CHRM3 | ENSG00000133019 | NCBI 1131

Details for: CHRM3

Gene ID: 1131

Symbol: CHRM3

Ensembl ID: ENSG00000133019

Description: cholinergic receptor muscarinic 3

Associated with

Acetylcholine regulates insulin secretion
(R-HSA-399997)
Amine ligand-binding receptors
(R-HSA-375280)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Integration of energy metabolism
(R-HSA-163685)
Metabolism
(R-HSA-1430728)
Muscarinic acetylcholine receptors
(R-HSA-390648)
Regulation of insulin secretion
(R-HSA-422356)
Signaling by gpcr
(R-HSA-372790)
Acetylcholine binding
(GO:0042166)
Acetylcholine receptor signaling pathway
(GO:0095500)
Adenylate cyclase-inhibiting g protein-coupled acetylcholine receptor signaling pathway
(GO:0007197)
Basal plasma membrane
(GO:0009925)
Basolateral plasma membrane
(GO:0016323)
Calcium-mediated signaling
(GO:0019722)
Chemical synaptic transmission
(GO:0007268)
Dendrite
(GO:0030425)
Endoplasmic reticulum membrane
(GO:0005789)
G protein-coupled acetylcholine receptor activity
(GO:0016907)
G protein-coupled acetylcholine receptor signaling pathway
(GO:0007213)
G protein-coupled receptor signaling pathway
(GO:0007186)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
(GO:0007187)
G protein-coupled serotonin receptor activity
(GO:0004993)
G protein-coupled serotonin receptor signaling pathway
(GO:0098664)
Ion channel modulating, g protein-coupled receptor signaling pathway
(GO:0099105)
Ligand-gated ion channel signaling pathway
(GO:1990806)
Nervous system development
(GO:0007399)
Phosphatidylinositol phospholipase c activity
(GO:0004435)
Phospholipase c-activating g protein-coupled acetylcholine receptor signaling pathway
(GO:0007207)
Plasma membrane
(GO:0005886)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of smooth muscle contraction
(GO:0045987)
Postsynaptic membrane
(GO:0045211)
Protein binding
(GO:0005515)
Protein modification process
(GO:0036211)
Regulation of monoatomic ion transmembrane transporter activity
(GO:0032412)
Regulation of vascular associated smooth muscle contraction
(GO:0003056)
Saliva secretion
(GO:0046541)
Signaling receptor activity
(GO:0038023)
Signal transduction
(GO:0007165)
Smooth muscle contraction
(GO:0006939)
Synapse
(GO:0045202)
Synaptic transmission, cholinergic
(GO:0007271)

Other Information

Proteins

Muscarinic acetylcholine receptor M3

Genular Protein ID: 226173587

Symbol: ACM3_HUMAN

Name: Muscarinic acetylcholine receptor M3

UniProtKB Accession Codes:

P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60

Database IDs:

Citations:

PubMed ID: 3443095

Title: Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

PubMed ID: 3443095

DOI: 10.1002/j.1460-2075.1987.tb02733.x

PubMed ID: 3272174

Title: Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes.

PubMed ID: 3272174

DOI: 10.1016/0896-6273(88)90190-0

PubMed ID: 15014171

Title: Human-specific amino acid changes found in 103 protein-coding genes.

PubMed ID: 15014171

DOI: 10.1093/molbev/msh100

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11238933

Title: Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes.

PubMed ID: 11238933

DOI: 10.1128/mcb.21.6.1973-1985.2001

PubMed ID: 7565628

Title: Mutation of carboxyl-terminal threonine residues in human M3 muscarinic acetylcholine receptor modulates the extent of sequestration and desensitization.

PubMed ID: 7565628

PubMed ID: 22077972

Title: Muscarinic acetylcholine receptor M3 mutation causes urinary bladder disease and a prune-belly-like syndrome.

PubMed ID: 22077972

DOI: 10.1016/j.ajhg.2011.10.007

PubMed ID: 21056967

Title: Regulation of M(3) muscarinic receptor expression and function by transmembrane protein 147.

PubMed ID: 21056967

DOI: 10.1124/mol.110.067363

PubMed ID: 23521066

Title: The muscarinic M3 acetylcholine receptor exists as two differently sized complexes at the plasma membrane.

PubMed ID: 23521066

DOI: 10.1042/bj20121902

PubMed ID: 15870063

Title: Identification and structural determination of the M(3) muscarinic acetylcholine receptor basolateral sorting signal.

PubMed ID: 15870063

DOI: 10.1074/jbc.m501264200

Sequence Information:

Length: 590
Mass: 66128
Checksum: 5CB473C57B9526E9
Sequence:

MTLHNNSTTS PLFPNISSSW IHSPSDAGLP PGTVTHFGSY NVSRAAGNFS SPDGTTDDPL 
GGHTVWQVVF IAFLTGILAL VTIIGNILVI VSFKVNKQLK TVNNYFLLSL ACADLIIGVI 
SMNLFTTYII MNRWALGNLA CDLWLAIDYV ASNASVMNLL VISFDRYFSI TRPLTYRAKR 
TTKRAGVMIG LAWVISFVLW APAILFWQYF VGKRTVPPGE CFIQFLSEPT ITFGTAIAAF 
YMPVTIMTIL YWRIYKETEK RTKELAGLQA SGTEAETENF VHPTGSSRSC SSYELQQQSM 
KRSNRRKYGR CHFWFTTKSW KPSSEQMDQD HSSSDSWNNN DAAASLENSA SSDEEDIGSE 
TRAIYSIVLK LPGHSTILNS TKLPSSDNLQ VPEEELGMVD LERKADKLQA QKSVDDGGSF 
PKSFSKLPIQ LESAVDTAKT SDVNSSVGKS TATLPLSFKE ATLAKRFALK TRSQITKRKR 
MSLVKEKKAA QTLSAILLAF IITWTPYNIM VLVNTFCDSC IPKTFWNLGY WLCYINSTVN 
PVCYALCNKT FRTTFKMLLL CQCDKKKRRK QQYQQRQSVI FHKRAPEQAL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CHRM3

Associated with

Other Information

Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. PubMed ID: 3443095

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. PubMed ID: 3272174

Human-specific amino acid changes found in 103 protein-coding genes. PubMed ID: 15014171

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes. PubMed ID: 11238933

Mutation of carboxyl-terminal threonine residues in human M3 muscarinic acetylcholine receptor modulates the extent of sequestration and desensitization. PubMed ID: 7565628

Muscarinic acetylcholine receptor M3 mutation causes urinary bladder disease and a prune-belly-like syndrome. PubMed ID: 22077972

Regulation of M(3) muscarinic receptor expression and function by transmembrane protein 147. PubMed ID: 21056967

The muscarinic M3 acetylcholine receptor exists as two differently sized complexes at the plasma membrane. PubMed ID: 23521066

Identification and structural determination of the M(3) muscarinic acetylcholine receptor basolateral sorting signal. PubMed ID: 15870063