Genular: Defining Cellular Identity and Function

Details for: Abcb7

Gene ID: 11306

Symbol: Abcb7

Ensembl ID: ENSMUSG00000031333

Description: ATP-binding cassette, sub-family B member 7

Associated with

Abc-family proteins mediated transport
(R-MMU-382556)
Mitochondrial abc transporters
(R-MMU-1369007)
Transport of small molecules
(R-MMU-382551)
Abc-type iron-sulfur cluster transporter activity
(GO:0140481)
Abc-type transporter activity
(GO:0140359)
Atpase-coupled transmembrane transporter activity
(GO:0042626)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Identical protein binding
(GO:0042802)
Intracellular iron ion homeostasis
(GO:0006879)
Iron-sulfur cluster assembly
(GO:0016226)
Iron-sulfur cluster export from the mitochondrion
(GO:0140466)
Iron ion transmembrane transport
(GO:0034755)
Membrane
(GO:0016020)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrion
(GO:0005739)
Negative regulation of reactive oxygen species biosynthetic process
(GO:1903427)
Nucleotide binding
(GO:0000166)
Positive regulation of heme biosynthetic process
(GO:0070455)
Positive regulation of iron-sulfur cluster assembly
(GO:1903331)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Transmembrane transport
(GO:0055085)

Other Information

Proteins

ATP-binding cassette sub-family B member 7, mitochondrial

Genular Protein ID: 3805371008

Symbol: ABCB7_MOUSE

Name: ATP-binding cassette sub-family B member 7, mitochondrial

UniProtKB Accession Codes:

Q61102 A2AC46 Q3U7S8

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9143506

Title: Isolation and chromosomal mapping of a novel ATP-binding cassette transporter conserved in mouse and human.

PubMed ID: 9143506

DOI: 10.1006/geno.1997.4658

PubMed ID: 16424901

Title: Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster.

PubMed ID: 16424901

DOI: 10.1038/sj.emboj.7600954

PubMed ID: 16467350

Title: The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis.

PubMed ID: 16467350

DOI: 10.1093/hmg/ddl012

PubMed ID: 17192398

Title: Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis.

PubMed ID: 17192398

DOI: 10.1182/blood-2006-04-015768

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23576753

Title: Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

PubMed ID: 23576753

DOI: 10.1073/pnas.1302961110

PubMed ID: 30765471

Title: Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.

PubMed ID: 30765471

DOI: 10.3324/haematol.2018.214320

Sequence Information:

Length: 752
Mass: 82581
Checksum: 79B2BC8A7A07555A
Sequence:

MALLAIHSWR WAAAAVAFEK HKHSAVLTRA LVSMCGSGPR WSSSQRGASG SARLSQTTES 
LRNTTQQRWG KDNSRQLLDA TKALQTWPLI EKRTCWHGHA GGGLHTDPKE GLKDVDTRKI 
IKAMLSYVWP EDRPDLRARV AISLGFLGGA KAMNIVVPFM FKYAVDSLNQ MSGNMLNLSD 
APNTVATMAT AVLIGYGVSR AGAAFFNEVR NAVFGKVAQN SIRRIAKNVF LHLHNLDLGF 
HLSRQTGALS KAIDRGTRGI SFVLSALVFN LLPIVFEMML VSSVLYYKCG AQFALVTLGT 
LGAYTAFTVA VTRWRTRFRI EMNKADNDAG NAAIDSLLNY ETVKYFNNEK YEAQRYDGFL 
KTYETASLKS TSTLAMLNFG QNAIFSVGLT AIMVLASQGI VAGALTVGDL VMVNGLLFQL 
SLPLNFLGTV YRETRQALID MNTLFTLLKV DTRIKDKVMA PPLQITPQTA TVAFDNVHFE 
YIEGQKVLNG VSFEVPAGKK VAIVGGSGSG KSTIVRLLFR FYEPQKGSIY LAGQNLQDVS 
LESLRRAVGV VPQDAVLFHN TIYYNLLYGN INASPEEVYA VAKLAGLHDA ILRMPHGYDT 
QVGERGLKLS GGEKQRVAIA RAILKNPPVI LYDEATSSLD SITEETILGA MRDVVKHRTS 
IFIAHRLSTV VDADEIIVLS QGKVAERGTH YGLLANSSSI YSEMWHTQSN RVQNQDSLGW 
DAKKESLSKE EERKKLQEEI VNSVKGCGNC SC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Abcb7

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation and chromosomal mapping of a novel ATP-binding cassette transporter conserved in mouse and human. PubMed ID: 9143506

Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster. PubMed ID: 16424901

The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis. PubMed ID: 16467350

Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis. PubMed ID: 17192398

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. PubMed ID: 23576753

Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis. PubMed ID: 30765471