Details for: CD300A

Gene ID: 11314

Symbol: CD300A

Ensembl ID: ENSG00000167851

Description: CD300a molecule

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.72
    Marker Score: 7,506
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.35
    Marker Score: 4,581
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.15
    Marker Score: 6,268
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.02
    Marker Score: 825
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.98
    Marker Score: 1,973
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.98
    Marker Score: 1,978
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.62
    Marker Score: 5,128
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.62
    Marker Score: 3,906
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.59
    Marker Score: 3,958
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1,152
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.53
    Marker Score: 6,253
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.53
    Marker Score: 3,106
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.51
    Marker Score: 496
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.46
    Marker Score: 804
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.39
    Marker Score: 1,411
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.37
    Marker Score: 347
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.33
    Marker Score: 74,099
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.28
    Marker Score: 14,824
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.24
    Marker Score: 841
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.15
    Marker Score: 2,985
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,788
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.14
    Marker Score: 2,163
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.08
    Marker Score: 465
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.06
    Marker Score: 1,151
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.05
    Marker Score: 1,553
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,772
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.03
    Marker Score: 1,246
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,789
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,014
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.94
    Marker Score: 1,071
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,276
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.92
    Marker Score: 553
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,731
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 364
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9
    Marker Score: 14,101
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,284
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.87
    Marker Score: 400
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.86
    Marker Score: 1,321
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.82
    Marker Score: 672
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.79
    Marker Score: 392
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 598
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 697
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.74
    Marker Score: 653
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.72
    Marker Score: 345
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.72
    Marker Score: 1,744
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.7
    Marker Score: 506
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.7
    Marker Score: 674
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.68
    Marker Score: 756
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.67
    Marker Score: 320
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.66
    Marker Score: 326
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.63
    Marker Score: 820
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.63
    Marker Score: 348
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.63
    Marker Score: 143
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.61
    Marker Score: 196
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.61
    Marker Score: 3,696
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.6
    Marker Score: 670
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.6
    Marker Score: 398
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.6
    Marker Score: 957
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.6
    Marker Score: 2,478
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.58
    Marker Score: 769
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 369
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.56
    Marker Score: 1,572
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.54
    Marker Score: 225
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.53
    Marker Score: 169
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.53
    Marker Score: 388
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.53
    Marker Score: 407
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.53
    Marker Score: 184
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.52
    Marker Score: 440
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.52
    Marker Score: 5,121
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.51
    Marker Score: 698
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.51
    Marker Score: 133
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.51
    Marker Score: 308
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.5
    Marker Score: 208
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.49
    Marker Score: 177
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.48
    Marker Score: 326
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.47
    Marker Score: 610
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.47
    Marker Score: 919
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.47
    Marker Score: 467
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.46
    Marker Score: 312
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.46
    Marker Score: 407
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.45
    Marker Score: 476
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.45
    Marker Score: 820
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.44
    Marker Score: 133
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.44
    Marker Score: 391
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.44
    Marker Score: 117
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.43
    Marker Score: 250
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.42
    Marker Score: 293
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.42
    Marker Score: 221
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.42
    Marker Score: 257
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.41
    Marker Score: 10,583
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.4
    Marker Score: 173

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane receptor**: CD300A is a transmembrane receptor with a unique structure, consisting of multiple immunoglobulin-like domains and a cytoplasmic tail. 2. **Negative regulation of immune responses**: CD300A has been shown to negatively regulate the activation of various immune cells, including eosinophils, mast cells, and neutrophils. 3. **Inhibition of B cell proliferation**: CD300A inhibits B cell proliferation and B cell receptor signaling, suggesting its role in regulating antibody production and immune responses. 4. **Regulation of T cell receptor signaling**: CD300A also regulates T cell receptor signaling, which is essential for the activation and proliferation of T cells. 5. **Expression on multiple cell types**: CD300A is expressed on a variety of cell types, including decidual natural killer cells, monocytes, and T cells, making it a key regulator of immune responses in different tissues. **Pathways and Functions:** 1. **Adaptive immune system**: CD300A regulates the adaptive immune response by inhibiting the activation of B cells and T cells. 2. **Innate immune system**: CD300A also regulates the innate immune response by inhibiting the activation of eosinophils, mast cells, and neutrophils. 3. **Cell adhesion**: CD300A interacts with phosphatidylethanolamine and phosphatidylserine, which are involved in cell adhesion and signaling. 4. **Extracellular exosome**: CD300A is also involved in the regulation of extracellular exosome-mediated signaling. 5. **Immunoregulatory interactions**: CD300A regulates immunoregulatory interactions between lymphoid and non-lymphoid cells, which is essential for maintaining immune homeostasis. **Clinical Significance:** The CD300A gene's involvement in immune regulation and tolerance makes it an important target for understanding immune-related diseases, such as autoimmune disorders, allergies, and cancer. Dysregulation of CD300A has been implicated in various diseases, including: 1. **Autoimmune disorders**: CD300A deficiency has been associated with autoimmune disorders, such as rheumatoid arthritis and lupus. 2. **Allergies**: CD300A regulates the activation of eosinophils, which are involved in allergic responses. 3. **Cancer**: CD300A has been implicated in the regulation of tumor immune escape and metastasis. 4. **Inflammatory diseases**: CD300A regulates inflammation by inhibiting the activation of immune cells, making it a potential target for treating inflammatory diseases. In conclusion, the CD300A gene plays a crucial role in regulating immune responses and tolerance. Its dysregulation has been implicated in various immune-related diseases, making it an important target for understanding and treating immune-related disorders.

Genular Protein ID: 3231682494

Symbol: CLM8_HUMAN

Name: CMRF35-like molecule 8

UniProtKB Accession Codes:

Q9UGN4 A8MW96 O95100 Q9HD97 Q9P0F3 Q9UBK4 Q9UMS9 Q9UMT0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 2 RefSeq 3 SAM 1 SASBDB 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10540326

Title: Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells.

PubMed ID: 10540326

DOI: 10.1002/(sici)1521-4141(199910)29:10<3148::aid-immu3148>3.0.co;2-l

PubMed ID: 9701027

Title: The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor.

PubMed ID: 9701027

DOI: 10.1093/intimm/10.7.891

PubMed ID: 10746781

Title: The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17.

PubMed ID: 10746781

DOI: 10.1034/j.1399-0039.2000.550201.x

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16339535

Title: The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells.

PubMed ID: 16339535

DOI: 10.4049/jimmunol.175.12.7989

PubMed ID: 22043923

Title: CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines.

PubMed ID: 22043923

DOI: 10.1111/j.1365-2567.2011.03528.x

PubMed ID: 12483297

Title: Novel immunoglobulin superfamily gene cluster, mapping to a region of human chromosome 17q25, linked to psoriasis susceptibility.

PubMed ID: 12483297

DOI: 10.1007/s00439-002-0851-y

Sequence Information:

  • Length: 299
  • Mass: 33201
  • Checksum: 978461DA87E86269
  • Sequence:
    • MWLPWALLLL WVPGCFALSK CRTVAGPVGG SLSVQCPYEK EHRTLNKYWC RPPQIFLCDK 
IVETKGSAGK RNGRVSIRDS PANLSFTVTL ENLTEEDAGT YWCGVDTPWL RDFHDPVVEV 
EVSVFPASTS MTPASITAAK TSTITTAFPP VSSTTLFAVG ATHSASIQEE TEEVVNSQLP 
LLLSLLALLL LLLVGASLLA WRMFQKWIKA GDHSELSQNP KQAATQSELH YANLELLMWP 
LQEKPAPPRE VEVEYSTVAS PREELHYASV VFDSNTNRIA AQRPREEEPD SDYSVIRKT

Genular Protein ID: 1223684999

Symbol: J3QKQ4_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3QKQ4

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 3 GO 1 GeneTree 1 GenomeRNAi 1 HGNC 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 Pfam 1 Proteomes 2 RefSeq 2 SAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 169
  • Mass: 18673
  • Checksum: 449763A1B1A47D06
  • Sequence:
    • MTPASITAAK TSTITTAFPP VSSTTLFAVG ATHSASIQEE TEEVVNSQLP LLLSLLALLL 
LLLVGASLLA WRMFQKWIKA GDHSELSQNP KQAATQSELH YANLELLMWP LQEKPAPPRE 
VEVEYSTVAS PREELHYASV VFDSNTNRIA AQRPREEEPD SDYSVIRKT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.