Details for: GABARAP

Gene ID: 11337

Symbol: GABARAP

Ensembl ID: ENSG00000170296

Description: GABA type A receptor-associated protein

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 4.95
    Marker Score: 29,364
  • Cell Name: germ cell (CL0000586)
    Fold Change: 4.22
    Marker Score: 7,373
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.21
    Marker Score: 235,615
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.02
    Marker Score: 46,771
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.57
    Marker Score: 121,633
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.49
    Marker Score: 6,793
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.45
    Marker Score: 22,417
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.39
    Marker Score: 8,277
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.37
    Marker Score: 10,628
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.36
    Marker Score: 3,162
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.21
    Marker Score: 3,103
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.14
    Marker Score: 4,619
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.1
    Marker Score: 13,309
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.09
    Marker Score: 1,467
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.08
    Marker Score: 22,921
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.05
    Marker Score: 2,680
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.05
    Marker Score: 2,597
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.94
    Marker Score: 155,311
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.82
    Marker Score: 4,840
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.79
    Marker Score: 17,840
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.78
    Marker Score: 2,013
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.78
    Marker Score: 7,789
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.77
    Marker Score: 5,430
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.77
    Marker Score: 1,152
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.76
    Marker Score: 4,929
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.75
    Marker Score: 3,301
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.74
    Marker Score: 3,386
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.73
    Marker Score: 1,007
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.73
    Marker Score: 8,093
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.72
    Marker Score: 27,388
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.67
    Marker Score: 7,260
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.62
    Marker Score: 1,291
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.62
    Marker Score: 2,326
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.61
    Marker Score: 1,531
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.6
    Marker Score: 15,787
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.57
    Marker Score: 1,508
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.57
    Marker Score: 912
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.45
    Marker Score: 4,025
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 2.43
    Marker Score: 2,019
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.43
    Marker Score: 6,053
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.43
    Marker Score: 2,582
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.42
    Marker Score: 1,611
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.35
    Marker Score: 772
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.34
    Marker Score: 1,289
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.33
    Marker Score: 3,292
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.31
    Marker Score: 1,695
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.31
    Marker Score: 30,518
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.31
    Marker Score: 2,492
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.29
    Marker Score: 1,657
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.28
    Marker Score: 7,155
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 2.28
    Marker Score: 1,397
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 2.27
    Marker Score: 987
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.24
    Marker Score: 1,833
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.23
    Marker Score: 3,076
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.21
    Marker Score: 2,607
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 2.19
    Marker Score: 883
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 2.18
    Marker Score: 700
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.13
    Marker Score: 4,467
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.13
    Marker Score: 3,711
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 2.12
    Marker Score: 1,167
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.12
    Marker Score: 10,411
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.11
    Marker Score: 736
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 2.11
    Marker Score: 2,801
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.1
    Marker Score: 1,532
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.08
    Marker Score: 667
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.08
    Marker Score: 2,985
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.08
    Marker Score: 3,017
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 2.06
    Marker Score: 475
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.04
    Marker Score: 1,255
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.02
    Marker Score: 20,012
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 2.01
    Marker Score: 1,969
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.01
    Marker Score: 837
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2
    Marker Score: 933
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 2
    Marker Score: 2,209
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.95
    Marker Score: 817
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.95
    Marker Score: 683
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.93
    Marker Score: 1,725
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.92
    Marker Score: 487
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.92
    Marker Score: 1,102
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.91
    Marker Score: 6,562
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.9
    Marker Score: 2,927
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.89
    Marker Score: 2,371
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.89
    Marker Score: 1,332
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.88
    Marker Score: 4,549
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.87
    Marker Score: 1,908
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.87
    Marker Score: 549
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 1.87
    Marker Score: 527
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.85
    Marker Score: 1,398
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.85
    Marker Score: 972
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.82
    Marker Score: 743
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.82
    Marker Score: 1,740
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.78
    Marker Score: 539
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.76
    Marker Score: 1,485
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.74
    Marker Score: 415
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.73
    Marker Score: 775
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.73
    Marker Score: 427
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.73
    Marker Score: 1,161
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.72
    Marker Score: 438
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.69
    Marker Score: 874
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.69
    Marker Score: 2,033

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GABARAP is a large protein with multiple domains, including a GABA type A receptor-binding domain, a protein-binding domain, and a ubiquitin-binding domain. Its structure allows it to interact with various proteins and lipids, including GABA receptors, microtubules, and phosphatidylethanolamine. GABARAP is highly expressed in cells involved in autophagy and other cellular processes, including Sertoli cells, germ cells, monocytes, and T cells. Its expression is also observed in other cell types, such as fibroblasts and blood cells. **Pathways and Functions** GABARAP is involved in several cellular pathways, including: 1. **Autophagy**: GABARAP plays a crucial role in the formation and maturation of autophagosomes, which are responsible for engulfing and degrading damaged or dysfunctional cellular components. 2. **Protein degradation**: GABARAP regulates the ubiquitin-dependent protein degradation pathway, which is essential for maintaining protein homeostasis and preventing protein aggregation. 3. **Membrane trafficking**: GABARAP interacts with microtubules and phosphatidylethanolamine to regulate membrane trafficking, including endocytosis and exocytosis. 4. **Signaling pathways**: GABARAP influences various signaling pathways, including the intrinsic apoptotic pathway, the extrinsic apoptotic pathway, and the regulation of rac protein signal transduction. 5. **Cell survival and proliferation**: GABARAP's involvement in autophagy and protein degradation ensures that cells maintain protein homeostasis and prevent damage, promoting cell survival and proliferation. **Clinical Significance** Dysregulation of GABARAP has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: Mutations in GABARAP have been associated with neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: GABARAP's involvement in autophagy and protein degradation suggests that it may play a role in cancer development and progression. 3. **Inflammatory disorders**: GABARAP's expression in monocytes and T cells suggests that it may be involved in the regulation of immune responses and the development of inflammatory disorders. 4. **Autophagy-related disorders**: GABARAP's role in autophagy highlights its potential as a therapeutic target for disorders related to autophagy dysfunction, such as lysosomal storage diseases. In conclusion, GABARAP is a multifunctional protein that plays a critical role in various cellular processes, including autophagy, protein degradation, and membrane trafficking. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying GABARAP's functions and its potential as a therapeutic target.

Genular Protein ID: 3767881771

Symbol: GBRAP_HUMAN

Name: GABA(A) receptor-associated protein

UniProtKB Accession Codes:

O95166

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 33 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9892355

Title: GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton.

PubMed ID: 9892355

DOI: 10.1038/16264

PubMed ID: 11146101

Title: Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation.

PubMed ID: 11146101

DOI: 10.1016/s0169-328x(00)00218-7

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 11096062

Title: The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3.

PubMed ID: 11096062

DOI: 10.1074/jbc.c000752200

PubMed ID: 11825910

Title: Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.

PubMed ID: 11825910

DOI: 10.1074/jbc.m200385200

PubMed ID: 12507496

Title: GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3.

PubMed ID: 12507496

DOI: 10.1016/s0006-291x(02)02907-8

PubMed ID: 15169837

Title: LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation.

PubMed ID: 15169837

DOI: 10.1242/jcs.01131

PubMed ID: 15977068

Title: GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47).

PubMed ID: 15977068

DOI: 10.1007/s10529-005-3628-2

PubMed ID: 17580304

Title: p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.

PubMed ID: 17580304

DOI: 10.1074/jbc.m702824200

PubMed ID: 19056683

Title: The TP53INP2 protein is required for autophagy in mammalian cells.

PubMed ID: 19056683

DOI: 10.1091/mbc.e08-07-0671

PubMed ID: 20818167

Title: Synthetic substrates for measuring activity of autophagy proteases: autophagins (Atg4).

PubMed ID: 20818167

DOI: 10.4161/auto.6.7.13075

PubMed ID: 20562859

Title: Network organization of the human autophagy system.

PubMed ID: 20562859

DOI: 10.1038/nature09204

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21383079

Title: OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation.

PubMed ID: 21383079

DOI: 10.1083/jcb.201008107

PubMed ID: 22948227

Title: MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins.

PubMed ID: 22948227

DOI: 10.4161/auto.21857

PubMed ID: 22421968

Title: TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death.

PubMed ID: 22421968

DOI: 10.1038/cdd.2012.30

PubMed ID: 23043107

Title: ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs.

PubMed ID: 23043107

DOI: 10.1074/jbc.m112.378109

PubMed ID: 22354992

Title: Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.

PubMed ID: 22354992

DOI: 10.1128/mcb.06717-11

PubMed ID: 22470510

Title: DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription.

PubMed ID: 22470510

DOI: 10.1371/journal.pone.0034034

PubMed ID: 24089205

Title: Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites.

PubMed ID: 24089205

DOI: 10.1038/nature12606

PubMed ID: 25126726

Title: FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation.

PubMed ID: 25126726

DOI: 10.4161/auto.29640

PubMed ID: 25127057

Title: TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.

PubMed ID: 25127057

DOI: 10.1016/j.devcel.2014.06.013

PubMed ID: 26347139

Title: TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.

PubMed ID: 26347139

DOI: 10.1083/jcb.201503023

PubMed ID: 26929408

Title: Structural and functional analysis of a novel interaction motif within UFM1-activating enzyme 5 (UBA5) required for binding to ubiquitin-like proteins and ufmylation.

PubMed ID: 26929408

DOI: 10.1074/jbc.m116.715474

PubMed ID: 29420192

Title: Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins.

PubMed ID: 29420192

DOI: 10.1083/jcb.201708039

PubMed ID: 30661429

Title: Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells.

PubMed ID: 30661429

DOI: 10.1080/15548627.2019.1569925

PubMed ID: 31006538

Title: Intrinsically disordered protein TEX264 mediates ER-phagy.

PubMed ID: 31006538

DOI: 10.1016/j.molcel.2019.03.033

PubMed ID: 31722778

Title: LIR motifs and the membrane-targeting domain are complementary in the function of RavZ.

PubMed ID: 31722778

DOI: 10.5483/bmbrep.2019.52.12.211

PubMed ID: 32315611

Title: A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy.

PubMed ID: 32315611

DOI: 10.1016/j.devcel.2020.03.018

PubMed ID: 34338405

Title: Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER-phagy, and Collagen quality control.

PubMed ID: 34338405

DOI: 10.15252/embr.202052289

PubMed ID: 33909989

Title: Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine.

PubMed ID: 33909989

DOI: 10.1016/j.molcel.2021.03.020

PubMed ID: 36481789

Title: Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.

PubMed ID: 36481789

DOI: 10.1038/s41418-022-01098-6

PubMed ID: 11729197

Title: The X-ray crystal structure and putative ligand-derived peptide binding properties of gamma-aminobutyric acid receptor type A receptor-associated protein.

PubMed ID: 11729197

DOI: 10.1074/jbc.m109753200

PubMed ID: 11875056

Title: Solution structure of human GABA(A) receptor-associated protein GABARAP: implications for biological function and its regulation.

PubMed ID: 11875056

DOI: 10.1074/jbc.c200050200

PubMed ID: 11885988

Title: 1H, 13C and '5N resonance assignments of GABARAP, GABAA receptor associated protein.

PubMed ID: 11885988

DOI: 10.1023/a:1013884402033

PubMed ID: 18638487

Title: Ligand binding mode of GABAA receptor-associated protein.

PubMed ID: 18638487

DOI: 10.1016/j.jmb.2008.06.086

PubMed ID: 19154346

Title: Structural framework of the GABARAP-calreticulin interface -- implications for substrate binding to endoplasmic reticulum chaperones.

PubMed ID: 19154346

DOI: 10.1111/j.1742-4658.2008.06857.x

PubMed ID: 24668264

Title: Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.

PubMed ID: 24668264

DOI: 10.1002/embr.201338003

PubMed ID: 25684205

Title: CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.

PubMed ID: 25684205

DOI: 10.1016/j.molcel.2014.12.040

PubMed ID: 32620754

Title: Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes.

PubMed ID: 32620754

DOI: 10.1038/s41467-020-17163-y

Sequence Information:

  • Length: 117
  • Mass: 13918
  • Checksum: BC0B84B8A51C1E32
  • Sequence:
    • MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL VPSDLTVGQF 
YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE EDFFLYIAYS DESVYGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.