Details for: Abl1
Associated with
Other Information
Genular Protein ID: 77213058
Symbol: ABL1_MOUSE
Name: Tyrosine-protein kinase ABL1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3317402
Title: Nucleotide sequence of testis-derived c-abl cDNAs: implications for testis-specific transcription and abl oncogene activation.
PubMed ID: 3317402
PubMed ID: 16141072
Title: The transcriptional landscape of the mammalian genome.
PubMed ID: 16141072
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7665185
Title: Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation.
PubMed ID: 7665185
PubMed ID: 6319018
Title: The mouse c-abl locus: molecular cloning and characterization.
PubMed ID: 6319018
PubMed ID: 3283651
Title: Four murine c-abl mRNAs arise by usage of two transcriptional promoters and alternative splicing.
PubMed ID: 3283651
PubMed ID: 2183353
Title: Differential phosphorylation of c-Abl in cell cycle determined by cdc2 kinase and phosphatase activity.
PubMed ID: 2183353
PubMed ID: 2065352
Title: Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene.
PubMed ID: 2065352
PubMed ID: 2065353
Title: Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations.
PubMed ID: 2065353
PubMed ID: 1566087
Title: Cell cycle-regulated binding of c-Abl tyrosine kinase to DNA.
PubMed ID: 1566087
PubMed ID: 8194526
Title: c-Abl kinase regulates the protein binding activity of c-Crk.
PubMed ID: 8194526
PubMed ID: 7780740
Title: Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases.
PubMed ID: 7780740
PubMed ID: 9109492
Title: Functional interaction between DNA-PK and c-Abl in response to DNA damage.
PubMed ID: 9109492
DOI: 10.1038/386732a0
PubMed ID: 9636171
Title: Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase.
PubMed ID: 9636171
PubMed ID: 10896159
Title: Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth.
PubMed ID: 10896159
PubMed ID: 11163214
Title: Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation.
PubMed ID: 11163214
PubMed ID: 11114745
Title: Regulation of cell death by the Abl tyrosine kinase.
PubMed ID: 11114745
PubMed ID: 11279004
Title: Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes.
PubMed ID: 11279004
PubMed ID: 11350980
Title: Targeting of the c-Abl tyrosine kinase to mitochondria in the necrotic cell death response to oxidative stress.
PubMed ID: 11350980
PubMed ID: 11279131
Title: The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene.
PubMed ID: 11279131
PubMed ID: 12021275
Title: Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity.
PubMed ID: 12021275
PubMed ID: 12107171
Title: Interaction between UV-damaged DNA binding activity proteins and the c-Abl tyrosine kinase.
PubMed ID: 12107171
PubMed ID: 12775773
Title: Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases.
PubMed ID: 12775773
DOI: 10.1242/jcs.00622
PubMed ID: 12748290
Title: Two distinct phosphorylation pathways have additive effects on Abl family kinase activation.
PubMed ID: 12748290
PubMed ID: 14993293
Title: Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor.
PubMed ID: 14993293
PubMed ID: 15686624
Title: Role of c-Abl in the DNA damage stress response.
PubMed ID: 15686624
PubMed ID: 19903482
Title: c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration.
PubMed ID: 19903482
PubMed ID: 20841568
Title: ABL tyrosine kinases: evolution of function, regulation, and specificity.
PubMed ID: 20841568
PubMed ID: 21690296
Title: c-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain regulates CD4+ T-cell differentiation and allergic lung inflammation.
PubMed ID: 21690296
DOI: 10.1128/mcb.05383-11
PubMed ID: 22810897
Title: Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1.
PubMed ID: 22810897
PubMed ID: 7664083
Title: High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides.
PubMed ID: 7664083
DOI: 10.1038/nsb0894-546
PubMed ID: 10988075
Title: Structural mechanism for STI-571 inhibition of Abelson tyrosine kinase.
PubMed ID: 10988075
PubMed ID: 12654251
Title: Structural basis for the autoinhibition of c-Abl tyrosine kinase.
PubMed ID: 12654251
PubMed ID: 17718712
Title: Crystal structure of the T315I mutant of AbI kinase.
PubMed ID: 17718712
PubMed ID: 19878872
Title: AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance.
PubMed ID: 19878872
PubMed ID: 19895503
Title: Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template.
PubMed ID: 19895503
PubMed ID: 20072125
Title: Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.
PubMed ID: 20072125
DOI: 10.1038/nature08675
Sequence Information:
- Length: 1123
- Mass: 122673
- Checksum: BD48ADE8557AE95C
- Sequence:
MLEICLKLVG CKSKKGLSSS SSCYLEEALQ RPVASDFEPQ GLSEAARWNS KENLLAGPSE NDPNLFVALY DFVASGDNTL SITKGEKLRV LGYNHNGEWC EAQTKNGQGW VPSNYITPVN SLEKHSWYHG PVSRNAAEYL LSSGINGSFL VRESESSPGQ RSISLRYEGR VYHYRINTAS DGKLYVSSES RFNTLAELVH HHSTVADGLI TTLHYPAPKR NKPTIYGVSP NYDKWEMERT DITMKHKLGG GQYGEVYEGV WKKYSLTVAV KTLKEDTMEV EEFLKEAAVM KEIKHPNLVQ LLGVCTREPP FYIITEFMTY GNLLDYLREC NRQEVSAVVL LYMATQISSA MEYLEKKNFI HRDLAARNCL VGENHLVKVA DFGLSRLMTG DTYTAHAGAK FPIKWTAPES LAYNKFSIKS DVWAFGVLLW EIATYGMSPY PGIDLSQVYE LLEKDYRMER PEGCPEKVYE LMRACWQWNP SDRPSFAEIH QAFETMFQES SISDEVEKEL GKRGTRGGAG SMLQAPELPT KTRTCRRAAE QKDAPDTPEL LHTKGLGESD ALDSEPAVSP LLPRKERGPP DGSLNEDERL LPRDRKTNLF SALIKKKKKM APTPPKRSSS FREMDGQPDR RGASEDDSRE LCNGPPALTS DAAEPTKSPK ASNGAGVPNG AFREPGNSGF RSPHMWKKSS TLTGSRLAAA EEESGMSSSK RFLRSCSASC MPHGARDTEW RSVTLPRDLP SAGKQFDSST FGGHKSEKPA LPRKRTSESR SEQVAKSTAM PPPRLVKKNE EAAEEGFKDT ESSPGSSPPS LTPKLLRRQV TASPSSGLSH KEEATKGSAS GMGTPATAEP APPSNKVGLS KASSEEMRVR RHKHSSESPG RDKGRLAKLK PAPPPPPACT GKAGKPAQSP SQEAGEAGGP TKTKCTSLAM DAVNTDPTKA GPPGEGLRKP VPPSVPKPQS TAKPPGTPTS PVSTPSTAPA PSPLAGDQQP SSAAFIPLIS TRVSLRKTRQ PPERIASGTI TKGVVLDSTE ALCLAISRNS EQMASHSAVL EAGKNLYTFC VSYVDSIQQM RNKFAFREAI NKLESNLREL QICPATASSG PAATQDFSKL LSSVKEISDI VRR
Genular Protein ID: 915546778
Symbol: Q3SYK5_MOUSE
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 1142
- Mass: 124769
- Checksum: 7A9DB9E772EAF05F
- Sequence:
MGQQPGKVLG DQRRPSLPAL HFIKGAGKRD SSRHGGPHCN VFVEHEALQR PVASDFEPQG LSEAARWNSK ENLLAGPSEN DPNLFVALYD FVASGDNTLS ITKGEKLRVL GYNHNGEWCE AQTKNGQGWV PSNYITPVNS LEKHSWYHGP VSRNAAEYLL SSGINGSFLV RESESSPGQR SISLRYEGRV YHYRINTASD GKLYVSSESR FNTLAELVHH HSTVADGLIT TLHYPAPKRN KPTIYGVSPN YDKWEMERTD ITMKHKLGGG QYGEVYEGVW KKYSLTVAVK TLKEDTMEVE EFLKEAAVMK EIKHPNLVQL LGVCTREPPF YIITEFMTYG NLLDYLRECN RQEVSAVVLL YMATQISSAM EYLEKKNFIH RDLAARNCLV GENHLVKVAD FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNKFSIKSD VWAFGVLLWE IATYGMSPYP GIDLSQVYEL LEKDYRMERP EGCPEKVYEL MRACWQWNPS DRPSFAEIHQ AFETMFQESS ISDEVEKELG KRGTRGGAGS MLQAPELPTK TRTCRRAAEQ KDAPDTPELL HTKGLGESDA LDSEPAVSPL LPRKERGPPD GSLNEDERLL PRDRKTNLFS ALIKKKKKMA PTPPKRSSSF REMDGQPDRR GASEDDSREL CNGPPALTSD AAEPTKSPKA SNGAGVPNGA FREPGNSGFR SPHMWKKSST LTGSRLAAAE EESGMSSSKR FLRSCSASCM PHGARDTEWR SVTLPRDLPS AGKQFDSSTF GGHKSEKPAL PRKRTSESRS EQVAKSTAMP PPRLVKKNEE AAEEGFKDTE SSPGSSPPSL TPKLLRRQVT ASPSSGLSHK EEATKGSASG MGTPATAEPA PPSNKVGLSK ASSEEMRVRR HKHSSESPGR DKGRLAKLKP APPPPPACTG KAGKPAQSPS QEAGEAGGPT KTKCTSLAMD AVNTDPTKAG PPGEGLRKPV PPSVPKPQST AKPPGTPTSP VSTPSTAPAP SPLAGDQQPS SAAFIPLIST RVSLRKTRQP PERIASGTIT KGVVLDSTEA LCLAISRNSE QMASHSAVLE AGKNLYTFCV SYVDSIQQMR NKFAFREAIN KLESNLRELQ ICPATASSGP AATQDFSKLL SSVKEISDIV RR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.