Details for: ECD

Gene ID: 11319

Symbol: ECD

Ensembl ID: ENSG00000122882

Description: ecdysoneless cell cycle regulator

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,963
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.16
    Marker Score: 9,976
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.15
    Marker Score: 10,968
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.14
    Marker Score: 11,795
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.12
    Marker Score: 68,804
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.11
    Marker Score: 4,518
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.11
    Marker Score: 1,707
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.09
    Marker Score: 10,220
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.03
    Marker Score: 945
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.01
    Marker Score: 37,324
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,694
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,918
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,392
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,395
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.93
    Marker Score: 375
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.93
    Marker Score: 3,585
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.91
    Marker Score: 18,114
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9
    Marker Score: 1,332
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,701
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.89
    Marker Score: 13,345
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.88
    Marker Score: 3,667
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,292
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.87
    Marker Score: 302
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.86
    Marker Score: 6,608
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.85
    Marker Score: 32,320
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4,775
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.81
    Marker Score: 900
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.81
    Marker Score: 589
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.81
    Marker Score: 975
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.79
    Marker Score: 651
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.79
    Marker Score: 835
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.79
    Marker Score: 382
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 317
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.79
    Marker Score: 534
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.78
    Marker Score: 1,916
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 594
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.77
    Marker Score: 822
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.77
    Marker Score: 372
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.73
    Marker Score: 630
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3,017
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.72
    Marker Score: 377
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.72
    Marker Score: 1,028
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.71
    Marker Score: 2,234
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.71
    Marker Score: 288
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.7
    Marker Score: 15,035
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.7
    Marker Score: 700
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.69
    Marker Score: 1,886
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.69
    Marker Score: 432
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.69
    Marker Score: 242
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.68
    Marker Score: 1,670
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.68
    Marker Score: 1,498
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.68
    Marker Score: 598
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.68
    Marker Score: 510
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.68
    Marker Score: 961
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.68
    Marker Score: 730
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 613
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.67
    Marker Score: 392
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 443
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.67
    Marker Score: 626
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.66
    Marker Score: 35,132
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.65
    Marker Score: 657
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.65
    Marker Score: 2,413
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.65
    Marker Score: 2,559
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.65
    Marker Score: 2,723
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.65
    Marker Score: 958
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.65
    Marker Score: 810
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.64
    Marker Score: 261
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.64
    Marker Score: 619
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.64
    Marker Score: 826
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.64
    Marker Score: 1,044
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.64
    Marker Score: 191
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.63
    Marker Score: 729
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.63
    Marker Score: 7,355
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.63
    Marker Score: 667
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.63
    Marker Score: 546
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.63
    Marker Score: 289
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.62
    Marker Score: 396
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.62
    Marker Score: 442
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.62
    Marker Score: 655
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.62
    Marker Score: 9,661
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.62
    Marker Score: 266
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.61
    Marker Score: 377
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.61
    Marker Score: 418
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.61
    Marker Score: 337
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.61
    Marker Score: 226
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.61
    Marker Score: 364
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.61
    Marker Score: 1,658
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6
    Marker Score: 144
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.6
    Marker Score: 209
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.6
    Marker Score: 643
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.6
    Marker Score: 827
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.6
    Marker Score: 434
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6
    Marker Score: 1,364
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.6
    Marker Score: 438

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cell Cycle Regulation**: ECD is a key regulator of the cell cycle, specifically in the transition from the G1 phase to the S phase of the mitotic cell cycle. 2. **Transcriptional Regulation**: ECD is involved in positive regulation of transcription by RNA polymerase II, suggesting its role in promoting gene expression. 3. **Histone Acetyltransferase Binding**: ECD is associated with histone acetyltransferase binding, which is a crucial step in chromatin remodeling and gene expression. 4. **Significant Expression in Various Cell Types**: ECD is significantly expressed in various cell types, including neural cells, mural cells, and epithelial cells, suggesting its broad functional significance. 5. **Protein-Binding Properties**: ECD has protein-binding properties, which may contribute to its regulatory functions. **Pathways and Functions** 1. **Regulation of G1/S Transition**: ECD is involved in the regulation of the G1/S transition of the mitotic cell cycle, which is a critical checkpoint in cell proliferation. 2. **Positive Regulation of Transcription by RNA Polymerase II**: ECD is a positive regulator of transcription by RNA polymerase II, which is essential for gene expression. 3. **Histone Acetyltransferase Binding**: ECD is associated with histone acetyltransferase binding, which is a key step in chromatin remodeling and gene expression. 4. **mRNA Processing**: ECD is involved in mRNA processing, which is essential for the regulation of gene expression. 5. **Protein Binding**: ECD has protein-binding properties, which may contribute to its regulatory functions. **Clinical Significance** 1. **Cancer Research**: ECD may play a role in cancer development and progression, as dysregulation of the cell cycle and gene expression is a hallmark of cancer. 2. **Neurological Disorders**: ECD may be involved in neurological disorders, such as Alzheimer's disease and Parkinson's disease, as it is expressed in neural cells and is involved in gene expression. 3. **Epithelial Cell Function**: ECD may play a role in epithelial cell function, particularly in the regulation of cell proliferation and differentiation. 4. **Regulation of Cell Proliferation**: ECD is involved in the regulation of cell proliferation, which is essential for tissue development and maintenance. In conclusion, ECD is a gene that plays a crucial role in regulating the cell cycle, particularly in the transition from the G1 phase to the S phase of the mitotic cell cycle. Its significant expression in various cell types and involvement in transcriptional regulation, histone acetyltransferase binding, and mRNA processing suggest its broad functional significance. Further research is needed to fully understand the clinical significance of ECD in various diseases.

Genular Protein ID: 3106121553

Symbol: ECD_HUMAN

Name: N/A

UniProtKB Accession Codes:

O95905 C9JX46 E9PAW8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 3 SAM 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9928932

Title: A human gene, hSGT1, can substitute for GCR2, which encodes a general regulatory factor of glycolytic gene expression in Saccharomyces cerevisiae.

PubMed ID: 9928932

DOI: 10.1007/s004380050926

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16849563

Title: The human orthologue of Drosophila ecdysoneless protein interacts with p53 and regulates its function.

PubMed ID: 16849563

DOI: 10.1158/0008-5472.can-06-0722

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19640839

Title: Role of mammalian Ecdysoneless in cell cycle regulation.

PubMed ID: 19640839

DOI: 10.1074/jbc.m109.030551

PubMed ID: 19919181

Title: Biochemical characterization of human Ecdysoneless reveals a role in transcriptional regulation.

PubMed ID: 19919181

DOI: 10.1515/bc.2010.004

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22270930

Title: Overexpression of a novel cell cycle regulator ecdysoneless in breast cancer: a marker of poor prognosis in HER2/neu-overexpressing breast cancer patients.

PubMed ID: 22270930

DOI: 10.1007/s10549-011-1946-8

PubMed ID: 22977192

Title: Overexpression of ecdysoneless in pancreatic cancer and its role in oncogenesis by regulating glycolysis.

PubMed ID: 22977192

DOI: 10.1158/1078-0432.ccr-12-1789

PubMed ID: 23880345

Title: TXNIP interacts with hEcd to increase p53 stability and activity.

PubMed ID: 23880345

DOI: 10.1016/j.bbrc.2013.07.036

PubMed ID: 24656813

Title: Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex.

PubMed ID: 24656813

DOI: 10.1016/j.celrep.2014.03.013

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24722212

Title: Unexpected role of the steroid-deficiency protein ecdysoneless in pre-mRNA splicing.

PubMed ID: 24722212

DOI: 10.1371/journal.pgen.1004287

PubMed ID: 26711270

Title: A novel interaction of ecdysoneless (ECD) protein with R2TP complex component RUVBL1 is required for the functional role of ECD in cell cycle progression.

PubMed ID: 26711270

DOI: 10.1128/mcb.00594-15

PubMed ID: 11090341

Title: Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of the novel cadherin-like gene CDH23.

PubMed ID: 11090341

DOI: 10.1086/316954

Sequence Information:

  • Length: 644
  • Mass: 72758
  • Checksum: F9B0D2BBFDB38CAF
  • Sequence:
    • MEETMKLATM EDTVEYCLFL IPDESRDSDK HKEILQKYIE RIITRFAPML VPYIWQNQPF 
NLKYKPGKGG VPAHMFGVTK FGDNIEDEWF IVYVIKQITK EFPELVARIE DNDGEFLLIE 
AADFLPKWLD PENSTNRVFF CHGELCIIPA PRKSGAESWL PTTPPTIPQA LNIITAHSEK 
ILASESIRAA VNRRIRGYPE KIQASLHRAH CFLPAGIVAV LKQRPRLVAA AVQAFYLRDP 
IDLRACRVFK TFLPETRIMT SVTFTKCLYA QLVQQRFVPD RRSGYRLPPP SDPQYRAHEL 
GMKLAHGFEI LCSKCSPHFS DCKKSLVTAS PLWASFLESL KKNDYFKGLI EGSAQYRERL 
EMAENYFQLS VDWPESSLAM SPGEEILTLL QTIPFDIEDL KKEAANLPPE DDDQWLDLSP 
DQLDQLLQEA VGKKESESVS KEEKEQNYDL TEVSESMKAF ISKVSTHKGA ELPREPSEAP 
ITFDADSFLN YFDKILGPRP NESDSDDLDD EDFECLDSDD DLDFETHEPG EEASLKGTLD 
NLKSYMAQMD QELAHTCISK SFTTRNQVEP VSQTTDNNSD EEDSGTGESV MAPVDVDLNL 
VSNILESYSS QAGLAGPASN LLQSMGVQLP DNTDHRPTSK PTKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.