Details for: CHRM4

Gene ID: 1132

Symbol: CHRM4

Ensembl ID: ENSG00000180720

Description: cholinergic receptor muscarinic 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6847
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3182
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2004
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1178
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.61
    Marker Score: 10714
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 862
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7577
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3656
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.19
    Marker Score: 695
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 492
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4825
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.11
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32728
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71835
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48060
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 514
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 467
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2398
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5329
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.86
    Marker Score: 344
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 738
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 466
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.63
    Marker Score: 1198
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.59
    Marker Score: 9187
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 438
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.4
    Marker Score: 814
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.28
    Marker Score: 1703
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.27
    Marker Score: 128
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.23
    Marker Score: 274
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.19
    Marker Score: 185
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.17
    Marker Score: 102
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.16
    Marker Score: 69
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.15
    Marker Score: 87
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.15
    Marker Score: 301
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.13
    Marker Score: 142.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.12
    Marker Score: 70
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.1
    Marker Score: 67
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.07
    Marker Score: 39
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.07
    Marker Score: 54
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.07
    Marker Score: 39
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.06
    Marker Score: 73
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.06
    Marker Score: 93
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.04
    Marker Score: 108
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.04
    Marker Score: 34
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.04
    Marker Score: 35
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.03
    Marker Score: 29
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.02
    Marker Score: 54
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.02
    Marker Score: 35
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.02
    Marker Score: 15

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Other Information

**Key characteristics:** * The CHRM4 gene is located on chromosome 17q21.1. * It is a single-exon gene that encodes a protein of 371 amino acids. * The protein is a transmembrane protein that is expressed in the plasma membrane. * It is a G protein-coupled receptor, which means that it is activated by the binding of a G protein. * The protein is a ligand for the muscarinic acetylcholine receptor. **Pathways and functions:** * The CHRM4 gene is involved in the regulation of locomotion. * It is expressed in microglial cells, which are a type of immune cell that is involved in the inflammatory response. * In microglial cells, the CHRM4 receptor is expressed on the surface of activated microglia. * When the receptor is activated by muscarinic acetylcholine, it inhibits the activity of adenylate cyclase, which is an enzyme that is involved in the production of cyclic AMP (cAMP). * cAMP is a second messenger that can activate a variety of cellular processes, including muscle contraction and mucus secretion. * The inhibition of adenylate cyclase by the CHRM4 receptor results in the inhibition of these cellular processes. **Clinical significance:** * Mutations in the CHRM4 gene have been linked to a number of human diseases, including asthma, migraines, and inflammatory bowel disease. * The CHRM4 receptor is a potential target for the treatment of these diseases. * By blocking the action of the CHRM4 receptor, it is possible to relieve the symptoms of these diseases.

Genular Protein ID: 351537845

Symbol: ACM4_HUMAN

Name: Muscarinic acetylcholine receptor M4

UniProtKB Accession Codes:

P08173 B2RPP4 Q0VD60 Q4VBK7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 62 DrugCentral 1 EMBL 8 EMDB 11 Ensembl 2 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 14 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3037705

Title: Identification of a family of muscarinic acetylcholine receptor genes.

PubMed ID: 3037705

DOI: 10.1126/science.3037705

PubMed ID: 3272174

Title: Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes.

PubMed ID: 3272174

DOI: 10.1016/0896-6273(88)90190-0

PubMed ID: 3443095

Title: Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

PubMed ID: 3443095

DOI: 10.1002/j.1460-2075.1987.tb02733.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 479
  • Mass: 53049
  • Checksum: 9C1B05B359A64289
  • Sequence:
    • MANFTPVNGS SGNQSVRLVT SSSHNRYETV EMVFIATVTG SLSLVTVVGN ILVMLSIKVN 
RQLQTVNNYF LFSLACADLI IGAFSMNLYT VYIIKGYWPL GAVVCDLWLA LDYVVSNASV 
MNLLIISFDR YFCVTKPLTY PARRTTKMAG LMIAAAWVLS FVLWAPAILF WQFVVGKRTV 
PDNQCFIQFL SNPAVTFGTA IAAFYLPVVI MTVLYIHISL ASRSRVHKHR PEGPKEKKAK 
TLAFLKSPLM KQSVKKPPPG EAAREELRNG KLEEAPPPAL PPPPRPVADK DTSNESSSGS 
ATQNTKERPA TELSTTEATT PAMPAPPLQP RALNPASRWS KIQIVTKQTG NECVTAIEIV 
PATPAGMRPA ANVARKFASI ARNQVRKKRQ MAARERKVTR TIFAILLAFI LTWTPYNVMV 
LVNTFCQSCI PDTVWSIGYW LCYVNSTINP ACYALCNATF KKTFRHLLLC QYRNIGTAR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.