Details for: CHRNA2

Gene ID: 1135

Symbol: CHRNA2

Ensembl ID: ENSG00000120903

Description: cholinergic receptor nicotinic alpha 2 subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.2834
    Cell Significance Index: 41.1100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.2721
    Cell Significance Index: 19.1700
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.2396
    Cell Significance Index: 10.6600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.1791
    Cell Significance Index: 14.6300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.0325
    Cell Significance Index: 25.0100
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.3483
    Cell Significance Index: 4.2100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3081
    Cell Significance Index: 4.4900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.3063
    Cell Significance Index: 3.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2819
    Cell Significance Index: 45.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2693
    Cell Significance Index: 14.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2680
    Cell Significance Index: 16.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1713
    Cell Significance Index: 4.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1580
    Cell Significance Index: 3.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1008
    Cell Significance Index: 9.9800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0779
    Cell Significance Index: 1.0100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0437
    Cell Significance Index: 4.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0381
    Cell Significance Index: 7.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0298
    Cell Significance Index: 10.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0285
    Cell Significance Index: 0.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0186
    Cell Significance Index: 25.2700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0145
    Cell Significance Index: 0.1500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0116
    Cell Significance Index: 0.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0072
    Cell Significance Index: 4.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0043
    Cell Significance Index: 0.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0009
    Cell Significance Index: 0.0200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0007
    Cell Significance Index: -0.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0012
    Cell Significance Index: -0.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0020
    Cell Significance Index: -3.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0021
    Cell Significance Index: -3.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0036
    Cell Significance Index: -2.6300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0042
    Cell Significance Index: -0.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0044
    Cell Significance Index: -0.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0053
    Cell Significance Index: -3.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0054
    Cell Significance Index: -4.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0055
    Cell Significance Index: -4.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0060
    Cell Significance Index: -3.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0076
    Cell Significance Index: -3.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0086
    Cell Significance Index: -1.7300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0108
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0165
    Cell Significance Index: -3.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0166
    Cell Significance Index: -2.9900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0194
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0208
    Cell Significance Index: -3.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0220
    Cell Significance Index: -3.2000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0223
    Cell Significance Index: -0.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0228
    Cell Significance Index: -2.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0247
    Cell Significance Index: -1.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0265
    Cell Significance Index: -3.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0276
    Cell Significance Index: -3.2600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0300
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0312
    Cell Significance Index: -3.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0335
    Cell Significance Index: -3.4200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0343
    Cell Significance Index: -0.4300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0363
    Cell Significance Index: -0.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0385
    Cell Significance Index: -1.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0423
    Cell Significance Index: -3.1500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0446
    Cell Significance Index: -1.4100
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.0505
    Cell Significance Index: -0.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0549
    Cell Significance Index: -3.6900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0627
    Cell Significance Index: -0.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0647
    Cell Significance Index: -3.3700
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.0651
    Cell Significance Index: -0.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0676
    Cell Significance Index: -1.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0702
    Cell Significance Index: -1.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0726
    Cell Significance Index: -3.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0807
    Cell Significance Index: -4.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0811
    Cell Significance Index: -2.8400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0823
    Cell Significance Index: -1.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0823
    Cell Significance Index: -2.2400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0844
    Cell Significance Index: -3.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0882
    Cell Significance Index: -3.9000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0903
    Cell Significance Index: -1.1400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1023
    Cell Significance Index: -2.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1035
    Cell Significance Index: -3.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1037
    Cell Significance Index: -3.4000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1056
    Cell Significance Index: -1.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1058
    Cell Significance Index: -3.3700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1141
    Cell Significance Index: -3.3600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1142
    Cell Significance Index: -2.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1168
    Cell Significance Index: -2.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1170
    Cell Significance Index: -4.1100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1215
    Cell Significance Index: -1.5700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1259
    Cell Significance Index: -3.1400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1316
    Cell Significance Index: -3.7600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1324
    Cell Significance Index: -2.9000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1347
    Cell Significance Index: -1.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1367
    Cell Significance Index: -3.6500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1368
    Cell Significance Index: -1.7700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1375
    Cell Significance Index: -3.4300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1391
    Cell Significance Index: -2.3800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1397
    Cell Significance Index: -3.5600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1398
    Cell Significance Index: -3.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1451
    Cell Significance Index: -3.8800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1459
    Cell Significance Index: -2.5000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1569
    Cell Significance Index: -3.3900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1582
    Cell Significance Index: -3.2200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1582
    Cell Significance Index: -2.2200
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.1619
    Cell Significance Index: -1.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Subunit structure**: The CHRNA2 gene encodes for the alpha 2 subunit of the nicotinic acetylcholine receptor, which is a heterotetrameric receptor composed of two alpha subunits and two beta subunits. 2. **Receptor function**: The alpha 2 subunit is involved in regulating the function of both presynaptic and postsynaptic nicotinic acetylcholine receptors, which are highly calcium-permeable, facilitating rapid neurotransmitter release and synaptic transmission. 3. **Expression**: The CHRNA2 gene is significantly expressed in various cell types, including conventional dendritic cells, blood vessel endothelial cells, colon goblet cells, GABAergic amacrine cells, and kidney proximal convoluted tubule epithelial cells. 4. **Regulation**: The alpha 2 subunit is regulated by various factors, including acetylcholine, nicotine, and other heterocyclic compounds, which can modulate receptor activity and synaptic transmission. **Pathways and Functions** 1. **Acetylcholine-gated channel complex**: The alpha 2 subunit is a key component of the acetylcholine-gated channel complex, which is responsible for regulating neurotransmission and synaptic transmission. 2. **Acetylcholine-gated monoatomic cation-selective channel activity**: The alpha 2 subunit is involved in regulating the activity of monoatomic cation-selective channels, which facilitate rapid neurotransmitter release and synaptic transmission. 3. **Acetylcholine binding and downstream events**: The alpha 2 subunit is involved in regulating the binding of acetylcholine to the receptor and downstream signaling events, which can modulate receptor activity and synaptic transmission. 4. **Excitatory postsynaptic potential**: The alpha 2 subunit is involved in regulating the excitatory postsynaptic potential (EPSP) in neurons, which is crucial for learning and memory. 5. **Heterocyclic compound binding**: The alpha 2 subunit is involved in regulating the binding of heterocyclic compounds, such as nicotine, to the receptor, which can modulate receptor activity and synaptic transmission. **Clinical Significance** 1. **Nicotine addiction**: The CHRNA2 gene has been implicated in nicotine addiction, as mutations in the gene have been associated with increased susceptibility to nicotine dependence. 2. **Neurodegenerative diseases**: The alpha 2 subunit has been implicated in various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cancer**: The alpha 2 subunit has been implicated in various types of cancer, including lung cancer, breast cancer, and colon cancer. 4. **Neurodevelopmental disorders**: The alpha 2 subunit has been implicated in various neurodevelopmental disorders, including attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder. In conclusion, the CHRNA2 gene plays a critical role in regulating various physiological processes, including neurotransmission, synaptic transmission, and cellular responses to nicotine. Further research is needed to fully understand the mechanisms by which the alpha 2 subunit regulates receptor activity and synaptic transmission, and to explore the clinical significance of the CHRNA2 gene in various diseases.

Genular Protein ID: 3651698929

Symbol: ACHA2_HUMAN

Name: Neuronal acetylcholine receptor subunit alpha-2

UniProtKB Accession Codes:

Q15822 A8KAX3 B4DK19 J3KMY9 Q9HAQ3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEMBL 2 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 25 DrugCentral 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 4 MalaCards 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8906617

Title: Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.

PubMed ID: 8906617

DOI: 10.1007/bf02736842

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 27493220

Title: Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound alpha2 homopentamer.

PubMed ID: 27493220

DOI: 10.1073/pnas.1602619113

PubMed ID: 16826524

Title: Increased sensitivity of the neuronal nicotinic receptor alpha2 subunit causes familial epilepsy with nocturnal wandering and ictal fear.

PubMed ID: 16826524

DOI: 10.1086/506459

PubMed ID: 25847220

Title: Mutation of CHRNA2 in a family with benign familial infantile seizures: Potential role of nicotinic acetylcholine receptor in various phenotypes of epilepsy.

PubMed ID: 25847220

DOI: 10.1111/epi.12967

Sequence Information:

  • Length: 529
  • Mass: 59765
  • Checksum: E47062A1145E8BCC
  • Sequence:
    • MGPSCPVFLS FTKLSLWWLL LTPAGGEEAK RPPPRAPGDP LSSPSPTALP QGGSHTETED 
RLFKHLFRGY NRWARPVPNT SDVVIVRFGL SIAQLIDVDE KNQMMTTNVW LKQEWSDYKL 
RWNPTDFGNI TSLRVPSEMI WIPDIVLYNN ADGEFAVTHM TKAHLFSTGT VHWVPPAIYK 
SSCSIDVTFF PFDQQNCKMK FGSWTYDKAK IDLEQMEQTV DLKDYWESGE WAIVNATGTY 
NSKKYDCCAE IYPDVTYAFV IRRLPLFYTI NLIIPCLLIS CLTVLVFYLP SDCGEKITLC 
ISVLLSLTVF LLLITEIIPS TSLVIPLIGE YLLFTMIFVT LSIVITVFVL NVHHRSPSTH 
TMPHWVRGAL LGCVPRWLLM NRPPPPVELC HPLRLKLSPS YHWLESNVDA EEREVVVEEE 
DRWACAGHVA PSVGTLCSHG HLHSGASGPK AEALLQEGEL LLSPHMQKAL EGVHYIADHL 
RSEDADSSVK EDWKYVAMVI DRIFLWLFII VCFLGTIGLF LPPFLAGMI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.