Details for: RNF13

Gene ID: 11342

Symbol: RNF13

Ensembl ID: ENSG00000082996

Description: ring finger protein 13

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.05
    Marker Score: 7,302
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.4
    Marker Score: 61,502
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.36
    Marker Score: 9,862
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.35
    Marker Score: 2,838
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.24
    Marker Score: 1,114
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.21
    Marker Score: 2,532
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.2
    Marker Score: 2,646
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.19
    Marker Score: 2,950
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.17
    Marker Score: 1,272
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.07
    Marker Score: 4,368
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.04
    Marker Score: 3,707
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.97
    Marker Score: 42,055
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.96
    Marker Score: 2,843
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.92
    Marker Score: 2,119
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.91
    Marker Score: 4,192
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.9
    Marker Score: 1,903
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9
    Marker Score: 1,995
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.89
    Marker Score: 116,148
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.88
    Marker Score: 28,157
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.88
    Marker Score: 787
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.87
    Marker Score: 675
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.86
    Marker Score: 4,500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.86
    Marker Score: 4,235
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.86
    Marker Score: 3,620
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.85
    Marker Score: 68,111
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.82
    Marker Score: 36,261
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.82
    Marker Score: 17,099
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.8
    Marker Score: 993
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.8
    Marker Score: 17,075
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.8
    Marker Score: 68,187
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.79
    Marker Score: 2,314
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.79
    Marker Score: 7,407
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.78
    Marker Score: 2,154
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.78
    Marker Score: 10,806
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.76
    Marker Score: 922
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.75
    Marker Score: 6,765
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.75
    Marker Score: 18,063
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.75
    Marker Score: 1,882
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.73
    Marker Score: 13,287
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.73
    Marker Score: 96,598
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.73
    Marker Score: 14,837
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.68
    Marker Score: 978
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.68
    Marker Score: 699
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.67
    Marker Score: 26,871
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.66
    Marker Score: 6,744
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.65
    Marker Score: 4,421
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.63
    Marker Score: 36,528
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.63
    Marker Score: 2,020
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.63
    Marker Score: 515
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.63
    Marker Score: 6,396
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.63
    Marker Score: 803
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.59
    Marker Score: 504
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.59
    Marker Score: 1,376
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.56
    Marker Score: 584
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.55
    Marker Score: 1,788
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.55
    Marker Score: 453
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.53
    Marker Score: 3,804
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.52
    Marker Score: 739
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.51
    Marker Score: 6,533
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.51
    Marker Score: 1,342
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.51
    Marker Score: 2,326
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.5
    Marker Score: 5,322
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.49
    Marker Score: 343
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.48
    Marker Score: 601
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.48
    Marker Score: 1,362
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.48
    Marker Score: 1,844
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.48
    Marker Score: 404
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.46
    Marker Score: 16,942
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.45
    Marker Score: 1,474
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.45
    Marker Score: 347
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.45
    Marker Score: 2,136
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.44
    Marker Score: 533
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.44
    Marker Score: 3,731
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.43
    Marker Score: 801
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.43
    Marker Score: 1,517
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.42
    Marker Score: 2,723
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.41
    Marker Score: 1,573
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.41
    Marker Score: 575
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.39
    Marker Score: 556
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.39
    Marker Score: 12,207
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.39
    Marker Score: 1,961
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.37
    Marker Score: 339
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.36
    Marker Score: 1,222
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.36
    Marker Score: 941
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.35
    Marker Score: 1,873
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.34
    Marker Score: 2,371
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.34
    Marker Score: 6,186
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.33
    Marker Score: 463
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.33
    Marker Score: 3,339
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.33
    Marker Score: 1,419
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.33
    Marker Score: 3,477
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.33
    Marker Score: 304
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.33
    Marker Score: 300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.32
    Marker Score: 2,409
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.32
    Marker Score: 2,183
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.32
    Marker Score: 1,490
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.31
    Marker Score: 873
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.31
    Marker Score: 457
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.31
    Marker Score: 378
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.31
    Marker Score: 5,649

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RING Finger Domain**: RNF13 possesses a characteristic RING finger domain, which is a crucial element for protein-protein interactions and ubiquitin ligase activity. 2. **F-box Protein**: RNF13 is classified as a F-box protein, a subunit of the SCF (Skp1-Cullin-F-box) complex, which is a key component of the ubiquitin-proteasome pathway. 3. **Ubiquitin Ligase Activity**: RNF13 exhibits ubiquitin ligase activity, enabling it to mediate protein degradation through the ubiquitin-proteasome pathway. 4. **Stress Response**: RNF13 is involved in the regulation of stress-activated protein kinase signaling cascade, which plays a critical role in responding to cellular stress and promoting cell survival. **Pathways and Functions:** RNF13 is implicated in various cellular pathways, including: 1. **Ubiquitin-Proteasome Pathway**: RNF13 regulates protein degradation through the ubiquitin-proteasome pathway, which is essential for maintaining protein homeostasis. 2. **Stress-Activated Protein Kinase Signaling Cascade**: RNF13 modulates the stress-activated protein kinase signaling cascade, which is a key component in responding to cellular stress and promoting cell survival. 3. **Protein Autoubiquitination**: RNF13 is involved in protein autoubiquitination, a process that regulates protein degradation and signaling. 4. **Cellular Stress Response**: RNF13 plays a crucial role in responding to cellular stress, including heat shock, oxidative stress, and endoplasmic reticulum stress. **Clinical Significance:** RNF13's dysregulation has been implicated in various diseases, including: 1. **Neurodegenerative Disorders**: RNF13 mutations have been associated with neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: RNF13 has been identified as a tumor suppressor gene, and its dysregulation has been linked to various types of cancer. 3. **Inflammatory Disorders**: RNF13 has been implicated in inflammatory disorders, such as rheumatoid arthritis and atherosclerosis. 4. **Neurological Disorders**: RNF13's involvement in stress response and protein regulation makes it a potential target for therapeutic interventions in neurological disorders. In conclusion, RNF13 is a complex gene that plays a crucial role in maintaining cellular homeostasis and responding to cellular stress. Its dysregulation has been implicated in various diseases, highlighting the importance of RNF13 in human health and disease. Further research is necessary to fully understand the mechanisms of RNF13 and its role in disease pathogenesis.

Genular Protein ID: 536946859

Symbol: RNF13_HUMAN

Name: RING finger protein 13

UniProtKB Accession Codes:

O43567 A6NC87 B3KR12 Q05D66 Q6IBJ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 17 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 12 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17897319

Title: Integral and associated lysosomal membrane proteins.

PubMed ID: 17897319

DOI: 10.1111/j.1600-0854.2007.00643.x

PubMed ID: 18794910

Title: RNF13: a novel RING-type ubiquitin ligase over-expressed in pancreatic cancer.

PubMed ID: 18794910

DOI: 10.1038/cr.2008.285

PubMed ID: 23378536

Title: RNF13, a RING finger protein, mediates endoplasmic reticulum stress-induced apoptosis through the inositol-requiring enzyme (IRE1alpha)/c-Jun NH2-terminal kinase pathway.

PubMed ID: 23378536

DOI: 10.1074/jbc.m112.368829

PubMed ID: 24387786

Title: Tumour-associated mutations of PA-TM-RING ubiquitin ligases RNF167/RNF13 identify the PA domain as a determinant for endosomal localization.

PubMed ID: 24387786

DOI: 10.1042/bj20131067

PubMed ID: 30595371

Title: Heterozygous RNF13 gain-of-function variants are associated with congenital microcephaly, epileptic encephalopathy, blindness, and failure to thrive.

PubMed ID: 30595371

DOI: 10.1016/j.ajhg.2018.11.018

Sequence Information:

  • Length: 381
  • Mass: 42814
  • Checksum: 4600727D0F197653
  • Sequence:
    • MLLSIGMLML SATQVYTILT VQLFAFLNLL PVEADILAYN FENASQTFDD LPARFGYRLP 
AEGLKGFLIN SKPENACEPI VPPPVKDNSS GTFIVLIRRL DCNFDIKVLN AQRAGYKAAI 
VHNVDSDDLI SMGSNDIEVL KKIDIPSVFI GESSANSLKD EFTYEKGGHL ILVPEFSLPL 
EYYLIPFLII VGICLILIVI FMITKFVQDR HRARRNRLRK DQLKKLPVHK FKKGDEYDVC 
AICLDEYEDG DKLRILPCSH AYHCKCVDPW LTKTKKTCPV CKQKVVPSQG DSDSDTDSSQ 
EENEVTEHTP LLRPLASVSA QSFGALSESR SHQNMTESSD YEEDDNEDTD SSDAENEINE 
HDVVVQLQPN GERDYNIANT V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.