSG00000143669

Description: lysosomal trafficking regulator

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 363.7527
    Cell Significance Index: -56.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 230.1657
    Cell Significance Index: -58.3800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 128.6212
    Cell Significance Index: -60.7300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 124.9455
    Cell Significance Index: -50.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 110.8313
    Cell Significance Index: -57.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 53.2080
    Cell Significance Index: -50.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 47.7065
    Cell Significance Index: -58.8200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.8932
    Cell Significance Index: -55.9700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 19.9156
    Cell Significance Index: -61.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.9803
    Cell Significance Index: -41.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.1924
    Cell Significance Index: -59.9500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.7632
    Cell Significance Index: 44.8600
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 2.6202
    Cell Significance Index: 3.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.5072
    Cell Significance Index: 502.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.0912
    Cell Significance Index: 79.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.0866
    Cell Significance Index: 140.3100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.0549
    Cell Significance Index: 43.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.0171
    Cell Significance Index: 89.2200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.9900
    Cell Significance Index: 36.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.7856
    Cell Significance Index: 34.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6899
    Cell Significance Index: 606.1500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.6741
    Cell Significance Index: 28.6900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.6231
    Cell Significance Index: 35.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2106
    Cell Significance Index: 240.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9993
    Cell Significance Index: 902.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9969
    Cell Significance Index: 689.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.9948
    Cell Significance Index: 26.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9940
    Cell Significance Index: 115.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8811
    Cell Significance Index: 55.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8808
    Cell Significance Index: 54.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8356
    Cell Significance Index: 64.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5873
    Cell Significance Index: 14.6800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.5047
    Cell Significance Index: 3.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4805
    Cell Significance Index: 59.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4564
    Cell Significance Index: 702.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4310
    Cell Significance Index: 12.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3817
    Cell Significance Index: 718.6700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3673
    Cell Significance Index: 39.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3671
    Cell Significance Index: 233.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3618
    Cell Significance Index: 65.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3295
    Cell Significance Index: 607.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2668
    Cell Significance Index: 26.4000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1739
    Cell Significance Index: 4.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1474
    Cell Significance Index: 8.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1230
    Cell Significance Index: 54.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1203
    Cell Significance Index: 163.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1120
    Cell Significance Index: 61.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1018
    Cell Significance Index: 13.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0960
    Cell Significance Index: 2.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0746
    Cell Significance Index: 2.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0737
    Cell Significance Index: 9.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0560
    Cell Significance Index: 25.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0064
    Cell Significance Index: 0.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0344
    Cell Significance Index: -0.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0365
    Cell Significance Index: -1.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0366
    Cell Significance Index: -1.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0389
    Cell Significance Index: -5.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0422
    Cell Significance Index: -31.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0495
    Cell Significance Index: -2.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0563
    Cell Significance Index: -41.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0573
    Cell Significance Index: -32.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0651
    Cell Significance Index: -40.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0666
    Cell Significance Index: -50.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0831
    Cell Significance Index: -15.8200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0954
    Cell Significance Index: -6.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1416
    Cell Significance Index: -24.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1803
    Cell Significance Index: -51.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1848
    Cell Significance Index: -38.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2206
    Cell Significance Index: -26.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2489
    Cell Significance Index: -32.1600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2588
    Cell Significance Index: -3.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2601
    Cell Significance Index: -26.5700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2834
    Cell Significance Index: -14.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2895
    Cell Significance Index: -7.8800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3129
    Cell Significance Index: -4.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3224
    Cell Significance Index: -24.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3770
    Cell Significance Index: -26.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3829
    Cell Significance Index: -19.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3860
    Cell Significance Index: -40.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4243
    Cell Significance Index: -19.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4269
    Cell Significance Index: -48.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4450
    Cell Significance Index: -31.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4723
    Cell Significance Index: -54.1200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4895
    Cell Significance Index: -7.0300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5076
    Cell Significance Index: -6.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6143
    Cell Significance Index: -15.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6853
    Cell Significance Index: -54.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6930
    Cell Significance Index: -42.4900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7460
    Cell Significance Index: -14.7500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7661
    Cell Significance Index: -16.2600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.7701
    Cell Significance Index: -9.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8648
    Cell Significance Index: -40.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9002
    Cell Significance Index: -28.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9737
    Cell Significance Index: -31.8800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.9738
    Cell Significance Index: -19.5500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.9969
    Cell Significance Index: -9.1800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.0178
    Cell Significance Index: -14.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.0652
    Cell Significance Index: -22.6900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.1308
    Cell Significance Index: -33.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.1374
    Cell Significance Index: -30.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization**: LYST is predominantly expressed in cells of the immune system, including monocytes, macrophages, and dendritic cells, as well as neurons and lens epithelial cells. 2. **Protein binding and trafficking**: LYST interacts with various proteins, including those involved in endosomal and lysosomal trafficking, membrane dynamics, and protein localization. 3. **Regulation of lysosomal function**: LYST modulates lysosomal acidification, membrane dynamics, and degradation processes, influencing the overall cellular environment. 4. **Disease associations**: Mutations in the LYST gene have been linked to several neurodegenerative and autoimmune disorders, including Chédiak-Higashi Syndrome (CHS) and Lysosomal Trafficking Disorder (LTD). **Pathways and Functions:** 1. **Endosomal and lysosomal trafficking**: LYST regulates the movement of endosomes and lysosomes through the cell, influencing the degradation and recycling of cellular components. 2. **Phagocytosis and natural killer cell-mediated cytotoxicity**: LYST is required for the efficient phagocytosis of pathogens and the regulation of natural killer cell-mediated cytotoxicity. 3. **Melanosome organization**: LYST influences the formation and function of melanosomes, the organelles responsible for melanin production and transport. 4. **Protein localization and transport**: LYST regulates the movement and localization of proteins within the cell, including those involved in membrane dynamics and cellular signaling. 5. **Cellular stress response**: LYST plays a role in the cellular response to stress, including the regulation of inflammation and immune responses. **Clinical Significance:** 1. **Neurodegenerative disorders**: Mutations in the LYST gene have been linked to CHS and LTD, two neurodegenerative disorders characterized by impaired lysosomal function and cellular trafficking. 2. **Autoimmune disorders**: Dysregulation of LYST has been implicated in autoimmune disorders, including lupus and rheumatoid arthritis, which may be related to impaired immune cell function and cellular trafficking. 3. **Cancer therapy**: LYST's role in cellular trafficking and protein localization makes it a potential target for cancer therapy, particularly in the context of immunotherapy and targeted therapies. 4. **Immunodeficiency disorders**: Mutations in the LYST gene can lead to impaired immune function, highlighting the gene's importance in maintaining cellular homeostasis and immune system function. In conclusion, the LYST gene is a critical regulator of cellular trafficking and lysosomal function, with far-reaching implications for our understanding of neurodegenerative, autoimmune, and immunodeficiency disorders. Further research into the complexities of LYST will undoubtedly shed light on the intricate mechanisms governing cellular homeostasis and the development of novel therapeutic strategies.

Genular Protein ID: 2059824034

Symbol: LYST_HUMAN

Name: Lysosomal-trafficking regulator

UniProtKB Accession Codes:

Q99698 O43274 Q5T2U9 Q96TD7 Q96TD8 Q99709 Q9H133

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8896560

Title: Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome.

PubMed ID: 8896560

DOI: 10.1038/ng1196-307

PubMed ID: 8717042

Title: Identification of the homologous beige and Chediak-Higashi syndrome genes.

PubMed ID: 8717042

DOI: 10.1038/382262a0

PubMed ID: 9215680

Title: Identification of mutations in two major mRNA isoforms of the Chediak-Higashi syndrome gene in human and mouse.

PubMed ID: 9215680

DOI: 10.1093/hmg/6.7.1091

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 11984006

Title: The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.

PubMed ID: 11984006

DOI: 10.1007/bf03402003

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 11857544

Title: Apparent genotype-phenotype correlation in childhood, adolescent, and adult Chediak-Higashi syndrome.

PubMed ID: 11857544

DOI: 10.1002/ajmg.10184.abs

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25216107

Title: LYST affects lysosome size and quantity, but not trafficking or degradation through autophagy or endocytosis.

PubMed ID: 25216107

DOI: 10.1111/tra.12227

PubMed ID: 25425525

Title: LYST controls the biogenesis of the endosomal compartment required for secretory lysosome function.

PubMed ID: 25425525

DOI: 10.1111/tra.12244

PubMed ID: 26478006

Title: Chediak-Higashi syndrome: Lysosomal trafficking regulator domains regulate exocytosis of lytic granules but not cytokine secretion by natural killer cells.

PubMed ID: 26478006

DOI: 10.1016/j.jaci.2015.08.039

PubMed ID: 27881733

Title: Lysosomal trafficking regulator Lyst links membrane trafficking to toll-like receptor-mediated inflammatory responses.

PubMed ID: 27881733

DOI: 10.1084/jem.20141461

PubMed ID: 20368792

Title: Two novel mutations identified in an african-american child with chediak-higashi syndrome.

PubMed ID: 20368792

DOI: 10.1155/2010/967535

PubMed ID: 24521565

Title: Autosomal-recessive complicated spastic paraplegia with a novel lysosomal trafficking regulator gene mutation.

PubMed ID: 24521565

DOI: 10.1136/jnnp-2013-306981

PubMed ID: 31906877

Title: Identification of a compound heterozygote in LYST gene: a case report on Chediak-Higashi syndrome.

PubMed ID: 31906877

DOI: 10.1186/s12881-019-0922-8

Sequence Information:

  • Length: 3801
  • Mass: 429139
  • Checksum: E11BAB6357059D17
  • Sequence:
    • MSTDSNSLAR EFLTDVNRLC NAVVQRVEAR EEEEEETHMA TLGQYLVHGR GFLLLTKLNS 
IIDQALTCRE ELLTLLLSLL PLVWKIPVQE EKATDFNLPL SADIILTKEK NSSSQRSTQE 
KLHLEGSALS SQVSAKVNVF RKSRRQRKIT HRYSVRDARK TQLSTSDSEA NSDEKGIAMN 
KHRRPHLLHH FLTSFPKQDH PKAKLDRLAT KEQTPPDAMA LENSREIIPR QGSNTDILSE 
PAALSVISNM NNSPFDLCHV LLSLLEKVCK FDVTLNHNSP LAASVVPTLT EFLAGFGDCC 
SLSDNLESRV VSAGWTEEPV ALIQRMLFRT VLHLLSVDVS TAEMMPENLR KNLTELLRAA 
LKIRICLEKQ PDPFAPRQKK TLQEVQEDFV FSKYRHRALL LPELLEGVLQ ILICCLQSAA 
SNPFYFSQAM DLVQEFIQHH GFNLFETAVL QMEWLVLRDG VPPEASEHLK ALINSVMKIM 
STVKKVKSEQ LHHSMCTRKR HRRCEYSHFM HHHRDLSGLL VSAFKNQVSK NPFEETADGD 
VYYPERCCCI AVCAHQCLRL LQQASLSSTC VQILSGVHNI GICCCMDPKS VIIPLLHAFK 
LPALKNFQQH ILNILNKLIL DQLGGAEISP KIKKAACNIC TVDSDQLAQL EETLQGNLCD 
AELSSSLSSP SYRFQGILPS SGSEDLLWKW DALKAYQNFV FEEDRLHSIQ IANHICNLIQ 
KGNIVVQWKL YNYIFNPVLQ RGVELAHHCQ HLSVTSAQSH VCSHHNQCLP QDVLQIYVKT 
LPILLKSRVI RDLFLSCNGV SQIIELNCLN GIRSHSLKAF ETLIISLGEQ QKDASVPDID 
GIDIEQKELS SVHVGTSFHH QQAYSDSPQS LSKFYAGLKE AYPKRRKTVN QDVHINTINL 
FLCVAFLCVS KEAESDRESA NDSEDTSGYD STASEPLSHM LPCISLESLV LPSPEHMHQA 
ADIWSMCRWI YMLSSVFQKQ FYRLGGFRVC HKLIFMIIQK LFRSHKEEQG KKEGDTSVNE 
NQDLNRISQP KRTMKEDLLS LAIKSDPIPS ELGSLKKSAD SLGKLELQHI SSINVEEVSA 
TEAAPEEAKL FTSQESETSL QSIRLLEALL AICLHGARTS QQKMELELPN QNLSVESILF 
EMRDHLSQSK VIETQLAKPL FDALLRVALG NYSADFEHND AMTEKSHQSA EELSSQPGDF 
SEEAEDSQCC SFKLLVEEEG YEADSESNPE DGETQDDGVD LKSETEGFSA SSSPNDLLEN 
LTQGEIIYPE ICMLELNLLS ASKAKLDVLA HVFESFLKII RQKEKNVFLL MQQGTVKNLL 
GGFLSILTQD DSDFQACQRV LVDLLVSLMS SRTCSEELTL LLRIFLEKSP CTKILLLGIL 
KIIESDTTMS PSQYLTFPLL HAPNLSNGVS SQKYPGILNS KAMGLLRRAR VSRSKKEADR 
ESFPHRLLSS WHIAPVHLPL LGQNCWPHLS EGFSVSLWFN VECIHEAEST TEKGKKIKKR 
NKSLILPDSS FDGTESDRPE GAEYINPGER LIEEGCIHII SLGSKALMIQ VWADPHNATL 
IFRVCMDSND DMKAVLLAQV ESQENIFLPS KWQHLVLTYL QQPQGKRRIH GKISIWVSGQ 
RKPDVTLDFM LPRKTSLSSD SNKTFCMIGH CLSSQEEFLQ LAGKWDLGNL LLFNGAKVGS 
QEAFYLYACG PNHTSVMPCK YGKPVNDYSK YINKEILRCE QIRELFMTKK DVDIGLLIES 
LSVVYTTYCP AQYTIYEPVI RLKGQMKTQL SQRPFSSKEV QSILLEPHHL KNLQPTEYKT 
IQGILHEIGG TGIFVFLFAR VVELSSCEET QALALRVILS LIKYNQQRVH ELENCNGLSM 
IHQVLIKQKC IVGFYILKTL LEGCCGEDII YMNENGEFKL DVDSNAIIQD VKLLEELLLD 
WKIWSKAEQG VWETLLAALE VLIRADHHQQ MFNIKQLLKA QVVHHFLLTC QVLQEYKEGQ 
LTPMPREVCR SFVKIIAEVL GSPPDLELLT IIFNFLLAVH PPTNTYVCHN PTNFYFSLHI 
DGKIFQEKVR SIMYLRHSSS GGRSLMSPGF MVISPSGFTA SPYEGENSSN IIPQQMAAHM 
LRSRSLPAFP TSSLLTQSQK LTGSLGCSID RLQNIADTYV ATQSKKQNSL GSSDTLKKGK 
EDAFISSCES AKTVCEMEAV LSAQVSVSDV PKGVLGFPVV KADHKQLGAE PRSEDDSPGD 
ESCPRRPDYL KGLASFQRSH STIASLGLAF PSQNGSAAVG RWPSLVDRNT DDWENFAYSL 
GYEPNYNRTA SAHSVTEDCL VPICCGLYEL LSGVLLILPD VLLEDVMDKL IQADTLLVLV 
NHPSPAIQQG VIKLLDAYFA RASKEQKDKF LKNRGFSLLA NQLYLHRGTQ ELLECFIEMF 
FGRHIGLDEE FDLEDVRNMG LFQKWSVIPI LGLIETSLYD NILLHNALLL LLQILNSCSK 
VADMLLDNGL LYVLCNTVAA LNGLEKNIPM SEYKLLACDI QQLFIAVTIH ACSSSGSQYF 
RVIEDLIVML GYLQNSKNKR TQNMAVALQL RVLQAAMEFI RTTANHDSEN LTDSLQSPSA 
PHHAVVQKRK SIAGPRKFPL AQTESLLMKM RSVANDELHV MMQRRMSQEN PSQATETELA 
QRLQRLTVLA VNRIIYQEFN SDIIDILRTP ENVTQSKTSV FQTEISEENI HHEQSSVFNP 
FQKEIFTYLV EGFKVSIGSS KASGSKQQWT KILWSCKETF RMQLGRLLVH ILSPAHAAQE 
RKQIFEIVHE PNHQEILRDC LSPSLQHGAK LVLYLSELIH NHQGELTEEE LGTAELLMNA 
LKLCGHKCIP PSASTKADLI KMIKEEQKKY ETEEGVNKAA WQKTVNNNQQ SLFQRLDSKS 
KDISKIAADI TQAVSLSQGN ERKKVIQHIR GMYKVDLSAS RHWQELIQQL THDRAVWYDP 
IYYPTSWQLD PTEGPNRERR RLQRCYLTIP NKYLLRDRQK SEDVVKPPLS YLFEDKTHSS 
FSSTVKDKAA SESIRVNRRC ISVAPSRETA GELLLGKCGM YFVEDNASDT VESSSLQGEL 
EPASFSWTYE EIKEVHKRWW QLRDNAVEIF LTNGRTLLLA FDNTKVRDDV YHNILTNNLP 
NLLEYGNITA LTNLWYTGQI TNFEYLTHLN KHAGRSFNDL MQYPVFPFIL ADYVSETLDL 
NDLLIYRNLS KPIAVQYKEK EDRYVDTYKY LEEEYRKGAR EDDPMPPVQP YHYGSHYSNS 
GTVLHFLVRM PPFTKMFLAY QDQSFDIPDR TFHSTNTTWR LSSFESMTDV KELIPEFFYL 
PEFLVNREGF DFGVRQNGER VNHVNLPPWA RNDPRLFILI HRQALESDYV SQNICQWIDL 
VFGYKQKGKA SVQAINVFHP ATYFGMDVSA VEDPVQRRAL ETMIKTYGQT PRQLFHMAHV 
SRPGAKLNIE GELPAAVGLL VQFAFRETRE QVKEITYPSP LSWIKGLKWG EYVGSPSAPV 
PVVCFSQPHG ERFGSLQALP TRAICGLSRN FCLLMTYSKE QGVRSMNSTD IQWSAILSWG 
YADNILRLKS KQSEPPVNFI QSSQQYQVTS CAWVPDSCQL FTGSKCGVIT AYTNRFTSST 
PSEIEMETQI HLYGHTEEIT SLFVCKPYSI LISVSRDGTC IIWDLNRLCY VQSLAGHKSP 
VTAVSASETS GDIATVCDSA GGGSDLRLWT VNGDLVGHVH CREIICSVAF SNQPEGVSIN 
VIAGGLENGI VRLWSTWDLK PVREITFPKS NKPIISLTFS CDGHHLYTAN SDGTVIAWCR 
KDQQRLKQPM FYSFLSSYAA G

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.