Genular: Defining Cellular Identity and Function

Details for: Abcg1

Gene ID: 11307

Symbol: Abcg1

Ensembl ID: ENSMUSG00000024030

Description: ATP binding cassette subfamily G member 1

Associated with

Abc-family proteins mediated transport
(R-MMU-382556)
Abc transporters in lipid homeostasis
(R-MMU-1369062)
Hdl remodeling
(R-MMU-8964058)
Plasma lipoprotein assembly, remodeling, and clearance
(R-MMU-174824)
Plasma lipoprotein remodeling
(R-MMU-8963899)
Transport of small molecules
(R-MMU-382551)
Abc-type sterol transporter activity
(GO:0034041)
Abc-type transporter activity
(GO:0140359)
Adp binding
(GO:0043531)
Amyloid precursor protein catabolic process
(GO:0042987)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cellular response to high density lipoprotein particle stimulus
(GO:0071403)
Cholesterol efflux
(GO:0033344)
Cholesterol homeostasis
(GO:0042632)
Cholesterol metabolic process
(GO:0008203)
Cholesterol transfer activity
(GO:0120020)
Cholesterol transport
(GO:0030301)
Endoplasmic reticulum
(GO:0005783)
Endosome
(GO:0005768)
External side of plasma membrane
(GO:0009897)
Floppase activity
(GO:0140328)
Glycoprotein transport
(GO:0034436)
Golgi apparatus
(GO:0005794)
High-density lipoprotein particle remodeling
(GO:0034375)
Intracellular cholesterol transport
(GO:0032367)
Lipid transport
(GO:0006869)
Low-density lipoprotein particle remodeling
(GO:0034374)
Membrane
(GO:0016020)
Mitochondrion
(GO:0005739)
Negative regulation of lipid storage
(GO:0010888)
Negative regulation of macrophage derived foam cell differentiation
(GO:0010745)
Nucleotide binding
(GO:0000166)
Phosphatidylcholine floppase activity
(GO:0090554)
Phospholipid efflux
(GO:0033700)
Phospholipid homeostasis
(GO:0055091)
Plasma membrane
(GO:0005886)
Positive regulation of amyloid-beta formation
(GO:1902004)
Positive regulation of cholesterol biosynthetic process
(GO:0045542)
Positive regulation of cholesterol efflux
(GO:0010875)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0035774)
Positive regulation of protein secretion
(GO:0050714)
Positive regulation of secretory granule organization
(GO:1904411)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Recycling endosome
(GO:0055037)
Regulation of cholesterol metabolic process
(GO:0090181)
Response to lipid
(GO:0033993)
Reverse cholesterol transport
(GO:0043691)
Toxin transmembrane transporter activity
(GO:0019534)
Transmembrane transport
(GO:0055085)

Other Information

Proteins

ATP-binding cassette transporter 8

Genular Protein ID: 1421203142

Symbol: ABCG1_MOUSE

Name: ATP-binding cassette transporter 8

UniProtKB Accession Codes:

Q64343

Database IDs:

Citations:

PubMed ID: 9034316

Title: Isolation and characterization of a mammalian homolog of the Drosophila white gene.

PubMed ID: 9034316

DOI: 10.1016/s0378-1119(96)00633-6

PubMed ID: 8703120

Title: Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene.

PubMed ID: 8703120

DOI: 10.1007/s003359900203

PubMed ID: 11162488

Title: Genomic sequence and structure of the human ABCG1 (ABC8) gene.

PubMed ID: 11162488

DOI: 10.1006/bbrc.2000.4089

PubMed ID: 10799558

Title: Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols.

PubMed ID: 10799558

DOI: 10.1074/jbc.275.19.14700

PubMed ID: 14668945

Title: Physiological function of ABCG1.

PubMed ID: 14668945

DOI: 10.1358/dnp.2003.16.8.829346

PubMed ID: 12777468

Title: Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR.

PubMed ID: 12777468

DOI: 10.1194/jlr.m300100-jlr200

PubMed ID: 23388354

Title: Characterization of palmitoylation of ATP binding cassette transporter G1: Effect on protein trafficking and function.

PubMed ID: 23388354

DOI: 10.1016/j.bbalip.2013.01.019

Sequence Information:

Length: 666
Mass: 74033
Checksum: EDDC6AFBD43950B6
Sequence:

MACLMAAFSV GTAMNASSYS AAMTEPKSVC VSVDEVVSSN VDEVETDLLN GHLKKVDNNF 
TEAQRFSSLP RRAAVNIEFK DLSYSVPEGP WWKKKGYKTL LKGISGKFNS GELVAIMGPS 
GAGKSTLMNI LAGYRETGMK GAVLINGMPR DLRCFRKVSC YIMQDDMLLP HLTVQEAMMV 
SAHLKLQEKD EGRREMVKEI LTALGLLPCA NTRTGSLSGG QRKRLAIALE LVNNPPVMFF 
DEPTSGLDSA SCFQVVSLMK GLAQGGRSIV CTIHQPSAKL FELFDQLYVL SQGQCVYRGK 
VSNLVPYLRD LGLNCPTYHN PADFVMEVAS GEYGDQNSRL VRAVREGMCD ADYKRDLGGD 
TDVNPFLWHR PAEEDSASME GCHSFSASCL TQFCILFKRT FLSIMRDSVL THLRITSHIG 
IGLLIGLLYL GIGNEAKKVL SNSGFLFFSM LFLMFAALMP TVLTFPLEMS VFLREHLNYW 
YSLKAYYLAK TMADVPFQIM FPVAYCSIVY WMTSQPSDAV RFVLFAALGT MTSLVAQSLG 
LLIGAASTSL QVATFVGPVT AIPVLLFSGF FVSFDTIPAY LQWMSYISYV RYGFEGVILS 
IYGLDREDLH CDIAETCHFQ KSEAILRELD VENAKLYLDF IVLGIFFISL RLIAYFVLRY 
KIRAER

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Abcg1

Associated with

Other Information

Isolation and characterization of a mammalian homolog of the Drosophila white gene. PubMed ID: 9034316

Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene. PubMed ID: 8703120

Genomic sequence and structure of the human ABCG1 (ABC8) gene. PubMed ID: 11162488

Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols. PubMed ID: 10799558

Physiological function of ABCG1. PubMed ID: 14668945

Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR. PubMed ID: 12777468

Characterization of palmitoylation of ATP binding cassette transporter G1: Effect on protein trafficking and function. PubMed ID: 23388354