Details for: SYNPO

Gene ID: 11346

Symbol: SYNPO

Ensembl ID: ENSG00000171992

Description: synaptopodin

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.87
    Marker Score: 586
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.68
    Marker Score: 1,545
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,472
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.37
    Marker Score: 11,793
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.37
    Marker Score: 1,651
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.34
    Marker Score: 20,930
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.33
    Marker Score: 12,673
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.28
    Marker Score: 1,970
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.23
    Marker Score: 27,416
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.22
    Marker Score: 1,267
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.2
    Marker Score: 2,401
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.19
    Marker Score: 1,729
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.17
    Marker Score: 71,948
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.17
    Marker Score: 4,886
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.14
    Marker Score: 983
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.14
    Marker Score: 2,684
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.04
    Marker Score: 266
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,762
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,782
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,006
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.95
    Marker Score: 902
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.94
    Marker Score: 545
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,217
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.89
    Marker Score: 330
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.89
    Marker Score: 425
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.88
    Marker Score: 791
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.87
    Marker Score: 3,110
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,276
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.86
    Marker Score: 335
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.84
    Marker Score: 196
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.84
    Marker Score: 790
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1,357
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.83
    Marker Score: 335
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 805
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.82
    Marker Score: 208
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.8
    Marker Score: 7,509
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 610
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.79
    Marker Score: 6,075
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.79
    Marker Score: 1,606
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.78
    Marker Score: 222
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.77
    Marker Score: 319
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.76
    Marker Score: 1,392
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.75
    Marker Score: 28,546
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.73
    Marker Score: 6,398
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.72
    Marker Score: 7,473
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 651
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.71
    Marker Score: 637
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.7
    Marker Score: 703
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2,927
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.69
    Marker Score: 2,171
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.69
    Marker Score: 165
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.68
    Marker Score: 482
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.67
    Marker Score: 175
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.67
    Marker Score: 381
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.66
    Marker Score: 434
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.66
    Marker Score: 290
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.65
    Marker Score: 370
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.65
    Marker Score: 3,398
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.63
    Marker Score: 3,765
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.62
    Marker Score: 672
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.62
    Marker Score: 1,627
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.61
    Marker Score: 1,178
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.61
    Marker Score: 1,155
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.6
    Marker Score: 22,239
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.6
    Marker Score: 224
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.6
    Marker Score: 349
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.6
    Marker Score: 164
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.59
    Marker Score: 688
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.58
    Marker Score: 2,803
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.58
    Marker Score: 219
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.58
    Marker Score: 153
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.58
    Marker Score: 834
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.58
    Marker Score: 346
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.57
    Marker Score: 10,096
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.57
    Marker Score: 2,454
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.57
    Marker Score: 160
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.56
    Marker Score: 3,599
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.56
    Marker Score: 2,320
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.56
    Marker Score: 551
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.55
    Marker Score: 160
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.55
    Marker Score: 127
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.53
    Marker Score: 141
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.53
    Marker Score: 509
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.53
    Marker Score: 197
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.53
    Marker Score: 724
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.52
    Marker Score: 883
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.52
    Marker Score: 253
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.52
    Marker Score: 177
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.52
    Marker Score: 256
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.52
    Marker Score: 241

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Actin-binding protein**: Synaptopodin interacts with actin filaments, modulating their dynamics and organization. 2. **Dendritic spine and postsynaptic density component**: Synaptopodin is integral to the structure and function of dendritic spines and postsynaptic densities, critical regions for synaptic plasticity and neurotransmission. 3. **Regulation of actin filament bundle assembly**: Synaptopodin influences the assembly and disassembly of actin filaments, impacting cytoskeleton organization and dynamics. 4. **Stress fiber and Z-disk component**: Synaptopodin is also associated with stress fibers and Z-disks, indicating its role in maintaining cellular architecture and responding to mechanical stress. **Pathways and Functions:** Synaptopodin is involved in various cellular processes, including: 1. **Actin cytoskeleton organization**: Synaptopodin regulates actin filament dynamics, influencing cytoskeleton organization and dynamics. 2. **Synaptic plasticity**: Synaptopodin is essential for maintaining the structure and function of dendritic spines and postsynaptic densities, critical for synaptic plasticity and learning. 3. **Cellular stress response**: Synaptopodin interacts with actin filaments and stress fibers, enabling cells to respond to mechanical stress and maintain cellular architecture. 4. **Cell signaling and communication**: Synaptopodin may influence cell signaling pathways, modulating the activity of various signaling proteins and influencing cellular behavior. **Clinical Significance:** Dysregulation of synaptopodin has been implicated in various neurological disorders, including: 1. **Autism spectrum disorder**: Synaptopodin mutations have been linked to autism, highlighting its role in synaptic plasticity and neural development. 2. **Schizophrenia**: Synaptopodin dysfunction has been implicated in schizophrenia, suggesting its involvement in neural circuitry and synaptic plasticity. 3. **Neurodegenerative diseases**: Synaptopodin has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where actin cytoskeleton dysfunction is a hallmark of disease progression. 4. **Muscle disorders**: Synaptopodin dysfunction has been linked to muscle disorders, such as muscular dystrophy, highlighting its role in maintaining muscle architecture and function. In conclusion, synaptopodin is a multifunctional protein that plays a critical role in maintaining the structural integrity of the actin cytoskeleton, regulating synaptic plasticity, and influencing cellular stress response. Dysregulation of synaptopodin has been implicated in various neurological disorders and muscle disorders, highlighting the need for further investigation into its role in human disease.

Genular Protein ID: 4193083707

Symbol: SYNPO_HUMAN

Name: Synaptopodin

UniProtKB Accession Codes:

Q8N3V7 A5PKZ8 D3DQG8 O15271 Q9UPX1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 4 GO 16 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 7 SAM 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9314539

Title: Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes.

PubMed ID: 9314539

DOI: 10.1083/jcb.139.1.193

PubMed ID: 10470851

Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10470851

DOI: 10.1093/dnares/6.3.197

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12042308

Title: Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.

PubMed ID: 12042308

DOI: 10.1074/jbc.m203072200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18596123

Title: KIBRA modulates directional migration of podocytes.

PubMed ID: 18596123

DOI: 10.1681/asn.2007080916

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30661770

Title: TBC1D8B Loss-of-Function Mutations Lead to X-Linked Nephrotic Syndrome via Defective Trafficking Pathways.

PubMed ID: 30661770

DOI: 10.1016/j.ajhg.2018.12.016

Sequence Information:

  • Length: 929
  • Mass: 99463
  • Checksum: 38723B6FDD046F15
  • Sequence:
    • MLGPHLPPPP LAPSEGRPTP CAFQIPDGSY RCLALEAEES SGEEGLQGEV GPTDLEEDEG 
VSRSGDDSAC RVTQGTPQLP KALGIQPPSC SREEQGASQH DDRASQDWDV VKAGQMMTAS 
PSPGPGPRVA QKPALGRSTS LTEKDLKEAK ARSQQIAAQL TTPPSSNSRG VQLFNRRRQR 
VNEFTLESHG QRGQKPSQES LRVLPSSLPG HAPGLSLSST SLPEPGPPRH PSPQSPDRGV 
PGHSMEGYSE EASLLRHLEK VASEEEEVPL VVYLKENAAL LTANGLHLSQ NREAQQSSPA 
PPPAEVHSPA ADVNQNLASP SATLTTPTSN SSHNPPATDV NQNPPATVVP QSLPLSSIQQ 
NSSEAQLPSN GTGPASKPST LCADGQPQAP AEEVRCSTLL IDKVSTPATT TSTFSREATL 
IPSSRPPASD FMSSSLLIDI QPNTLVVSAD QEMSGRAAAT TPTKVYSEVH FTLAKPPSVV 
NRTARPFGIQ APGGTSQMER SPMLERRHFG EKAPAPQPPS LPDRSPRPQR HIMSRSPMVE 
RRMMGQRSPA SERRPLGNFT APPTYTETLS TAPLASWVRS PPSYSVLYPS SDPKSSHLKG 
QAVPASKTGI LEESMARRGS RKSMFTFVEK PKVTPNPDLL DLVQTADEKR RQRDQGEVGV 
EEEPFALGAE ASNFQQEPAP RDRASPAAAE EVVPEWASCL KSPRIQAKPK PKPNQNLSEA 
SGKGAELYAR RQSRMEKYVI ESSSHTPELA RCPSPTMSLP SSWKYPTNAP GAFRVASRSP 
ARTPPASLYH GYLPENGVLR PEPTKQPPYQ LRPSLFVLSP IKEPAKVSPR AASPAKPSSL 
DLVPNLPKGA LPPSPALPRP SRSSPGLYTS PGQDSLQPTA VSPPYGGDIS PVSPSRAWSP 
RAKQAPRPSF STRNAGIEAQ VWKPSFCFK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.