Details for: PARK7

Gene ID: 11315

Symbol: PARK7

Ensembl ID: ENSG00000116288

Description: Parkinsonism associated deglycase

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.45
    Marker Score: 34,199
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.44
    Marker Score: 45,414
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.4
    Marker Score: 1,253
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.27
    Marker Score: 5,032
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.19
    Marker Score: 3,405
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.11
    Marker Score: 3,244
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.09
    Marker Score: 20,123
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.08
    Marker Score: 35,850
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.06
    Marker Score: 3,696
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.01
    Marker Score: 4,267
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.01
    Marker Score: 2,356
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3
    Marker Score: 7,337
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3
    Marker Score: 11,556
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.99
    Marker Score: 103,639
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.97
    Marker Score: 2,803
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.96
    Marker Score: 5,558
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.94
    Marker Score: 6,692
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.93
    Marker Score: 21,797
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.85
    Marker Score: 4,671
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.82
    Marker Score: 2,512
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.79
    Marker Score: 7,706
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.78
    Marker Score: 4,427
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.78
    Marker Score: 1,251
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.77
    Marker Score: 1,852
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.77
    Marker Score: 661
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.74
    Marker Score: 7,341
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.73
    Marker Score: 4,989
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.72
    Marker Score: 4,517
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.71
    Marker Score: 23,552
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.7
    Marker Score: 4,340
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.69
    Marker Score: 5,475
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.69
    Marker Score: 91,414
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.69
    Marker Score: 1,072
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.68
    Marker Score: 11,575
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.67
    Marker Score: 10,941
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.66
    Marker Score: 1,520
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.66
    Marker Score: 7,764
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.65
    Marker Score: 1,523
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.64
    Marker Score: 9,380
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.64
    Marker Score: 1,659
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.64
    Marker Score: 2,081
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.62
    Marker Score: 1,866
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.62
    Marker Score: 17,096
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.62
    Marker Score: 1,978
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.61
    Marker Score: 29,404
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.61
    Marker Score: 1,867
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.6
    Marker Score: 145,424
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.6
    Marker Score: 2,914
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.59
    Marker Score: 5,412
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.59
    Marker Score: 2,208
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.58
    Marker Score: 6,763
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.57
    Marker Score: 4,478
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.57
    Marker Score: 8,098
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.56
    Marker Score: 2,473
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.56
    Marker Score: 13,433
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.55
    Marker Score: 16,308
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.54
    Marker Score: 1,308
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.54
    Marker Score: 1,671
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.54
    Marker Score: 3,063
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.53
    Marker Score: 4,524
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.53
    Marker Score: 1,202
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.53
    Marker Score: 2,814
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.53
    Marker Score: 33,990
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.53
    Marker Score: 6,372
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.51
    Marker Score: 1,336
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.5
    Marker Score: 802
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.5
    Marker Score: 1,958
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.49
    Marker Score: 4,860
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.49
    Marker Score: 5,863
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.49
    Marker Score: 2,657
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.48
    Marker Score: 2,333
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.48
    Marker Score: 6,955
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.48
    Marker Score: 1,806
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.47
    Marker Score: 2,508
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.47
    Marker Score: 3,421
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.46
    Marker Score: 7,290
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.45
    Marker Score: 650
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.45
    Marker Score: 4,168
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.44
    Marker Score: 6,974
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.44
    Marker Score: 803
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.44
    Marker Score: 4,321
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.43
    Marker Score: 1,417
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 2.43
    Marker Score: 777
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.43
    Marker Score: 2,835
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.42
    Marker Score: 24,380
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.42
    Marker Score: 2,837
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.42
    Marker Score: 6,582
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.42
    Marker Score: 1,207
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.41
    Marker Score: 3,469
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.4
    Marker Score: 907
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.39
    Marker Score: 24,249
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.39
    Marker Score: 1,087
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.38
    Marker Score: 3,278
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.38
    Marker Score: 820
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.37
    Marker Score: 2,927
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.36
    Marker Score: 1,585
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.36
    Marker Score: 60,343
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.35
    Marker Score: 13,931
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.35
    Marker Score: 834
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.34
    Marker Score: 1,773

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PARK7 is a small, cytoplasmic protein with a molecular weight of approximately 18 kDa. It is a member of the DJ-1 family of proteins, which are characterized by their ability to bind copper ions. PARK7 is highly expressed in various cell types, including neurons, immune cells, and stem cells. It is also highly stable and resistant to proteolytic degradation. The PARK7 protein has several key domains, including a copper-binding domain, a proline-rich domain, and a C-terminal domain that interacts with other proteins. **Pathways and Functions** PARK7 is involved in several key cellular pathways, including: 1. **Autophagy**: PARK7 regulates autophagy by interacting with other proteins involved in this process, such as LC3 and Beclin-1. It also has a role in the regulation of autophagy-related genes. 2. **Glyoxalase activity**: PARK7 has a glyoxalase activity, which involves the conversion of methylglyoxal, a potent inhibitor of protein function, into a less toxic compound. 3. **Protein degradation**: PARK7 regulates protein degradation by interacting with proteasomal components and other protein-degrading pathways. 4. **Oxidative stress response**: PARK7 has a role in the regulation of oxidative stress by interacting with other proteins involved in this process, such as peroxiredoxin and superoxide dismutase. 5. **Cellular homeostasis**: PARK7 maintains cellular homeostasis by regulating various cellular processes, including metabolism, protein synthesis, and cell cycle progression. **Clinical Significance** Mutations in the PARK7 gene have been associated with Parkinson's disease, a neurodegenerative disorder characterized by the loss of dopamine-producing neurons in the brain. PARK7 mutations have been identified in approximately 10% of Parkinson's disease cases, making it one of the most common genetic risk factors for the disease. The PARK7 protein has also been implicated in other neurodegenerative disorders, including Alzheimer's disease and amyotrophic lateral sclerosis. In addition to its role in neurodegenerative disorders, PARK7 has been implicated in various other diseases, including: 1. **Cancer**: PARK7 has been shown to have a role in cancer development and progression, particularly in the context of oxidative stress and DNA damage. 2. **Atherosclerosis**: PARK7 has been implicated in the development of atherosclerosis, a condition characterized by the buildup of fatty deposits in the arteries. 3. **Neurodegenerative disorders**: PARK7 has been implicated in other neurodegenerative disorders, including Huntington's disease, frontotemporal dementia, and multiple sclerosis. Overall, PARK7 is a critical protein that plays a key role in maintaining cellular homeostasis and protecting against oxidative stress. Its dysfunction has been implicated in various diseases, including Parkinson's disease, cancer, and atherosclerosis.

Genular Protein ID: 3198801475

Symbol: PARK7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q99497 B2R4Z1 O14805 Q6DR95 Q7LFU2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 90 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 6 EMBL 9 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 68 PDBsum 64 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 4 RefSeq 3 Rhea 38 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9070310

Title: DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras.

PubMed ID: 9070310

DOI: 10.1006/bbrc.1997.6132

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11223268

Title: Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter.

PubMed ID: 11223268

DOI: 10.1016/s0378-1119(00)00590-4

PubMed ID: 11477070

Title: DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor.

PubMed ID: 11477070

DOI: 10.1074/jbc.m101730200

PubMed ID: 12851414

Title: L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system.

PubMed ID: 12851414

DOI: 10.1074/jbc.m304272200

PubMed ID: 14713311

Title: A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization.

PubMed ID: 14713311

DOI: 10.1111/j.1471-4159.2003.02265.x

PubMed ID: 12612053

Title: DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex.

PubMed ID: 12612053

PubMed ID: 14579415

Title: Immunocytochemical localization of DJ-1 in human male reproductive tissue.

PubMed ID: 14579415

DOI: 10.1002/mrd.10360

PubMed ID: 14705119

Title: DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia.

PubMed ID: 14705119

DOI: 10.1002/ana.10782

PubMed ID: 14662519

Title: The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease.

PubMed ID: 14662519

DOI: 10.1093/brain/awh054

PubMed ID: 14749723

Title: DJ-1 has a role in antioxidative stress to prevent cell death.

PubMed ID: 14749723

DOI: 10.1038/sj.embor.7400074

PubMed ID: 15502874

Title: DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation.

PubMed ID: 15502874

DOI: 10.1371/journal.pbio.0020362

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15976810

Title: Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities.

PubMed ID: 15976810

DOI: 10.1038/sj.cdd.4401704

PubMed ID: 16390825

Title: DJ-1 interacts with HIPK1 and affects H2O2-induced cell death.

PubMed ID: 16390825

DOI: 10.1080/10715760500456847

PubMed ID: 17015834

Title: DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2.

PubMed ID: 17015834

DOI: 10.1073/pnas.0607260103

PubMed ID: 18626009

Title: RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways.

PubMed ID: 18626009

DOI: 10.1073/pnas.0708518105

PubMed ID: 19229105

Title: Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation.

PubMed ID: 19229105

DOI: 10.1172/jci37617

PubMed ID: 18711745

Title: Mitochondrial localization of DJ-1 leads to enhanced neuroprotection.

PubMed ID: 18711745

DOI: 10.1002/jnr.21831

PubMed ID: 20304780

Title: Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage.

PubMed ID: 20304780

DOI: 10.1093/hmg/ddq113

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21097510

Title: DJ-1 enhances cell survival through the binding of cezanne, a negative regulator of NF-{kappa}B.

PubMed ID: 21097510

DOI: 10.1074/jbc.m110.147371

PubMed ID: 22523093

Title: Human DJ-1 and its homologs are novel glyoxalases.

PubMed ID: 22523093

DOI: 10.1093/hmg/dds155

PubMed ID: 22611253

Title: Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes.

PubMed ID: 22611253

DOI: 10.1093/jmcb/mjs025

PubMed ID: 23847046

Title: DJ-1 associates with lipid rafts by palmitoylation and regulates lipid rafts-dependent endocytosis in astrocytes.

PubMed ID: 23847046

DOI: 10.1093/hmg/ddt332

PubMed ID: 23792957

Title: Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity.

PubMed ID: 23792957

DOI: 10.1074/jbc.m113.482091

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25416785

Title: Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine and lysine residues.

PubMed ID: 25416785

DOI: 10.1074/jbc.m114.597815

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27903648

Title: Evidence against a role for the Parkinsonism-associated protein DJ-1 in methylglyoxal detoxification.

PubMed ID: 27903648

DOI: 10.1074/jbc.m116.743823

PubMed ID: 28013050

Title: Parkinsonism-associated protein DJ-1 is a bona fide deglycase.

PubMed ID: 28013050

DOI: 10.1016/j.bbrc.2016.12.134

PubMed ID: 26995087

Title: The Parkinsonism-associated protein DJ-1/Park7 prevents glycation damage in human keratinocyte.

PubMed ID: 26995087

DOI: 10.1016/j.bbrc.2016.03.056

PubMed ID: 28596309

Title: Guanine glycation repair by DJ-1/Park7 and its bacterial homologs.

PubMed ID: 28596309

DOI: 10.1126/science.aag1095

PubMed ID: 28993701

Title: Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro.

PubMed ID: 28993701

DOI: 10.1038/s41598-017-13146-0

PubMed ID: 30150385

Title: Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks.

PubMed ID: 30150385

DOI: 10.1073/pnas.1802901115

PubMed ID: 31536960

Title: Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

PubMed ID: 31536960

DOI: 10.1016/j.isci.2019.08.057

PubMed ID: 31653696

Title: The apparent deglycase activity of DJ-1 results from the conversion of free methylglyoxal present in fast equilibrium with hemithioacetals and hemiaminals.

PubMed ID: 31653696

DOI: 10.1074/jbc.ra119.011237

PubMed ID: 30894531

Title: Reversible histone glycation is associated with disease-related changes in chromatin architecture.

PubMed ID: 30894531

DOI: 10.1038/s41467-019-09192-z

PubMed ID: 12914946

Title: Crystal structure of DJ-1/RS and implication on familial Parkinson's disease.

PubMed ID: 12914946

DOI: 10.1016/s0014-5793(03)00764-6

PubMed ID: 12761214

Title: Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease.

PubMed ID: 12761214

DOI: 10.1074/jbc.m304221200

PubMed ID: 12796482

Title: The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease.

PubMed ID: 12796482

DOI: 10.1074/jbc.m305878200

PubMed ID: 12939276

Title: Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain.

PubMed ID: 12939276

DOI: 10.1074/jbc.m304517200

PubMed ID: 12855764

Title: The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease.

PubMed ID: 12855764

DOI: 10.1073/pnas.1133288100

PubMed ID: 15181200

Title: The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization.

PubMed ID: 15181200

DOI: 10.1073/pnas.0402959101

PubMed ID: 12953260

Title: The role of pathogenic DJ-1 mutations in Parkinson's disease.

PubMed ID: 12953260

DOI: 10.1002/ana.10675

PubMed ID: 12446870

Title: Mutations in the DJ-1 gene associated with autosomal recessive early-onset Parkinsonism.

PubMed ID: 12446870

DOI: 10.1126/science.1077209

PubMed ID: 14705128

Title: The R98Q variation in DJ-1 represents a rare polymorphism.

PubMed ID: 14705128

DOI: 10.1002/ana.10816

PubMed ID: 15365989

Title: Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7).

PubMed ID: 15365989

DOI: 10.1002/humu.20089

PubMed ID: 14607841

Title: Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1.

PubMed ID: 14607841

DOI: 10.1074/jbc.m309204200

PubMed ID: 15254937

Title: Analysis of an early-onset Parkinson's disease cohort for DJ-1 mutations.

PubMed ID: 15254937

DOI: 10.1002/mds.20131

PubMed ID: 14872018

Title: DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease.

PubMed ID: 14872018

DOI: 10.1212/01.wnl.0000113022.51739.88

PubMed ID: 16240358

Title: DJ-1 mutations and parkinsonism-dementia-amyotrophic lateral sclerosis complex.

PubMed ID: 16240358

DOI: 10.1002/ana.20666

PubMed ID: 16632486

Title: Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease.

PubMed ID: 16632486

DOI: 10.1093/hmg/ddl104

PubMed ID: 17846173

Title: Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6.

PubMed ID: 17846173

DOI: 10.1083/jcb.200611128

PubMed ID: 18785233

Title: Mutation analysis of Parkin, PINK1, DJ-1 and ATP13A2 genes in Chinese patients with autosomal recessive early-onset Parkinsonism.

PubMed ID: 18785233

DOI: 10.1002/mds.22156

PubMed ID: 20186336

Title: Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1.

PubMed ID: 20186336

DOI: 10.1371/journal.pone.0009367

PubMed ID: 26972524

Title: A novel homozygous DJ1 mutation causes parkinsonism and ALS in a Turkish family.

PubMed ID: 26972524

DOI: 10.1016/j.parkreldis.2016.03.001

PubMed ID: 30928208

Title: Familial early onset Parkinson's disease caused by a homozygous frameshift variant in PARK7: Clinical features and literature update.

PubMed ID: 30928208

DOI: 10.1016/j.parkreldis.2019.03.013

Sequence Information:

  • Length: 189
  • Mass: 19891
  • Checksum: 4B21661B3A76BC67
  • Sequence:
    • MASKRALVIL AKGAEEMETV IPVDVMRRAG IKVTVAGLAG KDPVQCSRDV VICPDASLED 
AKKEGPYDVV VLPGGNLGAQ NLSESAAVKE ILKEQENRKG LIAAICAGPT ALLAHEIGFG 
SKVTTHPLAK DKMMNGGHYT YSENRVEKDG LILTSRGPGT SFEFALAIVE ALNGKEVAAQ 
VKAPLVLKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.