Details for: SCRG1

Gene ID: 11341

Symbol: SCRG1

Ensembl ID: ENSG00000164106

Description: stimulator of chondrogenesis 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,162
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169,272
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.36
    Marker Score: 2,773
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.35
    Marker Score: 1,154
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.33
    Marker Score: 3,177
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.25
    Marker Score: 1,544
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.17
    Marker Score: 18,282
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.06
    Marker Score: 1,138
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.06
    Marker Score: 6,290
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.04
    Marker Score: 983
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.02
    Marker Score: 668
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.01
    Marker Score: 21,589
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,814
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,038
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.95
    Marker Score: 645
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.94
    Marker Score: 391
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.91
    Marker Score: 472
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.91
    Marker Score: 383
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,217
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,736
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.87
    Marker Score: 276
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,283
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.8
    Marker Score: 696
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 612
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.8
    Marker Score: 968
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,256
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3,179
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.75
    Marker Score: 4,477
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.73
    Marker Score: 912
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.73
    Marker Score: 1,129
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.69
    Marker Score: 412
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.65
    Marker Score: 177
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.62
    Marker Score: 254
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 372
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.58
    Marker Score: 381
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.57
    Marker Score: 333
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.54
    Marker Score: 1,261
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.53
    Marker Score: 256
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.52
    Marker Score: 277
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.52
    Marker Score: 721
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.51
    Marker Score: 4,396
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.51
    Marker Score: 18,796
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.5
    Marker Score: 315
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.48
    Marker Score: 211
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.46
    Marker Score: 1,946
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.44
    Marker Score: 4,525
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.43
    Marker Score: 180
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.43
    Marker Score: 136
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.42
    Marker Score: 1,090
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.41
    Marker Score: 551
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.41
    Marker Score: 25,023
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.4
    Marker Score: 255
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.38
    Marker Score: 183
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.38
    Marker Score: 426
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.38
    Marker Score: 137
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.37
    Marker Score: 5,569
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.37
    Marker Score: 166
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.36
    Marker Score: 177
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.34
    Marker Score: 448
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.34
    Marker Score: 195
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.34
    Marker Score: 3,181
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.34
    Marker Score: 84
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.34
    Marker Score: 140
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.33
    Marker Score: 223
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.32
    Marker Score: 147
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.31
    Marker Score: 648
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.31
    Marker Score: 2,959
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.31
    Marker Score: 299
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.3
    Marker Score: 413
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.3
    Marker Score: 141
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.3
    Marker Score: 79
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3
    Marker Score: 16,515
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.29
    Marker Score: 496
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.29
    Marker Score: 10,953
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.29
    Marker Score: 144
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.28
    Marker Score: 3,721
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.28
    Marker Score: 1,166
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.28
    Marker Score: 509
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.27
    Marker Score: 103
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.27
    Marker Score: 509
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.27
    Marker Score: 93
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.27
    Marker Score: 66
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.26
    Marker Score: 66
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.25
    Marker Score: 451
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.25
    Marker Score: 240
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.25
    Marker Score: 509
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.25
    Marker Score: 384
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.25
    Marker Score: 299
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.25
    Marker Score: 110

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SCRG1 is a protein-coding gene with a single nucleotide sequence, and its expression is widespread across different cell types, including colon goblet cells, mural cells, immune cells, and neural crest-derived cells. The gene is highly expressed in tissues involved in development, growth, and maintenance, such as the nervous system, prostate, and connective tissue. Notably, SCRG1 is also expressed in the enteric nervous system, where it may play a role in regulating the development and function of enteric neural crest cells. **Pathways and Functions:** SCRG1 is involved in various cellular pathways, including: 1. **Cell differentiation**: SCRG1 is required for the differentiation of neural crest cells, which are precursors to neurons and glial cells in the nervous system. 2. **Protein binding**: SCRG1 interacts with other proteins, such as transcription factors and signaling molecules, to regulate gene expression and cellular behavior. 3. **Extracellular matrix organization**: SCRG1 is involved in the organization and remodeling of the extracellular matrix, which is essential for tissue development and maintenance. 4. **Neurodevelopment**: SCRG1 is required for the development and function of the nervous system, including the formation of neural crest-derived cells and the regulation of neurotransmitter release. **Clinical Significance:** The dysregulation of SCRG1 has been implicated in various diseases, including: 1. **Neurodevelopmental disorders**: Mutations in SCRG1 have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Cancer**: SCRG1 is overexpressed in certain types of cancer, including prostate cancer, and may play a role in tumor progression and metastasis. 3. **Connective tissue disorders**: SCRG1 is involved in the development and maintenance of connective tissue, and its dysregulation may contribute to disorders such as osteoarthritis and fibrosis. In conclusion, SCRG1 is a critical gene involved in various cellular pathways, including cell differentiation, protein binding, extracellular matrix organization, and neurodevelopment. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functional and clinical significance of SCRG1.

Genular Protein ID: 489288110

Symbol: SCRG1_HUMAN

Name: Scrapie-responsive protein 1

UniProtKB Accession Codes:

O75711

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9660755

Title: Characterization of the human analogue of a scrapie-responsive gene.

PubMed ID: 9660755

DOI: 10.1074/jbc.273.29.18015

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

Sequence Information:

  • Length: 98
  • Mass: 11081
  • Checksum: A5F1FD40BF5401C0
  • Sequence:
    • MKLMVLVFTI GLTLLLGVQA MPANRLSCYR KILKDHNCHN LPEGVADLTQ IDVNVQDHFW 
DGKGCEMICY CNFSELLCCP KDVFFGPKIS FVIPCNNQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.