Details for: CTRC

Gene ID: 11330

Symbol: CTRC

Ensembl ID: ENSG00000162438

Description: chymotrypsin C

Associated with

Other Information

Genular Protein ID: 379262641

Symbol: CTRC_HUMAN

Name: Chymotrypsin-C

UniProtKB Accession Codes:

Q99895 A8K082 O00765 Q9NUH5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8635596

Title: Molecular cloning and expression of human caldecrin.

PubMed ID: 8635596

DOI: 10.1016/0014-5793(96)00377-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9538241

Title: Caldecrin is a novel-type serine protease expressed in pancreas, but its homologue, elastase IV, is an artifact during cloning derived from caldecrin gene.

PubMed ID: 9538241

DOI: 10.1093/oxfordjournals.jbchem.a021971

PubMed ID: 23430245

Title: Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation.

PubMed ID: 23430245

DOI: 10.1074/jbc.m113.457382

PubMed ID: 18172691

Title: Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis.

PubMed ID: 18172691

DOI: 10.1007/s00439-007-0459-3

PubMed ID: 18059268

Title: Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis.

PubMed ID: 18059268

DOI: 10.1038/ng.2007.44

PubMed ID: 19407484

Title: Association of novel chymotrypsin C gene variations and haplotypes in patients with chronic pancreatitis in Chinese in Taiwan.

PubMed ID: 19407484

DOI: 10.1159/000199437

PubMed ID: 23135764

Title: Identification of novel missense CTRC variants in Japanese patients with chronic pancreatitis.

PubMed ID: 23135764

DOI: 10.1136/gutjnl-2012-303860

PubMed ID: 22580415

Title: Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants.

PubMed ID: 22580415

DOI: 10.1136/gutjnl-2012-302448

PubMed ID: 22942235

Title: Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk.

PubMed ID: 22942235

DOI: 10.1136/gutjnl-2012-303090

Sequence Information:

  • Length: 268
  • Mass: 29484
  • Checksum: 460BF33B4A96516F
  • Sequence:
    • MLGITVLAAL LACASSCGVP SFPPNLSARV VGGEDARPHS WPWQISLQYL KNDTWRHTCG 
GTLIASNFVL TAAHCISNTR TYRVAVGKNN LEVEDEEGSL FVGVDTIHVH KRWNALLLRN 
DIALIKLAEH VELSDTIQVA CLPEKDSLLP KDYPCYVTGW GRLWTNGPIA DKLQQGLQPV 
VDHATCSRID WWGFRVKKTM VCAGGDGVIS ACNGDSGGPL NCQLENGSWE VFGIVSFGSR 
RGCNTRKKPV VYTRVSAYID WINEKMQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.