Details for: PDAP1

Gene ID: 11333

Symbol: PDAP1

Ensembl ID: ENSG00000106244

Description: PDGFA associated protein 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.12
    Marker Score: 73,296
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.1
    Marker Score: 4,381
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.08
    Marker Score: 16,206
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.03
    Marker Score: 2,282
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.02
    Marker Score: 7,948
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.99
    Marker Score: 2,071
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.98
    Marker Score: 22,297
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.97
    Marker Score: 7,308
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.96
    Marker Score: 8,466
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.95
    Marker Score: 2,810
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.94
    Marker Score: 3,296
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.93
    Marker Score: 2,067
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.93
    Marker Score: 25,478
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.93
    Marker Score: 1,816
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.91
    Marker Score: 5,210
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.9
    Marker Score: 3,871
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.88
    Marker Score: 4,277
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.86
    Marker Score: 12,100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.85
    Marker Score: 15,985
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.85
    Marker Score: 7,576
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.84
    Marker Score: 18,564
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.84
    Marker Score: 1,951
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.81
    Marker Score: 21,098
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.81
    Marker Score: 3,403
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8
    Marker Score: 2,658
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.8
    Marker Score: 2,553
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.8
    Marker Score: 2,176
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.8
    Marker Score: 1,502
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.79
    Marker Score: 1,899
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.79
    Marker Score: 4,203
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.77
    Marker Score: 1,184
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.77
    Marker Score: 2,905
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.77
    Marker Score: 1,109
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.76
    Marker Score: 1,662
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.74
    Marker Score: 1,182
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.72
    Marker Score: 1,732
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.7
    Marker Score: 3,012
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.7
    Marker Score: 4,616
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.7
    Marker Score: 2,255
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.68
    Marker Score: 1,814
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.68
    Marker Score: 863
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.66
    Marker Score: 6,415
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.66
    Marker Score: 2,639
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.65
    Marker Score: 16,746
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.65
    Marker Score: 10,563
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.65
    Marker Score: 778
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.64
    Marker Score: 12,173
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.63
    Marker Score: 900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.62
    Marker Score: 482
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.61
    Marker Score: 542
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.61
    Marker Score: 1,016
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.61
    Marker Score: 2,583
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.61
    Marker Score: 3,922
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.59
    Marker Score: 359
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.59
    Marker Score: 2,452
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.58
    Marker Score: 4,517
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.58
    Marker Score: 15,672
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.58
    Marker Score: 1,983
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.58
    Marker Score: 4,366
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.58
    Marker Score: 2,169
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.57
    Marker Score: 445
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.57
    Marker Score: 21,074
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.57
    Marker Score: 4,651
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.57
    Marker Score: 3,723
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.57
    Marker Score: 7,694
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.56
    Marker Score: 385
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.53
    Marker Score: 366
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.53
    Marker Score: 441
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.53
    Marker Score: 359
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.53
    Marker Score: 1,114
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.53
    Marker Score: 761
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.53
    Marker Score: 1,438
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.52
    Marker Score: 377
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.52
    Marker Score: 868
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.51
    Marker Score: 804
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.51
    Marker Score: 435
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.5
    Marker Score: 494
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.5
    Marker Score: 888
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.49
    Marker Score: 1,592
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.49
    Marker Score: 422
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.49
    Marker Score: 695
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.49
    Marker Score: 477
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.49
    Marker Score: 528
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.49
    Marker Score: 562
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.48
    Marker Score: 1,169
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.48
    Marker Score: 3,871
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.48
    Marker Score: 50,249
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.47
    Marker Score: 970
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.47
    Marker Score: 1,523
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.46
    Marker Score: 1,540
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.46
    Marker Score: 1,753
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.45
    Marker Score: 2,840
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.45
    Marker Score: 714
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.44
    Marker Score: 2,867
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.43
    Marker Score: 1,850
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.42
    Marker Score: 784
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.42
    Marker Score: 6,826
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.41
    Marker Score: 609
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.41
    Marker Score: 526
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.41
    Marker Score: 3,201

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The PDAP1 gene exhibits a broad expression pattern across various cell types, including: 1. **Cellular localization**: PDAP1 is primarily localized to the cytosol, extracellular region, and plasma membrane, suggesting its involvement in cell-cell interactions and signaling events. 2. **Protein binding**: The HAP28 protein encoded by PDAP1 interacts with other proteins, including those involved in immune system regulation, indicating its potential role in modulating immune responses. 3. **Signaling pathways**: PDAP1 is associated with multiple signaling pathways, including those involved in neutrophil degranulation, immune system regulation, and cellular differentiation. **Pathways and Functions:** The PDAP1 gene is implicated in various cellular processes, including: 1. **Immune system regulation**: PDAP1 is involved in the regulation of immune responses, including the activation of neutrophils and the modulation of immune cell function. 2. **Neutrophil degranulation**: The HAP28 protein encoded by PDAP1 is associated with the degranulation process of neutrophils, which is critical for the elimination of pathogens. 3. **Cellular differentiation**: PDAP1 is expressed in various cell types, including epithelial cells, immune cells, and neural cells, suggesting its role in cellular differentiation and development. 4. **Signal transduction**: PDAP1 is involved in signal transduction events, including those mediated by the Ficolin-1-rich granule lumen and the cytosol. **Clinical Significance:** The PDAP1 gene has potential implications for various diseases, including: 1. **Immune disorders**: Dysregulation of PDAP1 expression may contribute to immune disorders, such as autoimmune diseases and immunodeficiency syndromes. 2. **Cancer**: Alterations in PDAP1 expression may be involved in the development and progression of cancer, particularly in epithelial-derived cancers. 3. **Neurological disorders**: PDAP1 may be involved in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the PDAP1 gene plays a critical role in regulating immune responses, cellular signaling, and cellular differentiation. Further studies are needed to elucidate the functional significance of PDAP1 in various diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 3642604858

Symbol: HAP28_HUMAN

Name: 28 kDa heat- and acid-stable phosphoprotein

UniProtKB Accession Codes:

Q13442 D6W5S5 Q92906

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8780057

Title: Characterization of a novel platelet-derived growth factor-associated protein.

PubMed ID: 8780057

DOI: 10.1046/j.1471-4159.1996.66052213.x

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 181
  • Mass: 20630
  • Checksum: F97914C7920ABAB3
  • Sequence:
    • MPKGGRKGGH KGRARQYTSP EEIDAQLQAE KQKAREEEEQ KEGGDGAAGD PKKEKKSLDS 
DESEDEEDDY QQKRKGVEGL IDIENPNRVA QTTKKVTQLD LDGPKELSRR EREEIEKQKA 
KERYMKMHLA GKTEQAKADL ARLAIIRKQR EEAARKKEEE RKAKDDATLS GKRMQSLSLN 
K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.