Details for: VSIG4

Gene ID: 11326

Symbol: VSIG4

Ensembl ID: ENSG00000155659

Description: V-set and immunoglobulin domain containing 4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.92
    Marker Score: 3,920
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.24
    Marker Score: 3,705
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.77
    Marker Score: 70,935
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.39
    Marker Score: 1,316
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.24
    Marker Score: 13,619
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.24
    Marker Score: 914
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2
    Marker Score: 722
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.8
    Marker Score: 928
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.62
    Marker Score: 2,948
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169,967
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.34
    Marker Score: 3,482
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.26
    Marker Score: 2,568
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.09
    Marker Score: 454
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.09
    Marker Score: 1,210
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,808
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,034
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,338
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,736
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,283
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 616
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.81
    Marker Score: 789
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.75
    Marker Score: 3,122
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 496
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1,202
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.75
    Marker Score: 806
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 378
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.62
    Marker Score: 625
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.61
    Marker Score: 155
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.57
    Marker Score: 158
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.57
    Marker Score: 1,765
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.5
    Marker Score: 251
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.49
    Marker Score: 928
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.49
    Marker Score: 947
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.48
    Marker Score: 251
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.45
    Marker Score: 409
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.45
    Marker Score: 256
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.43
    Marker Score: 430
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.42
    Marker Score: 278
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 181
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.42
    Marker Score: 110
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.39
    Marker Score: 194
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.38
    Marker Score: 259
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.37
    Marker Score: 888
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.37
    Marker Score: 475
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.35
    Marker Score: 112
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.33
    Marker Score: 18,367
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.3
    Marker Score: 2,954
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.29
    Marker Score: 382
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.29
    Marker Score: 197
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.29
    Marker Score: 272
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.28
    Marker Score: 165
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.28
    Marker Score: 94
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.28
    Marker Score: 253
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.28
    Marker Score: 779
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.28
    Marker Score: 175
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.27
    Marker Score: 118
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.27
    Marker Score: 623
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 155
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.26
    Marker Score: 190
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.26
    Marker Score: 157
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.25
    Marker Score: 105
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.25
    Marker Score: 1,597
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.24
    Marker Score: 3,779
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.22
    Marker Score: 3,574
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.22
    Marker Score: 81
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.22
    Marker Score: 43
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.22
    Marker Score: 554
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.21
    Marker Score: 115
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.21
    Marker Score: 395
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.21
    Marker Score: 100
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.2
    Marker Score: 81
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.19
    Marker Score: 90
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.19
    Marker Score: 66
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.19
    Marker Score: 91
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.19
    Marker Score: 40
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.19
    Marker Score: 44
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.19
    Marker Score: 190
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.19
    Marker Score: 729
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.18
    Marker Score: 117
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.18
    Marker Score: 57
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.18
    Marker Score: 2,120
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.18
    Marker Score: 174
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.18
    Marker Score: 155
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.18
    Marker Score: 159
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.18
    Marker Score: 178
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.17
    Marker Score: 278
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.17
    Marker Score: 40
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.17
    Marker Score: 44
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.17
    Marker Score: 48
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.17
    Marker Score: 103
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.17
    Marker Score: 44

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunomodulatory function:** VSIG4 acts as a negative regulator of immune responses, inhibiting the activation of the alternative complement pathway and reducing the production of pro-inflammatory cytokines, such as IL-2. 2. **Cell-specific expression:** VSIG4 is highly expressed in immune cells, including Kupffer cells, lung macrophages, alveolar macrophages, and microglia, suggesting its role in regulating immune responses in these cells. 3. **C3b binding:** VSIG4 binds to C3b, a crucial component of the complement system, and inhibits its activation, thereby modulating the immune response. 4. **Protein-protein interactions:** VSIG4 interacts with various proteins, including complement components, cytokines, and receptors, highlighting its complex role in immune regulation. **Pathways and Functions:** 1. **Complement activation:** VSIG4 inhibits the activation of the alternative complement pathway, which is crucial for regulating immune responses and preventing tissue damage. 2. **Negative regulation of complement activation:** VSIG4 acts as a negative regulator of complement activation, preventing excessive immune response and tissue damage. 3. **Negative regulation of interleukin-2 production:** VSIG4 inhibits the production of IL-2, a key cytokine involved in T-cell proliferation and activation. 4. **Negative regulation of macrophage activation:** VSIG4 modulates the activation of macrophages, preventing excessive inflammation and tissue damage. 5. **Protein-containing complex:** VSIG4 interacts with various proteins, forming protein-containing complexes that regulate immune responses. **Clinical Significance:** Dysregulation of the VSIG4 gene has been implicated in various autoimmune and inflammatory diseases, including: 1. **Autoimmune disorders:** VSIG4 deficiency or dysfunction has been linked to autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Inflammatory diseases:** VSIG4 dysregulation has been implicated in inflammatory diseases, such as asthma, chronic obstructive pulmonary disease (COPD), and inflammatory bowel disease (IBD). 3. **Cancer:** VSIG4 has been identified as a potential biomarker for cancer, with its expression altered in various types of cancer, including lung, breast, and colon cancer. In conclusion, the VSIG4 gene plays a critical role in regulating immune responses and complement activation. Its dysregulation has significant clinical implications, highlighting the importance of understanding the function and regulation of this gene in maintaining immune homeostasis.

Genular Protein ID: 3490647059

Symbol: VSIG4_HUMAN

Name: V-set and immunoglobulin domain-containing protein 4

UniProtKB Accession Codes:

Q9Y279 Q6UXI4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 7 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 5 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11004523

Title: Cloning of Z39Ig, a novel gene with immunoglobulin-like domains located on human chromosome X.

PubMed ID: 11004523

DOI: 10.1016/s0167-4781(00)00131-7

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 17016562

Title: VSIG4, a B7 family-related protein, is a negative regulator of T cell activation.

PubMed ID: 17016562

DOI: 10.1172/jci25673

PubMed ID: 17051150

Title: Structure of C3b in complex with CRIg gives insights into regulation of complement activation.

PubMed ID: 17051150

DOI: 10.1038/nature05263

Sequence Information:

  • Length: 399
  • Mass: 43987
  • Checksum: 735CA3BC58185035
  • Sequence:
    • MGILLGLLLL GHLTVDTYGR PILEVPESVT GPWKGDVNLP CTYDPLQGYT QVLVKWLVQR 
GSDPVTIFLR DSSGDHIQQA KYQGRLHVSH KVPGDVSLQL STLEMDDRSH YTCEVTWQTP 
DGNQVVRDKI TELRVQKLSV SKPTVTTGSG YGFTVPQGMR ISLQCQARGS PPISYIWYKQ 
QTNNQEPIKV ATLSTLLFKP AVIADSGSYF CTAKGQVGSE QHSDIVKFVV KDSSKLLKTK 
TEAPTTMTYP LKATSTVKQS WDWTTDMDGY LGETSAGPGK SLPVFAIILI ISLCCMVVFT 
MAYIMLCRKT SQQEHVYEAA RAHAREANDS GETMRVAIFA SGCSSDEPTS QNLGNNYSDE 
PCIGQEYQII AQINGNYARL LDTVPLDYEF LATEGKSVC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.