Details for: OIP5

Gene ID: 11339

Symbol: OIP5

Ensembl ID: ENSG00000104147

Description: Opa interacting protein 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.66
    Marker Score: 30,957
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.89
    Marker Score: 1,180
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.77
    Marker Score: 3,672
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169,361
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.43
    Marker Score: 2,051
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.32
    Marker Score: 1,181
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.31
    Marker Score: 3,270
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.11
    Marker Score: 1,388
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.07
    Marker Score: 481
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.04
    Marker Score: 2,823
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,813
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,037
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,735
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.91
    Marker Score: 613
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,165
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.87
    Marker Score: 1,654
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.83
    Marker Score: 1,110
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.8
    Marker Score: 752
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 678
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 566
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.73
    Marker Score: 544
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.71
    Marker Score: 484
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.7
    Marker Score: 222
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,881
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.67
    Marker Score: 1,994
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.65
    Marker Score: 680
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.64
    Marker Score: 10,002
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.62
    Marker Score: 3,718
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.62
    Marker Score: 178
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.58
    Marker Score: 1,376
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.58
    Marker Score: 143
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.57
    Marker Score: 1,161
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 355
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.55
    Marker Score: 403
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.54
    Marker Score: 575
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.53
    Marker Score: 647
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.52
    Marker Score: 888
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 209
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.49
    Marker Score: 493
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.48
    Marker Score: 153
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.47
    Marker Score: 324
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.46
    Marker Score: 278
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.46
    Marker Score: 1,814
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.46
    Marker Score: 144
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.46
    Marker Score: 268
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.44
    Marker Score: 928
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.41
    Marker Score: 109
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.41
    Marker Score: 257
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.4
    Marker Score: 198
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.39
    Marker Score: 372
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.38
    Marker Score: 191
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.37
    Marker Score: 172
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.37
    Marker Score: 391
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.36
    Marker Score: 238
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.35
    Marker Score: 7,853
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.35
    Marker Score: 821
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.34
    Marker Score: 1,409
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.33
    Marker Score: 348
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.33
    Marker Score: 401
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.33
    Marker Score: 162
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.33
    Marker Score: 1,157
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.33
    Marker Score: 885
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.31
    Marker Score: 93
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.31
    Marker Score: 94
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.31
    Marker Score: 128
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.31
    Marker Score: 562
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.28
    Marker Score: 439
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.28
    Marker Score: 137
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.28
    Marker Score: 664
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.28
    Marker Score: 91
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.27
    Marker Score: 213
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.26
    Marker Score: 115
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.26
    Marker Score: 95
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.26
    Marker Score: 258
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.25
    Marker Score: 126
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.25
    Marker Score: 182
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.25
    Marker Score: 178
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.25
    Marker Score: 62
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 117
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.24
    Marker Score: 155
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.24
    Marker Score: 1,004
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.24
    Marker Score: 127
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.24
    Marker Score: 175
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.24
    Marker Score: 256
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.24
    Marker Score: 319
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.24
    Marker Score: 115
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.24
    Marker Score: 267
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.24
    Marker Score: 211

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cajal body localization**: OIP5 is specifically localized to the Cajal body, a nucleolar structure responsible for RNA processing and chromatin assembly. 2. **Chromosome segregation**: OIP5 is essential for accurate chromosome segregation during cell division, ensuring proper inheritance of genetic material. 3. **Centromere formation**: OIP5 is involved in the formation and maintenance of centromeres, critical regions on chromosomes that ensure proper segregation of genetic material. 4. **Nucleosome assembly**: OIP5 is required for the assembly of nucleosomes, the fundamental units of chromatin structure. 5. **Cell cycle regulation**: OIP5 is involved in regulating cell cycle progression, ensuring proper timing and coordination of cellular events. **Pathways and Functions:** 1. **Cajal body organization**: OIP5 is involved in the organization and maintenance of the Cajal body, a critical structure for RNA processing and chromatin assembly. 2. **Chromosome maintenance**: OIP5 is essential for maintaining chromosome structure and function, ensuring proper segregation of genetic material during cell division. 3. **Cell cycle regulation**: OIP5 regulates cell cycle progression, ensuring proper timing and coordination of cellular events. 4. **Nucleosome assembly**: OIP5 is required for the assembly of nucleosomes, the fundamental units of chromatin structure. 5. **Protein-protein interactions**: OIP5 interacts with various proteins, including those involved in chromosome segregation, centromere formation, and nucleosome assembly. **Clinical Significance:** 1. **Cancer**: Dysregulation of OIP5 has been linked to various cancers, including breast and ovarian cancer. 2. **Genomic disorders**: Mutations in OIP5 have been associated with genomic disorders, such as cancer and genomic instability. 3. **Neurological disorders**: OIP5 has been implicated in neurological disorders, including spinocerebellar ataxia type 3 (SCA3) and other neurodegenerative diseases. 4. **Reproductive disorders**: OIP5 is essential for oogenesis and spermatogenesis, and dysregulation has been linked to reproductive disorders, including infertility and miscarriage. In conclusion, OIP5 is a critical regulator of chromosome segregation, centromere formation, and nucleosome assembly. Its dysregulation has significant implications for various diseases, including cancer, genomic disorders, and neurological disorders. Further research is necessary to fully understand the function and clinical significance of OIP5.

Genular Protein ID: 765998312

Symbol: MS18B_HUMAN

Name: Protein Mis18-beta

UniProtKB Accession Codes:

O43482 Q96BX7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 4 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 2 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 14 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9466265

Title: Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth.

PubMed ID: 9466265

DOI: 10.1046/j.1365-2958.1998.00670.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17199038

Title: Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1.

PubMed ID: 17199038

DOI: 10.1016/j.devcel.2006.11.002

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26921242

Title: Centromere localization and function of Mis18 requires Yippee-like domain-mediated oligomerization.

PubMed ID: 26921242

DOI: 10.15252/embr.201541520

Sequence Information:

  • Length: 229
  • Mass: 24691
  • Checksum: 0EBD4006193A3106
  • Sequence:
    • MAAQPLRHRS RCATPPRGDF CGGTERAIDQ ASFTTSMEWD TQVVKGSSPL GPAGLGAEEP 
AAGPQLPSWL QPERCAVFQC AQCHAVLADS VHLAWDLSRS LGAVVFSRVT NNVVLEAPFL 
VGIEGSLKGS TYNLLFCGSC GIPVGFHLYS THAALAALRG HFCLSSDKMV CYLLKTKAIV 
NASEMDIQNV PLSEKIAELK EKIVLTHNRL KSLMKILSEV TPDQSKPEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.