Details for: CHRM3

Gene ID: 1131

Symbol: CHRM3

Ensembl ID: ENSG00000133019

Description: cholinergic receptor muscarinic 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 243.5947
    Cell Significance Index: -37.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 141.2613
    Cell Significance Index: -35.8300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 78.9155
    Cell Significance Index: -32.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.7148
    Cell Significance Index: -37.8700
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 16.5393
    Cell Significance Index: 11.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 12.2039
    Cell Significance Index: 5538.9600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 6.4541
    Cell Significance Index: 184.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 6.0245
    Cell Significance Index: 2160.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 5.9637
    Cell Significance Index: 263.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 5.6006
    Cell Significance Index: 583.1600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 5.3607
    Cell Significance Index: 71.5100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 4.5765
    Cell Significance Index: 59.3500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 4.4493
    Cell Significance Index: 95.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.5320
    Cell Significance Index: 708.5200
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 2.3698
    Cell Significance Index: 24.5500
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.3455
    Cell Significance Index: 17.9900
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 2.1025
    Cell Significance Index: 21.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8969
    Cell Significance Index: 25.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.8346
    Cell Significance Index: 45.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3306
    Cell Significance Index: 920.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0664
    Cell Significance Index: 40.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0431
    Cell Significance Index: 30.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9218
    Cell Significance Index: 19.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8975
    Cell Significance Index: 810.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7918
    Cell Significance Index: 35.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7367
    Cell Significance Index: 45.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7108
    Cell Significance Index: 77.3100
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.7097
    Cell Significance Index: 7.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6514
    Cell Significance Index: 30.3700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6270
    Cell Significance Index: 9.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4837
    Cell Significance Index: 47.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2676
    Cell Significance Index: 50.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2555
    Cell Significance Index: 17.6700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2547
    Cell Significance Index: 3.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2381
    Cell Significance Index: 40.6600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2316
    Cell Significance Index: 5.5600
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.1313
    Cell Significance Index: 1.3900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0857
    Cell Significance Index: 1.7200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0627
    Cell Significance Index: 1.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0553
    Cell Significance Index: 35.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0026
    Cell Significance Index: -3.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0039
    Cell Significance Index: -2.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0046
    Cell Significance Index: -8.6800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0053
    Cell Significance Index: -0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0105
    Cell Significance Index: -19.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0135
    Cell Significance Index: -20.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0224
    Cell Significance Index: -16.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0270
    Cell Significance Index: -0.9500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0272
    Cell Significance Index: -0.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0331
    Cell Significance Index: -18.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0338
    Cell Significance Index: -0.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0401
    Cell Significance Index: -7.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0409
    Cell Significance Index: -22.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0463
    Cell Significance Index: -35.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0471
    Cell Significance Index: -34.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0870
    Cell Significance Index: -15.6900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0973
    Cell Significance Index: -1.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1039
    Cell Significance Index: -15.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1105
    Cell Significance Index: -31.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1128
    Cell Significance Index: -23.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1148
    Cell Significance Index: -3.7600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1652
    Cell Significance Index: -2.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1904
    Cell Significance Index: -3.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1932
    Cell Significance Index: -12.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2003
    Cell Significance Index: -23.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2007
    Cell Significance Index: -5.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2196
    Cell Significance Index: -30.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2203
    Cell Significance Index: -27.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2440
    Cell Significance Index: -7.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2482
    Cell Significance Index: -32.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2691
    Cell Significance Index: -14.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2737
    Cell Significance Index: -31.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2881
    Cell Significance Index: -36.9300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3177
    Cell Significance Index: -36.2700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3510
    Cell Significance Index: -7.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3551
    Cell Significance Index: -36.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3594
    Cell Significance Index: -11.5100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3780
    Cell Significance Index: -4.7700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3851
    Cell Significance Index: -8.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3879
    Cell Significance Index: -23.7800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4330
    Cell Significance Index: -5.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4366
    Cell Significance Index: -11.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4515
    Cell Significance Index: -35.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4579
    Cell Significance Index: -35.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4741
    Cell Significance Index: -22.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4966
    Cell Significance Index: -37.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5139
    Cell Significance Index: -28.8400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.5360
    Cell Significance Index: -6.4100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.5477
    Cell Significance Index: -10.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5819
    Cell Significance Index: -30.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5834
    Cell Significance Index: -37.6400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5846
    Cell Significance Index: -20.4800
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -0.6044
    Cell Significance Index: -4.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6219
    Cell Significance Index: -39.2000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.6385
    Cell Significance Index: -5.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6475
    Cell Significance Index: -17.2900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.6520
    Cell Significance Index: -6.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6689
    Cell Significance Index: -34.7500
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.7077
    Cell Significance Index: -14.7600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.7462
    Cell Significance Index: -7.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The CHRM3 gene is located on chromosome 11q13.1 and consists of 15 exons, encoding a 509-amino acid protein. The M3 receptor is a G protein-coupled receptor that responds to acetylcholine, the primary neurotransmitter released by the parasympathetic nervous system. The receptor is characterized by its high affinity for acetylcholine and its ability to activate various signaling pathways, including adenylate cyclase-inhibiting pathways, phospholipase C-activating pathways, and calcium-mediated signaling. **Pathways and Functions:** The CHRM3 receptor is involved in numerous physiological processes, including: 1. **Acetylcholine binding and signaling**: The M3 receptor binds to acetylcholine, triggering a cascade of signaling events that modulate various cellular processes, including insulin secretion, smooth muscle contraction, and salivary gland function. 2. **Insulin secretion regulation**: The M3 receptor is activated by acetylcholine, leading to the release of insulin from pancreatic beta cells, thereby regulating glucose metabolism. 3. **Smooth muscle contraction**: The M3 receptor stimulates the contraction of smooth muscle cells, including those found in the sphincter of the pupil and blood vessels, modulating blood pressure and blood flow. 4. **Saliva secretion regulation**: The M3 receptor is involved in regulating salivary gland function, influencing the production and secretion of saliva in response to stimuli. 5. **Neurotransmission and synaptic transmission**: The M3 receptor plays a crucial role in neurotransmission, modulating the release of neurotransmitters and influencing synaptic plasticity. **Clinical Significance:** Dysregulation of the CHRM3 receptor has been implicated in various diseases, including: 1. **Asthma**: Overexpression of the M3 receptor has been linked to increased airway responsiveness and inflammation in asthma. 2. **Diabetes**: Alterations in M3 receptor function have been associated with impaired insulin secretion and glucose metabolism in diabetes. 3. **Neurodegenerative diseases**: The M3 receptor has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Cancer**: The M3 receptor has been shown to play a role in cancer progression, including tumor growth and metastasis. In conclusion, the CHRM3 gene and its product, the muscarinic acetylcholine receptor M3, are complex molecules with far-reaching implications in human health and disease. Further research into the mechanisms of action and clinical significance of this receptor is essential for the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 226173587

Symbol: ACM3_HUMAN

Name: Muscarinic acetylcholine receptor M3

UniProtKB Accession Codes:

P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 88 DrugCentral 1 EMBL 8 EMDB 4 Ensembl 5 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 20 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3443095

Title: Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

PubMed ID: 3443095

DOI: 10.1002/j.1460-2075.1987.tb02733.x

PubMed ID: 3272174

Title: Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes.

PubMed ID: 3272174

DOI: 10.1016/0896-6273(88)90190-0

PubMed ID: 15014171

Title: Human-specific amino acid changes found in 103 protein-coding genes.

PubMed ID: 15014171

DOI: 10.1093/molbev/msh100

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11238933

Title: Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes.

PubMed ID: 11238933

DOI: 10.1128/mcb.21.6.1973-1985.2001

PubMed ID: 7565628

Title: Mutation of carboxyl-terminal threonine residues in human M3 muscarinic acetylcholine receptor modulates the extent of sequestration and desensitization.

PubMed ID: 7565628

PubMed ID: 22077972

Title: Muscarinic acetylcholine receptor M3 mutation causes urinary bladder disease and a prune-belly-like syndrome.

PubMed ID: 22077972

DOI: 10.1016/j.ajhg.2011.10.007

PubMed ID: 21056967

Title: Regulation of M(3) muscarinic receptor expression and function by transmembrane protein 147.

PubMed ID: 21056967

DOI: 10.1124/mol.110.067363

PubMed ID: 23521066

Title: The muscarinic M3 acetylcholine receptor exists as two differently sized complexes at the plasma membrane.

PubMed ID: 23521066

DOI: 10.1042/bj20121902

PubMed ID: 15870063

Title: Identification and structural determination of the M(3) muscarinic acetylcholine receptor basolateral sorting signal.

PubMed ID: 15870063

DOI: 10.1074/jbc.m501264200

Sequence Information:

  • Length: 590
  • Mass: 66128
  • Checksum: 5CB473C57B9526E9
  • Sequence:
    • MTLHNNSTTS PLFPNISSSW IHSPSDAGLP PGTVTHFGSY NVSRAAGNFS SPDGTTDDPL 
GGHTVWQVVF IAFLTGILAL VTIIGNILVI VSFKVNKQLK TVNNYFLLSL ACADLIIGVI 
SMNLFTTYII MNRWALGNLA CDLWLAIDYV ASNASVMNLL VISFDRYFSI TRPLTYRAKR 
TTKRAGVMIG LAWVISFVLW APAILFWQYF VGKRTVPPGE CFIQFLSEPT ITFGTAIAAF 
YMPVTIMTIL YWRIYKETEK RTKELAGLQA SGTEAETENF VHPTGSSRSC SSYELQQQSM 
KRSNRRKYGR CHFWFTTKSW KPSSEQMDQD HSSSDSWNNN DAAASLENSA SSDEEDIGSE 
TRAIYSIVLK LPGHSTILNS TKLPSSDNLQ VPEEELGMVD LERKADKLQA QKSVDDGGSF 
PKSFSKLPIQ LESAVDTAKT SDVNSSVGKS TATLPLSFKE ATLAKRFALK TRSQITKRKR 
MSLVKEKKAA QTLSAILLAF IITWTPYNIM VLVNTFCDSC IPKTFWNLGY WLCYINSTVN 
PVCYALCNKT FRTTFKMLLL CQCDKKKRRK QQYQQRQSVI FHKRAPEQAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.