Details for: CHRNA3

Gene ID: 1136

Symbol: CHRNA3

Ensembl ID: ENSG00000080644

Description: cholinergic receptor nicotinic alpha 3 subunit

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 5.74
    Marker Score: 11250
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.79
    Marker Score: 3128
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.73
    Marker Score: 3845
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.24
    Marker Score: 752
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.22
    Marker Score: 1395
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.12
    Marker Score: 702
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.1
    Marker Score: 2112.5
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.09
    Marker Score: 989
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1993
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.97
    Marker Score: 1172
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.97
    Marker Score: 1481
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.6
    Marker Score: 1100
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.52
    Marker Score: 735
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.52
    Marker Score: 2648
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.23
    Marker Score: 928
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.22
    Marker Score: 1689
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.17
    Marker Score: 290
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4813
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 502
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.98
    Marker Score: 665
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.97
    Marker Score: 1037
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.94
    Marker Score: 1053
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.94
    Marker Score: 881
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5335
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 622.5
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.81
    Marker Score: 1008
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.76
    Marker Score: 958
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.72
    Marker Score: 210
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.68
    Marker Score: 198
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.65
    Marker Score: 675.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 420
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 470
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 231
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.5
    Marker Score: 143
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.45
    Marker Score: 941.5
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.45
    Marker Score: 131
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.43
    Marker Score: 245
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.43
    Marker Score: 1225
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.41
    Marker Score: 1164
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.39
    Marker Score: 736
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.39
    Marker Score: 372
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.38
    Marker Score: 5943
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.38
    Marker Score: 541
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.37
    Marker Score: 366.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.37
    Marker Score: 12383
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.36
    Marker Score: 108
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.35
    Marker Score: 136
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.33
    Marker Score: 175
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.31
    Marker Score: 182
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.31
    Marker Score: 291
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.31
    Marker Score: 337
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.29
    Marker Score: 1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.27
    Marker Score: 330
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.26
    Marker Score: 538
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.26
    Marker Score: 1104
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.25
    Marker Score: 133
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.23
    Marker Score: 260
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.23
    Marker Score: 169
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.22
    Marker Score: 69
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.22
    Marker Score: 147
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.2
    Marker Score: 91
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.19
    Marker Score: 273
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.19
    Marker Score: 101
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.17
    Marker Score: 99
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.17
    Marker Score: 68
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.15
    Marker Score: 92
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.15
    Marker Score: 160
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.14
    Marker Score: 340
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.14
    Marker Score: 96
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.14
    Marker Score: 49
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.14
    Marker Score: 66
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.13
    Marker Score: 53
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.13
    Marker Score: 53
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.13
    Marker Score: 58
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.13
    Marker Score: 99
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.13
    Marker Score: 511

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Other Information

**Key characteristics:** * It belongs to the acetylcholine receptor family of ion channels. * It is a tetrameric protein with a molecular weight of approximately 140 kDa. * It is expressed in a wide range of cell types, including neurons, endothelial cells, and immune cells. * It is known to be a ligand-gated ion channel, meaning it opens upon binding of acetylcholine. **Pathways and functions:** * Acetylcholine binding to ACHA3 triggers the opening of the channel, allowing sodium ions to flow into the cell. * This depolarization of the cell can lead to downstream signaling pathways, including activation of downstream signaling proteins such as MAPK and PI3K/Akt. * It is involved in a variety of cellular processes, including muscle contraction, secretion, and inflammation. **Clinical significance:** * Mutations in the CHRNA3 gene have been linked to several neurological and psychiatric disorders, including schizophrenia, epilepsy, and hypertension. * ACHA3 is a potential therapeutic target for these disorders, as it is involved in the pathogenesis of these conditions. * Studies on animal models have shown that blocking ACHA3 signaling can ameliorate disease symptoms. **Additional notes:** * The CHRNA3 gene is also known as NMDA3A, as it is involved in the regulation of neuromuscular junctional potentials. * It is a highly calcium-permeable channel, indicating that it is likely to be involved in the transduction of calcium signals. * ACHA3 is a key component of the muscarinic cholinergic system, which is involved in various physiological and behavioral functions, including pupil dilation, bronchial constriction, and cardiac rate.

Genular Protein ID: 1954824543

Symbol: ACHA3_HUMAN

Name: Neuronal acetylcholine receptor subunit alpha-3

UniProtKB Accession Codes:

P32297 Q15823 Q4KMN8 Q86U77 Q96RH3 Q99553 Q9BQ93 Q9BRR4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 6 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 17 DrugCentral 1 EMBL 20 EMDB 2 Ensembl 3 ExpressionAtlas 1 GO 31 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 4 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PIR 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2336208

Title: Molecular cloning of human neuronal nicotinic receptor alpha 3-subunit.

PubMed ID: 2336208

DOI: 10.1016/0304-3940(90)90287-j

PubMed ID: 1989896

Title: Expression of mRNAs in human thymus coding for the alpha 3 subunit of a neuronal acetylcholine receptor.

PubMed ID: 1989896

DOI: 10.1016/0014-4886(91)90004-v

PubMed ID: 8906617

Title: Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.

PubMed ID: 8906617

DOI: 10.1007/bf02736842

PubMed ID: 9009220

Title: Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32.

PubMed ID: 9009220

DOI: 10.1016/s0014-5793(96)01383-x

PubMed ID: 9921897

Title: The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3).

PubMed ID: 9921897

DOI: 10.1007/s004390050885

PubMed ID: 11450844

Title: Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4.

PubMed ID: 11450844

DOI: 10.1007/pl00010921

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15609996

Title: Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes.

PubMed ID: 15609996

DOI: 10.1021/bi048918g

PubMed ID: 16120769

Title: RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells.

PubMed ID: 16120769

DOI: 10.1124/mol.105.017459

PubMed ID: 18385720

Title: Genomics: when the smoke clears.

PubMed ID: 18385720

DOI: 10.1038/452537a

PubMed ID: 18385738

Title: A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.

PubMed ID: 18385738

DOI: 10.1038/nature06885

PubMed ID: 18385739

Title: A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.

PubMed ID: 18385739

DOI: 10.1038/nature06846

PubMed ID: 18385676

Title: Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.

PubMed ID: 18385676

DOI: 10.1038/ng.109

PubMed ID: 26265139

Title: UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP.

PubMed ID: 26265139

DOI: 10.1016/j.bcp.2015.08.084

PubMed ID: 27344019

Title: Functional interaction between Lypd6 and nicotinic acetylcholine receptors.

PubMed ID: 27344019

DOI: 10.1111/jnc.13718

PubMed ID: 31708116

Title: CAKUT and autonomic dysfunction caused by acetylcholine receptor mutations.

PubMed ID: 31708116

DOI: 10.1016/j.ajhg.2019.10.004

Sequence Information:

  • Length: 505
  • Mass: 57480
  • Checksum: 478D7712D59ACB2D
  • Sequence:
    • MGSGPLSLPL ALSPPRLLLL LLLSLLPVAR ASEAEHRLFE RLFEDYNEII RPVANVSDPV 
IIHFEVSMSQ LVKVDEVNQI METNLWLKQI WNDYKLKWNP SDYGGAEFMR VPAQKIWKPD 
IVLYNNAVGD FQVDDKTKAL LKYTGEVTWI PPAIFKSSCK IDVTYFPFDY QNCTMKFGSW 
SYDKAKIDLV LIGSSMNLKD YWESGEWAII KAPGYKHDIK YNCCEEIYPD ITYSLYIRRL 
PLFYTINLII PCLLISFLTV LVFYLPSDCG EKVTLCISVL LSLTVFLLVI TETIPSTSLV 
IPLIGEYLLF TMIFVTLSIV ITVFVLNVHY RTPTTHTMPS WVKTVFLNLL PRVMFMTRPT 
SNEGNAQKPR PLYGAELSNL NCFSRAESKG CKEGYPCQDG MCGYCHHRRI KISNFSANLT 
RSSSSESVDA VLSLSALSPE IKEAIQSVKY IAENMKAQNE AKEIQDDWKY VAMVIDRIFL 
WVFTLVCILG TAGLFLQPLM AREDA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.