CBX3 | ENSG00000122565 | NCBI 11335

Details for: CBX3

Gene ID: 11335

Symbol: CBX3

Ensembl ID: ENSG00000122565

Description: chromobox 3

Associated with

Epigenetic regulation of gene expression
(R-HSA-212165)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i transcription
(R-HSA-73864)
Transcriptional regulation by e2f6
(R-HSA-8953750)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin lock complex
(GO:0061793)
Chromatin organization
(GO:0006325)
Chromatin remodeling
(GO:0006338)
Chromosome, centromeric region
(GO:0000775)
Chromosome, telomeric region
(GO:0000781)
Condensed chromosome, centromeric region
(GO:0000779)
Dna damage response
(GO:0006974)
Enzyme binding
(GO:0019899)
Euchromatin
(GO:0000791)
Heterochromatin
(GO:0000792)
Heterochromatin formation
(GO:0031507)
Histone methyltransferase binding
(GO:1990226)
Identical protein binding
(GO:0042802)
Methylated histone binding
(GO:0035064)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear envelope
(GO:0005635)
Nuclear inner membrane
(GO:0005637)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pericentric heterochromatin
(GO:0005721)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Rhythmic process
(GO:0048511)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Site of dna damage
(GO:0090734)
Spindle
(GO:0005819)
Transcription coregulator binding
(GO:0001221)

Other Information

Proteins

Chromobox protein homolog 3

Genular Protein ID: 4136332196

Symbol: CBX3_HUMAN

Name: Chromobox protein homolog 3

UniProtKB Accession Codes:

Q13185 Q96CD7 Q99409 Q9BVS3 Q9P0Z6

Database IDs:

Citations:

PubMed ID: 8663349

Title: Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1.

PubMed ID: 8663349

DOI: 10.1074/jbc.271.25.14653

PubMed ID: 10664448

Title: Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1.

PubMed ID: 10664448

DOI: 10.1016/s0014-5793(00)01105-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9169472

Title: Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR.

PubMed ID: 9169472

DOI: 10.1074/jbc.272.23.14983

PubMed ID: 9864353

Title: INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1.

PubMed ID: 9864353

DOI: 10.1083/jcb.143.7.1763

PubMed ID: 9636146

Title: Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment.

PubMed ID: 9636146

DOI: 10.1073/pnas.95.13.7316

PubMed ID: 10460410

Title: Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells.

PubMed ID: 10460410

DOI: 10.1007/s004120050372

PubMed ID: 10330177

Title: KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Kruppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing.

PubMed ID: 10330177

DOI: 10.1128/mcb.19.6.4366

PubMed ID: 11242053

Title: Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.

PubMed ID: 11242053

DOI: 10.1038/35065132

PubMed ID: 12004135

Title: A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.

PubMed ID: 12004135

DOI: 10.1126/science.1069861

PubMed ID: 15502821

Title: A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1.

PubMed ID: 15502821

DOI: 10.1038/ncb1187

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20850016

Title: Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.

PubMed ID: 20850016

DOI: 10.1016/j.cell.2010.08.020

PubMed ID: 19880879

Title: ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1.

PubMed ID: 19880879

DOI: 10.1074/jbc.m109.065862

PubMed ID: 25750265

Title: Retraction: 'ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1'.

PubMed ID: 25750265

DOI: 10.1074/jbc.a109.065862

PubMed ID: 20562864

Title: Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.

PubMed ID: 20562864

DOI: 10.1038/ncb2075

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21346195

Title: Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells.

PubMed ID: 21346195

DOI: 10.1091/mbc.e11-01-0009

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23251473

Title: Tubulin tyrosine ligase like 12, a TTLL family member with SET- and TTL-like domains and roles in histone and tubulin modifications and mitosis.

PubMed ID: 23251473

DOI: 10.1371/journal.pone.0051258

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23542155

Title: Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway.

PubMed ID: 23542155

DOI: 10.1038/nsmb.2532

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28167679

Title: Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage.

PubMed ID: 28167679

DOI: 10.1242/jcs.197236

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28977666

Title: CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

PubMed ID: 28977666

DOI: 10.1093/nar/gkx711

PubMed ID: 32051553

Title: The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.

PubMed ID: 32051553

DOI: 10.1038/s41388-020-1206-7

Sequence Information:

Length: 183
Mass: 20811
Checksum: 5928C63E0C93A76A
Sequence:

MASNKTTLQK MGKKQNGKSK KVEEAEPEEF VVEKVLDRRV VNGKVEYFLK WKGFTDADNT 
WEPEENLDCP ELIEAFLNSQ KAGKEKDGTK RKSLSDSESD DSKSKKKRDA ADKPRGFARG 
LDPERIIGAT DSSGELMFLM KWKDSDEADL VLAKEANMKC PQIVIAFYEE RLTWHSCPED 
EAQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CBX3

Associated with

Other Information

Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1. PubMed ID: 8663349

Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1. PubMed ID: 10664448

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR. PubMed ID: 9169472

INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1. PubMed ID: 9864353

Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment. PubMed ID: 9636146

Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells. PubMed ID: 10460410

KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Kruppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing. PubMed ID: 10330177

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. PubMed ID: 11242053

A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. PubMed ID: 12004135

A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. PubMed ID: 15502821

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. PubMed ID: 18318008

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. PubMed ID: 20850016

ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1. PubMed ID: 19880879

Retraction: 'ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1'. PubMed ID: 25750265

Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. PubMed ID: 20562864

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells. PubMed ID: 21346195

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Tubulin tyrosine ligase like 12, a TTLL family member with SET- and TTL-like domains and roles in histone and tubulin modifications and mitosis. PubMed ID: 23251473

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway. PubMed ID: 23542155

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. PubMed ID: 25755297

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage. PubMed ID: 28167679

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality. PubMed ID: 28977666

The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically. PubMed ID: 32051553