Details for: CTRC

Gene ID: 11330

Symbol: CTRC

Ensembl ID: ENSG00000162438

Description: chymotrypsin C

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell (CL0000622)
    Fold Change: 7.24
    Marker Score: 5,105
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 6
    Marker Score: 3,383
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.57
    Marker Score: 5,420
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.87
    Marker Score: 1,937
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.73
    Marker Score: 390
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,173
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.38
    Marker Score: 870
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,820
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.08
    Marker Score: 686
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 799
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,833
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,058
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.99
    Marker Score: 673
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,354
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.92
    Marker Score: 382
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,290
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.85
    Marker Score: 392
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.74
    Marker Score: 720
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 465
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 365
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.56
    Marker Score: 562
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.49
    Marker Score: 191
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.45
    Marker Score: 906
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 441
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.41
    Marker Score: 777
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.38
    Marker Score: 368
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.38
    Marker Score: 165
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.32
    Marker Score: 5,069
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.21
    Marker Score: 71
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.21
    Marker Score: 83
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.18
    Marker Score: 59
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.17
    Marker Score: 100
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.16
    Marker Score: 335
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.15
    Marker Score: 222
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.15
    Marker Score: 186
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.14
    Marker Score: 69
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.14
    Marker Score: 72
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.11
    Marker Score: 113
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.11
    Marker Score: 61
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1
    Marker Score: 59
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.09
    Marker Score: 61
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.09
    Marker Score: 67
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.08
    Marker Score: 146
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.08
    Marker Score: 548
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.08
    Marker Score: 230
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.08
    Marker Score: 52
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.07
    Marker Score: 69
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.06
    Marker Score: 56
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.06
    Marker Score: 56
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.06
    Marker Score: 69
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.06
    Marker Score: 188
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.06
    Marker Score: 147
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.06
    Marker Score: 83
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.06
    Marker Score: 137
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.05
    Marker Score: 3,070
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.05
    Marker Score: 52
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.05
    Marker Score: 70
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.05
    Marker Score: 56
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.05
    Marker Score: 13

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CTRC is a member of the chymase family, which is a subgroup of serine proteases. It is predominantly expressed in various cell types, including acinar cells, epithelial cells of the exocrine pancreas, pancreatic stellate cells, and enterocytes of the small intestine. CTRC's enzymatic activity is characterized by its ability to cleave peptide bonds, leading to the generation of bioactive peptides, which can modulate immune responses, inflammation, and tissue repair. **Pathways and Functions:** CTRC's involvement in various signaling pathways underscores its multifaceted role in immunological processes. Some of the key pathways and functions of CTRC include: 1. **Intracellular calcium ion homeostasis**: CTRC has been shown to regulate intracellular calcium levels, which is crucial for various cellular processes, including cell signaling, muscle contraction, and neurotransmission. 2. **Peptidase activity**: As a serine protease, CTRC exhibits peptidase activity, which enables it to cleave peptide bonds and generate bioactive peptides. 3. **Protein binding**: CTRC's ability to bind proteins, such as growth factors and cytokines, suggests its involvement in protein-protein interactions, which can modulate immune responses and tissue repair. 4. **Proteolysis**: CTRC's proteolytic activity can lead to the degradation of proteins, which can have significant implications for tissue homeostasis and immune function. 5. **Serine-type endopeptidase activity**: CTRC's serine-type endopeptidase activity is essential for its ability to cleave peptide bonds and generate bioactive peptides. **Clinical Significance:** CTRC's involvement in various diseases highlights its potential as a therapeutic target. Some of the clinical implications of CTRC include: 1. **Pancreatitis**: CTRC's expression in pancreatic acinar cells and its role in pancreatic stellate cell activation suggest its involvement in pancreatitis, a disease characterized by inflammation and tissue damage in the pancreas. 2. **Atherosclerosis**: CTRC's ability to generate bioactive peptides, which can modulate immune responses and inflammation, suggests its potential involvement in atherosclerosis, a disease characterized by the buildup of plaque in arterial walls. 3. **Cancer**: CTRC's expression in various cancers, including pancreatic cancer, suggests its potential role in tumor progression and metastasis. 4. **Inflammatory diseases**: CTRC's involvement in inflammatory processes, including asthma and rheumatoid arthritis, highlights its potential as a therapeutic target for these diseases. In conclusion, CTRC's multifaceted role in immunological processes underscores its significance in various physiological and pathological processes. Further research is necessary to fully elucidate CTRC's function and to explore its therapeutic potential in diseases such as pancreatitis, atherosclerosis, cancer, and inflammatory diseases.

Genular Protein ID: 379262641

Symbol: CTRC_HUMAN

Name: Chymotrypsin-C

UniProtKB Accession Codes:

Q99895 A8K082 O00765 Q9NUH5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8635596

Title: Molecular cloning and expression of human caldecrin.

PubMed ID: 8635596

DOI: 10.1016/0014-5793(96)00377-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9538241

Title: Caldecrin is a novel-type serine protease expressed in pancreas, but its homologue, elastase IV, is an artifact during cloning derived from caldecrin gene.

PubMed ID: 9538241

DOI: 10.1093/oxfordjournals.jbchem.a021971

PubMed ID: 23430245

Title: Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation.

PubMed ID: 23430245

DOI: 10.1074/jbc.m113.457382

PubMed ID: 18172691

Title: Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis.

PubMed ID: 18172691

DOI: 10.1007/s00439-007-0459-3

PubMed ID: 18059268

Title: Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis.

PubMed ID: 18059268

DOI: 10.1038/ng.2007.44

PubMed ID: 19407484

Title: Association of novel chymotrypsin C gene variations and haplotypes in patients with chronic pancreatitis in Chinese in Taiwan.

PubMed ID: 19407484

DOI: 10.1159/000199437

PubMed ID: 23135764

Title: Identification of novel missense CTRC variants in Japanese patients with chronic pancreatitis.

PubMed ID: 23135764

DOI: 10.1136/gutjnl-2012-303860

PubMed ID: 22580415

Title: Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants.

PubMed ID: 22580415

DOI: 10.1136/gutjnl-2012-302448

PubMed ID: 22942235

Title: Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk.

PubMed ID: 22942235

DOI: 10.1136/gutjnl-2012-303090

Sequence Information:

  • Length: 268
  • Mass: 29484
  • Checksum: 460BF33B4A96516F
  • Sequence:
    • MLGITVLAAL LACASSCGVP SFPPNLSARV VGGEDARPHS WPWQISLQYL KNDTWRHTCG 
GTLIASNFVL TAAHCISNTR TYRVAVGKNN LEVEDEEGSL FVGVDTIHVH KRWNALLLRN 
DIALIKLAEH VELSDTIQVA CLPEKDSLLP KDYPCYVTGW GRLWTNGPIA DKLQQGLQPV 
VDHATCSRID WWGFRVKKTM VCAGGDGVIS ACNGDSGGPL NCQLENGSWE VFGIVSFGSR 
RGCNTRKKPV VYTRVSAYID WINEKMQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.