Details for: DDX42

Gene ID: 11325

Symbol: DDX42

Ensembl ID: ENSG00000198231

Description: DEAD-box helicase 42

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.61
    Marker Score: 5,525
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.55
    Marker Score: 1,034
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.54
    Marker Score: 2,265
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.49
    Marker Score: 91,525
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.48
    Marker Score: 3,362
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.45
    Marker Score: 2,087
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.42
    Marker Score: 1,535
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.39
    Marker Score: 1,462
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.36
    Marker Score: 11,800
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.36
    Marker Score: 1,443
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.35
    Marker Score: 12,803
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.35
    Marker Score: 12,675
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.33
    Marker Score: 1,711
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.32
    Marker Score: 11,358
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.32
    Marker Score: 4,880
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.31
    Marker Score: 14,798
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.31
    Marker Score: 764
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.31
    Marker Score: 890
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.31
    Marker Score: 2,869
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.31
    Marker Score: 2,757
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.29
    Marker Score: 1,430
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.29
    Marker Score: 5,366
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.28
    Marker Score: 47,251
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.25
    Marker Score: 9,275
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.24
    Marker Score: 358
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.24
    Marker Score: 1,913
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.24
    Marker Score: 1,549
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.24
    Marker Score: 5,169
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.23
    Marker Score: 607
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.23
    Marker Score: 12,682
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.22
    Marker Score: 3,329
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.21
    Marker Score: 46,108
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.21
    Marker Score: 2,146
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.21
    Marker Score: 24,051
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.21
    Marker Score: 4,667
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2
    Marker Score: 10,539
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.19
    Marker Score: 556
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.18
    Marker Score: 11,891
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.17
    Marker Score: 1,220
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.17
    Marker Score: 339
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.14
    Marker Score: 1,218
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.13
    Marker Score: 7,356
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.12
    Marker Score: 16,805
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.11
    Marker Score: 8,531
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.11
    Marker Score: 757
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.11
    Marker Score: 750
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.11
    Marker Score: 323
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1
    Marker Score: 11,161
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.1
    Marker Score: 6,520
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.09
    Marker Score: 2,077
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.09
    Marker Score: 530
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.08
    Marker Score: 535
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.08
    Marker Score: 1,244
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.07
    Marker Score: 4,450
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.07
    Marker Score: 36,960
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.06
    Marker Score: 243
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.05
    Marker Score: 259
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.04
    Marker Score: 596
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.04
    Marker Score: 420
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.02
    Marker Score: 243
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.01
    Marker Score: 691
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.01
    Marker Score: 1,357
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1
    Marker Score: 21,414
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1
    Marker Score: 34,129
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1
    Marker Score: 431
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1
    Marker Score: 952
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1
    Marker Score: 917
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,594
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1
    Marker Score: 548
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,818
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.99
    Marker Score: 1,861
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.99
    Marker Score: 1,900
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.98
    Marker Score: 364
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.98
    Marker Score: 1,059
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,370
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.98
    Marker Score: 1,183
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.98
    Marker Score: 15,287
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.97
    Marker Score: 234
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.97
    Marker Score: 565
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.96
    Marker Score: 4,737
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.95
    Marker Score: 1,155
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.95
    Marker Score: 3,886
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.95
    Marker Score: 1,111
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.95
    Marker Score: 1,000
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.94
    Marker Score: 385
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.94
    Marker Score: 431
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.94
    Marker Score: 395
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.94
    Marker Score: 947
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.94
    Marker Score: 328
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,379
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.93
    Marker Score: 582
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.93
    Marker Score: 1,860
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.93
    Marker Score: 1,118
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.93
    Marker Score: 2,179
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.92
    Marker Score: 1,308
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.92
    Marker Score: 2,095
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.92
    Marker Score: 320
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.92
    Marker Score: 4,841
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.92
    Marker Score: 290
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.92
    Marker Score: 227

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DDX42 is a member of the DEAD-box family of RNA helicases, characterized by its ability to unwind double-stranded RNA (dsRNA) and single-stranded RNA (ssRNA) molecules. This protein possesses a conserved ATP-dependent RNA helicase activity, which is crucial for its function. DDX42 is widely expressed in various tissues and cell types, including the nasal mucosa, bladder urothelial cells, and neurons. Its expression is also observed in specific cell types, such as ciliated cells and goblet cells, which are involved in the maintenance of epithelial integrity. **Pathways and Functions:** DDX42 plays a crucial role in various cellular processes, including: 1. **RNA Splicing:** DDX42 is involved in the processing of capped intron-containing pre-mRNAs, which is essential for the production of mature mRNAs. 2. **Transcription:** This protein regulates the expression of genes by modulating the assembly of U2-type prespliceosomes, which are essential for the splicing of pre-mRNAs. 3. **Translation:** DDX42 may also influence the translation of mRNAs by regulating the assembly of ribosomes and the processing of translation initiation complexes. 4. **Apoptosis:** DDX42 has been implicated in the regulation of the apoptotic process, which is crucial for maintaining cellular homeostasis. **Clinical Significance:** The DDX42 gene has been associated with various diseases, including: 1. **Neurological Disorders:** Mutations in the DDX42 gene have been linked to neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 2. **Cancer:** Aberrant expression of DDX42 has been observed in various types of cancer, including lung, breast, and colon cancer. 3. **Epithelial Disorders:** Mutations in the DDX42 gene have been associated with epithelial disorders, such as ciliopathies and epithelial cancers. In conclusion, the DDX42 gene plays a critical role in regulating RNA metabolism and cellular function. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis. Further research is necessary to elucidate the mechanisms by which DDX42 regulates RNA metabolism and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 2230411837

Symbol: DDX42_HUMAN

Name: ATP-dependent RNA helicase DDX42

UniProtKB Accession Codes:

Q86XP3 A6NML1 A8KA43 O75619 Q68G51 Q96BK1 Q96HR7 Q9Y3V8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 11 EMDB 2 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PIR 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 Rhea 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10727850

Title: Identification of a novel human member of the DEAD box protein family.

PubMed ID: 10727850

DOI: 10.1016/s0925-4439(00)00010-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12234937

Title: Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein.

PubMed ID: 12234937

DOI: 10.1093/emboj/cdf480

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16397294

Title: Ddx42p -- a human DEAD box protein with RNA chaperone activities.

PubMed ID: 16397294

DOI: 10.1093/nar/gkj403

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19377511

Title: The DEAD box protein Ddx42p modulates the function of ASPP2, a stimulator of apoptosis.

PubMed ID: 19377511

DOI: 10.1038/onc.2009.75

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 36797247

Title: Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.

PubMed ID: 36797247

DOI: 10.1038/s41467-023-36489-x

Sequence Information:

  • Length: 938
  • Mass: 102975
  • Checksum: D89A252E095D8913
  • Sequence:
    • MNWNKGGPGT KRGFGFGGFA ISAGKKEEPK LPQQSHSAFG ATSSSSGFGK SAPPQLPSFY 
KIGSKRANFD EENAYFEDEE EDSSNVDLPY IPAENSPTRQ QFHSKPVDSD SDDDPLEAFM 
AEVEDQAARD MKRLEEKDKE RKNVKGIRDD IEEEDDQEAY FRYMAENPTA GVVQEEEEDN 
LEYDSDGNPI APTKKIIDPL PPIDHSEIDY PPFEKNFYNE HEEITNLTPQ QLIDLRHKLN 
LRVSGAAPPR PGSSFAHFGF DEQLMHQIRK SEYTQPTPIQ CQGVPVALSG RDMIGIAKTG 
SGKTAAFIWP MLIHIMDQKE LEPGDGPIAV IVCPTRELCQ QIHAECKRFG KAYNLRSVAV 
YGGGSMWEQA KALQEGAEIV VCTPGRLIDH VKKKATNLQR VSYLVFDEAD RMFDMGFEYQ 
VRSIASHVRP DRQTLLFSAT FRKKIEKLAR DILIDPIRVV QGDIGEANED VTQIVEILHS 
GPSKWNWLTR RLVEFTSSGS VLLFVTKKAN AEELANNLKQ EGHNLGLLHG DMDQSERNKV 
ISDFKKKDIP VLVATDVAAR GLDIPSIKTV INYDVARDID THTHRIGRTG RAGEKGVAYT 
LLTPKDSNFA GDLVRNLEGA NQHVSKELLD LAMQNAWFRK SRFKGGKGKK LNIGGGGLGY 
RERPGLGSEN MDRGNNNVMS NYEAYKPSTG AMGDRLTAMK AAFQSQYKSH FVAASLSNQK 
AGSSAAGASG WTSAGSLNSV PTNSAQQGHN SPDSPVTSAA KGIPGFGNTG NISGAPVTYP 
SAGAQGVNNT ASGNNSREGT GGSNGKRERY TENRGSSRHS HGETGNRHSD SPRHGDGGRH 
GDGYRHPESS SRHTDGHRHG ENRHGGSAGR HGENRGANDG RNGESRKEAF NRESKMEPKM 
EPKVDSSKMD KVDSKTDKTA DGFAVPEPPK RKKSRWDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.