Details for: GABARAP

Gene ID: 11337

Symbol: GABARAP

Ensembl ID: ENSG00000170296

Description: GABA type A receptor-associated protein

Associated with

Other Information

Genular Protein ID: 3767881771

Symbol: GBRAP_HUMAN

Name: GABA(A) receptor-associated protein

UniProtKB Accession Codes:

O95166

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 33 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9892355

Title: GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton.

PubMed ID: 9892355

DOI: 10.1038/16264

PubMed ID: 11146101

Title: Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation.

PubMed ID: 11146101

DOI: 10.1016/s0169-328x(00)00218-7

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 11096062

Title: The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3.

PubMed ID: 11096062

DOI: 10.1074/jbc.c000752200

PubMed ID: 11825910

Title: Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.

PubMed ID: 11825910

DOI: 10.1074/jbc.m200385200

PubMed ID: 12507496

Title: GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3.

PubMed ID: 12507496

DOI: 10.1016/s0006-291x(02)02907-8

PubMed ID: 15169837

Title: LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation.

PubMed ID: 15169837

DOI: 10.1242/jcs.01131

PubMed ID: 15977068

Title: GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47).

PubMed ID: 15977068

DOI: 10.1007/s10529-005-3628-2

PubMed ID: 17580304

Title: p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.

PubMed ID: 17580304

DOI: 10.1074/jbc.m702824200

PubMed ID: 19056683

Title: The TP53INP2 protein is required for autophagy in mammalian cells.

PubMed ID: 19056683

DOI: 10.1091/mbc.e08-07-0671

PubMed ID: 20818167

Title: Synthetic substrates for measuring activity of autophagy proteases: autophagins (Atg4).

PubMed ID: 20818167

DOI: 10.4161/auto.6.7.13075

PubMed ID: 20562859

Title: Network organization of the human autophagy system.

PubMed ID: 20562859

DOI: 10.1038/nature09204

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21383079

Title: OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation.

PubMed ID: 21383079

DOI: 10.1083/jcb.201008107

PubMed ID: 22948227

Title: MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins.

PubMed ID: 22948227

DOI: 10.4161/auto.21857

PubMed ID: 22421968

Title: TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death.

PubMed ID: 22421968

DOI: 10.1038/cdd.2012.30

PubMed ID: 23043107

Title: ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs.

PubMed ID: 23043107

DOI: 10.1074/jbc.m112.378109

PubMed ID: 22354992

Title: Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.

PubMed ID: 22354992

DOI: 10.1128/mcb.06717-11

PubMed ID: 22470510

Title: DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription.

PubMed ID: 22470510

DOI: 10.1371/journal.pone.0034034

PubMed ID: 24089205

Title: Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites.

PubMed ID: 24089205

DOI: 10.1038/nature12606

PubMed ID: 25126726

Title: FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation.

PubMed ID: 25126726

DOI: 10.4161/auto.29640

PubMed ID: 25127057

Title: TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.

PubMed ID: 25127057

DOI: 10.1016/j.devcel.2014.06.013

PubMed ID: 26347139

Title: TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.

PubMed ID: 26347139

DOI: 10.1083/jcb.201503023

PubMed ID: 26929408

Title: Structural and functional analysis of a novel interaction motif within UFM1-activating enzyme 5 (UBA5) required for binding to ubiquitin-like proteins and ufmylation.

PubMed ID: 26929408

DOI: 10.1074/jbc.m116.715474

PubMed ID: 29420192

Title: Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins.

PubMed ID: 29420192

DOI: 10.1083/jcb.201708039

PubMed ID: 30661429

Title: Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells.

PubMed ID: 30661429

DOI: 10.1080/15548627.2019.1569925

PubMed ID: 31006538

Title: Intrinsically disordered protein TEX264 mediates ER-phagy.

PubMed ID: 31006538

DOI: 10.1016/j.molcel.2019.03.033

PubMed ID: 31722778

Title: LIR motifs and the membrane-targeting domain are complementary in the function of RavZ.

PubMed ID: 31722778

DOI: 10.5483/bmbrep.2019.52.12.211

PubMed ID: 32315611

Title: A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy.

PubMed ID: 32315611

DOI: 10.1016/j.devcel.2020.03.018

PubMed ID: 34338405

Title: Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER-phagy, and Collagen quality control.

PubMed ID: 34338405

DOI: 10.15252/embr.202052289

PubMed ID: 33909989

Title: Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine.

PubMed ID: 33909989

DOI: 10.1016/j.molcel.2021.03.020

PubMed ID: 36481789

Title: Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.

PubMed ID: 36481789

DOI: 10.1038/s41418-022-01098-6

PubMed ID: 11729197

Title: The X-ray crystal structure and putative ligand-derived peptide binding properties of gamma-aminobutyric acid receptor type A receptor-associated protein.

PubMed ID: 11729197

DOI: 10.1074/jbc.m109753200

PubMed ID: 11875056

Title: Solution structure of human GABA(A) receptor-associated protein GABARAP: implications for biological function and its regulation.

PubMed ID: 11875056

DOI: 10.1074/jbc.c200050200

PubMed ID: 11885988

Title: 1H, 13C and '5N resonance assignments of GABARAP, GABAA receptor associated protein.

PubMed ID: 11885988

DOI: 10.1023/a:1013884402033

PubMed ID: 18638487

Title: Ligand binding mode of GABAA receptor-associated protein.

PubMed ID: 18638487

DOI: 10.1016/j.jmb.2008.06.086

PubMed ID: 19154346

Title: Structural framework of the GABARAP-calreticulin interface -- implications for substrate binding to endoplasmic reticulum chaperones.

PubMed ID: 19154346

DOI: 10.1111/j.1742-4658.2008.06857.x

PubMed ID: 24668264

Title: Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.

PubMed ID: 24668264

DOI: 10.1002/embr.201338003

PubMed ID: 25684205

Title: CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.

PubMed ID: 25684205

DOI: 10.1016/j.molcel.2014.12.040

PubMed ID: 32620754

Title: Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes.

PubMed ID: 32620754

DOI: 10.1038/s41467-020-17163-y

Sequence Information:

  • Length: 117
  • Mass: 13918
  • Checksum: BC0B84B8A51C1E32
  • Sequence:
    • MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL VPSDLTVGQF 
YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE EDFFLYIAYS DESVYGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.