PHB2 | ENSG00000215021 | NCBI 11331

Details for: PHB2

Gene ID: 11331

Symbol: PHB2

Ensembl ID: ENSG00000215021

Description: prohibitin 2

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to mitochondrial stress
(R-HSA-9840373)
Mitochondrial calcium ion transport
(R-HSA-8949215)
Processing of smdt1
(R-HSA-8949664)
Transport of small molecules
(R-HSA-382551)
Activation of phospholipase c activity
(GO:0007202)
Activation of protein kinase c activity
(GO:1990051)
Amide binding
(GO:0033218)
Antiviral innate immune response
(GO:0140374)
Axon
(GO:0030424)
B cell activation
(GO:0042113)
Cd40 signaling pathway
(GO:0023035)
Cell migration
(GO:0016477)
Cell periphery
(GO:0071944)
Cell surface
(GO:0009986)
Cellular response to hypoxia
(GO:0071456)
Cellular response to retinoic acid
(GO:0071300)
Cytoplasm
(GO:0005737)
Gaba-ergic synapse
(GO:0098982)
Glutamatergic synapse
(GO:0098978)
Identical protein binding
(GO:0042802)
Intracellular estrogen receptor signaling pathway
(GO:0030520)
Mammary gland alveolus development
(GO:0060749)
Mammary gland branching involved in thelarche
(GO:0060744)
Mammary gland epithelial cell proliferation
(GO:0033598)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrial prohibitin complex
(GO:0035632)
Mitochondrion
(GO:0005739)
Mitochondrion organization
(GO:0007005)
Mitophagy
(GO:0000423)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of dna-binding transcription factor activity
(GO:0043433)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of intracellular estrogen receptor signaling pathway
(GO:0033147)
Negative regulation of mammary gland epithelial cell proliferation
(GO:0033600)
Nuclear estrogen receptor binding
(GO:0030331)
Nuclear matrix
(GO:0016363)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of cell cycle g1/s phase transition
(GO:1902808)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of exit from mitosis
(GO:0031536)
Positive regulation of immunoglobulin production
(GO:0002639)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of non-canonical nf-kappab signal transduction
(GO:1901224)
Postsynaptic density
(GO:0014069)
Presynaptic active zone
(GO:0048786)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein import into nucleus
(GO:0006606)
Protein stabilization
(GO:0050821)
Regulation of branching involved in mammary gland duct morphogenesis
(GO:0060762)
Regulation of cardiolipin metabolic process
(GO:1900208)
Regulation of complement activation
(GO:0030449)
Regulation of cytochrome-c oxidase activity
(GO:1904959)
Rig-i signaling pathway
(GO:0039529)
Sister chromatid cohesion
(GO:0007062)
Sphingolipid binding
(GO:0046625)

Other Information

Proteins

Prohibitin-2

Genular Protein ID: 968528418

Symbol: PHB2_HUMAN

Name: Prohibitin-2

UniProtKB Accession Codes:

Q99623 B4DP75 Q2YDA4 Q7KYU3 Q92978

Database IDs:

Citations:

PubMed ID: 9074930

Title: Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.

PubMed ID: 9074930

DOI: 10.1101/gr.7.3.268

PubMed ID: 10359819

Title: An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens.

PubMed ID: 10359819

DOI: 10.1073/pnas.96.12.6947

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11302691

Title: Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence.

PubMed ID: 11302691

DOI: 10.1006/excr.2001.5166

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19496786

Title: Activation of an estrogen/estrogen receptor signaling by BIG3 through its inhibitory effect on nuclear transport of PHB2/REA in breast cancer.

PubMed ID: 19496786

DOI: 10.1111/j.1349-7006.2009.01209.x

PubMed ID: 19640993

Title: Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling.

PubMed ID: 19640993

DOI: 10.1128/jvi.00842-09

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 19906925

Title: Identification of the cellular prohibitin 1/prohibitin 2 heterodimer as an interaction partner of the C-terminal cytoplasmic domain of the HIV-1 glycoprotein.

PubMed ID: 19906925

DOI: 10.1128/jvi.01641-09

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21328542

Title: ZNF703 gene amplification at 8p12 specifies luminal B breast cancer.

PubMed ID: 21328542

DOI: 10.1002/emmm.201100121

PubMed ID: 20959514

Title: Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration.

PubMed ID: 20959514

DOI: 10.1096/fj.10-167502

PubMed ID: 21746876

Title: Stomatin-like protein 2 binds cardiolipin and regulates mitochondrial biogenesis and function.

PubMed ID: 21746876

DOI: 10.1128/mcb.05393-11

PubMed ID: 22997079

Title: Identification of prohibitin as a Chikungunya virus receptor protein.

PubMed ID: 22997079

DOI: 10.1002/jmv.23403

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24003225

Title: Prohibitin-2 binding modulates insulin-like growth factor-binding protein-6 (IGFBP-6)-induced rhabdomyosarcoma cell migration.

PubMed ID: 24003225

DOI: 10.1074/jbc.m113.510826

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25904163

Title: Prohibitin 2: At a communications crossroads.

PubMed ID: 25904163

DOI: 10.1002/iub.1366

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28017329

Title: Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor.

PubMed ID: 28017329

DOI: 10.1016/j.cell.2016.11.042

PubMed ID: 32276428

Title: Interaction between PHB2 and Enterovirus A71 VP1 Induces Autophagy and Affects EV-A71 Infection.

PubMed ID: 32276428

DOI: 10.3390/v12040414

PubMed ID: 31522117

Title: Structural Basis of Mitochondrial Scaffolds by Prohibitin Complexes: Insight into a Role of the Coiled-Coil Region.

PubMed ID: 31522117

DOI: 10.1016/j.isci.2019.08.056

Sequence Information:

Length: 299
Mass: 33296
Checksum: A887CC982BF85C80
Sequence:

MAQNLKDLAG RLPAGPRGMG TALKLLLGAG AVAYGVRESV FTVEGGHRAI FFNRIGGVQQ 
DTILAEGLHF RIPWFQYPII YDIRARPRKI SSPTGSKDLQ MVNISLRVLS RPNAQELPSM 
YQRLGLDYEE RVLPSIVNEV LKSVVAKFNA SQLITQRAQV SLLIRRELTE RAKDFSLILD 
DVAITELSFS REYTAAVEAK QVAQQEAQRA QFLVEKAKQE QRQKIVQAEG EAEAAKMLGE 
ALSKNPGYIK LRKIRAAQNI SKTIATSQNR IYLTADNLVL NLQDESFTRG SDSLIKGKK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PHB2

Associated with

Other Information

Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. PubMed ID: 9074930

An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens. PubMed ID: 10359819

Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. PubMed ID: 10931946

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence. PubMed ID: 11302691

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Activation of an estrogen/estrogen receptor signaling by BIG3 through its inhibitory effect on nuclear transport of PHB2/REA in breast cancer. PubMed ID: 19496786

Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling. PubMed ID: 19640993

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Identification of the cellular prohibitin 1/prohibitin 2 heterodimer as an interaction partner of the C-terminal cytoplasmic domain of the HIV-1 glycoprotein. PubMed ID: 19906925

Initial characterization of the human central proteome. PubMed ID: 21269460

ZNF703 gene amplification at 8p12 specifies luminal B breast cancer. PubMed ID: 21328542

Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. PubMed ID: 20959514

Stomatin-like protein 2 binds cardiolipin and regulates mitochondrial biogenesis and function. PubMed ID: 21746876

Identification of prohibitin as a Chikungunya virus receptor protein. PubMed ID: 22997079

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Prohibitin-2 binding modulates insulin-like growth factor-binding protein-6 (IGFBP-6)-induced rhabdomyosarcoma cell migration. PubMed ID: 24003225

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Prohibitin 2: At a communications crossroads. PubMed ID: 25904163

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor. PubMed ID: 28017329

Interaction between PHB2 and Enterovirus A71 VP1 Induces Autophagy and Affects EV-A71 Infection. PubMed ID: 32276428

Structural Basis of Mitochondrial Scaffolds by Prohibitin Complexes: Insight into a Role of the Coiled-Coil Region. PubMed ID: 31522117