Details for: ACOT7

Gene ID: 11332

Symbol: ACOT7

Ensembl ID: ENSG00000097021

Description: acyl-CoA thioesterase 7

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.1
    Marker Score: 4,268
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.86
    Marker Score: 19,245
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.71
    Marker Score: 574
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.7
    Marker Score: 807
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.68
    Marker Score: 1,891
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.67
    Marker Score: 621
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.67
    Marker Score: 6,905
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.66
    Marker Score: 101,922
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.65
    Marker Score: 61,053
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.62
    Marker Score: 61,545
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.61
    Marker Score: 6,219
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.6
    Marker Score: 3,770
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.56
    Marker Score: 7,478
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.54
    Marker Score: 646
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.52
    Marker Score: 13,032
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.51
    Marker Score: 1,829
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.48
    Marker Score: 11,323
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.47
    Marker Score: 22,016
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.45
    Marker Score: 28,792
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.43
    Marker Score: 2,209
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.42
    Marker Score: 13,532
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.39
    Marker Score: 13,108
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.39
    Marker Score: 35,508
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.39
    Marker Score: 5,644
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.38
    Marker Score: 1,733
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.38
    Marker Score: 1,300
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.35
    Marker Score: 1,292
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.32
    Marker Score: 4,682
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.24
    Marker Score: 1,913
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.2
    Marker Score: 567
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.19
    Marker Score: 18,569
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.18
    Marker Score: 322
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.16
    Marker Score: 5,372
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.13
    Marker Score: 1,625
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.11
    Marker Score: 320
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.09
    Marker Score: 341
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.08
    Marker Score: 1,014
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.04
    Marker Score: 1,469
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.03
    Marker Score: 2,807
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1
    Marker Score: 33,795
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,731
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,955
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.99
    Marker Score: 673
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,398
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.95
    Marker Score: 570
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,403
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.92
    Marker Score: 1,923
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.92
    Marker Score: 667
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,217
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,714
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.91
    Marker Score: 680
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.9
    Marker Score: 568
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.9
    Marker Score: 960
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.87
    Marker Score: 214
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.86
    Marker Score: 322
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.85
    Marker Score: 1,426
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.84
    Marker Score: 271
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.83
    Marker Score: 494
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.82
    Marker Score: 1,924
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.8
    Marker Score: 194
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.79
    Marker Score: 3,295
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.79
    Marker Score: 6,768
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,266
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.78
    Marker Score: 1,580
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 591
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.77
    Marker Score: 810
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.76
    Marker Score: 291
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.75
    Marker Score: 3,945
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.75
    Marker Score: 374
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.75
    Marker Score: 2,032
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 299
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 376
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3,017
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.72
    Marker Score: 229
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.69
    Marker Score: 726
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.68
    Marker Score: 909
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.68
    Marker Score: 363
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.68
    Marker Score: 176
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 617
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.67
    Marker Score: 221
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.67
    Marker Score: 193
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.67
    Marker Score: 737
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.66
    Marker Score: 4,247
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.66
    Marker Score: 1,892
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.65
    Marker Score: 616
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.64
    Marker Score: 268
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.64
    Marker Score: 224
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.64
    Marker Score: 306
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.64
    Marker Score: 1,512
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.63
    Marker Score: 638
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.63
    Marker Score: 365
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.63
    Marker Score: 364
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.63
    Marker Score: 163
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.63
    Marker Score: 13,366
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.62
    Marker Score: 1,055

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ACOT7 is a cytosolic enzyme that exhibits thioesterase activity, specifically hydrolyzing acyl-CoA esters to form free fatty acids and CoA. This enzyme is highly expressed in various cell types, including neurons, basophils, and enterendocrine cells. ACOT7 is also known to interact with other proteins, such as BACH, to regulate its activity. The gene is encoded in humans (ENSG00000097021) and has been associated with several diseases, including metabolic disorders and neurodegenerative conditions. **Pathways and Functions:** ACOT7 is involved in several key pathways, including: 1. **Fatty Acid Metabolism:** ACOT7 plays a crucial role in the breakdown of fatty acids, which is essential for energy production and storage. 2. **Coenzyme A Biosynthesis:** ACOT7 is involved in the synthesis of CoA, a vital coenzyme in various metabolic processes. 3. **Long-chain Fatty Acid Catabolic Process:** ACOT7 is responsible for the degradation of long-chain fatty acids, which is essential for energy homeostasis. 4. **Mitochondrial Fatty Acid Beta-oxidation:** ACOT7 is involved in the mitochondrial breakdown of fatty acids, which is crucial for energy production. **Clinical Significance:** Dysregulation of ACOT7 has been implicated in various diseases, including: 1. **Metabolic Disorders:** ACOT7 has been associated with metabolic disorders, such as obesity and insulin resistance. 2. **Neurodegenerative Conditions:** ACOT7 has been linked to neurodegenerative conditions, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular Diseases:** ACOT7 has been implicated in cardiovascular diseases, including atherosclerosis and cardiac hypertrophy. In conclusion, ACOT7 is a critical gene that plays a vital role in fatty acid metabolism and beyond. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its mechanisms and clinical significance. **Future Directions:** 1. **Investigating ACOT7's role in disease modeling:** Further studies are needed to elucidate ACOT7's role in disease modeling and to identify potential therapeutic targets. 2. **Exploring ACOT7's interaction with other proteins:** The interaction between ACOT7 and other proteins, such as BACH, needs to be further investigated to understand its regulatory mechanisms. 3. **Developing novel therapeutic strategies:** ACOT7's dysregulation has been implicated in various diseases, making it a potential target for novel therapeutic strategies. By continuing to explore the intricacies of ACOT7, we can gain a deeper understanding of its role in fatty acid metabolism and its implications for human health.

Genular Protein ID: 442073005

Symbol: BACH_HUMAN

Name: Cytosolic acyl coenzyme A thioester hydrolase

UniProtKB Accession Codes:

O00154 A8K0K7 A8K232 A8K6B8 A8K837 B3KQ12 O43703 Q53Y78 Q5JYL2 Q5JYL3 Q5JYL4 Q5JYL5 Q5JYL6 Q5TGR4 Q9UJM9 Q9Y539 Q9Y540

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CPTAC 2 CTD 1 ChEBI 35 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 19 EPD 1 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 14 SABIO-RK 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10578051

Title: Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase.

PubMed ID: 10578051

DOI: 10.1093/oxfordjournals.jbchem.a022544

PubMed ID: 12435388

Title: Human brain acyl-CoA hydrolase isoforms encoded by a single gene.

PubMed ID: 12435388

DOI: 10.1016/s0006-291x(02)02587-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 380
  • Mass: 41796
  • Checksum: BDD75D62A60095BC
  • Sequence:
    • MKLLARALRL CEFGRQASSR RLVAGQGCVG PRRGCCAPVQ VVGPRADLPP CGACITGRIM 
RPDDANVAGN VHGGTILKMI EEAGAIISTR HCNSQNGERC VAALARVERT DFLSPMCIGE 
VAHVSAEITY TSKHSVEVQV NVMSENILTG AKKLTNKATL WYVPLSLKNV DKVLEVPPVV 
YSRQEQEEEG RKRYEAQKLE RMETKWRNGD IVQPVLNPEP NTVSYSQSSL IHLVGPSDCT 
LHGFVHGGVT MKLMDEVAGI VAARHCKTNI VTASVDAINF HDKIRKGCVI TISGRMTFTS 
NKSMEIEVLV DADPVVDSSQ KRYRAASAFF TYVSLSQEGR SLPVPQLVPE TEDEKKRFEE 
GKGRYLQMKA KRQGHAEPQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.