Details for: PARK7
Associated with
Other Information
Genular Protein ID: 3198801475
Symbol: PARK7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9070310
Title: DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras.
PubMed ID: 9070310
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11223268
Title: Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter.
PubMed ID: 11223268
PubMed ID: 11477070
Title: DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor.
PubMed ID: 11477070
PubMed ID: 12851414
Title: L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system.
PubMed ID: 12851414
PubMed ID: 14713311
Title: A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization.
PubMed ID: 14713311
PubMed ID: 12612053
Title: DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex.
PubMed ID: 12612053
PubMed ID: 14579415
Title: Immunocytochemical localization of DJ-1 in human male reproductive tissue.
PubMed ID: 14579415
DOI: 10.1002/mrd.10360
PubMed ID: 14705119
Title: DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia.
PubMed ID: 14705119
DOI: 10.1002/ana.10782
PubMed ID: 14662519
Title: The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease.
PubMed ID: 14662519
DOI: 10.1093/brain/awh054
PubMed ID: 14749723
Title: DJ-1 has a role in antioxidative stress to prevent cell death.
PubMed ID: 14749723
PubMed ID: 15502874
Title: DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation.
PubMed ID: 15502874
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 15976810
Title: Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities.
PubMed ID: 15976810
PubMed ID: 16390825
Title: DJ-1 interacts with HIPK1 and affects H2O2-induced cell death.
PubMed ID: 16390825
PubMed ID: 17015834
Title: DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2.
PubMed ID: 17015834
PubMed ID: 18626009
Title: RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways.
PubMed ID: 18626009
PubMed ID: 19229105
Title: Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation.
PubMed ID: 19229105
DOI: 10.1172/jci37617
PubMed ID: 18711745
Title: Mitochondrial localization of DJ-1 leads to enhanced neuroprotection.
PubMed ID: 18711745
DOI: 10.1002/jnr.21831
PubMed ID: 20304780
Title: Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage.
PubMed ID: 20304780
DOI: 10.1093/hmg/ddq113
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21097510
Title: DJ-1 enhances cell survival through the binding of cezanne, a negative regulator of NF-{kappa}B.
PubMed ID: 21097510
PubMed ID: 22523093
Title: Human DJ-1 and its homologs are novel glyoxalases.
PubMed ID: 22523093
DOI: 10.1093/hmg/dds155
PubMed ID: 22611253
Title: Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes.
PubMed ID: 22611253
DOI: 10.1093/jmcb/mjs025
PubMed ID: 23847046
Title: DJ-1 associates with lipid rafts by palmitoylation and regulates lipid rafts-dependent endocytosis in astrocytes.
PubMed ID: 23847046
DOI: 10.1093/hmg/ddt332
PubMed ID: 23792957
Title: Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity.
PubMed ID: 23792957
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25416785
Title: Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine and lysine residues.
PubMed ID: 25416785
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27903648
Title: Evidence against a role for the Parkinsonism-associated protein DJ-1 in methylglyoxal detoxification.
PubMed ID: 27903648
PubMed ID: 28013050
Title: Parkinsonism-associated protein DJ-1 is a bona fide deglycase.
PubMed ID: 28013050
PubMed ID: 26995087
Title: The Parkinsonism-associated protein DJ-1/Park7 prevents glycation damage in human keratinocyte.
PubMed ID: 26995087
PubMed ID: 28596309
Title: Guanine glycation repair by DJ-1/Park7 and its bacterial homologs.
PubMed ID: 28596309
PubMed ID: 28993701
Title: Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro.
PubMed ID: 28993701
PubMed ID: 30150385
Title: Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks.
PubMed ID: 30150385
PubMed ID: 31536960
Title: Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.
PubMed ID: 31536960
PubMed ID: 31653696
Title: The apparent deglycase activity of DJ-1 results from the conversion of free methylglyoxal present in fast equilibrium with hemithioacetals and hemiaminals.
PubMed ID: 31653696
PubMed ID: 30894531
Title: Reversible histone glycation is associated with disease-related changes in chromatin architecture.
PubMed ID: 30894531
PubMed ID: 12914946
Title: Crystal structure of DJ-1/RS and implication on familial Parkinson's disease.
PubMed ID: 12914946
PubMed ID: 12761214
Title: Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease.
PubMed ID: 12761214
PubMed ID: 12796482
Title: The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease.
PubMed ID: 12796482
PubMed ID: 12939276
Title: Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain.
PubMed ID: 12939276
PubMed ID: 12855764
Title: The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease.
PubMed ID: 12855764
PubMed ID: 15181200
Title: The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization.
PubMed ID: 15181200
PubMed ID: 12953260
Title: The role of pathogenic DJ-1 mutations in Parkinson's disease.
PubMed ID: 12953260
DOI: 10.1002/ana.10675
PubMed ID: 12446870
Title: Mutations in the DJ-1 gene associated with autosomal recessive early-onset Parkinsonism.
PubMed ID: 12446870
PubMed ID: 14705128
Title: The R98Q variation in DJ-1 represents a rare polymorphism.
PubMed ID: 14705128
DOI: 10.1002/ana.10816
PubMed ID: 15365989
Title: Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7).
PubMed ID: 15365989
DOI: 10.1002/humu.20089
PubMed ID: 14607841
Title: Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1.
PubMed ID: 14607841
PubMed ID: 15254937
Title: Analysis of an early-onset Parkinson's disease cohort for DJ-1 mutations.
PubMed ID: 15254937
DOI: 10.1002/mds.20131
PubMed ID: 14872018
Title: DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease.
PubMed ID: 14872018
PubMed ID: 16240358
Title: DJ-1 mutations and parkinsonism-dementia-amyotrophic lateral sclerosis complex.
PubMed ID: 16240358
DOI: 10.1002/ana.20666
PubMed ID: 16632486
Title: Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease.
PubMed ID: 16632486
DOI: 10.1093/hmg/ddl104
PubMed ID: 17846173
Title: Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6.
PubMed ID: 17846173
PubMed ID: 18785233
Title: Mutation analysis of Parkin, PINK1, DJ-1 and ATP13A2 genes in Chinese patients with autosomal recessive early-onset Parkinsonism.
PubMed ID: 18785233
DOI: 10.1002/mds.22156
PubMed ID: 20186336
Title: Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1.
PubMed ID: 20186336
PubMed ID: 26972524
Title: A novel homozygous DJ1 mutation causes parkinsonism and ALS in a Turkish family.
PubMed ID: 26972524
PubMed ID: 30928208
Title: Familial early onset Parkinson's disease caused by a homozygous frameshift variant in PARK7: Clinical features and literature update.
PubMed ID: 30928208
Sequence Information:
- Length: 189
- Mass: 19891
- Checksum: 4B21661B3A76BC67
- Sequence:
MASKRALVIL AKGAEEMETV IPVDVMRRAG IKVTVAGLAG KDPVQCSRDV VICPDASLED AKKEGPYDVV VLPGGNLGAQ NLSESAAVKE ILKEQENRKG LIAAICAGPT ALLAHEIGFG SKVTTHPLAK DKMMNGGHYT YSENRVEKDG LILTSRGPGT SFEFALAIVE ALNGKEVAAQ VKAPLVLKD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.