Details for: CHRNA4

Gene ID: 1137

Symbol: CHRNA4

Ensembl ID: ENSG00000101204

Description: cholinergic receptor nicotinic alpha 4 subunit

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 2.02
    Marker Score: 443
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.96
    Marker Score: 2,187
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.85
    Marker Score: 3,182
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.48
    Marker Score: 3,492
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.41
    Marker Score: 14,572
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.16
    Marker Score: 1,103
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,692
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.03
    Marker Score: 5,516
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,811
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,035
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.95
    Marker Score: 360
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,414
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,346
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.93
    Marker Score: 4,021
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,283
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.85
    Marker Score: 5,490
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 492
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.83
    Marker Score: 13,000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.77
    Marker Score: 1,188
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.76
    Marker Score: 5,833
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1,193
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.73
    Marker Score: 500
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7
    Marker Score: 2,692
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.65
    Marker Score: 9,652
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.64
    Marker Score: 371
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.63
    Marker Score: 504
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.61
    Marker Score: 2,466
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.59
    Marker Score: 1,121
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.55
    Marker Score: 20,817
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.53
    Marker Score: 571
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.52
    Marker Score: 4,940
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.52
    Marker Score: 4,425
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.45
    Marker Score: 27,643
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.45
    Marker Score: 450
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.44
    Marker Score: 418
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.44
    Marker Score: 4,133
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.4
    Marker Score: 192
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.39
    Marker Score: 377
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.39
    Marker Score: 797
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.39
    Marker Score: 131
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.38
    Marker Score: 143
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.38
    Marker Score: 455
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.36
    Marker Score: 165
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.36
    Marker Score: 728
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.35
    Marker Score: 208
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.32
    Marker Score: 1,354
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.32
    Marker Score: 82
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.31
    Marker Score: 1,104
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.31
    Marker Score: 1,283
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.3
    Marker Score: 258
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.29
    Marker Score: 455
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.28
    Marker Score: 166
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.27
    Marker Score: 336
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.27
    Marker Score: 5,366
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.27
    Marker Score: 554
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.27
    Marker Score: 93
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.24
    Marker Score: 76
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.23
    Marker Score: 208
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.23
    Marker Score: 152
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.23
    Marker Score: 74
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.22
    Marker Score: 67
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.21
    Marker Score: 112
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.2
    Marker Score: 247
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.2
    Marker Score: 196
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.19
    Marker Score: 72
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.19
    Marker Score: 41
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.18
    Marker Score: 121
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.18
    Marker Score: 121
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.18
    Marker Score: 56
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.18
    Marker Score: 41
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.17
    Marker Score: 50
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.17
    Marker Score: 495
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.17
    Marker Score: 69
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.17
    Marker Score: 5,693
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.17
    Marker Score: 397
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.16
    Marker Score: 763
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.16
    Marker Score: 68
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.16
    Marker Score: 43
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.16
    Marker Score: 325
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.16
    Marker Score: 89
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.15
    Marker Score: 77
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.15
    Marker Score: 72
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.15
    Marker Score: 39
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.15
    Marker Score: 125
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.15
    Marker Score: 266
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.14
    Marker Score: 34
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.14
    Marker Score: 41
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.13
    Marker Score: 37
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.13
    Marker Score: 118
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.13
    Marker Score: 143
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.12
    Marker Score: 40
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.12
    Marker Score: 207
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.12
    Marker Score: 39

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene structure:** The CHRNA4 gene is a single-copy gene located on chromosome 15q24.3. 2. **Protein structure:** The alpha-4 subunit of the CHRNA4 gene is a transmembrane protein that forms a channel complex with other subunits to create a functional nAChR. 3. **Expression:** The CHRNA4 gene is highly expressed in various cell types, including neurons, immune cells, and epithelial cells. 4. **Function:** The alpha-4 subunit of the CHRNA4 gene is essential for the proper functioning of nAChRs, which are involved in neurotransmission, synaptic plasticity, and immune responses. **Pathways and Functions:** 1. **Acetylcholine-gated channel complex:** The CHRNA4 gene is part of the acetylcholine-gated channel complex, which is a type of nAChR that responds to acetylcholine. 2. **Acetylcholine binding:** The alpha-4 subunit of the CHRNA4 gene is involved in the binding of acetylcholine to the nAChR, which triggers the opening of the channel complex. 3. **Signal transduction:** The activation of nAChRs by acetylcholine triggers a series of downstream signaling events, including the activation of G-proteins and the modulation of neurotransmitter release. 4. **Immune responses:** The CHRNA4 gene is also involved in immune responses, including the activation of B cells and the regulation of dopamine secretion. **Clinical Significance:** 1. **Nicotine addiction:** The CHRNA4 gene is a key target for nicotine addiction, as it plays a crucial role in the development of nicotine dependence. 2. **Neurodegenerative diseases:** The CHRNA4 gene has been implicated in various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where nAChRs are thought to play a key role in disease progression. 3. **Immune system disorders:** The CHRNA4 gene is also involved in immune system disorders, including autoimmune diseases and allergies, where nAChRs are thought to play a key role in immune regulation. 4. **Cancer:** The CHRNA4 gene has been implicated in cancer, where nAChRs are thought to play a key role in tumor growth and metastasis. In conclusion, the CHRNA4 gene is a critical component of nicotinic acetylcholine receptors, which are involved in various physiological processes, including neurotransmission, synaptic plasticity, and immune responses. The clinical significance of the CHRNA4 gene is vast, with implications for nicotine addiction, neurodegenerative diseases, immune system disorders, and cancer. Further research is needed to fully understand the role of the CHRNA4 gene in human health and disease.

Genular Protein ID: 3668001480

Symbol: ACHA4_HUMAN

Name: Neuronal acetylcholine receptor subunit alpha-4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7721089

Title: Cloning and transient expression of genes encoding the human alpha-4 and beta-2 neuronal nicotinic acetylcholine receptor (nAChR) subunits.

PubMed ID: 7721089

DOI: 10.1016/0378-1119(94)00914-e

PubMed ID: 8833159

Title: Exon-intron structure of the human neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4).

PubMed ID: 8833159

DOI: 10.1006/geno.1996.0119

PubMed ID: 8906617

Title: Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.

PubMed ID: 8906617

DOI: 10.1007/bf02736842

PubMed ID: 9009220

Title: Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32.

PubMed ID: 9009220

DOI: 10.1016/s0014-5793(96)01383-x

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16120769

Title: RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells.

PubMed ID: 16120769

DOI: 10.1124/mol.105.017459

PubMed ID: 27344019

Title: Functional interaction between Lypd6 and nicotinic acetylcholine receptors.

PubMed ID: 27344019

DOI: 10.1111/jnc.13718

PubMed ID: 22361591

Title: NMR structures of the transmembrane domains of the alpha4beta2 nAChR.

PubMed ID: 22361591

DOI: 10.1016/j.bbamem.2012.02.008

PubMed ID: 7550350

Title: A missense mutation in the neuronal nicotinic acetylcholine receptor alpha-4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy.

PubMed ID: 7550350

DOI: 10.1038/ng1095-201

PubMed ID: 10563623

Title: A novel mutation of CHRNA4 responsible for autosomal dominant nocturnal frontal lobe epilepsy.

PubMed ID: 10563623

DOI: 10.1212/wnl.53.8.1749

PubMed ID: 14623738

Title: A Korean kindred with autosomal dominant nocturnal frontal lobe epilepsy and mental retardation.

PubMed ID: 14623738

DOI: 10.1001/archneur.60.11.1625

Sequence Information:

  • Length: 627
  • Mass: 69957
  • Checksum: B3A0C0151E5A2AA8
  • Sequence:
  • MELGGPGAPR LLPPLLLLLG TGLLRASSHV ETRAHAEERL LKKLFSGYNK WSRPVANISD 
    VVLVRFGLSI AQLIDVDEKN QMMTTNVWVK QEWHDYKLRW DPADYENVTS IRIPSELIWR 
    PDIVLYNNAD GDFAVTHLTK AHLFHDGRVQ WTPPAIYKSS CSIDVTFFPF DQQNCTMKFG 
    SWTYDKAKID LVNMHSRVDQ LDFWESGEWV IVDAVGTYNT RKYECCAEIY PDITYAFVIR 
    RLPLFYTINL IIPCLLISCL TVLVFYLPSE CGEKITLCIS VLLSLTVFLL LITEIIPSTS 
    LVIPLIGEYL LFTMIFVTLS IVITVFVLNV HHRSPRTHTM PTWVRRVFLD IVPRLLLMKR 
    PSVVKDNCRR LIESMHKMAS APRFWPEPEG EPPATSGTQS LHPPSPSFCV PLDVPAEPGP 
    SCKSPSDQLP PQQPLEAEKA SPHPSPGPCR PPHGTQAPGL AKARSLSVQH MSSPGEAVEG 
    GVRCRSRSIQ YCVPRDDAAP EADGQAAGAL ASRNTHSAEL PPPDQPSPCK CTCKKEPSSV 
    SPSATVKTRS TKAPPPHLPL SPALTRAVEG VQYIADHLKA EDTDFSVKED WKYVAMVIDR 
    IFLWMFIIVC LLGTVGLFLP PWLAGMI

Genular Protein ID: 209298424

Symbol: Q59FV0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 533
  • Mass: 58869
  • Checksum: 1939A02DBF569C5A
  • Sequence:
  • APEPGEAPRL DRAHPGCACA ELSLLWLCCC TFTSADGDFA VTHLTKAHLF HDGRVQWTPP 
    AIYKSSCSID VTFFPFDQQN CTMKFGSWTY DKAKIDLVNM HSRVDQLDFW ESGEWVIVDA 
    VGTYNTRKYE CCAEIYPDIT YAFVIRRLPL FYTINLIIPC LLISCLTVLV FYLPSECGEK 
    ITLCISVLLS LTVFLLLITE IIPSTSLVIP LIGEYLLFTM IFVTLSIVIT VFVLNVHHRS 
    PRTHTMPTWV RRVFLDIVPR LLLMKRPSVV KDNCRRLIES MHKMASAPRF WPEPEGEPPA 
    TSGTQSLHPP SPSFCVPLDV PAEPGPSCKS PSDQLPPQQP LEAEKASPHP SPGPCRPPHG 
    TQAPGLAKAR SLSVQHMSSP GEAVEGGVRC RSRSIQYCVP RDDAAPEADG QAAGALASRN 
    THSAELPPPD QPSPCKCTCK KEPSSVSPSA TVKTRSTKAP PPHLPLSPAL TRAVEGVQYI 
    ADHLKAEDTD FSVKEDWKYV AMVIDRIFLW MFIIVCLLGT VGLFLPPWLA GMI

Genular Protein ID: 1212308056

Symbol: B4DK78_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 216
  • Mass: 22757
  • Checksum: 388663C659882EED
  • Sequence:
  • MHMQEGALFG VPECHGQDPQ HQSTAPAPAP VAGPDPGGGG RPVHCRPPEG RRHRLLGEGG 
    LEVRGHGHRP HLPLDVHHRL PAGDGGPLPA ALAGWHDLGR DREPAWPGAA VHGASIHAAG 
    LGPGWLLPGL CGATRLPNFP SCSVSAVRRP WTGTRPLGRP SVELLPVGLW PQEAVAWSRG 
    GGRRLLPAGL GLSPVQESPE LPCRWNSLLP VSQQIW

Genular Protein ID: 4102445759

Symbol: Q4VAQ3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 451
  • Mass: 49872
  • Checksum: 43355984FB7B5383
  • Sequence:
  • MKFGSWTYDK AKIDLVNMHS RVDQLDFWES GEWVIVDAVG TYNTRKYECC AEIYPDITYA 
    FVIRRLPLFY TINLIIPCLL ISCLTVLVFY LPSECGEKIT LCISVLLSLT VFLLLITEII 
    PSTSLVIPLI GEYLLFTMIF VTLSIVITVF VLNVHHRSPR THTMPTWVRR VFLDIVPRLL 
    LMKRPSVVKD NCRRLIESMH KMASAPRFWP EPEGEPPATS GTQSLHPPSP SFCVPLDVPA 
    EPGPSCKSPS DQLPPQQPLE AEKASPHPSP GPCRPPHGTQ APGLAKARSL SVQHMSSPGE 
    AVEGGVRCRS RSIQYCVPRD DAAPEADGQA AGALASRNTH SAELPPPDQP SPCKCTCKKE 
    PSSVSPSATV KTRSTKAPPP HLPLSPALTR AVEGVQYIAD HLKAEDTDFS VKEDWKYVAM 
    VIDRIFLWMF IIVCLLGTVG LFLPPWLAGM I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.