Details for: TWF2

Gene ID: 11344

Symbol: TWF2

Ensembl ID: ENSG00000247596

Description: twinfilin actin binding protein 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 8.98
    Marker Score: 12,898
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.29
    Marker Score: 2,324
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.88
    Marker Score: 11,136
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.62
    Marker Score: 3,163
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.18
    Marker Score: 25,395
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.14
    Marker Score: 119,860
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.1
    Marker Score: 12,743
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.76
    Marker Score: 17,458
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.75
    Marker Score: 964
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.73
    Marker Score: 754
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.69
    Marker Score: 2,390
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.64
    Marker Score: 1,873
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.63
    Marker Score: 4,007
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.6
    Marker Score: 1,612
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.58
    Marker Score: 1,523
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.57
    Marker Score: 3,912
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.55
    Marker Score: 39,692
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.55
    Marker Score: 6,326
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.52
    Marker Score: 619
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.52
    Marker Score: 15,357
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.5
    Marker Score: 4,444
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.49
    Marker Score: 742
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.43
    Marker Score: 2,805
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.39
    Marker Score: 1,016
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.39
    Marker Score: 3,592
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.38
    Marker Score: 4,365
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.36
    Marker Score: 2,371
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.32
    Marker Score: 1,163
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.32
    Marker Score: 3,644
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.32
    Marker Score: 3,216
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.32
    Marker Score: 953
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.31
    Marker Score: 1,933
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.29
    Marker Score: 5,541
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.25
    Marker Score: 1,839
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.25
    Marker Score: 43,129
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.24
    Marker Score: 1,167
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.24
    Marker Score: 517
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.23
    Marker Score: 3,595
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.23
    Marker Score: 1,254
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.22
    Marker Score: 64,542
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.21
    Marker Score: 3,299
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.2
    Marker Score: 1,445
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.2
    Marker Score: 1,199
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.19
    Marker Score: 417
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.19
    Marker Score: 582
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.19
    Marker Score: 585
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.16
    Marker Score: 678
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.13
    Marker Score: 1,496
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.11
    Marker Score: 812
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.11
    Marker Score: 382
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.1
    Marker Score: 313
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.1
    Marker Score: 1,190
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.1
    Marker Score: 633
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.1
    Marker Score: 1,079
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.1
    Marker Score: 979
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.09
    Marker Score: 4,715
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.09
    Marker Score: 9,380
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.08
    Marker Score: 347
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.08
    Marker Score: 1,355
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.08
    Marker Score: 1,963
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.07
    Marker Score: 247
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.07
    Marker Score: 737
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.07
    Marker Score: 2,995
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.06
    Marker Score: 621
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.05
    Marker Score: 665
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.05
    Marker Score: 438
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.04
    Marker Score: 549
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.04
    Marker Score: 849
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.03
    Marker Score: 4,051
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.03
    Marker Score: 16,103
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.03
    Marker Score: 591
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.03
    Marker Score: 966
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.02
    Marker Score: 803
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.02
    Marker Score: 685
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.01
    Marker Score: 555
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.01
    Marker Score: 1,054
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1
    Marker Score: 735
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,626
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.99
    Marker Score: 480
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,851
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.99
    Marker Score: 428
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.99
    Marker Score: 284
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,382
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.98
    Marker Score: 297
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.98
    Marker Score: 650
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.98
    Marker Score: 347
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.97
    Marker Score: 335
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.97
    Marker Score: 484
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.96
    Marker Score: 1,023
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.95
    Marker Score: 296
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.94
    Marker Score: 881
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.94
    Marker Score: 709
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,378
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.93
    Marker Score: 1,656
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.93
    Marker Score: 982
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.93
    Marker Score: 6,037
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.93
    Marker Score: 636
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.93
    Marker Score: 187
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TWF2 exhibits several key characteristics that make it an essential component of the actin cytoskeleton: 1. **Actin binding**: TWF2 interacts with actin filaments, regulating their dynamics and stability. 2. **Depolymerization**: TWF2 promotes the depolymerization of actin filaments, which is crucial for cellular processes such as cell migration and differentiation. 3. **Capping**: TWF2 also capping actin filaments at their barbed ends, preventing their rapid depolymerization. 4. **Sequestering**: TWF2 sequesters actin monomers, regulating their availability and influencing actin filament assembly. **Pathways and Functions** TWF2 is involved in a wide range of cellular processes, including: 1. **Cell migration**: TWF2 regulates actin filament dynamics, enabling cell migration and invasion. 2. **Cell adhesion**: TWF2 interacts with cadherins and other adhesion molecules, influencing cell-cell interactions and tissue organization. 3. **Neuron projection development**: TWF2 regulates axon extension and lamellipodium assembly, crucial for neuronal development and function. 4. **Immune cell function**: TWF2 is expressed in immune cells, including macrophages and T cells, and regulates their migration, adhesion, and cytokine production. **Clinical Significance** TWF2 dysregulation has been implicated in various diseases, including: 1. **Immunodeficiency**: TWF2 mutations have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Cancer**: TWF2 expression is altered in various types of cancer, including leukemia and lymphoma. 3. **Neurological disorders**: TWF2 dysregulation has been implicated in neurological disorders, such as autism spectrum disorder and schizophrenia. In conclusion, TWF2 is a critical component of the actin cytoskeleton that plays a pivotal role in various cellular processes. Its dysregulation has been implicated in a range of diseases, highlighting the importance of understanding its mechanisms of action and regulation. Further research on TWF2 is necessary to elucidate its role in immune function and disease, and to develop novel therapeutic strategies for the treatment of related disorders.

Genular Protein ID: 1507420428

Symbol: TWF2_HUMAN

Name: Twinfilin-2

UniProtKB Accession Codes:

Q6IBS0 Q9Y3F5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10406962

Title: Cloning, expression and characterization of an A6 related protein.

PubMed ID: 10406962

DOI: 10.1046/j.1432-1327.1999.00537.x

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 349
  • Mass: 39548
  • Checksum: 635EF8C04EFCE92B
  • Sequence:
    • MAHQTGIHAT EELKEFFAKA RAGSVRLIKV VIEDEQLVLG ASQEPVGRWD QDYDRAVLPL 
LDAQQPCYLL YRLDSQNAQG FEWLFLAWSP DNSPVRLKML YAATRATVKK EFGGGHIKDE 
LFGTVKDDLS FAGYQKHLSS CAAPAPLTSA ERELQQIRIN EVKTEISVES KHQTLQGLAF 
PLQPEAQRAL QQLKQKMVNY IQMKLDLERE TIELVHTEPT DVAQLPSRVP RDAARYHFFL 
YKHTHEGDPL ESVVFIYSMP GYKCSIKERM LYSSCKSRLL DSVEQDFHLE IAKKIEIGDG 
AELTAEFLYD EVHPKQHAFK QAFAKPKGPG GKRGHKRLIR GPGENGDDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.