Details for: U2AF2

Gene ID: 11338

Symbol: U2AF2

Ensembl ID: ENSG00000063244

Description: U2 small nuclear RNA auxiliary factor 2

Associated with

Other Information

Genular Protein ID: 2084893903

Symbol: U2AF2_HUMAN

Name: Splicing factor U2AF 65 kDa subunit

UniProtKB Accession Codes:

P26368 Q96HC5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 4 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 50 PDBsum 37 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1538748

Title: Cloning and domain structure of the mammalian splicing factor U2AF.

PubMed ID: 1538748

DOI: 10.1038/355609a0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12176931

Title: Large-scale proteomic analysis of the human spliceosome.

PubMed ID: 12176931

DOI: 10.1101/gr.473902

PubMed ID: 9237760

Title: A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA.

PubMed ID: 9237760

DOI: 10.1038/41137

PubMed ID: 9447963

Title: Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing.

PubMed ID: 9447963

DOI: 10.1128/mcb.18.2.676

PubMed ID: 10449420

Title: Phosphorylation of splicing factor SF1 on Ser20 by cGMP-dependent protein kinase regulates spliceosome assembly.

PubMed ID: 10449420

DOI: 10.1093/emboj/18.16.4549

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15009664

Title: Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors.

PubMed ID: 15009664

DOI: 10.1046/j.1471-4159.2003.02232.x

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17024186

Title: An interaction between U2AF 65 and CF I(m) links the splicing and 3' end processing machineries.

PubMed ID: 17024186

DOI: 10.1038/sj.emboj.7601331

PubMed ID: 17589525

Title: U2AF-homology motif interactions are required for alternative splicing regulation by SPF45.

PubMed ID: 17589525

DOI: 10.1038/nsmb1260

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19641227

Title: Blom7alpha is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4.

PubMed ID: 19641227

DOI: 10.1074/jbc.m109.036632

PubMed ID: 19470458

Title: The protein factors MBNL1 and U2AF65 bind alternative RNA structures to regulate splicing.

PubMed ID: 19470458

DOI: 10.1073/pnas.0900342106

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 19574390

Title: Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing.

PubMed ID: 19574390

DOI: 10.1126/science.1175865

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21460037

Title: SKIP counteracts p53-mediated apoptosis via selective regulation of p21Cip1 mRNA splicing.

PubMed ID: 21460037

DOI: 10.1101/gad.2002611

PubMed ID: 21536736

Title: The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex.

PubMed ID: 21536736

DOI: 10.1101/gad.2038011

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 27720643

Title: Molecular architecture of SF3b and structural consequences of its cancer-related mutations.

PubMed ID: 27720643

DOI: 10.1016/j.molcel.2016.08.036

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10449418

Title: Solution structures of the first and second RNA-binding domains of human U2 small nuclear ribonucleoprotein particle auxiliary factor (U2AF(65)).

PubMed ID: 10449418

DOI: 10.1093/emboj/18.16.4523

PubMed ID: 12718882

Title: Structural basis for the molecular recognition between human splicing factors U2AF65 and SF1/mBBP.

PubMed ID: 12718882

DOI: 10.1016/s1097-2765(03)00115-1

PubMed ID: 11551507

Title: A novel peptide recognition mode revealed by the X-ray structure of a core U2AF35/U2AF65 heterodimer.

PubMed ID: 11551507

DOI: 10.1016/s0092-8674(01)00480-9

Sequence Information:

  • Length: 475
  • Mass: 53501
  • Checksum: 26AD271CD8FC6211
  • Sequence:
    • MSDFDEFERQ LNENKQERDK ENRHRKRSHS RSRSRDRKRR SRSRDRRNRD QRSASRDRRR 
RSKPLTRGAK EEHGGLIRSP RHEKKKKVRK YWDVPPPGFE HITPMQYKAM QAAGQIPATA 
LLPTMTPDGL AVTPTPVPVV GSQMTRQARR LYVGNIPFGI TEEAMMDFFN AQMRLGGLTQ 
APGNPVLAVQ INQDKNFAFL EFRSVDETTQ AMAFDGIIFQ GQSLKIRRPH DYQPLPGMSE 
NPSVYVPGVV STVVPDSAHK LFIGGLPNYL NDDQVKELLT SFGPLKAFNL VKDSATGLSK 
GYAFCEYVDI NVTDQAIAGL NGMQLGDKKL LVQRASVGAK NATLVSPPST INQTPVTLQV 
PGLMSSQVQM GGHPTEVLCL MNMVLPEELL DDEEYEEIVE DVRDECSKYG LVKSIEIPRP 
VDGVEVPGCG KIFVEFTSVF DCQKAMQGLT GRKFANRVVV TKYCDPDSYH RRDFW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.