Details for: SLCO2B1

Gene ID: 11309

Symbol: SLCO2B1

Ensembl ID: ENSG00000137491

Description: solute carrier organic anion transporter family member 2B1

Associated with

Other Information

Genular Protein ID: 1659690833

Symbol: SO2B1_HUMAN

Name: Solute carrier organic anion transporter family member 2B1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10873595

Title: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.

PubMed ID: 10873595

DOI: 10.1006/bbrc.2000.2922

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11159893

Title: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver.

PubMed ID: 11159893

DOI: 10.1053/gast.2001.21176

PubMed ID: 11932330

Title: Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta.

PubMed ID: 11932330

DOI: 10.1210/jcem.87.4.8431

PubMed ID: 12409283

Title: Characterization and identification of steroid sulfate transporters of human placenta.

PubMed ID: 12409283

DOI: 10.1152/ajpendo.00257.2002

PubMed ID: 12724351

Title: Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane.

PubMed ID: 12724351

DOI: 10.1124/jpet.103.051300

PubMed ID: 14610227

Title: Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human.

PubMed ID: 14610227

DOI: 10.1124/jpet.103.060194

PubMed ID: 16908597

Title: Modification of OATP2B1-mediated transport by steroid hormones.

PubMed ID: 16908597

DOI: 10.1124/mol.106.026450

PubMed ID: 16754786

Title: Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1.

PubMed ID: 16754786

DOI: 10.1124/mol.105.019547

PubMed ID: 18501590

Title: Functional differences in steroid sulfate uptake of organic anion transporter 4 (OAT4) and organic anion transporting polypeptide 2B1 (OATP2B1) in human placenta.

PubMed ID: 18501590

DOI: 10.1016/j.jsbmb.2008.04.001

PubMed ID: 19129463

Title: Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters.

PubMed ID: 19129463

DOI: 10.1152/ajpcell.00436.2008

PubMed ID: 20507927

Title: pH dependence of organic anion-transporting polypeptide 2B1 in Caco-2 cells: potential role in antiretroviral drug oral bioavailability and drug-drug interactions.

PubMed ID: 20507927

DOI: 10.1124/jpet.110.166314

PubMed ID: 22201122

Title: Functional pleiotropy of organic anion transporting polypeptide OATP2B1 due to multiple binding sites.

PubMed ID: 22201122

DOI: 10.2133/dmpk.dmpk-11-sh-080

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23531488

Title: Transport function and transcriptional regulation of a liver-enriched human organic anion transporting polypeptide 2B1 transcriptional start site variant.

PubMed ID: 23531488

DOI: 10.1124/mol.112.083618

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26277985

Title: Glutamate cycling may drive organic anion transport on the basal membrane of human placental syncytiotrophoblast.

PubMed ID: 26277985

DOI: 10.1113/jp270743

PubMed ID: 25132355

Title: Differential cellular expression of organic anion transporting peptides OATP1A2 and OATP2B1 in the human retina and brain: implications for carrier-mediated transport of neuropeptides and neurosteriods in the CNS.

PubMed ID: 25132355

DOI: 10.1007/s00424-014-1596-x

Title: Molecular localization and characterization of multiple binding sites of organic anion transporting polypeptide 2B1 (OATP2B1) as the mechanism for substrate and modulator dependent drug-drug interaction.

DOI: 10.1039/C6MD00235H

PubMed ID: 27576593

Title: Tryptophan Residue Located at the Middle of Putative Transmembrane Domain 11 Is Critical for the Function of Organic Anion Transporting Polypeptide 2B1.

PubMed ID: 27576593

DOI: 10.1021/acs.molpharmaceut.6b00648

PubMed ID: 26383540

Title: Organic anion transporting polypeptide (OATP)-mediated transport of coproporphyrins I and III.

PubMed ID: 26383540

DOI: 10.3109/00498254.2015.1085111

PubMed ID: 28408210

Title: The Organic Anion-Transporting Peptide 2B1 Is Localized in the Basolateral Membrane of the Human Jejunum and Caco-2 Monolayers.

PubMed ID: 28408210

DOI: 10.1016/j.xphs.2017.04.001

PubMed ID: 29871943

Title: Transmembrane Domain 1 of Human Organic Anion Transporting Polypeptide 2B1 Is Essential for Transporter Function and Stability.

PubMed ID: 29871943

DOI: 10.1124/mol.118.111914

PubMed ID: 34628357

Title: Differences in transport function of the human and rat orthologue of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1).

PubMed ID: 34628357

DOI: 10.1016/j.dmpk.2021.100418

PubMed ID: 35307651

Title: Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.

PubMed ID: 35307651

DOI: 10.1124/dmd.121.000748

PubMed ID: 35714613

Title: Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability.

PubMed ID: 35714613

DOI: 10.1016/j.molcel.2022.05.024

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 709
  • Mass: 76699
  • Checksum: 61087C5E00F86D04
  • Sequence:
  • MGPRIGPAGE VPQVPDKETK ATMGTENTPG GKASPDPQDV RPSVFHNIKL FVLCHSLLQL 
    AQLMISGYLK SSISTVEKRF GLSSQTSGLL ASFNEVGNTA LIVFVSYFGS RVHRPRMIGY 
    GAILVALAGL LMTLPHFISE PYRYDNTSPE DMPQDFKASL CLPTTSAPAS APSNGNCSSY 
    TETQHLSVVG IMFVAQTLLG VGGVPIQPFG ISYIDDFAHN SNSPLYLGIL FAVTMMGPGL 
    AFGLGSLMLR LYVDINQMPE GGISLTIKDP RWVGAWWLGF LIAAGAVALA AIPYFFFPKE 
    MPKEKRELQF RRKVLAVTDS PARKGKDSPS KQSPGESTKK QDGLVQIAPN LTVIQFIKVF 
    PRVLLQTLRH PIFLLVVLSQ VCLSSMAAGM ATFLPKFLER QFSITASYAN LLIGCLSFPS 
    VIVGIVVGGV LVKRLHLGPV GCGALCLLGM LLCLFFSLPL FFIGCSSHQI AGITHQTSAH 
    PGLELSPSCM EACSCPLDGF NPVCDPSTRV EYITPCHAGC SSWVVQDALD NSQVFYTNCS 
    CVVEGNPVLA GSCDSTCSHL VVPFLLLVSL GSALACLTHT PSFMLILRGV KKEDKTLAVG 
    IQFMFLRILA WMPSPVIHGS AIDTTCVHWA LSCGRRAVCR YYNNDLLRNR FIGLQFFFKT 
    GSVICFALVL AVLRQQDKEA RTKESRSSPA VEQQLLVSGP GKKPEDSRV

Genular Protein ID: 1696534060

Symbol: A0A0A0MTF1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 565
  • Mass: 61165
  • Checksum: ABDA6585DF53034F
  • Sequence:
  • MGPRIEDMPQ DFKASLCLPT TSAPASAPSN GNCSSYTETQ HLSVVGIMFV AQTLLGVGGV 
    PIQPFGISYI DDFAHNSNSP LYLGILFAVT MMGPGLAFGL GSLMLRLYVD INQMPEGGIS 
    LTIKDPRWVG AWWLGFLIAA GAVALAAIPY FFFPKEMPKE KRELQFRRKV LAVTDSPARK 
    GKDSPSKQSP GESTKKQDGL VQIAPNLTVI QFIKVFPRVL LQTLRHPIFL LVVLSQVCLS 
    SMAAGMATFL PKFLERQFSI TASYANLLIG CLSFPSVIVG IVVGGVLVKR LHLGPVGCGA 
    LCLLGMLLCL FFSLPLFFIG CSSHQIAGIT HQTSAHPGLE LSPSCMEACS CPLDGFNPVC 
    DPSTRVEYIT PCHAGCSSWV VQDALDNSQV FYTNCSCVVE GNPVLAGSCD STCSHLVVPF 
    LLLVSLGSAL ACLTHTPSFM LILRGVKKED KTLAVGIQFM FLRILAWMPS PVIHGSAIDT 
    TCVHWALSCG RRAVCRYYNN DLLRNRFIGL QFFFKTGSVI CFALVLAVLR QQDKEARTKE 
    SRSSPAVEQQ LLVSGPGKKP EDSRV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.