Details for: GPN1

Gene ID: 11321

Symbol: GPN1

Ensembl ID: ENSG00000198522

Description: GPN-loop GTPase 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.62
    Marker Score: 1,295
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.07
    Marker Score: 4,189
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.05
    Marker Score: 2,191
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.01
    Marker Score: 1,064
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1
    Marker Score: 1,006
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,705
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,929
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,394
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.98
    Marker Score: 4,003
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,394
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.94
    Marker Score: 1,590
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,696
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.86
    Marker Score: 585
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.86
    Marker Score: 2,345
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,227
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.85
    Marker Score: 565
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 304
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.84
    Marker Score: 902
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4,802
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.81
    Marker Score: 1,011
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.81
    Marker Score: 758
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.8
    Marker Score: 845
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.79
    Marker Score: 504
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 310
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.77
    Marker Score: 2,848
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 571
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.74
    Marker Score: 357
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.74
    Marker Score: 9,744
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.74
    Marker Score: 6,352
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 371
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.71
    Marker Score: 355
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.71
    Marker Score: 686
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.71
    Marker Score: 4,533
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.71
    Marker Score: 1,044
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.7
    Marker Score: 385
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.69
    Marker Score: 1,648
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.69
    Marker Score: 162
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.68
    Marker Score: 2,941
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.68
    Marker Score: 375
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.68
    Marker Score: 424
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 173
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.67
    Marker Score: 1,827
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2,810
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.67
    Marker Score: 1,645
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.67
    Marker Score: 1,164
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.66
    Marker Score: 693
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.66
    Marker Score: 188
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 605
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.66
    Marker Score: 191
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.66
    Marker Score: 483
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.66
    Marker Score: 422
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.66
    Marker Score: 1,547
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.65
    Marker Score: 2,535
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.65
    Marker Score: 616
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.65
    Marker Score: 915
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.65
    Marker Score: 226
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.64
    Marker Score: 192
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.64
    Marker Score: 687
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.64
    Marker Score: 478
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.63
    Marker Score: 307
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.63
    Marker Score: 424
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.63
    Marker Score: 6,202
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.63
    Marker Score: 360
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.62
    Marker Score: 1,717
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.62
    Marker Score: 727
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.61
    Marker Score: 406
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.61
    Marker Score: 735
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.61
    Marker Score: 684
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.61
    Marker Score: 6,161
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.61
    Marker Score: 195
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.61
    Marker Score: 542
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.6
    Marker Score: 430
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.6
    Marker Score: 441
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.6
    Marker Score: 3,910
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.6
    Marker Score: 297
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.59
    Marker Score: 395
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.58
    Marker Score: 215
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.58
    Marker Score: 310
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.58
    Marker Score: 114
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.58
    Marker Score: 154
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.58
    Marker Score: 833
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.58
    Marker Score: 892
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.58
    Marker Score: 199
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.57
    Marker Score: 477
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.56
    Marker Score: 259
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.56
    Marker Score: 744
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.56
    Marker Score: 332
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.56
    Marker Score: 405
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.56
    Marker Score: 1,274
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.56
    Marker Score: 231
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.55
    Marker Score: 261
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.55
    Marker Score: 121
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.55
    Marker Score: 132
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.55
    Marker Score: 269
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.55
    Marker Score: 535
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.55
    Marker Score: 841
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.54
    Marker Score: 362

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GPN1 is a GTPase enzyme that belongs to the loop GTPase family. This family of enzymes is characterized by their ability to hydrolyze GTP into GDP, regulating various cellular processes. GPN1 is specifically involved in regulating the activity of other proteins and cellular signaling pathways. The protein has a high affinity for GTP and exhibits ATP hydrolysis activity, indicating its role in energy metabolism. Additionally, GPN1 interacts with other proteins, such as MBD2, to regulate cellular functions. **Pathways and Functions** GPN1 is involved in several cellular pathways, including: 1. **ATP Hydrolysis Activity**: GPN1's ATP hydrolysis activity regulates energy metabolism in cells, particularly in the mitochondria. This process is essential for maintaining cellular energy homeostasis. 2. **GTP Binding**: GPN1's high affinity for GTP allows it to regulate the activity of other proteins and signaling pathways. This is particularly important in the regulation of cellular processes such as cell growth, differentiation, and survival. 3. **Mitochondrial Function**: GPN1's involvement in ATP hydrolysis activity and GTP binding suggests its role in regulating mitochondrial function. Mitochondria are the primary site of energy production in cells, and GPN1's regulation of mitochondrial function is critical for maintaining cellular energy homeostasis. 4. **Protein Binding**: GPN1 interacts with other proteins, such as MBD2, to regulate cellular functions. This interaction is essential for maintaining cellular homeostasis and regulating protein activity. **Clinical Significance** GPN1's involvement in various cellular processes makes it an important gene for understanding human health and disease. While the clinical significance of GPN1 is still unclear, research has identified several potential associations with human diseases. For example: 1. **Cancer**: GPN1's role in regulating cellular signaling pathways and energy metabolism makes it a potential target for cancer therapy. 2. **Neurological Disorders**: GPN1's involvement in regulating mitochondrial function and protein binding makes it a potential target for neurological disorders such as Alzheimer's disease and Parkinson's disease. 3. **Metabolic Disorders**: GPN1's role in regulating energy metabolism makes it a potential target for metabolic disorders such as diabetes and obesity. In conclusion, GPN1 is a gene that plays a crucial role in regulating various cellular processes, including energy metabolism, cell signaling, and protein-protein interactions. Further research is necessary to uncover the full significance of GPN1 in human health and disease, but its potential associations with human diseases make it an important area of study.

Genular Protein ID: 4253811033

Symbol: GPN1_HUMAN

Name: MBD2-interacting protein

UniProtKB Accession Codes:

Q9HCN4 B4DQJ5 B4DQM4 B4DXU4 B5MBZ5 O76004

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CPTAC 1 CTD 1 ChEBI 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 8 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 4 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11058119

Title: A novel cytoplasmic GTPase XAB1 interacts with DNA repair protein XPA.

PubMed ID: 11058119

DOI: 10.1093/nar/28.21.4212

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11124703

Title: Characterization of 16 novel human genes showing high similarity to yeast sequences.

PubMed ID: 11124703

DOI: 10.1002/1097-0061(200101)18:1<69::aid-yea647>3.0.co;2-h

PubMed ID: 17643375

Title: Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.

PubMed ID: 17643375

DOI: 10.1016/j.molcel.2007.06.027

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20855544

Title: The protein interaction network of the human transcription machinery reveals a role for the conserved GTPase RPAP4/GPN1 and microtubule assembly in nuclear import and biogenesis of RNA polymerase II.

PubMed ID: 20855544

DOI: 10.1074/mcp.m110.003616

PubMed ID: 20864038

Title: HSP90 and its R2TP/Prefoldin-like cochaperone are involved in the cytoplasmic assembly of RNA polymerase II.

PubMed ID: 20864038

DOI: 10.1016/j.molcel.2010.08.023

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21844196

Title: GTP-dependent binding and nuclear transport of RNA polymerase II by Npa3 protein.

PubMed ID: 21844196

DOI: 10.1074/jbc.m111.286161

PubMed ID: 21768307

Title: Human GTPases associate with RNA polymerase II to mediate its nuclear import.

PubMed ID: 21768307

DOI: 10.1128/mcb.05442-11

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 374
  • Mass: 41740
  • Checksum: 9B96F452FAFE955C
  • Sequence:
    • MAASAAAAEL QASGGPRHPV CLLVLGMAGS GKTTFVQRLT GHLHAQGTPP YVINLDPAVH 
EVPFPANIDI RDTVKYKEVM KQYGLGPNGG IVTSLNLFAT RFDQVMKFIE KAQNMSKYVL 
IDTPGQIEVF TWSASGTIIT EALASSFPTV VIYVMDTSRS TNPVTFMSNM LYACSILYKT 
KLPFIVVMNK TDIIDHSFAV EWMQDFEAFQ DALNQETTYV SNLTRSMSLV LDEFYSSLRV 
VGVSAVLGTG LDELFVQVTS AAEEYEREYR PEYERLKKSL ANAESQQQRE QLERLRKDMG 
SVALDAGTAK DSLSPVLHPS DLILTRGTLD EEDEEADSDT DDIDHRVTEE SHEEPAFQNF 
MQESMAQYWK RNNK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.