Details for: MGAT4A
Gene ID: 11320
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: MGAT4A
Ensembl ID: ENSG00000071073
Description: alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 24.87rCSI 82.43%PRS 36.81
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CSI 19.67rCSI 24.33%PRS 30.66
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CSI 13.21rCSI 53.29%PRS 33.1
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CSI 12.25rCSI 46.28%PRS 22.61
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CSI 12.14rCSI 9.09%PRS 48.38
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CSI 11.63rCSI 8.09%PRS 41.15
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CSI 11.29rCSI 35.28%PRS 22.81
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CSI 10.3rCSI 23.09%PRS 22.35
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CSI 9.4rCSI 53.12%PRS 23.12
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CSI 9.22rCSI 6.47%PRS 59.67
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CSI 8.97rCSI 22.76%PRS 26.8
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CSI 8.56rCSI 20.81%PRS 21.18
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CSI 8.45rCSI 49.74%PRS 22.93
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CSI 8.09rCSI 17.81%PRS 48.34
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CSI 7.59rCSI 17.21%PRS 40.55
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CSI 7.16rCSI 7.47%PRS 34.81
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CSI 6.97rCSI 28.06%PRS 48.81
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CSI 6.86rCSI 5.45%PRS 54.94
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CSI 6.18rCSI 9.94%PRS 23.61
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CSI 6.09rCSI 9.68%PRS 28.99
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CSI 6.06rCSI 13.85%PRS 33.76
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CSI 6.03rCSI 17.44%PRS 55.36
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CSI 5.43rCSI 10.17%PRS 26.04
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CSI 5.28rCSI 32.96%PRS 28.25
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CSI 5.24rCSI 6.14%PRS 47.4
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CSI 5.08rCSI 11.72%PRS 28.3
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CSI 5.04rCSI 5.26%PRS 67.58
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CSI 4.99rCSI 3.47%PRS 45.87
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CSI 4.92rCSI 6.96%PRS 44.01
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CSI 4.88rCSI 3.91%PRS 54.83
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CSI 4.64rCSI 8.85%PRS 50.42
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CSI 4.53rCSI 6.56%PRS 49.22
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CSI 4.45rCSI 3.37%PRS 45.2
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CSI 4.25rCSI 3.05%PRS 45.6
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CSI 4.24rCSI 5.81%PRS 32.54
-
CSI 4.2rCSI 5.07%PRS 40.7
-
CSI 4.12rCSI 4.92%PRS 21.69
-
CSI 3.93rCSI 7.1%PRS 60.53
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CSI 3.71rCSI 7.69%PRS 33.26
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CSI 3.67rCSI 4.62%PRS 77.7
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CSI 3.58rCSI 2.9%PRS 45.83
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CSI 3.56rCSI 4.43%PRS 20.55
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CSI 3.51rCSI 25.81%PRS 24.3
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CSI 3.44rCSI 4.44%PRS 22.57
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CSI 3.38rCSI 5.84%PRS 26.73
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CSI 3.37rCSI 3.12%PRS 54.19
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CSI 3.35rCSI 3.99%PRS 53.39
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CSI 3.32rCSI 5.67%PRS 60.49
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CSI 3.21rCSI 2.41%PRS 36.85
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CSI 3.17rCSI 5.98%PRS 42.94
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CSI 3.15rCSI 75.41%PRS 21.24
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CSI 3.15rCSI 7.79%PRS 32.51
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CSI 3.14rCSI 1.85%PRS 47
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CSI 3.12rCSI 75.17%PRS 22.05
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CSI 3.11rCSI 2.33%PRS 68.9
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CSI 3.09rCSI 2.98%PRS 26.42
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CSI 2.98rCSI 3.17%PRS 50.23
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CSI 2.91rCSI 10.48%PRS 20.79
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CSI 2.91rCSI 11.85%PRS 33.7
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CSI 2.87rCSI 2%PRS 35.91
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CSI 2.81rCSI 2.65%PRS 35.39
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CSI 2.79rCSI 2.13%PRS 43.95
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CSI 2.77rCSI 1.85%PRS 62.01
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CSI 2.76rCSI 6.58%PRS 37.29
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CSI 2.73rCSI 7.11%PRS 33.33
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CSI 2.72rCSI 2.5%PRS 40.38
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CSI 2.66rCSI 4.55%PRS 43.26
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CSI 2.63rCSI 1.95%PRS 29.42
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CSI 2.6rCSI 3.57%PRS 55.01
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CSI 2.57rCSI 3.69%PRS 42.25
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CSI 2.51rCSI 5.5%PRS 43.77
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CSI 2.49rCSI 3.4%PRS 36.93
-
CSI 2.48rCSI 1.67%PRS 42.6
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CSI 2.47rCSI 2.17%PRS 38.84
-
CSI 2.47rCSI 5.63%PRS 29.47
-
CSI 2.36rCSI 6.29%PRS 29.17
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CSI 2.33rCSI 2.04%PRS 43.43
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CSI 2.32rCSI 10.81%PRS 59.11
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CSI 2.28rCSI 2.25%PRS 36.36
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CSI 2.22rCSI 3.46%PRS 61.35
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CSI 2.17rCSI 2.96%PRS 46.76
-
CSI 2.17rCSI 5.64%PRS 40.27
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CSI 2.15rCSI 1.99%PRS 35.39
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CSI 2.15rCSI 4.29%PRS 51.85
-
CSI 2.13rCSI 3.38%PRS 43.26
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CSI 2.11rCSI 2.21%PRS 32
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CSI 2.07rCSI 2.75%PRS 37.79
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CSI 2.06rCSI 3.38%PRS 26.91
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CSI 2.02rCSI 2.97%PRS 31.77
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CSI 2rCSI 4.11%PRS 31.49
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CSI 2rCSI 1.55%PRS 49.09
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CSI 1.99rCSI 3.05%PRS 42.55
-
CSI 1.99rCSI 3.21%PRS 44.88
-
CSI 1.95rCSI 4.23%PRS 26.93
-
CSI 1.94rCSI 1.53%PRS 39.96
-
CSI 1.94rCSI 1.91%PRS 64.96
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CSI 1.93rCSI 5%PRS 31.43
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CSI 1.92rCSI 4.48%PRS 62.04
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CSI 1.92rCSI 3.45%PRS 28.97
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CSI 1.91rCSI 1.74%PRS 48.61
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CSI 0.2rCSI 1.1%PRS 46.5%
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CSI 0.3rCSI 5.5%PRS 82.4%
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CSI 0.3rCSI 0.5%PRS 50.4%
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CSI 0.4rCSI 2.6%PRS 54.5%
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CSI 0.4rCSI 2.3%PRS 59.5%
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CSI 0.5rCSI 1.0%PRS 31.7%
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CSI 0.5rCSI 1.9%PRS 53.3%
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CSI 0.5rCSI 2.3%PRS 62.8%
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CSI 0.5rCSI 1.0%PRS 64.4%
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CSI 0.5rCSI 1.7%PRS 24.7%
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CSI 0.6rCSI 13.2%PRS 57.0%
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CSI 0.6rCSI 0.9%PRS 43.9%
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CSI 0.6rCSI 3.0%PRS 43.9%
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CSI 0.6rCSI 4.4%PRS 64.1%
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CSI 0.7rCSI 3.2%PRS 35.4%
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CSI 0.7rCSI 2.1%PRS 25.5%
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CSI 0.7rCSI 3.5%PRS 50.1%
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CSI 0.7rCSI 1.6%PRS 46.7%
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CSI 0.7rCSI 2.4%PRS 25.7%
-
CSI 0.8rCSI 3.3%PRS 29.6%
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CSI 0.8rCSI 3.0%PRS 30.4%
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CSI 0.8rCSI 2.5%PRS 34.7%
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CSI 0.8rCSI 1.4%PRS 21.8%
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CSI 0.8rCSI 1.9%PRS 25.8%
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CSI 0.8rCSI 3.1%PRS 52.5%
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CSI 0.9rCSI 1.3%PRS 35.5%
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CSI 0.9rCSI 1.6%PRS 49.5%
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CSI 0.9rCSI 1.4%PRS 38.5%
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CSI 1.0rCSI 1.0%PRS 36.2%
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CSI 1.0rCSI 2.6%PRS 42.8%
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CSI 1.0rCSI 2.4%PRS 82.5%
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CSI 1.0rCSI 6.5%PRS 70.7%
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CSI 1.0rCSI 1.9%PRS 55.2%
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CSI 1.0rCSI 1.8%PRS 21.1%
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CSI 1.0rCSI 1.6%PRS 31.8%
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CSI 1.1rCSI 3.6%PRS 28.8%
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CSI 1.1rCSI 2.0%PRS 69.9%
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CSI 1.1rCSI 1.4%PRS 43.0%
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CSI 1.1rCSI 1.5%PRS 46.5%
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CSI 1.1rCSI 2.2%PRS 35.6%
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CSI 1.2rCSI 1.1%PRS 31.5%
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CSI 1.2rCSI 3.1%PRS 66.8%
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CSI 1.2rCSI 4.9%PRS 50.2%
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CSI 1.2rCSI 4.4%PRS 48.4%
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CSI 1.2rCSI 1.9%PRS 51.8%
-
CSI 1.3rCSI 3.5%PRS 32.1%
-
CSI 1.3rCSI 1.8%PRS 27.4%
-
CSI 1.3rCSI 1.6%PRS 36.6%
-
CSI 1.3rCSI 1.8%PRS 62.9%
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CSI 1.4rCSI 2.5%PRS 62.8%
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CSI 1.4rCSI 2.2%PRS 39.2%
-
CSI 1.4rCSI 1.4%PRS 46.1%
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CSI 1.4rCSI 3.1%PRS 25.1%
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CSI 1.4rCSI 4.0%PRS 49.7%
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CSI 1.4rCSI 21.6%PRS 63.1%
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CSI 1.4rCSI 3.4%PRS 32.0%
-
CSI 1.4rCSI 2.3%PRS 37.2%
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CSI 1.4rCSI 3.2%PRS 39.8%
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CSI 1.4rCSI 3.6%PRS 41.5%
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CSI 1.4rCSI 4.1%PRS 27.6%
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CSI 1.4rCSI 1.6%PRS 49.7%
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CSI 1.5rCSI 1.3%PRS 33.8%
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CSI 1.5rCSI 2.2%PRS 34.6%
-
CSI 1.5rCSI 8.0%PRS 41.2%
-
CSI 1.5rCSI 1.2%PRS 34.9%
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CSI 1.5rCSI 3.0%PRS 26.1%
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CSI 1.5rCSI 1.3%PRS 37.8%
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CSI 1.5rCSI 1.6%PRS 32.1%
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CSI 1.6rCSI 3.4%PRS 38.1%
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CSI 1.6rCSI 2.0%PRS 47.5%
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CSI 1.6rCSI 4.4%PRS 49.0%
-
CSI 1.6rCSI 2.8%PRS 55.4%
-
CSI 1.6rCSI 1.9%PRS 37.8%
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CSI 1.7rCSI 2.0%PRS 34.7%
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CSI 1.7rCSI 1.8%PRS 34.6%
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CSI 1.7rCSI 2.1%PRS 41.2%
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CSI 1.7rCSI 2.4%PRS 32.0%
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CSI 1.7rCSI 3.1%PRS 32.5%
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CSI 1.7rCSI 8.5%PRS 44.5%
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CSI 1.7rCSI 1.4%PRS 34.6%
-
CSI 1.7rCSI 7.2%PRS 37.6%
-
CSI 1.8rCSI 2.6%PRS 38.5%
-
CSI 1.8rCSI 2.3%PRS 38.8%
-
CSI 1.8rCSI 7.8%PRS 54.3%
-
CSI 1.8rCSI 3.7%PRS 43.1%
-
CSI 1.8rCSI 4.8%PRS 29.1%
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CSI 1.8rCSI 3.3%PRS 68.6%
-
CSI 1.8rCSI 2.8%PRS 50.5%
-
CSI 1.8rCSI 2.8%PRS 40.2%
-
CSI 1.9rCSI 4.2%PRS 56.1%
-
CSI 1.9rCSI 8.7%PRS 57.6%
-
CSI 1.9rCSI 16.3%PRS 23.3%
-
CSI 1.9rCSI 1.7%PRS 48.6%
-
CSI 1.9rCSI 3.5%PRS 29.0%
-
CSI 1.9rCSI 4.5%PRS 62.0%
-
CSI 1.9rCSI 5.0%PRS 31.4%
-
CSI 1.9rCSI 1.9%PRS 65.0%
-
CSI 1.9rCSI 1.5%PRS 40.0%
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CSI 2.0rCSI 4.2%PRS 26.9%
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CSI 2.0rCSI 3.2%PRS 44.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2958112144
Symbol: MGT4A_HUMAN
Name: N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10024668
Title: Tissue specific expression and chromosomal mapping of a human UDP-N-acetylglucosamine: alpha1,3-d-mannoside beta1, 4-N-acetylglucosaminyltransferase.
PubMed ID: 10024668
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10463590
Title: Unusually high expression of N-acetylglucosaminyltransferase-IVa in human choriocarcinoma cell lines: a possible enzymatic basis of the formation of abnormal biantennary sugar chain.
PubMed ID: 10463590
PubMed ID: 16434023
Title: Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer.
PubMed ID: 16434023
PubMed ID: 17006639
Title: Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes.
PubMed ID: 17006639
PubMed ID: 26091039
Title: A single kinase generates the majority of the secreted phosphoproteome.
PubMed ID: 26091039
Sequence Information:
- Length: 535
- Mass: 61544
- Checksum: C139E5F323A083A1
- Sequence:
MRLRNGTVAT ALAFITSFLT LSWYTTWQNG KEKLIAYQRE FLALKERLRI AEHRISQRSS ELNTIVQQFK RVGAETNGSK DALNKFSDNT LKLLKELTSK KSLQVPSIYY HLPHLLKNEG SLQPAVQIGN GRTGVSIVMG IPTVKREVKS YLIETLHSLI DNLYPEEKLD CVIVVFIGET DIDYVHGVVA NLEKEFSKEI SSGLVEVISP PESYYPDLTN LKETFGDSKE RVRWRTKQNL DYCFLMMYAQ EKGIYYIQLE DDIIVKQNYF NTIKNFALQL SSEEWMILEF SQLGFIGKMF QAPDLTLIVE FIFMFYKEKP IDWLLDHILW VKVCNPEKDA KHCDRQKANL RIRFRPSLFQ HVGLHSSLSG KIQKLTDKDY MKPLLLKIHV NPPAEVSTSL KVYQGHTLEK TYMGEDFFWA ITPIAGDYIL FKFDKPVNVE SYLFHSGNQE HPGDILLNTT VEVLPFKSEG LEISKETKDK RLEDGYFRIG KFENGVAEGM VDPSLNPISA FRLSVIQNSA VWAILNEIHI KKATN