Details for: RBPJL

Gene ID: 11317

Symbol: RBPJL

Ensembl ID: ENSG00000124232

Description: recombination signal binding protein for immunoglobulin kappa J region like

Associated with

  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Signal transduction
    (GO:0007165)
  • Transcription regulator complex
    (GO:0005667)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell (CL0000622)
    Fold Change: 6.21
    Marker Score: 4,378
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.71
    Marker Score: 30,357
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3,169
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.25
    Marker Score: 4,752
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.96
    Marker Score: 2,191
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.09
    Marker Score: 7,250
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,046
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2,478
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,356
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,289
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 491
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.66
    Marker Score: 385
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.61
    Marker Score: 978
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 485
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.57
    Marker Score: 321
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.57
    Marker Score: 8,864
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.43
    Marker Score: 817
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.41
    Marker Score: 833
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.41
    Marker Score: 210
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.4
    Marker Score: 823
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.27
    Marker Score: 260
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 91
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.24
    Marker Score: 159
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.24
    Marker Score: 76
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.22
    Marker Score: 228
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.21
    Marker Score: 128
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.21
    Marker Score: 230
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.19
    Marker Score: 98
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.18
    Marker Score: 95
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.16
    Marker Score: 78
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.15
    Marker Score: 68
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.15
    Marker Score: 118
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.15
    Marker Score: 102
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.13
    Marker Score: 59
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.13
    Marker Score: 29
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.11
    Marker Score: 52
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.11
    Marker Score: 158
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.11
    Marker Score: 47
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1
    Marker Score: 177
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.09
    Marker Score: 103
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.09
    Marker Score: 101
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.09
    Marker Score: 148
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.08
    Marker Score: 199
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.07
    Marker Score: 79
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 60
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 61
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.06
    Marker Score: 31
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.06
    Marker Score: 38
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.06
    Marker Score: 226
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.06
    Marker Score: 48
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.05
    Marker Score: 71
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.05
    Marker Score: 55
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.05
    Marker Score: 80
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.05
    Marker Score: 56
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.05
    Marker Score: 48
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.05
    Marker Score: 56

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RBPJL is a member of the ETS family of transcription factors, which are known for their role in regulating cell growth, differentiation, and survival. RBPJL is specifically involved in the regulation of genes involved in the immune system, including those involved in B-cell development and function. The gene is highly expressed in various immune cells, including plasma cells, goblet cells, and GABAergic interneurons. **Pathways and Functions:** RBPJL is involved in several key pathways, including: 1. **Chromatin remodeling:** RBPJL regulates chromatin structure and accessibility, allowing for the transcription of genes involved in immune cell development and function. 2. **DNA binding:** RBPJL binds to specific DNA sequences, regulating the expression of target genes involved in immune cell development and function. 3. **Signal transduction:** RBPJL is involved in signal transduction pathways, regulating the response to immune signals and allowing for the proper development and function of immune cells. 4. **Transcription regulation:** RBPJL regulates transcription by binding to RNA polymerase II-specific cis-regulatory regions, allowing for the transcription of target genes involved in immune cell development and function. **Functions:** RBPJL has several key functions in the immune system, including: 1. **B-cell development:** RBPJL regulates the development of B cells, including the expression of genes involved in B-cell maturation and function. 2. **Plasma cell development:** RBPJL regulates the development of plasma cells, including the expression of genes involved in antibody production and function. 3. **Immune cell survival:** RBPJL regulates the survival of immune cells, including the expression of genes involved in cell survival and apoptosis. 4. **Tissue development:** RBPJL regulates the development of various tissues, including the pancreas, intestine, and brain. **Clinical Significance:** RBPJL has been implicated in several immune-related disorders, including: 1. **Immunodeficiency diseases:** RBPJL mutations have been associated with immunodeficiency diseases, including X-linked agammaglobulinemia and hyper-IgM syndrome. 2. **Autoimmune diseases:** RBPJL has been implicated in the development of autoimmune diseases, including rheumatoid arthritis and lupus. 3. **Cancer:** RBPJL has been implicated in the development of various cancers, including leukemia and lymphoma. 4. **Neurological disorders:** RBPJL has been implicated in the development of neurological disorders, including autism and schizophrenia. In conclusion, RBPJL plays a critical role in the development and function of the immune system. Its dysregulation has been implicated in a range of immune-related disorders, highlighting the importance of further research into the mechanisms of RBPJL function and its role in disease.

Genular Protein ID: 3141801521

Symbol: RBPJL_HUMAN

Name: Recombining binding protein suppressor of hairless-like protein

UniProtKB Accession Codes:

Q9UBG7 O95723 Q5QPU9 Q5QPV0 Q9ULV9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

Sequence Information:

  • Length: 517
  • Mass: 56751
  • Checksum: 1DB1505A800F7788
  • Sequence:
    • MDPAGAADPS VPPNPLTHLS LQDRSEMQLQ SEADRRSLPG TWTRSSPEHT TILRGGVRRC 
LQQQCEQTVR ILHAKVAQKS YGNEKRFFCP PPCVYLSGPG WRVKPGQDQA HQAGETGPTV 
CGYMGLDSAS GSATETQKLN FEQQPDSREF GCAKTLYISD ADKRKHFRLV LRLVLRGGRE 
LGTFHSRLIK VISKPSQKKQ SLKNTDLCIS SGSKVSLFNR LRSQTVSTRY LSVEDGAFVA 
SARQWAAFTL HLADGHSAQG DFPPREGYVR YGSLVQLVCT VTGITLPPMI IRKVAKQCAL 
LDVDEPISQL HKCAFQFPGS PPGGGGTYLC LATEKVVQFQ ASPCPKEANR ALLNDSSCWT 
IIGTESVEFS FSTSLACTLE PVTPVPLIST LELSGGGDVA TLELHGENFH AGLKVWFGDV 
EAETMYRSPR SLVCVVPDVA AFCSDWRWLR APITIPMSLV RADGLFYPSA FSFTYTPEYS 
VRPGHPGVPE PATDADALLE SIHQEFTRTN FHLFIQT

Genular Protein ID: 3639292417

Symbol: Q5QPV1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5QPV1

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 GO 3 Gene3D 3 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 9 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 4 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 471
  • Mass: 51270
  • Checksum: AC6752EA43E93B2C
  • Sequence:
    • MDPAGAADPS VPPNPLTHLS LQDRSEMQLQ SEADRRSLPG TWTRSSPEHT TILRGGVRRC 
LQQQCEQTVR ILHAKVAQKS YGNEKRFFCP PPCVYLSGPG WRVKPGQDQA HQAGETGPTV 
CGYMGLDSAS GSATETQKLN FEQQPDSREF GCAKTLYISD ADKRKHFRLV LRLVLRGGRE 
LGTFHSRLIK VISKPSQKKQ SLKNTDLCIS SGSKVSLFNR LRSQTVSTRY LSVEDGAFVA 
SARQWAAFTL HLADGHSAQG DFPPREGYVR YGSLVQLVCT VTGITLPPMI IRKVAKQCAL 
LDVDEPISQL HKCAFQFPGS PPGGGGTYLC LATEKVVQFQ ASPCPKEANR ALLNDSSCWT 
IIGTESVEFS FSTSLACTLE PVTPVPLIST LELSGGGDVA TLELHGENFH AGLKVWFGDV 
EAETMYRYGV EPAVPGVRGA GRGGLLQRLA LAARSHHNPH EPGARRRALL P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.