Details for: MGLL

Gene ID: 11343

Symbol: MGLL

Ensembl ID: ENSG00000074416

Description: monoglyceride lipase

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.96
    Marker Score: 3,564
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.74
    Marker Score: 58,406
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.34
    Marker Score: 7,353
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.29
    Marker Score: 2,198
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.17
    Marker Score: 32,418
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.13
    Marker Score: 5,240
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.12
    Marker Score: 2,439
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.07
    Marker Score: 15,859
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.07
    Marker Score: 41,093
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.02
    Marker Score: 3,411
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.99
    Marker Score: 4,536
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.99
    Marker Score: 12,948
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.97
    Marker Score: 1,176
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.95
    Marker Score: 18,355
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.95
    Marker Score: 8,082
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.91
    Marker Score: 858
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.91
    Marker Score: 7,384
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9
    Marker Score: 117,143
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.87
    Marker Score: 16,090
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.84
    Marker Score: 674
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.81
    Marker Score: 29,002
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.78
    Marker Score: 16,954
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.78
    Marker Score: 4,772
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.76
    Marker Score: 2,828
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.75
    Marker Score: 3,838
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.75
    Marker Score: 8,388
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.74
    Marker Score: 726
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.74
    Marker Score: 66,094
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.74
    Marker Score: 9,135
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.73
    Marker Score: 14,892
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.72
    Marker Score: 688
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.69
    Marker Score: 1,611
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.59
    Marker Score: 1,928
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.59
    Marker Score: 12,426
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.59
    Marker Score: 58,510
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.58
    Marker Score: 1,037
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.57
    Marker Score: 5,393
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.54
    Marker Score: 9,849
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 1.52
    Marker Score: 555
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.51
    Marker Score: 1,419
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.49
    Marker Score: 6,056
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.49
    Marker Score: 12,909
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.48
    Marker Score: 1,826
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.47
    Marker Score: 1,229
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.47
    Marker Score: 1,063
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 166,991
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.45
    Marker Score: 605
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.44
    Marker Score: 982
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.42
    Marker Score: 415
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.42
    Marker Score: 6,110
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.41
    Marker Score: 786
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.39
    Marker Score: 479
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.38
    Marker Score: 643
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.36
    Marker Score: 2,167
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.34
    Marker Score: 652
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.34
    Marker Score: 727
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.34
    Marker Score: 5,268
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.33
    Marker Score: 1,352
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.32
    Marker Score: 412
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.31
    Marker Score: 421
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.29
    Marker Score: 1,901
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.28
    Marker Score: 3,015
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.28
    Marker Score: 404
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.28
    Marker Score: 1,174
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.27
    Marker Score: 403
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.27
    Marker Score: 6,840
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.27
    Marker Score: 1,101
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.27
    Marker Score: 2,403
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.25
    Marker Score: 1,933
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.24
    Marker Score: 9,212
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.24
    Marker Score: 2,516
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.23
    Marker Score: 4,733
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.21
    Marker Score: 2,452
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.2
    Marker Score: 7,691
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.19
    Marker Score: 628
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.19
    Marker Score: 18,553
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.18
    Marker Score: 689
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.17
    Marker Score: 683
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.17
    Marker Score: 290
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.17
    Marker Score: 1,938
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.17
    Marker Score: 1,045
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.17
    Marker Score: 441
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.15
    Marker Score: 4,711
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.15
    Marker Score: 2,184
  • Cell Name: platelet (CL0000233)
    Fold Change: 1.15
    Marker Score: 520
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.15
    Marker Score: 269
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.15
    Marker Score: 1,236
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.15
    Marker Score: 477
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.14
    Marker Score: 702
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.14
    Marker Score: 2,689
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.13
    Marker Score: 358
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.12
    Marker Score: 800
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.11
    Marker Score: 1,003
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.11
    Marker Score: 1,106
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.09
    Marker Score: 2,757
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.09
    Marker Score: 314
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.08
    Marker Score: 318
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.08
    Marker Score: 449
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.08
    Marker Score: 269
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.07
    Marker Score: 534

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Lysophospholipase activity:** MGLL is a member of the lysophospholipase family, which hydrolyzes MAGs and LPLs into fatty acids and phosphates. 2. **Expression in various cell types:** MGLL is widely expressed in different tissues, including the lung, brain, colon, and peripheral blood cells. 3. **Multifunctional enzyme:** MGLL participates in various signaling pathways, including those involved in inflammation, pain perception, and endocannabinoid signaling. 4. **Regulation of lipid metabolism:** MGLL is involved in the catabolism of MAGs and LPLs, which are essential for lipid homeostasis. **Pathways and Functions:** 1. **Acyl chain remodeling of DAG and TAG:** MGLL hydrolyzes MAGs to produce fatty acids, which can then be re-esterified to form triglycerides (TAG) or diacylglycerols (DAG). 2. **Acylglycerol catabolic process:** MGLL participates in the breakdown of MAGs and LPLs, releasing fatty acids and phosphates. 3. **Arachidonate production from DAG:** MGLL can convert DAG into arachidonic acid, a precursor for eicosanoid synthesis. 4. **Inflammatory response:** MGLL modulates the inflammatory response by regulating the production of pro-inflammatory eicosanoids. 5. **Endocannabinoid signaling pathway:** MGLL is involved in the regulation of endocannabinoid signaling, which plays a crucial role in pain perception and appetite control. 6. **Regulation of sensory perception of pain:** MGLL modulates pain perception by regulating the production of pro-inflammatory eicosanoids and endocannabinoids. 7. **Regulation of signal transduction:** MGLL participates in various signaling pathways, including those involved in inflammation, pain perception, and endocannabinoid signaling. **Clinical Significance:** 1. **Inflammatory disorders:** MGLL has been implicated in the pathogenesis of inflammatory disorders, such as atherosclerosis, arthritis, and inflammatory bowel disease. 2. **Pain management:** MGLL's role in pain perception and modulation makes it a potential target for the development of novel pain therapies. 3. **Endocannabinoid dysfunction:** MGLL's involvement in endocannabinoid signaling suggests that alterations in its activity may contribute to endocannabinoid dysfunction, which is implicated in various neurological and psychiatric disorders. 4. **Cancer:** MGLL has been identified as a potential biomarker for cancer, as its expression is altered in various cancer types, including lung, breast, and colon cancer. In conclusion, MGLL is a multifunctional enzyme that plays a crucial role in lipid metabolism and modulates various signaling pathways, influencing inflammation, pain perception, and endocannabinoid signaling. Its clinical significance is underscored by its involvement in inflammatory disorders, pain management, endocannabinoid dysfunction, and cancer. Further research is necessary to fully elucidate the complex roles of MGLL in human health and disease.

Genular Protein ID: 2292719060

Symbol: MGLL_HUMAN

Name: Lysophospholipase homolog

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9495531

Title: A novel poxvirus gene and its human homolog are similar to an E. coli lysophospholipase.

PubMed ID: 9495531

DOI: 10.1016/s0168-1702(97)00122-6

PubMed ID: 11470505

Title: Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase gene.

PubMed ID: 11470505

DOI: 10.1016/s0378-1119(01)00559-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 19029917

Title: Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects.

PubMed ID: 19029917

DOI: 10.1038/nchembio.129

PubMed ID: 20079333

Title: Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis.

PubMed ID: 20079333

DOI: 10.1016/j.cell.2009.11.027

PubMed ID: 21049984

Title: Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2.

PubMed ID: 21049984

DOI: 10.1021/tx1002194

PubMed ID: 22969151

Title: Biochemical and pharmacological characterization of human alpha/beta-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).

PubMed ID: 22969151

DOI: 10.1194/jlr.m030411

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19957260

Title: Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling.

PubMed ID: 19957260

DOI: 10.1002/cbic.200900621

PubMed ID: 24368842

Title: Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency.

PubMed ID: 24368842

DOI: 10.1124/mol.113.090795

PubMed ID: 19962385

Title: Structural basis for human monoglyceride lipase inhibition.

PubMed ID: 19962385

DOI: 10.1016/j.jmb.2009.11.060

Sequence Information:

  • Length: 303
  • Mass: 33261
  • Checksum: 80E754F126EE64DE
  • Sequence:
  • MPEESSPRRT PQSIPYQDLP HLVNADGQYL FCRYWKPTGT PKALIFVSHG AGEHSGRYEE 
    LARMLMGLDL LVFAHDHVGH GQSEGERMVV SDFHVFVRDV LQHVDSMQKD YPGLPVFLLG 
    HSMGGAIAIL TAAERPGHFA GMVLISPLVL ANPESATTFK VLAAKVLNLV LPNLSLGPID 
    SSVLSRNKTE VDIYNSDPLI CRAGLKVCFG IQLLNAVSRV ERALPKLTVP FLLLQGSADR 
    LCDSKGAYLL MELAKSQDKT LKIYEGAYHV LHKELPEVTN SVFHEINMWV SQRTATAGTA 
    SPP

Genular Protein ID: 3152007866

Symbol: A0A0C4DFN3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 313
  • Mass: 34292
  • Checksum: D5C556E17B55E252
  • Sequence:
  • METGPEDPSS MPEESSPRRT PQSIPYQDLP HLVNADGQYL FCRYWKPTGT PKALIFVSHG 
    AGEHSGRYEE LARMLMGLDL LVFAHDHVGH GQSEGERMVV SDFHVFVRDV LQHVDSMQKD 
    YPGLPVFLLG HSMGGAIAIL TAAERPGHFA GMVLISPLVL ANPESATTFK VLAAKVLNLV 
    LPNLSLGPID SSVLSRNKTE VDIYNSDPLI CRAGLKVCFG IQLLNAVSRV ERALPKLTVP 
    FLLLQGSADR LCDSKGAYLL MELAKSQDKT LKIYEGAYHV LHKELPEVTN SVFHEINMWV 
    SQRTATAGTA SPP

Genular Protein ID: 1413844812

Symbol: B2ZGL7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 273
  • Mass: 30118
  • Checksum: 0CCB6780E674D031
  • Sequence:
  • MPEESSPRRT PQSIPYQDLP HLVNADGQYL FCRYWKPTGT PKALIFVSHG AGEHSGRYEE 
    LARMLMGLDL LVFAHDHVGH GQSEGERMVV SDFHVFVRDV LQHVDSMQKD YPGLPVFLLG 
    HSMGGAIAIL TAAERPGHFA GMVLISPLVL ANPESATTFK VDIYNSDPLI CRAGLKVCFG 
    IQLLNAVSRV ERALPKLTVP FLLLQGSADR LCDSKGAYLL MELAKSQDKT LKIYEGAYHV 
    LHKELPEVTN SVFHEINMWV SQRTATAGTA SPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.