Details for: TMC6

Gene ID: 11322

Symbol: TMC6

Ensembl ID: ENSG00000141524

Description: transmembrane channel like 6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.44
    Marker Score: 9,433
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.76
    Marker Score: 5,549
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.75
    Marker Score: 4,822
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.73
    Marker Score: 1,618
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.65
    Marker Score: 7,078
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.62
    Marker Score: 85,539
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.6
    Marker Score: 10,260
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.59
    Marker Score: 3,818
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.54
    Marker Score: 3,753
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.49
    Marker Score: 17,376
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.48
    Marker Score: 4,156
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.46
    Marker Score: 882
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,505
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.45
    Marker Score: 37,168
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.43
    Marker Score: 470
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.41
    Marker Score: 1,363
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.4
    Marker Score: 13,878
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.36
    Marker Score: 2,660
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.34
    Marker Score: 1,344
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.34
    Marker Score: 1,191
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.34
    Marker Score: 2,334
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.33
    Marker Score: 573
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.33
    Marker Score: 470
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.32
    Marker Score: 1,944
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.27
    Marker Score: 1,375
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.27
    Marker Score: 636
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.27
    Marker Score: 848
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.26
    Marker Score: 3,277
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.26
    Marker Score: 1,680
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.26
    Marker Score: 3,686
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.26
    Marker Score: 3,743
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.26
    Marker Score: 923
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.26
    Marker Score: 1,058
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.26
    Marker Score: 1,103
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.24
    Marker Score: 1,219
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.23
    Marker Score: 1,159
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.23
    Marker Score: 929
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.21
    Marker Score: 367
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.2
    Marker Score: 2,148
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.19
    Marker Score: 1,645
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.19
    Marker Score: 1,682
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.19
    Marker Score: 368
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.18
    Marker Score: 1,231
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.17
    Marker Score: 713
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.16
    Marker Score: 1,986
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.13
    Marker Score: 821
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.12
    Marker Score: 759
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.12
    Marker Score: 656
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.1
    Marker Score: 606
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.09
    Marker Score: 970
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.08
    Marker Score: 667
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.07
    Marker Score: 641
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.06
    Marker Score: 867
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.06
    Marker Score: 369
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.06
    Marker Score: 607
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16,446
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.05
    Marker Score: 365
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.04
    Marker Score: 511
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.03
    Marker Score: 1,511
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.02
    Marker Score: 868
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.02
    Marker Score: 764
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.01
    Marker Score: 840
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,645
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,870
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.99
    Marker Score: 251
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.99
    Marker Score: 1,920
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.98
    Marker Score: 234
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.98
    Marker Score: 743
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,388
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.96
    Marker Score: 475
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.95
    Marker Score: 1,801
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.95
    Marker Score: 686
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,392
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.94
    Marker Score: 216
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.93
    Marker Score: 463
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.93
    Marker Score: 600
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.93
    Marker Score: 581
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.93
    Marker Score: 455
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.93
    Marker Score: 632
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.93
    Marker Score: 511
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.92
    Marker Score: 540
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.91
    Marker Score: 203
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.91
    Marker Score: 986
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,695
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.9
    Marker Score: 2,234
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.9
    Marker Score: 202
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.89
    Marker Score: 458
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.88
    Marker Score: 595
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.88
    Marker Score: 1,012
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.88
    Marker Score: 931
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.88
    Marker Score: 637
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.88
    Marker Score: 974
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.88
    Marker Score: 5,330
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,287
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.87
    Marker Score: 189
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.86
    Marker Score: 960
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.86
    Marker Score: 297

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane domain:** TMC6 contains a transmembrane domain, which is a characteristic feature of channel proteins. This domain allows the protein to span the cell membrane, enabling it to interact with the extracellular environment. 2. **Monoatomic ion channel activity:** TMC6 has been shown to exhibit monoatomic ion channel activity, which involves the transport of single atoms across the cell membrane. This activity has been linked to the regulation of cellular signaling pathways. 3. **Expression in immune cells:** TMC6 is significantly expressed in various immune cells, including mature gamma-delta T cells, decidual natural killer cells, and alpha-beta T cells. This expression suggests a crucial role in immune regulation and cell signaling. 4. **Cellular localization:** TMC6 has been localized to the plasma membrane, Golgi apparatus, and endoplasmic reticulum, indicating its involvement in multiple cellular processes. **Pathways and Functions:** 1. **Immune system regulation:** TMC6 has been implicated in the regulation of immune responses, including neutrophil degranulation and the innate immune system. Its expression in immune cells suggests a role in modulating immune cell behavior. 2. **Cell signaling:** TMC6 has been shown to participate in cell signaling pathways, including the regulation of protein binding and the transport of ions across the cell membrane. 3. **Cellular homeostasis:** TMC6 has been linked to the regulation of cellular homeostasis, including the maintenance of ion balances and the regulation of cellular behavior. 4. **Mechanosensitive activity:** TMC6 has been shown to exhibit mechanosensitive activity, which involves the response to mechanical stimuli, such as changes in pressure or stretch. **Clinical Significance:** 1. **Autoimmune diseases:** Dysregulation of TMC6 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. Understanding the role of TMC6 in immune regulation may provide insights into the development of novel therapeutic strategies. 2. **Immunodeficiency disorders:** TMC6 has been linked to immunodeficiency disorders, such as severe combined immunodeficiency (SCID). Further research on TMC6 may provide insights into the underlying mechanisms of these disorders. 3. **Cancer:** TMC6 has been implicated in cancer, including the regulation of tumor cell behavior and the modulation of immune responses. Understanding the role of TMC6 in cancer may provide insights into the development of novel therapeutic strategies. 4. **Neurological disorders:** TMC6 has been linked to neurological disorders, such as multiple sclerosis and Parkinson's disease. Further research on TMC6 may provide insights into the underlying mechanisms of these disorders. In conclusion, TMC6 is a crucial gene that plays a significant role in immune regulation, cellular homeostasis, and cell signaling. Its dysregulation has been implicated in various diseases, including autoimmune disorders, immunodeficiency disorders, cancer, and neurological disorders. Further research on TMC6 may provide insights into the underlying mechanisms of these disorders and the development of novel therapeutic strategies.

Genular Protein ID: 3608415149

Symbol: TMC6_HUMAN

Name: Transmembrane channel-like protein 6

UniProtKB Accession Codes:

Q7Z403 O43284 Q45VJ2 Q8IU98 Q8IUI7 Q8IWU8 Q8TEQ7 Q9HAG5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 7 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 SAM 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12426567

Title: Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis.

PubMed ID: 12426567

DOI: 10.1038/ng1044

PubMed ID: 12906855

Title: Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis.

PubMed ID: 12906855

DOI: 10.1016/s0888-7543(03)00154-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15042430

Title: Novel mutations of EVER1/TMC6 gene in a Japanese patient with epidermodysplasia verruciformis.

PubMed ID: 15042430

DOI: 10.1007/s10038-004-0135-6

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 30068544

Title: The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to beta-papillomaviruses.

PubMed ID: 30068544

DOI: 10.1084/jem.20170308

Sequence Information:

  • Length: 805
  • Mass: 90045
  • Checksum: 9A9A5C43FBA86AD4
  • Sequence:
    • MAQPLAFILD VPETPGDQGQ GPSPYDESEV HDSFQQLIQE QSQCTAQEGL ELQQREREVT 
GSSQQTLWRP EGTQSTATLR ILASMPSRTI GRSRGAIISQ YYNRTVQLRC RSSRPLLGNF 
VRSAWPSLRL YDLELDPTAL EEEEKQSLLV KELQSLAVAQ RDHMLRGMPL SLAEKRSLRE 
KSRTPRGKWR GQPGSGGVCS CCGRLRYACV LALHSLGLAL LSALQALMPW RYALKRIGGQ 
FGSSVLSYFL FLKTLLAFNA LLLLLLVAFI MGPQVAFPPA LPGPAPVCTG LELLTGAGCF 
THTVMYYGHY SNATLNQPCG SPLDGSQCTP RVGGLPYNMP LAYLSTVGVS FFITCITLVY 
SMAHSFGESY RVGSTSGIHA ITVFCSWDYK VTQKRASRLQ QDNIRTRLKE LLAEWQLRHS 
PRSVCGRLRQ AAVLGLVWLL CLGTALGCAV AVHVFSEFMI QSPEAAGQEA VLLVLPLVVG 
LLNLGAPYLC RVLAALEPHD SPVLEVYVAI CRNLILKLAI LGTLCYHWLG RRVGVLQGQC 
WEDFVGQELY RFLVMDFVLM LLDTLFGELV WRIISEKKLK RRRKPEFDIA RNVLELIYGQ 
TLTWLGVLFS PLLPAVQIIK LLLVFYVKKT SLLANCQAPR RPWLASHMST VFLTLLCFPA 
FLGAAVFLCY AVWQVKPSST CGPFRTLDTM YEAGRVWVRH LEAAGPRVSW LPWVHRYLME 
NTFFVFLVSA LLLAVIYLNI QVVRGQRKVI CLLKEQISNE GEDKIFLINK LHSIYERKER 
EERSRVGTTE EAAAPPALLT DEQDA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.