Details for: TUSC2

Gene ID: 11334

Symbol: TUSC2

Ensembl ID: ENSG00000114383

Description: tumor suppressor 2, mitochondrial calcium regulator

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 3.41
    Marker Score: 3,341
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.49
    Marker Score: 2,223
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.84
    Marker Score: 3,882
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.72
    Marker Score: 3,494
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.64
    Marker Score: 14,207
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.48
    Marker Score: 433
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.38
    Marker Score: 432
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.37
    Marker Score: 1,653
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.34
    Marker Score: 1,968
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.33
    Marker Score: 5,222
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.31
    Marker Score: 45,495
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.31
    Marker Score: 2,174
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.3
    Marker Score: 1,873
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.3
    Marker Score: 2,468
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.28
    Marker Score: 1,211
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.27
    Marker Score: 9,892
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.25
    Marker Score: 10,793
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.23
    Marker Score: 679
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.23
    Marker Score: 303
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.21
    Marker Score: 824
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.21
    Marker Score: 3,050
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.21
    Marker Score: 2,755
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.18
    Marker Score: 4,546
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.17
    Marker Score: 508
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.17
    Marker Score: 1,875
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.14
    Marker Score: 477
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.14
    Marker Score: 801
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.13
    Marker Score: 538
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.12
    Marker Score: 3,993
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.12
    Marker Score: 557
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.1
    Marker Score: 614
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.1
    Marker Score: 1,141
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.09
    Marker Score: 1,446
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.06
    Marker Score: 1,115
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.06
    Marker Score: 903
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.06
    Marker Score: 1,075
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.06
    Marker Score: 6,438
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.05
    Marker Score: 2,823
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.05
    Marker Score: 635
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.04
    Marker Score: 2,351
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.02
    Marker Score: 1,285
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.02
    Marker Score: 768
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.02
    Marker Score: 6,485
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.01
    Marker Score: 4,870
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1
    Marker Score: 1,416
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1
    Marker Score: 456
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.99
    Marker Score: 1,368
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.98
    Marker Score: 1,042
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,381
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.97
    Marker Score: 1,030
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.97
    Marker Score: 565
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.96
    Marker Score: 277
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.96
    Marker Score: 1,001
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.95
    Marker Score: 638
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.95
    Marker Score: 2,248
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.94
    Marker Score: 1,502
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.94
    Marker Score: 299
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,384
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.93
    Marker Score: 734
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.92
    Marker Score: 12,330
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.91
    Marker Score: 5,923
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.91
    Marker Score: 213
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.91
    Marker Score: 1,607
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.9
    Marker Score: 3,757
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.9
    Marker Score: 1,015
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.9
    Marker Score: 513
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.9
    Marker Score: 602
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9
    Marker Score: 2,674
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,137
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9
    Marker Score: 5,745
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.9
    Marker Score: 597
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.89
    Marker Score: 2,198
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.89
    Marker Score: 2,676
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.89
    Marker Score: 797
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.88
    Marker Score: 2,772
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.88
    Marker Score: 469
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.88
    Marker Score: 735
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.87
    Marker Score: 259
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.86
    Marker Score: 2,464
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.86
    Marker Score: 10,025
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.86
    Marker Score: 2,030
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.86
    Marker Score: 424
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,202
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.85
    Marker Score: 4,483
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.85
    Marker Score: 245
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.85
    Marker Score: 202
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.84
    Marker Score: 795
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.84
    Marker Score: 887
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.84
    Marker Score: 612
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.84
    Marker Score: 316
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.84
    Marker Score: 189
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.84
    Marker Score: 8,292
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.84
    Marker Score: 3,100
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.84
    Marker Score: 527
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.83
    Marker Score: 21,293
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.83
    Marker Score: 6,174
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.83
    Marker Score: 1,732

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TUSC2 is a mitochondrial protein that regulates calcium levels within the mitochondria. It is a calcium-binding protein that interacts with the mitochondrial calcium ATPase (MICAT) to control calcium influx into the mitochondria. This regulation is crucial for maintaining mitochondrial membrane potential and preventing reactive oxygen species (ROS) production. Additionally, TUSC2 has been shown to interact with other proteins involved in the regulation of cell cycle progression, including cyclin-dependent kinases and cyclin-dependent phosphatases. **Pathways and Functions** TUSC2 is involved in several cellular pathways, including: 1. **Cell cycle regulation**: TUSC2 modulates cell cycle progression by regulating the activity of cyclin-dependent kinases and cyclin-dependent phosphatases. 2. **Mitochondrial function**: TUSC2 regulates mitochondrial calcium levels, which is essential for maintaining mitochondrial energy homeostasis and preventing oxidative stress. 3. **Immune response regulation**: TUSC2 modulates immune responses by regulating the production of pro-inflammatory and anti-inflammatory cytokines, such as interleukin-17 and interleukin-10. 4. **Neurotransmission**: TUSC2 is involved in the regulation of neurotransmitter release and synaptic plasticity, particularly in the context of GABAergic neurons. **Clinical Significance** Dysregulation of TUSC2 has been implicated in various diseases, including: 1. **Cancer**: TUSC2 is a tumor suppressor gene that is frequently inactivated in various types of cancer, including pancreatic cancer, lung cancer, and breast cancer. 2. **Neurodegenerative diseases**: TUSC2 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where mitochondrial dysfunction and oxidative stress play a key role. 3. **Autoimmune diseases**: TUSC2 has been shown to regulate immune responses and has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, TUSC2 is a critical gene that regulates mitochondrial function, cell cycle progression, and immune responses. Its dysregulation has been implicated in various diseases, highlighting its importance as a therapeutic target for the treatment of these conditions. Further research is needed to fully elucidate the mechanisms by which TUSC2 regulates cellular processes and to explore its potential as a therapeutic agent.

Genular Protein ID: 3059349658

Symbol: TUSC2_HUMAN

Name: Tumor suppressor candidate 2

UniProtKB Accession Codes:

O75896 B2R4Y9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11593436

Title: Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells.

PubMed ID: 11593436

DOI: 10.1038/sj.onc.1204832

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15126327

Title: Myristoylation of the fus1 protein is required for tumor suppression in human lung cancer cells.

PubMed ID: 15126327

DOI: 10.1158/0008-5472.can-03-3702

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 110
  • Mass: 12074
  • Checksum: 9503BD10637C1504
  • Sequence:
    • MGASGSKARG LWPFASAAGG GGSEAAGAEQ ALVRPRGRAV PPFVFTRRGS MFYDEDGDLA 
HEFYEETIVT KNGQKRAKLR RVHKNLIPQG IVKLDHPRIH VDFPVILYEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.