Details for: CHRNA2
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 2.2
Marker Score: 1518 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.15
Marker Score: 2160.5 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.62
Marker Score: 1176.5 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.44
Marker Score: 2918 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.38
Marker Score: 877 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 862 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.24
Marker Score: 47103 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.21
Marker Score: 2501 - Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7693 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4819.5 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.1
Marker Score: 579 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.04
Marker Score: 1107 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.02
Marker Score: 423 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71831 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48056 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1
Marker Score: 514 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.99
Marker Score: 467 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.96
Marker Score: 439 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 378 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5353 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.92
Marker Score: 330 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2743 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.87
Marker Score: 668 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5290 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1266 - Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 711 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 401 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.73
Marker Score: 1386 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.71
Marker Score: 182 - Cell Name: interneuron (CL0000099)
Fold Change: 0.63
Marker Score: 290 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.62
Marker Score: 398 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.6
Marker Score: 480 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.59
Marker Score: 393 - Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.57
Marker Score: 1117 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.57
Marker Score: 151 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.56
Marker Score: 177 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.55
Marker Score: 1128 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.54
Marker Score: 316 - Cell Name: pericyte (CL0000669)
Fold Change: 0.53
Marker Score: 310 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.5
Marker Score: 480 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.44
Marker Score: 1036 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.44
Marker Score: 263.5 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.44
Marker Score: 6824 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.42
Marker Score: 396 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.41
Marker Score: 660.5 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.41
Marker Score: 240 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.39
Marker Score: 207 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 376 - Cell Name: stromal cell (CL0000499)
Fold Change: 0.37
Marker Score: 434 - Cell Name: B cell (CL0000236)
Fold Change: 0.34
Marker Score: 324 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.33
Marker Score: 396 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.3
Marker Score: 94 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.29
Marker Score: 294 - Cell Name: mast cell (CL0000097)
Fold Change: 0.29
Marker Score: 168 - Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.25
Marker Score: 75 - Cell Name: plasma cell (CL0000786)
Fold Change: 0.25
Marker Score: 278 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 66 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.23
Marker Score: 138 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.23
Marker Score: 228 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 76 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.22
Marker Score: 147 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.22
Marker Score: 2278 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.21
Marker Score: 100 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.2
Marker Score: 153 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.2
Marker Score: 1495 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.19
Marker Score: 231.5 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.18
Marker Score: 105 - Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.18
Marker Score: 261 - Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.18
Marker Score: 519 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.18
Marker Score: 74 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.17
Marker Score: 56 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 43 - Cell Name: macrophage (CL0000235)
Fold Change: 0.17
Marker Score: 186 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.17
Marker Score: 43 - Cell Name: erythrocyte (CL0000232)
Fold Change: 0.16
Marker Score: 86 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.14
Marker Score: 64 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.14
Marker Score: 44 - Cell Name: podocyte (CL0000653)
Fold Change: 0.14
Marker Score: 51 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.14
Marker Score: 188 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.13
Marker Score: 49 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.13
Marker Score: 67 - Cell Name: dendritic cell (CL0000451)
Fold Change: 0.12
Marker Score: 80 - Cell Name: thymocyte (CL0000893)
Fold Change: 0.12
Marker Score: 121.5 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.11
Marker Score: 96 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.1
Marker Score: 79 - Cell Name: neuron (CL0000540)
Fold Change: 0.1
Marker Score: 403.5 - Cell Name: platelet (CL0000233)
Fold Change: 0.09
Marker Score: 43 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.08
Marker Score: 346 - Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.08
Marker Score: 36 - Cell Name: fibroblast (CL0000057)
Fold Change: 0.08
Marker Score: 75 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.08
Marker Score: 65 - Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.07
Marker Score: 29 - Cell Name: Mueller cell (CL0000636)
Fold Change: 0.07
Marker Score: 103 - Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.07
Marker Score: 46 - Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.07
Marker Score: 20 - Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.07
Marker Score: 70 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.07
Marker Score: 201 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.07
Marker Score: 207
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Other Information
Genular Protein ID: 3651698929
Symbol: ACHA2_HUMAN
Name: Neuronal acetylcholine receptor subunit alpha-2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8906617
Title: Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.
PubMed ID: 8906617
DOI: 10.1007/bf02736842
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 27493220
Title: Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound alpha2 homopentamer.
PubMed ID: 27493220
PubMed ID: 16826524
Title: Increased sensitivity of the neuronal nicotinic receptor alpha2 subunit causes familial epilepsy with nocturnal wandering and ictal fear.
PubMed ID: 16826524
DOI: 10.1086/506459
PubMed ID: 25847220
Title: Mutation of CHRNA2 in a family with benign familial infantile seizures: Potential role of nicotinic acetylcholine receptor in various phenotypes of epilepsy.
PubMed ID: 25847220
DOI: 10.1111/epi.12967
Sequence Information:
- Length: 529
- Mass: 59765
- Checksum: E47062A1145E8BCC
- Sequence:
MGPSCPVFLS FTKLSLWWLL LTPAGGEEAK RPPPRAPGDP LSSPSPTALP QGGSHTETED RLFKHLFRGY NRWARPVPNT SDVVIVRFGL SIAQLIDVDE KNQMMTTNVW LKQEWSDYKL RWNPTDFGNI TSLRVPSEMI WIPDIVLYNN ADGEFAVTHM TKAHLFSTGT VHWVPPAIYK SSCSIDVTFF PFDQQNCKMK FGSWTYDKAK IDLEQMEQTV DLKDYWESGE WAIVNATGTY NSKKYDCCAE IYPDVTYAFV IRRLPLFYTI NLIIPCLLIS CLTVLVFYLP SDCGEKITLC ISVLLSLTVF LLLITEIIPS TSLVIPLIGE YLLFTMIFVT LSIVITVFVL NVHHRSPSTH TMPHWVRGAL LGCVPRWLLM NRPPPPVELC HPLRLKLSPS YHWLESNVDA EEREVVVEEE DRWACAGHVA PSVGTLCSHG HLHSGASGPK AEALLQEGEL LLSPHMQKAL EGVHYIADHL RSEDADSSVK EDWKYVAMVI DRIFLWLFII VCFLGTIGLF LPPFLAGMI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.