Details for: MGAT4A

Gene ID: 11320

Symbol: MGAT4A

Ensembl ID: ENSG00000071073

Description: alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.07
    Marker Score: 1,526
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.93
    Marker Score: 1,059
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.74
    Marker Score: 11,433
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.47
    Marker Score: 9,564
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.22
    Marker Score: 117,464
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.06
    Marker Score: 1,925
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.06
    Marker Score: 8,819
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.94
    Marker Score: 38,514
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.87
    Marker Score: 808
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.87
    Marker Score: 1,116
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.82
    Marker Score: 17,148
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.78
    Marker Score: 2,460
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.77
    Marker Score: 1,578
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.77
    Marker Score: 4,326
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.76
    Marker Score: 108,532
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.76
    Marker Score: 5,550
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.76
    Marker Score: 1,897
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.73
    Marker Score: 16,424
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.72
    Marker Score: 2,502
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.66
    Marker Score: 14,300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.64
    Marker Score: 2,995
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.64
    Marker Score: 3,209
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.64
    Marker Score: 4,388
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.63
    Marker Score: 4,571
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.61
    Marker Score: 6,560
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.6
    Marker Score: 654
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.58
    Marker Score: 58,394
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.52
    Marker Score: 1,465
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.51
    Marker Score: 1,103
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.5
    Marker Score: 3,528
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.49
    Marker Score: 3,404
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.49
    Marker Score: 1,604
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.48
    Marker Score: 56,383
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.48
    Marker Score: 11,378
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.46
    Marker Score: 452
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166,864
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.44
    Marker Score: 719
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.44
    Marker Score: 16,712
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.44
    Marker Score: 14,212
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.41
    Marker Score: 866
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.39
    Marker Score: 1,217
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.38
    Marker Score: 2,123
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.37
    Marker Score: 46,212
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.37
    Marker Score: 1,036
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.36
    Marker Score: 14,052
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.35
    Marker Score: 7,274
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.31
    Marker Score: 675
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.31
    Marker Score: 1,427
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.31
    Marker Score: 953
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.29
    Marker Score: 2,205
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.27
    Marker Score: 1,073
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.27
    Marker Score: 817
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.25
    Marker Score: 6,022
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.25
    Marker Score: 1,435
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.23
    Marker Score: 1,247
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.22
    Marker Score: 456
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.22
    Marker Score: 3,091
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.21
    Marker Score: 881
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.2
    Marker Score: 3,515
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.19
    Marker Score: 262
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.19
    Marker Score: 391
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.19
    Marker Score: 2,372
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.19
    Marker Score: 2,119
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.18
    Marker Score: 3,706
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.17
    Marker Score: 1,728
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.17
    Marker Score: 17,518
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.15
    Marker Score: 364
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.14
    Marker Score: 258
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.14
    Marker Score: 397
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.14
    Marker Score: 876
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.13
    Marker Score: 681
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.12
    Marker Score: 2,355
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.09
    Marker Score: 550
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.09
    Marker Score: 17,026
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.09
    Marker Score: 890
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.08
    Marker Score: 918
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.08
    Marker Score: 1,198
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.06
    Marker Score: 1,540
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.06
    Marker Score: 1,853
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.06
    Marker Score: 5,564
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.06
    Marker Score: 370
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.04
    Marker Score: 325
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.03
    Marker Score: 1,590
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.01
    Marker Score: 1,311
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1
    Marker Score: 2,256
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1
    Marker Score: 2,522
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1
    Marker Score: 375
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,634
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,860
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.99
    Marker Score: 21,166
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.98
    Marker Score: 888
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,381
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.98
    Marker Score: 875
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.98
    Marker Score: 218
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.97
    Marker Score: 219
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.97
    Marker Score: 1,374
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.97
    Marker Score: 294
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.96
    Marker Score: 309
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.96
    Marker Score: 5,826

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MGAT4A is a type I transmembrane glycoprotein that belongs to the glycosyltransferase family. It is primarily expressed in cells of the central nervous system, including macrophages, microglial cells, neurons, and T cells. The gene is also expressed in various other cell types, such as endothelial cells and GABAergic neurons. MGAT4A is highly specific for N-acetylglucosamine (GlcNAc) as the acceptor molecule for the glycosylation reaction, and its activity is essential for the formation of specific N-glycan structures. **Pathways and Functions** MGAT4A plays a critical role in the following pathways: 1. **N-glycan processing**: MGAT4A is involved in the elongation of N-glycan antennae in the medial/trans-Golgi compartment, which is essential for the formation of complex glycosylation patterns on proteins. 2. **Protein glycosylation**: MGAT4A is responsible for the glycosylation of proteins, which affects their stability, function, and interactions with other molecules. 3. **Viral infection pathways**: MGAT4A has been implicated in the processing and glycosylation of viral proteins, such as the SARS-CoV-2 spike protein. 4. **Regulation of insulin-like growth factor (IGF) transport and uptake**: MGAT4A has been shown to regulate the transport and uptake of IGFs by insulin-like growth factor binding proteins (IGFBPs). **Clinical Significance** MGAT4A has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: MGAT4A has been associated with neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer**: MGAT4A has been implicated in cancer development and progression, particularly in tumors of the central nervous system. 3. **Viral infections**: MGAT4A has been shown to play a role in the processing and glycosylation of viral proteins, such as the SARS-CoV-2 spike protein. 4. **Immunological disorders**: MGAT4A has been implicated in immunological disorders, such as multiple sclerosis and rheumatoid arthritis. In conclusion, MGAT4A is a crucial enzyme involved in the post-translational modification of glycoproteins, and its dysregulation has been implicated in various diseases. Further studies are needed to fully understand the role of MGAT4A in human health and disease.

Genular Protein ID: 2958112144

Symbol: MGT4A_HUMAN

Name: N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa

UniProtKB Accession Codes:

Q9UM21 B4E2R6 D3DVH6 E9PEN2 Q53S97 Q86Z15

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 2 CTD 1 ChEBI 36 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 9 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 17 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 2 Rhea 28 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10024668

Title: Tissue specific expression and chromosomal mapping of a human UDP-N-acetylglucosamine: alpha1,3-d-mannoside beta1, 4-N-acetylglucosaminyltransferase.

PubMed ID: 10024668

DOI: 10.1093/glycob/9.3.303

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10463590

Title: Unusually high expression of N-acetylglucosaminyltransferase-IVa in human choriocarcinoma cell lines: a possible enzymatic basis of the formation of abnormal biantennary sugar chain.

PubMed ID: 10463590

PubMed ID: 16434023

Title: Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer.

PubMed ID: 16434023

DOI: 10.1016/j.bbrc.2005.12.208

PubMed ID: 17006639

Title: Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes.

PubMed ID: 17006639

DOI: 10.1007/s10719-006-6216-3

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

Sequence Information:

  • Length: 535
  • Mass: 61544
  • Checksum: C139E5F323A083A1
  • Sequence:
    • MRLRNGTVAT ALAFITSFLT LSWYTTWQNG KEKLIAYQRE FLALKERLRI AEHRISQRSS 
ELNTIVQQFK RVGAETNGSK DALNKFSDNT LKLLKELTSK KSLQVPSIYY HLPHLLKNEG 
SLQPAVQIGN GRTGVSIVMG IPTVKREVKS YLIETLHSLI DNLYPEEKLD CVIVVFIGET 
DIDYVHGVVA NLEKEFSKEI SSGLVEVISP PESYYPDLTN LKETFGDSKE RVRWRTKQNL 
DYCFLMMYAQ EKGIYYIQLE DDIIVKQNYF NTIKNFALQL SSEEWMILEF SQLGFIGKMF 
QAPDLTLIVE FIFMFYKEKP IDWLLDHILW VKVCNPEKDA KHCDRQKANL RIRFRPSLFQ 
HVGLHSSLSG KIQKLTDKDY MKPLLLKIHV NPPAEVSTSL KVYQGHTLEK TYMGEDFFWA 
ITPIAGDYIL FKFDKPVNVE SYLFHSGNQE HPGDILLNTT VEVLPFKSEG LEISKETKDK 
RLEDGYFRIG KFENGVAEGM VDPSLNPISA FRLSVIQNSA VWAILNEIHI KKATN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.