EXOSC8 | ENSG00000120699 | NCBI 11340

Details for: EXOSC8

Gene ID: 11340

Symbol: EXOSC8

Ensembl ID: ENSG00000120699

Description: exosome component 8

Associated with

Atf4 activates genes in response to endoplasmic reticulum stress
(R-HSA-380994)
Butyrate response factor 1 (brf1) binds and destabilizes mrna
(R-HSA-450385)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Deadenylation-dependent mrna decay
(R-HSA-429914)
Ksrp (khsrp) binds and destabilizes mrna
(R-HSA-450604)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism of rna
(R-HSA-8953854)
Mrna decay by 3' to 5' exoribonuclease
(R-HSA-429958)
Perk regulates gene expression
(R-HSA-381042)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Tristetraprolin (ttp, zfp36) binds and destabilizes mrna
(R-HSA-450513)
Unfolded protein response (upr)
(R-HSA-381119)
Chromosome
(GO:0005694)
Cytoplasm
(GO:0005737)
Cytoplasmic exosome (rnase complex)
(GO:0000177)
Cytosol
(GO:0005829)
Exonucleolytic catabolism of deadenylated mrna
(GO:0043928)
Exonucleolytic trimming to generate mature 3'-end of 5.8s rrna from tricistronic rrna transcript (ssu-rrna, 5.8s rrna, lsu-rrna)
(GO:0000467)
Exosome (rnase complex)
(GO:0000178)
Fibrillar center
(GO:0001650)
Identical protein binding
(GO:0042802)
Intracellular membrane-bounded organelle
(GO:0043231)
Mrna 3'-utr au-rich region binding
(GO:0035925)
Nuclear-transcribed mrna catabolic process, exonucleolytic, 3'-5'
(GO:0034427)
Nuclear exosome (rnase complex)
(GO:0000176)
Nuclear mrna surveillance
(GO:0071028)
Nuclear polyadenylation-dependent mrna catabolic process
(GO:0071042)
Nuclear polyadenylation-dependent rrna catabolic process
(GO:0071035)
Nuclear polyadenylation-dependent trna catabolic process
(GO:0071038)
Nucleolar exosome (rnase complex)
(GO:0101019)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Rna catabolic process
(GO:0006401)
Rna exonuclease activity
(GO:0004532)
Rna processing
(GO:0006396)
U1 snrna 3'-end processing
(GO:0034473)
U4 snrna 3'-end processing
(GO:0034475)
U5 snrna 3'-end processing
(GO:0034476)

Other Information

Proteins

Exosome complex component RRP43

Genular Protein ID: 3020685117

Symbol: EXOS8_HUMAN

Name: Exosome complex component RRP43

UniProtKB Accession Codes:

Q96B26 O43480 Q5TBA5

Database IDs:

Citations:

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9466265

Title: Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth.

PubMed ID: 9466265

DOI: 10.1046/j.1365-2958.1998.00670.x

PubMed ID: 11719186

Title: AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.

PubMed ID: 11719186

DOI: 10.1016/s0092-8674(01)00578-5

PubMed ID: 12419256

Title: Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.

PubMed ID: 12419256

DOI: 10.1016/s0022-2836(02)00947-6

PubMed ID: 15231747

Title: A protein interaction framework for human mRNA degradation.

PubMed ID: 15231747

DOI: 10.1101/gr.2122004

PubMed ID: 16912217

Title: Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome.

PubMed ID: 16912217

DOI: 10.1261/rna.144606

PubMed ID: 17545563

Title: Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways.

PubMed ID: 17545563

DOI: 10.1261/rna.575107

PubMed ID: 20531389

Title: Dis3-like 1: a novel exoribonuclease associated with the human exosome.

PubMed ID: 20531389

DOI: 10.1038/emboj.2010.122

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24989451

Title: EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia.

PubMed ID: 24989451

DOI: 10.1038/ncomms5287

PubMed ID: 17174896

Title: Reconstitution, activities, and structure of the eukaryotic RNA exosome.

PubMed ID: 17174896

DOI: 10.1016/j.cell.2006.10.037

PubMed ID: 29906447

Title: Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex.

PubMed ID: 29906447

DOI: 10.1016/j.cell.2018.05.041

Sequence Information:

Length: 276
Mass: 30040
Checksum: FC8F5BAE74A1FF55
Sequence:

MAAGFKTVEP LEYYRRFLKE NCRPDGRELG EFRTTTVNIG SISTADGSAL VKLGNTTVIC 
GVKAEFAAPS TDAPDKGYVV PNVDLPPLCS SRFRSGPPGE EAQVASQFIA DVIENSQIIQ 
KEDLCISPGK LVWVLYCDLI CLDYDGNILD ACTFALLAAL KNVQLPEVTI NEETALAEVN 
LKKKSYLNIR THPVATSFAV FDDTLLIVDP TGEEEHLATG TLTIVMDEEG KLCCLHKPGG 
SGLTGAKLQD CMSRAVTRHK EVKKLMDEVI KSMKPK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: EXOSC8

Associated with

Other Information

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth. PubMed ID: 9466265

AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. PubMed ID: 11719186

Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. PubMed ID: 12419256

A protein interaction framework for human mRNA degradation. PubMed ID: 15231747

Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome. PubMed ID: 16912217

Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. PubMed ID: 17545563

Dis3-like 1: a novel exoribonuclease associated with the human exosome. PubMed ID: 20531389

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia. PubMed ID: 24989451

Reconstitution, activities, and structure of the eukaryotic RNA exosome. PubMed ID: 17174896

Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex. PubMed ID: 29906447