Details for: EXOC3

Gene ID: 11336

Symbol: EXOC3

Ensembl ID: ENSG00000180104

Description: exocyst complex component 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.32
    Marker Score: 4,538
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.24
    Marker Score: 828
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.17
    Marker Score: 2,045
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.16
    Marker Score: 1,798
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.11
    Marker Score: 1,340
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.03
    Marker Score: 9,758
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.02
    Marker Score: 8,775
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1
    Marker Score: 1,475
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,696
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,921
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.98
    Marker Score: 1,033
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,390
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.97
    Marker Score: 2,047
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.97
    Marker Score: 10,002
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.95
    Marker Score: 2,169
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.95
    Marker Score: 58,379
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,394
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.92
    Marker Score: 908
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,706
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.89
    Marker Score: 988
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.87
    Marker Score: 8,218
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,291
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.86
    Marker Score: 2,306
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.86
    Marker Score: 6,402
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.85
    Marker Score: 421
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.85
    Marker Score: 31,396
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4,782
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.83
    Marker Score: 290
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.81
    Marker Score: 6,970
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.8
    Marker Score: 17,143
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.8
    Marker Score: 669
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.79
    Marker Score: 3,236
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.79
    Marker Score: 1,022
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.78
    Marker Score: 813
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.77
    Marker Score: 380
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 306
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 583
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.75
    Marker Score: 28,334
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.74
    Marker Score: 6,470
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.73
    Marker Score: 792
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.73
    Marker Score: 823
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.71
    Marker Score: 14,117
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.71
    Marker Score: 2,737
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.7
    Marker Score: 329
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7
    Marker Score: 2,761
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.7
    Marker Score: 5,478
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.69
    Marker Score: 7,015
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.69
    Marker Score: 2,896
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,896
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.69
    Marker Score: 469
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.68
    Marker Score: 1,498
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.67
    Marker Score: 274
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 606
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.66
    Marker Score: 574
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.66
    Marker Score: 10,340
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.65
    Marker Score: 941
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.65
    Marker Score: 1,146
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.64
    Marker Score: 1,620
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.64
    Marker Score: 676
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.64
    Marker Score: 35,618
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 421
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.64
    Marker Score: 2,355
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.63
    Marker Score: 583
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.63
    Marker Score: 630
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.63
    Marker Score: 4,839
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.63
    Marker Score: 263
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.62
    Marker Score: 632
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.62
    Marker Score: 359
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.61
    Marker Score: 151
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.61
    Marker Score: 210
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.6
    Marker Score: 603
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6
    Marker Score: 20,755
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.6
    Marker Score: 405
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.6
    Marker Score: 147
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.59
    Marker Score: 241
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.59
    Marker Score: 139
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.59
    Marker Score: 1,476
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.59
    Marker Score: 142
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.59
    Marker Score: 135
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.59
    Marker Score: 140
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.58
    Marker Score: 202
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.58
    Marker Score: 827
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.58
    Marker Score: 290
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.58
    Marker Score: 2,070
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 373
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.58
    Marker Score: 520
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.58
    Marker Score: 1,182
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.58
    Marker Score: 8,654
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.58
    Marker Score: 3,687
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.58
    Marker Score: 2,389
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.58
    Marker Score: 1,807
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.57
    Marker Score: 212
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.57
    Marker Score: 128
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.57
    Marker Score: 124

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EXOC3 is a protein component of the exocyst complex, which is a conserved multiprotein complex found in eukaryotic cells. The exocyst complex is responsible for regulating the targeting and fusion of vesicles with the plasma membrane, ensuring the proper delivery of proteins and lipids to their destination. EXOC3 is a key component of this complex, interacting with other proteins to regulate the assembly and function of the exocyst complex. **Pathways and Functions:** EXOC3 is involved in various cellular processes, including: 1. **Cargo trafficking to the periciliary membrane:** EXOC3 regulates the targeting of vesicles to the periciliary membrane, a structure that plays a critical role in the maintenance of cilia and the sensing of the extracellular environment. 2. **Cilium assembly:** EXOC3 is involved in the assembly and maintenance of cilia, which are essential for sensing the extracellular environment and maintaining cellular homeostasis. 3. **Insulin processing:** EXOC3 regulates the targeting of insulin-containing vesicles to the plasma membrane, ensuring proper insulin processing and secretion. 4. **Vesicle-mediated transport:** EXOC3 is involved in the regulation of vesicle-mediated transport, ensuring the proper delivery of proteins and lipids to their destination. **Clinical Significance:** Dysregulation of EXOC3 has been implicated in various diseases, including: 1. **Ciliopathies:** EXOC3 mutations have been identified in patients with ciliopathies, a group of disorders characterized by defects in cilia structure and function. 2. **Neurological disorders:** EXOC3 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Immunological disorders:** EXOC3 has been implicated in the pathogenesis of immunological disorders, including autoimmune diseases and cancer. In conclusion, EXOC3 is a critical component of the exocyst complex, regulating various cellular processes, including cargo trafficking to the periciliary membrane, cilium assembly, and insulin processing. Its dysregulation has been implicated in various diseases, highlighting its importance in maintaining cellular homeostasis and function. Further research is needed to fully understand the mechanisms of EXOC3 and its role in human disease. **References:** * [Insert references to studies that have investigated the role of EXOC3 in various diseases] Note: The references should be up-to-date and include studies that have investigated the role of EXOC3 in various diseases.

Genular Protein ID: 850451146

Symbol: EXOC3_HUMAN

Name: Exocyst complex component 3

UniProtKB Accession Codes:

O60645 Q6P2E8 Q8TEN6 Q8WUW0 Q96DI4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 20736409

Title: Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins.

PubMed ID: 20736409

DOI: 10.1074/mcp.m110.001719

PubMed ID: 12693554

Title: Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.

PubMed ID: 12693554

DOI: 10.1093/dnares/10.1.49

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18329369

Title: Final stages of cytokinesis and midbody ring formation are controlled by BRUCE.

PubMed ID: 18329369

DOI: 10.1016/j.cell.2008.01.012

PubMed ID: 18756269

Title: Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs.

PubMed ID: 18756269

DOI: 10.1038/emboj.2008.166

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 745
  • Mass: 85567
  • Checksum: 81D03FB3351A995D
  • Sequence:
    • MKETDREAVA TAVQRVAGML QRPDQLDKVE QYRRREARKK ASVEARLKAA IQSQLDGVRT 
GLSQLHNALN DVKDIQQSLA DVSKDWRQSI NTIESLKDVK DAVVQHSQLA AAVENLKNIF 
SVPEIVRETQ DLIEQGALLQ AHRKLMDLEC SRDGLMYEQY RMDSGNTRDM TLIHGYFGST 
QGLSDELAKQ LWMVLQRSLV TVRRDPTLLV SVVRIIEREE KIDRRILDRK KQTGFVPPGR 
PKNWKEKMFT ILERTVTTRI EGTQADTRES DKMWLVRHLE IIRKYVLDDL IVAKNLMVQC 
FPPHYEIFKN LLNMYHQALS TRMQDLASED LEANEIVSLL TWVLNTYTST EMMRNVELAP 
EVDVGTLEPL LSPHVVSELL DTYMSTLTSN IIAWLRKALE TDKKDWVKET EPEADQDGYY 
QTTLPAIVFQ MFEQNLQVAA QISEDLKTKV LVLCLQQMNS FLSRYKDEAQ LYKEEHLRNR 
QHPHCYVQYM IAIINNCQTF KESIVSLKRK YLKNEVEEGV SPSQPSMDGI LDAIAKEGCS 
GLLEEVFLDL EQHLNELMTK KWLLGSNAVD IICVTVEDYF NDFAKIKKPY KKRMTAEAHR 
RVVVEYLRAV MQKRISFRSP EERKEGAEKM VREAEQLRFL FRKLASGFGE DVDGYCDTIV 
AVAEVIKLTD PSLLYLEVST LVSKYPDIRD DHIGALLAVR GDASRDMKQT IMETLEQGPA 
QASPSYVPLF KDIVVPSLNV AKLLK

Genular Protein ID: 998815138

Symbol: Q69YP2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q69YP2

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1

Sequence Information:

  • Length: 673
  • Mass: 77469
  • Checksum: CB58E0B714CF07CE
  • Sequence:
    • KDIQQSLADV SKDWRQSINT IESLKDVKDA VVQHSQLAAA VENLKNIFSV PEIVRETQDL 
IEQGALLQAH RKLMDLECSR DGLMYEQYRM DSGNTRDMTL IHGYFGSTQG LSDELAKQLW 
MVLQRSLVTV RRDPTLLVSV VRIIEREEKI DRRILDRKKQ TGFVPPGRPK NWKEKMFTIL 
ERTVTTRIEG TQADTRESDK MWLVRHLEII RKYVLDDLIV AKNLMVQCFP PHYEIFKNLL 
NMYHQALSTR MQDLASEDLE ANEIVSLLTW VLNTYTSTEM MRNVELAPEV DVGTLEPLLS 
PHVVSELLDT YMSTLTSNII AWLRKALETD KKDWVKETEP EADQDGYYQT TLPAIVFQMF 
EQNLQVAAQI SEDLKTKVLV LCLQQMNSFL SRYKDEAQLY KEEHLRNRQH PHCYVQYMIA 
IINNCQTFKE SIVSLKRKYL KNEVEEGVSP SQPSMDGILD AIAKEGCSGL LEEVFLDLEQ 
HLNELMTKKW LLGSNAVDII CVTVEDYFND FAKIKKPYKK RMTAEAHRRV VVEYLRAVMQ 
KRISFRSPEE RKEGAEKMVR EAEQLRFLFR KLASGFGEDV DGYCDTIVAV AEVIKLTDPS 
LLYLEVSTLV SKYPDIRDDH IGALLAVRGD ASRDMKQTIM ETLEQGPAQA SPSYVPLFKD 
IVVPSLNVAK LLK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.