Details for: CHRM4

Gene ID: 1132

Symbol: CHRM4

Ensembl ID: ENSG00000180720

Description: cholinergic receptor muscarinic 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.8705
    Cell Significance Index: 59.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.8533
    Cell Significance Index: 113.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6531
    Cell Significance Index: 124.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4317
    Cell Significance Index: 9.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3416
    Cell Significance Index: 20.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3054
    Cell Significance Index: 30.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2663
    Cell Significance Index: 240.4300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2654
    Cell Significance Index: 28.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1749
    Cell Significance Index: 28.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1484
    Cell Significance Index: 10.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1167
    Cell Significance Index: 4.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1013
    Cell Significance Index: 1.4500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0530
    Cell Significance Index: 0.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0297
    Cell Significance Index: 20.5600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0181
    Cell Significance Index: 0.2000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0159
    Cell Significance Index: 0.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0126
    Cell Significance Index: 0.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0090
    Cell Significance Index: 0.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0060
    Cell Significance Index: 0.1500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0043
    Cell Significance Index: 0.0600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0039
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0028
    Cell Significance Index: -0.0600
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0034
    Cell Significance Index: -0.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0037
    Cell Significance Index: -2.0100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0053
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0056
    Cell Significance Index: -4.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0078
    Cell Significance Index: -2.7900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0086
    Cell Significance Index: -0.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0103
    Cell Significance Index: -1.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0108
    Cell Significance Index: -2.1600
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0118
    Cell Significance Index: -0.1600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0122
    Cell Significance Index: -0.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0138
    Cell Significance Index: -7.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0155
    Cell Significance Index: -9.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0157
    Cell Significance Index: -2.1500
  • Cell Name: metallothionein-positive alveolar macrophage (CL4033042)
    Fold Change: -0.0170
    Cell Significance Index: -0.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0171
    Cell Significance Index: -1.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0177
    Cell Significance Index: -2.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0186
    Cell Significance Index: -2.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0189
    Cell Significance Index: -0.8800
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0211
    Cell Significance Index: -0.2100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0266
    Cell Significance Index: -0.4600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0305
    Cell Significance Index: -0.3900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0323
    Cell Significance Index: -0.3000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0400
    Cell Significance Index: -0.5400
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0401
    Cell Significance Index: -0.3100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0439
    Cell Significance Index: -0.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0450
    Cell Significance Index: -1.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0461
    Cell Significance Index: -9.7200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0477
    Cell Significance Index: -0.5800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0489
    Cell Significance Index: -0.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0527
    Cell Significance Index: -2.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0542
    Cell Significance Index: -1.3000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0658
    Cell Significance Index: -1.0700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0719
    Cell Significance Index: -1.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0728
    Cell Significance Index: -3.2200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0730
    Cell Significance Index: -1.8600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0812
    Cell Significance Index: -0.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0829
    Cell Significance Index: -4.6500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0836
    Cell Significance Index: -0.5800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0877
    Cell Significance Index: -1.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0892
    Cell Significance Index: -2.9200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0908
    Cell Significance Index: -3.1800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0918
    Cell Significance Index: -1.4200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0963
    Cell Significance Index: -1.2600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0973
    Cell Significance Index: -3.1000
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0980
    Cell Significance Index: -1.0700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0981
    Cell Significance Index: -1.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1000
    Cell Significance Index: -2.6800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1001
    Cell Significance Index: -0.9900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1018
    Cell Significance Index: -2.2000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1029
    Cell Significance Index: -1.0900
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.1046
    Cell Significance Index: -1.3400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1079
    Cell Significance Index: -3.0800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1113
    Cell Significance Index: -2.3800
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.1129
    Cell Significance Index: -1.2900
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.1134
    Cell Significance Index: -1.2500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1135
    Cell Significance Index: -1.3700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1154
    Cell Significance Index: -1.5900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1160
    Cell Significance Index: -1.4700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1193
    Cell Significance Index: -1.5900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1200
    Cell Significance Index: -1.2900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1205
    Cell Significance Index: -1.4200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1205
    Cell Significance Index: -1.4000
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1225
    Cell Significance Index: -1.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1243
    Cell Significance Index: -3.1000
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1252
    Cell Significance Index: -1.1100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1269
    Cell Significance Index: -2.5300
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1274
    Cell Significance Index: -1.1100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1291
    Cell Significance Index: -1.1100
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.1298
    Cell Significance Index: -1.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1303
    Cell Significance Index: -2.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1336
    Cell Significance Index: -2.8400
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1357
    Cell Significance Index: -1.4500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1366
    Cell Significance Index: -3.3100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1386
    Cell Significance Index: -1.9000
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1417
    Cell Significance Index: -1.8000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1430
    Cell Significance Index: -2.8700
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.1434
    Cell Significance Index: -1.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The CHRM4 gene is a member of the G protein-coupled receptor (GPCR) family, specifically belonging to the muscarinic subfamily. It is characterized by its high expression in various cell types, including microglial cells, blood vessel endothelial cells, and intestinal epithelial cells. The CHRM4 receptor is a ligand-gated ion channel that responds to acetylcholine, a neurotransmitter released by cholinergic neurons. This receptor is distinct from other muscarinic receptors, such as M1, M2, M3, and M5, which have different tissue distributions and functions. **Pathways and Functions:** The CHRM4 receptor is involved in various signaling pathways, including: 1. **Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway**: This pathway is characterized by the inhibition of adenylate cyclase activity, leading to reduced cAMP levels and decreased downstream signaling. 2. **G alpha (i) signaling events**: The CHRM4 receptor activates Gi proteins, which in turn inhibit adenylate cyclase and reduce cAMP levels. 3. **G protein-coupled acetylcholine receptor activity**: The CHRM4 receptor is a ligand-gated ion channel that responds to acetylcholine, leading to changes in ion flux and membrane potential. 4. **Regulation of locomotion**: The CHRM4 receptor has been implicated in the regulation of locomotor behavior, suggesting its potential role in neuromodulation and behavior regulation. **Clinical Significance:** The CHRM4 gene has been implicated in various diseases and disorders, including: 1. **Neurodegenerative diseases**: CHRM4 has been associated with Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders, where its dysregulation may contribute to disease progression. 2. **Inflammatory disorders**: The CHRM4 receptor has been shown to modulate inflammatory responses, suggesting its potential role in the pathogenesis of inflammatory diseases. 3. **Cardiovascular diseases**: CHRM4 has been implicated in the regulation of cardiovascular function, including blood pressure regulation and cardiac function. In conclusion, the CHRM4 gene plays a critical role in regulating various physiological processes, including immune system function, neuromodulation, and behavior regulation. Further research is necessary to fully elucidate the mechanisms by which CHRM4 contributes to disease pathology and to explore its potential as a therapeutic target for the treatment of various diseases. **Recommendations:** 1. **Immunological studies**: Further studies are needed to investigate the role of CHRM4 in immune system regulation and its potential as a therapeutic target for immunological disorders. 2. **Neurological studies**: Research should focus on the role of CHRM4 in neurodegenerative diseases and its potential as a therapeutic target for the treatment of these conditions. 3. **Pharmacological studies**: Investigations into the pharmacological properties of CHRM4 and its potential as a therapeutic target for cardiovascular diseases and other conditions are warranted. By exploring the CHRM4 gene in greater detail, we may uncover new insights into its immunological significance and its potential as a therapeutic target for various diseases.

Genular Protein ID: 351537845

Symbol: ACM4_HUMAN

Name: Muscarinic acetylcholine receptor M4

UniProtKB Accession Codes:

P08173 B2RPP4 Q0VD60 Q4VBK7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 62 DrugCentral 1 EMBL 8 EMDB 12 Ensembl 2 EvolutionaryTrace 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 18 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3037705

Title: Identification of a family of muscarinic acetylcholine receptor genes.

PubMed ID: 3037705

DOI: 10.1126/science.3037705

PubMed ID: 3272174

Title: Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes.

PubMed ID: 3272174

DOI: 10.1016/0896-6273(88)90190-0

PubMed ID: 3443095

Title: Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

PubMed ID: 3443095

DOI: 10.1002/j.1460-2075.1987.tb02733.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 479
  • Mass: 53049
  • Checksum: 9C1B05B359A64289
  • Sequence:
    • MANFTPVNGS SGNQSVRLVT SSSHNRYETV EMVFIATVTG SLSLVTVVGN ILVMLSIKVN 
RQLQTVNNYF LFSLACADLI IGAFSMNLYT VYIIKGYWPL GAVVCDLWLA LDYVVSNASV 
MNLLIISFDR YFCVTKPLTY PARRTTKMAG LMIAAAWVLS FVLWAPAILF WQFVVGKRTV 
PDNQCFIQFL SNPAVTFGTA IAAFYLPVVI MTVLYIHISL ASRSRVHKHR PEGPKEKKAK 
TLAFLKSPLM KQSVKKPPPG EAAREELRNG KLEEAPPPAL PPPPRPVADK DTSNESSSGS 
ATQNTKERPA TELSTTEATT PAMPAPPLQP RALNPASRWS KIQIVTKQTG NECVTAIEIV 
PATPAGMRPA ANVARKFASI ARNQVRKKRQ MAARERKVTR TIFAILLAFI LTWTPYNVMV 
LVNTFCQSCI PDTVWSIGYW LCYVNSTINP ACYALCNATF KKTFRHLLLC QYRNIGTAR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.