Details for: GPR182

Gene ID: 11318

Symbol: GPR182

Ensembl ID: ENSG00000166856

Description: G protein-coupled receptor 182

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7694
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.02
    Marker Score: 2582
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71837
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48062
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.91
    Marker Score: 220
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1470
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.8
    Marker Score: 445
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.74
    Marker Score: 431
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.71
    Marker Score: 1352
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 515
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.58
    Marker Score: 126
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.57
    Marker Score: 1158
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.53
    Marker Score: 241
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.52
    Marker Score: 293
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.43
    Marker Score: 135
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.36
    Marker Score: 5590
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.35
    Marker Score: 3048
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.32
    Marker Score: 202
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.32
    Marker Score: 166
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.27
    Marker Score: 241
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.23
    Marker Score: 54
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2
    Marker Score: 1187
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.19
    Marker Score: 114
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.18
    Marker Score: 374
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.17
    Marker Score: 169
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.16
    Marker Score: 66
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.16
    Marker Score: 56
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.14
    Marker Score: 33
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.14
    Marker Score: 69
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.13
    Marker Score: 61
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.13
    Marker Score: 35
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.12
    Marker Score: 128
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.12
    Marker Score: 211
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.11
    Marker Score: 72
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.1
    Marker Score: 104
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.09
    Marker Score: 25
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.07
    Marker Score: 48
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.07
    Marker Score: 60
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.04
    Marker Score: 234
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.03
    Marker Score: 102
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: dermis microvascular lymphatic vessel endothelial cell (CL2000041)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.03
    Marker Score: 15.5
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.03
    Marker Score: 67
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.02
    Marker Score: 31
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.02
    Marker Score: 11.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.01
    Marker Score: 35
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 13

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** GPR182 is a transmembrane GPCR, characterized by its ability to interact with G proteins and initiate signaling cascades. The receptor's structure consists of seven transmembrane alpha-helices, which form a binding pocket for ligands. The expression of GPR182 is widespread, with notable presence in cells involved in immune responses, epithelial barrier function, and neuronal communication. Notably, the receptor's expression is also observed in abnormal and neoplastic cells, suggesting its involvement in tumorigenesis and cancer progression. **Pathways and Functions:** GPR182's signaling pathway involves the activation of G proteins, which in turn modulate downstream effectors, including adenylyl cyclase, phospholipase C, and protein kinase C. These signaling events regulate various cellular processes, including: 1. **Immune regulation:** GPR182 modulates the activity of immune cells, such as T cells and dendritic cells, influencing their proliferation, differentiation, and cytokine production. 2. **Cellular homeostasis:** The receptor regulates epithelial barrier function, influencing the secretion of mucus and the maintenance of the intestinal epithelial barrier. 3. **Neuronal communication:** GPR182 interacts with GABAergic interneurons, modulating their activity and influencing neuronal signaling pathways. 4. **Tumorigenesis:** The receptor's expression is elevated in neoplastic cells, suggesting its involvement in cancer progression and metastasis. **Clinical Significance:** GPR182's involvement in immune regulation, cellular homeostasis, and tumorigenesis renders it a promising target for therapeutic interventions. Potential applications of GPR182-targeting therapies include: 1. **Cancer treatment:** Inhibiting GPR182 signaling may suppress tumor growth and metastasis. 2. **Autoimmune diseases:** Modulating GPR182 signaling may alleviate autoimmune responses and inflammation. 3. **Gastrointestinal disorders:** Targeting GPR182 may improve epithelial barrier function and alleviate symptoms of gastrointestinal diseases, such as inflammatory bowel disease. 4. **Neurological disorders:** GPR182's role in neuronal communication and immune regulation may provide new avenues for treating neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, GPR182 is a multifunctional receptor with far-reaching implications for our understanding of immune regulation, cellular homeostasis, and tumorigenesis. Further research into the signaling mechanisms and clinical applications of GPR182 holds great promise for the development of novel therapeutic strategies.

Genular Protein ID: 2653085883

Symbol: GP182_HUMAN

Name: G-protein coupled receptor 182

UniProtKB Accession Codes:

O15218

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9367907

Title: Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system.

PubMed ID: 9367907

DOI: 10.1006/bbrc.1997.7631

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9535752

Title: Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response.

PubMed ID: 9535752

DOI: 10.1006/bbrc.1998.8349

Sequence Information:

  • Length: 404
  • Mass: 45323
  • Checksum: EF187ECFDF2DC6C1
  • Sequence:
    • MSVKPSWGPG PSEGVTAVPT SDLGEIHNWT ELLDLFNHTL SECHVELSQS TKRVVLFALY 
LAMFVVGLVE NLLVICVNWR GSGRAGLMNL YILNMAIADL GIVLSLPVWM LEVTLDYTWL 
WGSFSCRFTH YFYFVNMYSS IFFLVCLSVD RYVTLTSASP SWQRYQHRVR RAMCAGIWVL 
SAIIPLPEVV HIQLVEGPEP MCLFMAPFET YSTWALAVAL STTILGFLLP FPLITVFNVL 
TACRLRQPGQ PKSRRHCLLL CAYVAVFVMC WLPYHVTLLL LTLHGTHISL HCHLVHLLYF 
FYDVIDCFSM LHCVINPILY NFLSPHFRGR LLNAVVHYLP KDQTKAGTCA SSSSCSTQHS 
IIITKGDSQP AAAAPHPEPS LSFQAHHLLP NTSPISPTQP LTPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.