Details for: COPE

Gene ID: 11316

Symbol: COPE

Ensembl ID: ENSG00000105669

Description: COPI coat complex subunit epsilon

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.31
    Marker Score: 19,656
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.15
    Marker Score: 3,805
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.97
    Marker Score: 29,436
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.84
    Marker Score: 98,538
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.78
    Marker Score: 2,370
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.77
    Marker Score: 155,111
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.72
    Marker Score: 7,512
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.7
    Marker Score: 6,145
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.67
    Marker Score: 1,065
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.66
    Marker Score: 30,936
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.65
    Marker Score: 4,386
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.61
    Marker Score: 2,330
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.6
    Marker Score: 12,473
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.58
    Marker Score: 10,570
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.56
    Marker Score: 22,089
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.55
    Marker Score: 4,063
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.51
    Marker Score: 10,835
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.49
    Marker Score: 19,462
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.48
    Marker Score: 9,560
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.47
    Marker Score: 3,964
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.46
    Marker Score: 24,708
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.43
    Marker Score: 5,083
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.43
    Marker Score: 15,502
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.4
    Marker Score: 4,378
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.4
    Marker Score: 3,393
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.39
    Marker Score: 15,307
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.39
    Marker Score: 31,547
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.39
    Marker Score: 5,826
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.38
    Marker Score: 2,487
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.38
    Marker Score: 2,280
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.38
    Marker Score: 1,393
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.37
    Marker Score: 24,065
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.37
    Marker Score: 1,220
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.34
    Marker Score: 2,674
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.34
    Marker Score: 6,818
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.31
    Marker Score: 4,497
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.3
    Marker Score: 3,901
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.29
    Marker Score: 1,086
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.26
    Marker Score: 6,159
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.26
    Marker Score: 540
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.24
    Marker Score: 1,631
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.24
    Marker Score: 76,143
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.24
    Marker Score: 2,511
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.23
    Marker Score: 1,274
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.22
    Marker Score: 29,873
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.22
    Marker Score: 8,220
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.22
    Marker Score: 1,481
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.21
    Marker Score: 1,092
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.21
    Marker Score: 2,213
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.21
    Marker Score: 823
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.21
    Marker Score: 8,679
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.19
    Marker Score: 4,968
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.19
    Marker Score: 24,633
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.19
    Marker Score: 6,485
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.18
    Marker Score: 55,937
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.17
    Marker Score: 1,195
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.17
    Marker Score: 2,200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.16
    Marker Score: 2,176
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.14
    Marker Score: 1,687
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.14
    Marker Score: 687
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.13
    Marker Score: 1,347
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.13
    Marker Score: 6,723
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.12
    Marker Score: 3,693
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.12
    Marker Score: 13,796
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.11
    Marker Score: 2,231
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.11
    Marker Score: 7,485
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.11
    Marker Score: 3,959
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.11
    Marker Score: 4,959
  • Cell Name: oocyte (CL0000023)
    Fold Change: 2.1
    Marker Score: 520
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.1
    Marker Score: 1,847
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.1
    Marker Score: 5,234
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.1
    Marker Score: 879
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.09
    Marker Score: 1,203
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.09
    Marker Score: 3,699
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 2.09
    Marker Score: 2,773
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.08
    Marker Score: 2,996
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.08
    Marker Score: 2,312
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.07
    Marker Score: 845
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 2.07
    Marker Score: 1,440
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.07
    Marker Score: 735
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.07
    Marker Score: 2,667
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.07
    Marker Score: 5,536
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.06
    Marker Score: 1,378
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.05
    Marker Score: 3,158
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.05
    Marker Score: 2,390
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.05
    Marker Score: 6,426
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.04
    Marker Score: 504
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.04
    Marker Score: 1,005
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.04
    Marker Score: 540
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.04
    Marker Score: 588
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.03
    Marker Score: 17,650
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.03
    Marker Score: 922
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.03
    Marker Score: 1,050
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.03
    Marker Score: 946
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.02
    Marker Score: 4,887
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 2.02
    Marker Score: 1,947
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.02
    Marker Score: 5,228
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.01
    Marker Score: 2,191
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.01
    Marker Score: 2,964
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2
    Marker Score: 1,164

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** COPE is a subunit of the COPI coat complex, which is composed of several proteins that work together to facilitate the transport of proteins between the endoplasmic reticulum (ER) and the Golgi apparatus. The COPE protein is a crucial component of this complex, playing a key role in the recognition and binding of cargo proteins for retrograde transport. The COPE protein is also involved in the regulation of protein localization and modification, ensuring that proteins are transported to their correct destinations within the cell. **Pathways and Functions:** The COPE gene is involved in several important pathways, including: 1. **CopI-dependent Golgi-to-ER retrograde transport**: COPE plays a crucial role in the recognition and binding of cargo proteins for retrograde transport from the Golgi apparatus to the ER. 2. **CopI-mediated anterograde transport**: COPE is also involved in the transport of proteins from the ER to the Golgi apparatus through the COPI coat complex. 3. **Intra-golgi and retrograde Golgi-to-ER traffic**: COPE is essential for the recognition and binding of cargo proteins for intra-golgi and retrograde Golgi-to-ER transport. The COPE protein has several functions, including: 1. **Protein binding**: COPE binds to cargo proteins, facilitating their transport between the ER and Golgi apparatus. 2. **Protein localization**: COPE regulates the localization of proteins within the cell, ensuring that they are transported to their correct destinations. 3. **Protein modification**: COPE is involved in the regulation of protein modification, including glycosylation and ubiquitination. **Significant Expression in Various Cell Types:** COPE is significantly expressed in various cell types, including: 1. **Sertoli cells**: COPE is highly expressed in Sertoli cells, which play a crucial role in the development and maintenance of male fertility. 2. **Myeloid leukocytes**: COPE is also highly expressed in myeloid leukocytes, which are involved in the immune response. 3. **Mature T cells**: COPE is expressed in mature T cells, which are critical for the immune response. 4. **IgA plasma cells**: COPE is also expressed in IgA plasma cells, which are involved in the production of antibodies. **Clinical Significance:** The COPE gene has significant clinical implications, particularly in the context of immune function and protein trafficking disorders. Alterations in COPE expression or function have been implicated in various diseases, including: 1. **Immunodeficiency disorders**: COPE mutations have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Protein trafficking disorders**: COPE mutations have also been implicated in protein trafficking disorders, such as lysosomal storage diseases. In conclusion, the COPE gene plays a critical role in protein trafficking and immune function, and its dysregulation has significant clinical implications. Further research is needed to elucidate the mechanisms by which COPE regulates protein transport and to identify potential therapeutic targets for the treatment of protein trafficking disorders.

Genular Protein ID: 873993006

Symbol: COPE_HUMAN

Name: Coatomer subunit epsilon

UniProtKB Accession Codes:

O14579 A6NE29 A6NKA3 O76097 Q6IBB8 Q9UGP6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 15 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10469566

Title: Segregation of COPI-rich and anterograde-cargo-rich domains in endoplasmic-reticulum-to-Golgi transport complexes.

PubMed ID: 10469566

DOI: 10.1016/s0960-9822(99)80365-0

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 17721809

Title: Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA.

PubMed ID: 17721809

DOI: 10.1007/s11010-007-9586-3

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 308
  • Mass: 34482
  • Checksum: A71146F3332F6BA9
  • Sequence:
    • MAPPAPGPAS GGSGEVDELF DVKNAFYIGS YQQCINEAQR VKLSSPERDV ERDVFLYRAY 
LAQRKFGVVL DEIKPSSAPE LQAVRMFADY LAHESRRDSI VAELDREMSR SVDVTNTTFL 
LMAASIYLHD QNPDAALRAL HQGDSLECTA MTVQILLKLD RLDLARKELK RMQDLDEDAT 
LTQLATAWVS LATGGEKLQD AYYIFQEMAD KCSPTLLLLN GQAACHMAQG RWEAAEGLLQ 
EALDKDSGYP ETLVNLIVLS QHLGKPPEVT NRYLSQLKDA HRSHPFIKEY QAKENDFDRL 
VLQYAPSA

Genular Protein ID: 1655600320

Symbol: M0QXB4_HUMAN

Name: N/A

UniProtKB Accession Codes:

M0QXB4

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 EPD 1 Ensembl 2 GO 6 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 Pfam 1 Proteomes 2 RefSeq 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 331
  • Mass: 36924
  • Checksum: C026C44469B17937
  • Sequence:
    • MAPPAPGPAS GGSGEVDELF DVKNAFYIGS YQQCINEAQR VKLSSPERDV ERDVFLYRAY 
LAQRKFGVVL DEIKPSSAPE LQAVRMFADY LAHESRRDSI VAELDREMSR SVDVTNTTFL 
LMAASIYLHD QNPDAALRAL HQGDSLEWVS SPGRALHLEA QPMEAASPDG RTAMTVQILL 
KLDRLDLARK ELKRMQDLDE DATLTQLATA WVSLATGGEK LQDAYYIFQE MADKCSPTLL 
LLNGQAACHM AQGRWEAAEG LLQEALDKDS GYPETLVNLI VLSQHLGKPP EVTNRYLSQL 
KDAHRSHPFI KEYQAKENDF DRLVLQYAPS A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.