Details for: FKBP9

Gene ID: 11328

Symbol: FKBP9

Ensembl ID: ENSG00000122642

Description: FKBP prolyl isomerase 9

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.57
    Marker Score: 1,476
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.32
    Marker Score: 1,814
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.3
    Marker Score: 1,198
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.29
    Marker Score: 366
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.27
    Marker Score: 8,238
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.25
    Marker Score: 3,278
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.25
    Marker Score: 2,495
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.19
    Marker Score: 294
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.19
    Marker Score: 479
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.19
    Marker Score: 273
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.18
    Marker Score: 3,166
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.14
    Marker Score: 10,021
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.14
    Marker Score: 15,277
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.09
    Marker Score: 988
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.08
    Marker Score: 16,876
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.05
    Marker Score: 944
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.05
    Marker Score: 253
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.04
    Marker Score: 1,282
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.03
    Marker Score: 1,241
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.02
    Marker Score: 372
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.01
    Marker Score: 2,558
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.01
    Marker Score: 13,341
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,753
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,977
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.98
    Marker Score: 616
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.97
    Marker Score: 578
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.96
    Marker Score: 1,402
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.96
    Marker Score: 1,029
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,407
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.94
    Marker Score: 303
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.94
    Marker Score: 1,000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.94
    Marker Score: 1,904
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.91
    Marker Score: 212
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,724
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.91
    Marker Score: 30,836
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.89
    Marker Score: 941
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.88
    Marker Score: 188
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.88
    Marker Score: 1,494
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.88
    Marker Score: 205
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.87
    Marker Score: 480
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.87
    Marker Score: 1,342
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.87
    Marker Score: 748
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.86
    Marker Score: 2,032
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4,856
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 623
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 325
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.8
    Marker Score: 193
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.79
    Marker Score: 805
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.78
    Marker Score: 182
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.76
    Marker Score: 327
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.76
    Marker Score: 170
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.75
    Marker Score: 1,164
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.75
    Marker Score: 539
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.75
    Marker Score: 424
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.75
    Marker Score: 715
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.75
    Marker Score: 3,231
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.75
    Marker Score: 337
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.74
    Marker Score: 8,361
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.73
    Marker Score: 1,035
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 467
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.72
    Marker Score: 698
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.72
    Marker Score: 4,332
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 648
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.7
    Marker Score: 14,997
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.7
    Marker Score: 178
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.7
    Marker Score: 1,341
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.68
    Marker Score: 457
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.68
    Marker Score: 711
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,847
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.67
    Marker Score: 6,296
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.67
    Marker Score: 209
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.67
    Marker Score: 1,261
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.66
    Marker Score: 269
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.66
    Marker Score: 356
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.66
    Marker Score: 387
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.66
    Marker Score: 470
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.66
    Marker Score: 434
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.66
    Marker Score: 1,669
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.65
    Marker Score: 702
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.65
    Marker Score: 4,827
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.65
    Marker Score: 1,072
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.65
    Marker Score: 1,364
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.64
    Marker Score: 409
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.64
    Marker Score: 1,332
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.64
    Marker Score: 543
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.63
    Marker Score: 263
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.63
    Marker Score: 637
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.63
    Marker Score: 1,429
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.63
    Marker Score: 2,154
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.63
    Marker Score: 141
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.63
    Marker Score: 1,486
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.63
    Marker Score: 670

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FKBP9 is characterized by its: 1. **Peptidyl-prolyl cis-trans isomerase activity**: This activity is crucial for the proper folding of proteins, as it enables the cis-trans isomerization of proline residues, which can either facilitate or hinder protein folding. 2. **Calcium ion binding**: FKBP9's ability to bind calcium ions suggests its involvement in calcium-dependent signaling pathways, which are essential for various cellular processes, including cell migration, proliferation, and differentiation. 3. **Association with chaperonin-mediated protein folding**: FKBP9's interaction with chaperonins highlights its role in protein folding and quality control, which is essential for maintaining cellular homeostasis. **Pathways and Functions** FKBP9 is involved in several pathways, including: 1. **Association of tric/cct with target proteins during biosynthesis**: FKBP9's interaction with tric/cct (a trimeric complex of chaperone proteins) suggests its role in regulating protein biosynthesis and folding. 2. **Calcium ion binding**: FKBP9's calcium-binding ability is essential for its role in calcium-dependent signaling pathways. 3. **Chaperonin-mediated protein folding**: FKBP9's association with chaperonins highlights its involvement in protein folding and quality control. 4. **Metabolism of proteins**: FKBP9's peptidyl-prolyl cis-trans isomerase activity is essential for the proper folding of proteins, which is critical for protein metabolism. **Clinical Significance** FKBP9's involvement in protein folding and metabolism makes it an important gene in various diseases. For instance: 1. **Neurodegenerative diseases**: Dysregulation of protein folding pathways, including those involving FKBP9, has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Cancer**: Aberrant protein folding and metabolism can contribute to cancer development and progression. FKBP9's role in regulating protein folding may be essential for understanding cancer biology. 3. **Endocrine disorders**: FKBP9's expression in enteroendocrine cells suggests its potential involvement in endocrine disorders, such as diabetes and thyroid disease. In conclusion, FKBP9 is a crucial gene involved in protein folding and metabolism. Its involvement in various pathways, including calcium-dependent signaling and chaperonin-mediated protein folding, highlights its importance in maintaining cellular homeostasis. Further research is necessary to fully elucidate the clinical significance of FKBP9 in various diseases.

Genular Protein ID: 3195847431

Symbol: FKBP9_HUMAN

Name: Peptidyl-prolyl cis-trans isomerase FKBP9

UniProtKB Accession Codes:

O95302 B3KY35 B7Z1G9 B7Z6H3 Q2M2A1 Q3MIR7 Q6IN76 Q6P2N1 Q96EX5 Q96IJ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 10 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 4 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10524204

Title: Biochemical analysis of mouse FKBP60, a novel member of the FKBP family.

PubMed ID: 10524204

DOI: 10.1016/s0167-4781(99)00080-9

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 570
  • Mass: 63084
  • Checksum: E1F44A2FA6E112F8
  • Sequence:
    • MAFRGWRPPP PPLLLLLLWV TGQAAPVAGL GSDAELQIER RFVPDECPRT VRSGDFVRYH 
YVGTFPDGQK FDSSYDRDST FNVFVGKGQL ITGMDQALVG MCVNERRFVK IPPKLAYGNE 
GVSGVIPPNS VLHFDVLLMD IWNSEDQVQI HTYFKPPSCP RTIQVSDFVR YHYNGTFLDG 
TLFDSSHNRM KTYDTYVGIG WLIPGMDKGL LGMCVGEKRI ITIPPFLAYG EDGDGKDIPG 
QASLVFDVAL LDLHNPKDSI SIENKVVPEN CERISQSGDF LRYHYNGTLL DGTLFDSSYS 
RNRTFDTYIG QGYVIPGMDE GLLGVCIGEK RRIVVPPHLG YGEEGRGNIP GSAVLVFDIH 
VIDFHNPSDS ISITSHYKPP DCSVLSKKGD YLKYHYNASL LDGTLLDSTW NLGKTYNIVL 
GSGQVVLGMD MGLREMCVGE KRTVIIPPHL GYGEAGVDGE VPGSAVLVFD IELLELVAGL 
PEGYMFIWNG EVSPNLFEEI DKDGNGEVLL EEFSEYIHAQ VASGKGKLAP GFDAELIVKN 
MFTNQDRNGD GKVTAEEFKL KDQEAKHDEL

Genular Protein ID: 3774840139

Symbol: A7YQ73_HUMAN

Name: N/A

UniProtKB Accession Codes:

A7YQ73

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 2 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 3 Rhea 3 SMART 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 147
  • Mass: 16096
  • Checksum: 47C4BB81375C9B0F
  • Sequence:
    • QVVLGMDMGL REMCVGEKRT VIIPPHLGYG EAGVDGEVPG SAVLVFDIEL LELVAGLPEG 
YMFIWNGEVS PNLFEEIDKD GNGEVLLEEF SEYIHAQVAS GKGKLAPGFD AELIVKNMFT 
NQDRNGDGKV TAEEFKLKDQ EAKHDEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.