Details for: CHRNA3

Gene ID: 1136

Symbol: CHRNA3

Ensembl ID: ENSG00000080644

Description: cholinergic receptor nicotinic alpha 3 subunit

Associated with

Other Information

Genular Protein ID: 1954824543

Symbol: ACHA3_HUMAN

Name: Neuronal acetylcholine receptor subunit alpha-3

UniProtKB Accession Codes:

P32297 Q15823 Q4KMN8 Q86U77 Q96RH3 Q99553 Q9BQ93 Q9BRR4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 6 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 17 DrugCentral 1 EMBL 20 EMDB 2 Ensembl 3 ExpressionAtlas 1 GO 31 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 4 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PIR 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2336208

Title: Molecular cloning of human neuronal nicotinic receptor alpha 3-subunit.

PubMed ID: 2336208

DOI: 10.1016/0304-3940(90)90287-j

PubMed ID: 1989896

Title: Expression of mRNAs in human thymus coding for the alpha 3 subunit of a neuronal acetylcholine receptor.

PubMed ID: 1989896

DOI: 10.1016/0014-4886(91)90004-v

PubMed ID: 8906617

Title: Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.

PubMed ID: 8906617

DOI: 10.1007/bf02736842

PubMed ID: 9009220

Title: Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32.

PubMed ID: 9009220

DOI: 10.1016/s0014-5793(96)01383-x

PubMed ID: 9921897

Title: The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3).

PubMed ID: 9921897

DOI: 10.1007/s004390050885

PubMed ID: 11450844

Title: Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4.

PubMed ID: 11450844

DOI: 10.1007/pl00010921

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15609996

Title: Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes.

PubMed ID: 15609996

DOI: 10.1021/bi048918g

PubMed ID: 16120769

Title: RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells.

PubMed ID: 16120769

DOI: 10.1124/mol.105.017459

PubMed ID: 18385720

Title: Genomics: when the smoke clears.

PubMed ID: 18385720

DOI: 10.1038/452537a

PubMed ID: 18385738

Title: A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.

PubMed ID: 18385738

DOI: 10.1038/nature06885

PubMed ID: 18385739

Title: A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.

PubMed ID: 18385739

DOI: 10.1038/nature06846

PubMed ID: 18385676

Title: Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.

PubMed ID: 18385676

DOI: 10.1038/ng.109

PubMed ID: 26265139

Title: UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP.

PubMed ID: 26265139

DOI: 10.1016/j.bcp.2015.08.084

PubMed ID: 27344019

Title: Functional interaction between Lypd6 and nicotinic acetylcholine receptors.

PubMed ID: 27344019

DOI: 10.1111/jnc.13718

PubMed ID: 31708116

Title: CAKUT and autonomic dysfunction caused by acetylcholine receptor mutations.

PubMed ID: 31708116

DOI: 10.1016/j.ajhg.2019.10.004

Sequence Information:

  • Length: 505
  • Mass: 57480
  • Checksum: 478D7712D59ACB2D
  • Sequence:
    • MGSGPLSLPL ALSPPRLLLL LLLSLLPVAR ASEAEHRLFE RLFEDYNEII RPVANVSDPV 
IIHFEVSMSQ LVKVDEVNQI METNLWLKQI WNDYKLKWNP SDYGGAEFMR VPAQKIWKPD 
IVLYNNAVGD FQVDDKTKAL LKYTGEVTWI PPAIFKSSCK IDVTYFPFDY QNCTMKFGSW 
SYDKAKIDLV LIGSSMNLKD YWESGEWAII KAPGYKHDIK YNCCEEIYPD ITYSLYIRRL 
PLFYTINLII PCLLISFLTV LVFYLPSDCG EKVTLCISVL LSLTVFLLVI TETIPSTSLV 
IPLIGEYLLF TMIFVTLSIV ITVFVLNVHY RTPTTHTMPS WVKTVFLNLL PRVMFMTRPT 
SNEGNAQKPR PLYGAELSNL NCFSRAESKG CKEGYPCQDG MCGYCHHRRI KISNFSANLT 
RSSSSESVDA VLSLSALSPE IKEAIQSVKY IAENMKAQNE AKEIQDDWKY VAMVIDRIFL 
WVFTLVCILG TAGLFLQPLM AREDA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.