Details for: STK38

Gene ID: 11329

Symbol: STK38

Ensembl ID: ENSG00000112079

Description: serine/threonine kinase 38

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 4.65
    Marker Score: 18,010
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 3.32
    Marker Score: 13,827
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.31
    Marker Score: 2,661
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2
    Marker Score: 1,340
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.91
    Marker Score: 4,202
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.87
    Marker Score: 2,062
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.85
    Marker Score: 1,282
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.74
    Marker Score: 7,270
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.73
    Marker Score: 2,329
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.69
    Marker Score: 19,632
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.66
    Marker Score: 1,794
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.64
    Marker Score: 15,598
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.64
    Marker Score: 6,668
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.63
    Marker Score: 5,145
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.62
    Marker Score: 701
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.62
    Marker Score: 467
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.6
    Marker Score: 16,522
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.59
    Marker Score: 84,325
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.58
    Marker Score: 1,077
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.57
    Marker Score: 1,890
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.54
    Marker Score: 14,506
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.5
    Marker Score: 11,171
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.49
    Marker Score: 22,271
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.49
    Marker Score: 91,406
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.49
    Marker Score: 2,595
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.48
    Marker Score: 12,710
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.46
    Marker Score: 1,537
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.45
    Marker Score: 868
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.45
    Marker Score: 3,534
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.41
    Marker Score: 3,832
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.4
    Marker Score: 1,656
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.4
    Marker Score: 3,488
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.4
    Marker Score: 2,154
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.38
    Marker Score: 2,037
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.38
    Marker Score: 1,215
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.38
    Marker Score: 1,332
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.38
    Marker Score: 802
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.38
    Marker Score: 1,666
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.38
    Marker Score: 1,559
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.37
    Marker Score: 76,599
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.36
    Marker Score: 2,664
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.36
    Marker Score: 670
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.35
    Marker Score: 28,759
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.34
    Marker Score: 5,184
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.32
    Marker Score: 29,589
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.31
    Marker Score: 383
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.3
    Marker Score: 412
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.29
    Marker Score: 1,114
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.27
    Marker Score: 924
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.24
    Marker Score: 315
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.24
    Marker Score: 1,097
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.24
    Marker Score: 462
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.22
    Marker Score: 806
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.22
    Marker Score: 425
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.21
    Marker Score: 564
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.19
    Marker Score: 2,311
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.17
    Marker Score: 4,173
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.17
    Marker Score: 1,959
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.16
    Marker Score: 1,500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.16
    Marker Score: 1,709
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.15
    Marker Score: 42,557
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.14
    Marker Score: 8,735
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.13
    Marker Score: 228
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.12
    Marker Score: 689
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.12
    Marker Score: 11,345
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.12
    Marker Score: 1,305
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.12
    Marker Score: 2,149
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.11
    Marker Score: 4,767
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.11
    Marker Score: 1,069
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.1
    Marker Score: 462
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.1
    Marker Score: 548
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.09
    Marker Score: 404
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.09
    Marker Score: 1,028
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.09
    Marker Score: 528
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.08
    Marker Score: 886
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.08
    Marker Score: 466
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.07
    Marker Score: 1,078
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.07
    Marker Score: 4,436
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.07
    Marker Score: 433
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.05
    Marker Score: 367
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.05
    Marker Score: 769
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.04
    Marker Score: 3,259
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.03
    Marker Score: 1,248
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.03
    Marker Score: 39,212
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.03
    Marker Score: 3,528
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.02
    Marker Score: 20,314
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.02
    Marker Score: 1,442
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.01
    Marker Score: 308
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.01
    Marker Score: 1,261
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.01
    Marker Score: 565
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.01
    Marker Score: 291
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.01
    Marker Score: 1,389
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1
    Marker Score: 15,647
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,635
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,860
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.99
    Marker Score: 581
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.99
    Marker Score: 2,330
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.98
    Marker Score: 980
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,377
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.97
    Marker Score: 543

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine/Threonine Kinase Activity:** STK38 possesses serine/threonine kinase activity, which enables it to phosphorylate and regulate the activity of downstream targets. 2. **ROCK Family Member:** STK38 is a member of the ROCK family, which is characterized by its ability to modulate Rho GTPase activity. 3. **Cellular Localization:** STK38 is primarily localized to the cytosol and nucleus, where it interacts with various signaling proteins. 4. **Signaling Pathways:** STK38 is involved in multiple signaling pathways, including the MAPK, PI3K, and JAK/STAT pathways. **Pathways and Functions:** 1. **Rho GTPase Cycle:** STK38 regulates the activity of Rho GTPases, which are essential for modulating actin cytoskeleton dynamics, cell migration, and cell cycle progression. 2. **Intracellular Signaling:** STK38 modulates the activity of various signaling proteins, including MAPK, PI3K, and JAK/STAT, to regulate cell growth, differentiation, and survival. 3. **Cell Migration and Invasion:** STK38 plays a critical role in regulating cell migration and invasion, which are essential processes in cancer metastasis. 4. **Neurological Disorders:** STK38 has been implicated in the pathogenesis of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and stroke. 5. **Cancer:** STK38 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and its expression is associated with tumor progression and metastasis. **Clinical Significance:** 1. **Cancer Therapy:** STK38 is a potential therapeutic target for cancer treatment, as its inhibition can lead to reduced tumor growth and metastasis. 2. **Neurological Disorders:** STK38 may serve as a biomarker for neurological disorders, and its inhibition or modulation may provide therapeutic benefits. 3. **Cardiovascular Diseases:** STK38 is involved in the regulation of vascular smooth muscle cell proliferation and migration, making it a potential target for cardiovascular disease treatment. 4. **Immunology:** STK38 has been implicated in the regulation of immune cell function, and its dysregulation may contribute to autoimmune diseases. In conclusion, STK38 is a multifaceted serine/threonine kinase that plays a crucial role in various cellular processes, including signal transduction, cell growth, and differentiation. Its involvement in multiple diseases, including cancer, neurological disorders, and cardiovascular diseases, highlights the importance of understanding its pathways and functions. As a potential therapeutic target, STK38 holds promise for the development of novel treatments for various diseases.

Genular Protein ID: 3096575804

Symbol: STK38_HUMAN

Name: Serine/threonine-protein kinase 38

UniProtKB Accession Codes:

Q15208 Q503A1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CPTAC 2 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 3 EMBL 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 Rhea 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7761441

Title: Molecular cloning and characterization of a conserved nuclear serine/threonine protein kinase.

PubMed ID: 7761441

DOI: 10.1073/pnas.92.11.5022

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12493777

Title: Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase.

PubMed ID: 12493777

DOI: 10.1074/jbc.m210590200

PubMed ID: 15067004

Title: Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases.

PubMed ID: 15067004

DOI: 10.1074/jbc.m401999200

PubMed ID: 15197186

Title: Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein.

PubMed ID: 15197186

DOI: 10.1074/jbc.m404542200

PubMed ID: 16884686

Title: Identification and Herc5-mediated ISGylation of novel target proteins.

PubMed ID: 16884686

DOI: 10.1016/j.bbrc.2006.07.076

PubMed ID: 18362890

Title: Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1.

PubMed ID: 18362890

DOI: 10.1038/onc.2008.66

PubMed ID: 17906693

Title: Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38).

PubMed ID: 17906693

DOI: 10.1038/sj.onc.1210828

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19377461

Title: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.

PubMed ID: 19377461

DOI: 10.1038/nature07954

PubMed ID: 24336203

Title: Retraction: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.

PubMed ID: 24336203

DOI: 10.1038/nature12896

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 14661952

Title: Structure of the Ca2+/S100B/NDR kinase peptide complex: insights into S100 target specificity and activation of the kinase.

PubMed ID: 14661952

DOI: 10.1021/bi035089a

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 465
  • Mass: 54190
  • Checksum: 7262221DBFFAF83C
  • Sequence:
    • MAMTGSTPCS SMSNHTKERV TMTKVTLENF YSNLIAQHEE REMRQKKLEK VMEEEGLKDE 
EKRLRRSAHA RKETEFLRLK RTRLGLEDFE SLKVIGRGAF GEVRLVQKKD TGHVYAMKIL 
RKADMLEKEQ VGHIRAERDI LVEADSLWVV KMFYSFQDKL NLYLIMEFLP GGDMMTLLMK 
KDTLTEEETQ FYIAETVLAI DSIHQLGFIH RDIKPDNLLL DSKGHVKLSD FGLCTGLKKA 
HRTEFYRNLN HSLPSDFTFQ NMNSKRKAET WKRNRRQLAF STVGTPDYIA PEVFMQTGYN 
KLCDWWSLGV IMYEMLIGYP PFCSETPQET YKKVMNWKET LTFPPEVPIS EKAKDLILRF 
CCEWEHRIGA PGVEEIKSNS FFEGVDWEHI RERPAAISIE IKSIDDTSNF DEFPESDILK 
PTVATSNHPE TDYKNKDWVF INYTYKRFEG LTARGAIPSY MKAAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.