Details for: CHRM3

Gene ID: 1131

Symbol: CHRM3

Ensembl ID: ENSG00000133019

Description: cholinergic receptor muscarinic 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.73
    Marker Score: 25,401
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3.93
    Marker Score: 20,603
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.81
    Marker Score: 8,357
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 3.37
    Marker Score: 7,739
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.26
    Marker Score: 24,616
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 3.13
    Marker Score: 1,122
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.89
    Marker Score: 913
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.87
    Marker Score: 57,078
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.8
    Marker Score: 1,078
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.79
    Marker Score: 21,404
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.73
    Marker Score: 103,600
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.56
    Marker Score: 4,298
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.5
    Marker Score: 11,557
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.41
    Marker Score: 36,041
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.33
    Marker Score: 9,002
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.22
    Marker Score: 1,289
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.06
    Marker Score: 126,902
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18,309
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.87
    Marker Score: 7,738
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.78
    Marker Score: 4,062
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.73
    Marker Score: 14,825
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.72
    Marker Score: 7,166
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.72
    Marker Score: 1,323
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.62
    Marker Score: 2,499
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.61
    Marker Score: 3,267
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.58
    Marker Score: 495
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.48
    Marker Score: 832
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,237
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.46
    Marker Score: 3,441
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.44
    Marker Score: 5,879
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.44
    Marker Score: 1,794
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.35
    Marker Score: 565
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.34
    Marker Score: 804
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.31
    Marker Score: 48,259
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.18
    Marker Score: 480
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.14
    Marker Score: 1,308
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.12
    Marker Score: 1,577
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.1
    Marker Score: 370
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.1
    Marker Score: 2,582
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.06
    Marker Score: 749
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.05
    Marker Score: 2,226
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.02
    Marker Score: 488
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.01
    Marker Score: 1,835
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,793
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,018
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.97
    Marker Score: 578
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.95
    Marker Score: 20,328
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.95
    Marker Score: 14,833
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.9
    Marker Score: 1,578
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.9
    Marker Score: 443
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,110
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.88
    Marker Score: 370
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.88
    Marker Score: 1,431
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.87
    Marker Score: 238
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,279
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.85
    Marker Score: 8,816
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.85
    Marker Score: 1,204
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 630
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.82
    Marker Score: 7,700
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.81
    Marker Score: 387
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 325
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.78
    Marker Score: 731
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.76
    Marker Score: 177
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.76
    Marker Score: 2,160
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3,141
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.75
    Marker Score: 2,510
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 661
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.71
    Marker Score: 929
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.71
    Marker Score: 269
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.7
    Marker Score: 341
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.7
    Marker Score: 178
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.7
    Marker Score: 574
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.69
    Marker Score: 1,557
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.68
    Marker Score: 838
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.68
    Marker Score: 6,845
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.65
    Marker Score: 169
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 422
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.63
    Marker Score: 556
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.62
    Marker Score: 701
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.61
    Marker Score: 196
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.61
    Marker Score: 175
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.6
    Marker Score: 352
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.6
    Marker Score: 1,027
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.6
    Marker Score: 392
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.59
    Marker Score: 205
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 378
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.58
    Marker Score: 418
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.58
    Marker Score: 365
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.57
    Marker Score: 689
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.57
    Marker Score: 522
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.57
    Marker Score: 5,687
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The CHRM3 gene is located on chromosome 11q13.1 and consists of 15 exons, encoding a 509-amino acid protein. The M3 receptor is a G protein-coupled receptor that responds to acetylcholine, the primary neurotransmitter released by the parasympathetic nervous system. The receptor is characterized by its high affinity for acetylcholine and its ability to activate various signaling pathways, including adenylate cyclase-inhibiting pathways, phospholipase C-activating pathways, and calcium-mediated signaling. **Pathways and Functions:** The CHRM3 receptor is involved in numerous physiological processes, including: 1. **Acetylcholine binding and signaling**: The M3 receptor binds to acetylcholine, triggering a cascade of signaling events that modulate various cellular processes, including insulin secretion, smooth muscle contraction, and salivary gland function. 2. **Insulin secretion regulation**: The M3 receptor is activated by acetylcholine, leading to the release of insulin from pancreatic beta cells, thereby regulating glucose metabolism. 3. **Smooth muscle contraction**: The M3 receptor stimulates the contraction of smooth muscle cells, including those found in the sphincter of the pupil and blood vessels, modulating blood pressure and blood flow. 4. **Saliva secretion regulation**: The M3 receptor is involved in regulating salivary gland function, influencing the production and secretion of saliva in response to stimuli. 5. **Neurotransmission and synaptic transmission**: The M3 receptor plays a crucial role in neurotransmission, modulating the release of neurotransmitters and influencing synaptic plasticity. **Clinical Significance:** Dysregulation of the CHRM3 receptor has been implicated in various diseases, including: 1. **Asthma**: Overexpression of the M3 receptor has been linked to increased airway responsiveness and inflammation in asthma. 2. **Diabetes**: Alterations in M3 receptor function have been associated with impaired insulin secretion and glucose metabolism in diabetes. 3. **Neurodegenerative diseases**: The M3 receptor has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Cancer**: The M3 receptor has been shown to play a role in cancer progression, including tumor growth and metastasis. In conclusion, the CHRM3 gene and its product, the muscarinic acetylcholine receptor M3, are complex molecules with far-reaching implications in human health and disease. Further research into the mechanisms of action and clinical significance of this receptor is essential for the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 226173587

Symbol: ACM3_HUMAN

Name: Muscarinic acetylcholine receptor M3

UniProtKB Accession Codes:

P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 88 DrugCentral 1 EMBL 8 EMDB 4 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 5 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 20 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3443095

Title: Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

PubMed ID: 3443095

DOI: 10.1002/j.1460-2075.1987.tb02733.x

PubMed ID: 3272174

Title: Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes.

PubMed ID: 3272174

DOI: 10.1016/0896-6273(88)90190-0

PubMed ID: 15014171

Title: Human-specific amino acid changes found in 103 protein-coding genes.

PubMed ID: 15014171

DOI: 10.1093/molbev/msh100

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11238933

Title: Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes.

PubMed ID: 11238933

DOI: 10.1128/mcb.21.6.1973-1985.2001

PubMed ID: 7565628

Title: Mutation of carboxyl-terminal threonine residues in human M3 muscarinic acetylcholine receptor modulates the extent of sequestration and desensitization.

PubMed ID: 7565628

PubMed ID: 22077972

Title: Muscarinic acetylcholine receptor M3 mutation causes urinary bladder disease and a prune-belly-like syndrome.

PubMed ID: 22077972

DOI: 10.1016/j.ajhg.2011.10.007

PubMed ID: 21056967

Title: Regulation of M(3) muscarinic receptor expression and function by transmembrane protein 147.

PubMed ID: 21056967

DOI: 10.1124/mol.110.067363

PubMed ID: 23521066

Title: The muscarinic M3 acetylcholine receptor exists as two differently sized complexes at the plasma membrane.

PubMed ID: 23521066

DOI: 10.1042/bj20121902

PubMed ID: 15870063

Title: Identification and structural determination of the M(3) muscarinic acetylcholine receptor basolateral sorting signal.

PubMed ID: 15870063

DOI: 10.1074/jbc.m501264200

Sequence Information:

  • Length: 590
  • Mass: 66128
  • Checksum: 5CB473C57B9526E9
  • Sequence:
    • MTLHNNSTTS PLFPNISSSW IHSPSDAGLP PGTVTHFGSY NVSRAAGNFS SPDGTTDDPL 
GGHTVWQVVF IAFLTGILAL VTIIGNILVI VSFKVNKQLK TVNNYFLLSL ACADLIIGVI 
SMNLFTTYII MNRWALGNLA CDLWLAIDYV ASNASVMNLL VISFDRYFSI TRPLTYRAKR 
TTKRAGVMIG LAWVISFVLW APAILFWQYF VGKRTVPPGE CFIQFLSEPT ITFGTAIAAF 
YMPVTIMTIL YWRIYKETEK RTKELAGLQA SGTEAETENF VHPTGSSRSC SSYELQQQSM 
KRSNRRKYGR CHFWFTTKSW KPSSEQMDQD HSSSDSWNNN DAAASLENSA SSDEEDIGSE 
TRAIYSIVLK LPGHSTILNS TKLPSSDNLQ VPEEELGMVD LERKADKLQA QKSVDDGGSF 
PKSFSKLPIQ LESAVDTAKT SDVNSSVGKS TATLPLSFKE ATLAKRFALK TRSQITKRKR 
MSLVKEKKAA QTLSAILLAF IITWTPYNIM VLVNTFCDSC IPKTFWNLGY WLCYINSTVN 
PVCYALCNKT FRTTFKMLLL CQCDKKKRRK QQYQQRQSVI FHKRAPEQAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.