Details for: CHRNA4
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 2.02
Marker Score: 443 - Cell Name: plasma cell (CL0000786)
Fold Change: 1.96
Marker Score: 2,187 - Cell Name: T cell (CL0000084)
Fold Change: 1.85
Marker Score: 3,182 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.48
Marker Score: 3,492 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.41
Marker Score: 14,572 - Cell Name: B cell (CL0000236)
Fold Change: 1.16
Marker Score: 1,103 - Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7,692 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.03
Marker Score: 5,516 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,811 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,035 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,406 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.95
Marker Score: 360 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,414 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,346 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.93
Marker Score: 4,021 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,741 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,283 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.85
Marker Score: 5,490 - Cell Name: mast cell (CL0000097)
Fold Change: 0.85
Marker Score: 492 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.83
Marker Score: 13,000 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,266 - Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 711 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 400 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.77
Marker Score: 1,188 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.76
Marker Score: 5,833 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.74
Marker Score: 1,193 - Cell Name: hepatocyte (CL0000182)
Fold Change: 0.73
Marker Score: 500 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.7
Marker Score: 2,692 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.65
Marker Score: 9,652 - Cell Name: pericyte (CL0000669)
Fold Change: 0.64
Marker Score: 371 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.63
Marker Score: 504 - Cell Name: neuron (CL0000540)
Fold Change: 0.61
Marker Score: 2,466 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.59
Marker Score: 1,121 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.55
Marker Score: 20,817 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.53
Marker Score: 571 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.52
Marker Score: 4,940 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.52
Marker Score: 4,425 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.45
Marker Score: 27,643 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.45
Marker Score: 450 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.44
Marker Score: 418 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.44
Marker Score: 4,133 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.4
Marker Score: 192 - Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.39
Marker Score: 377 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.39
Marker Score: 797 - Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.39
Marker Score: 131 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.38
Marker Score: 143 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.38
Marker Score: 455 - Cell Name: interneuron (CL0000099)
Fold Change: 0.36
Marker Score: 165 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.36
Marker Score: 728 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.35
Marker Score: 208 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.32
Marker Score: 1,354 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.32
Marker Score: 82 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.31
Marker Score: 1,104 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.31
Marker Score: 1,283 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.3
Marker Score: 258 - Cell Name: epithelial cell (CL0000066)
Fold Change: 0.29
Marker Score: 455 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.28
Marker Score: 166 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.27
Marker Score: 336 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.27
Marker Score: 5,366 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.27
Marker Score: 554 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.27
Marker Score: 93 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.24
Marker Score: 76 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.23
Marker Score: 208 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.23
Marker Score: 152 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.23
Marker Score: 74 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.22
Marker Score: 67 - Cell Name: enteric neuron (CL0007011)
Fold Change: 0.21
Marker Score: 112 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.2
Marker Score: 247 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.2
Marker Score: 196 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.19
Marker Score: 72 - Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.19
Marker Score: 41 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.18
Marker Score: 121 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.18
Marker Score: 121 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.18
Marker Score: 56 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.18
Marker Score: 41 - Cell Name: male germ cell (CL0000015)
Fold Change: 0.17
Marker Score: 50 - Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.17
Marker Score: 495 - Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.17
Marker Score: 69 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.17
Marker Score: 5,693 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.17
Marker Score: 397 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.16
Marker Score: 763 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.16
Marker Score: 68 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.16
Marker Score: 43 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.16
Marker Score: 325 - Cell Name: leukocyte (CL0000738)
Fold Change: 0.16
Marker Score: 89 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.15
Marker Score: 77 - Cell Name: neural cell (CL0002319)
Fold Change: 0.15
Marker Score: 72 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.15
Marker Score: 39 - Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.15
Marker Score: 125 - Cell Name: microglial cell (CL0000129)
Fold Change: 0.15
Marker Score: 266 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.14
Marker Score: 34 - Cell Name: lung neuroendocrine cell (CL1000223)
Fold Change: 0.14
Marker Score: 41 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.14
Marker Score: 36 - Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.13
Marker Score: 38 - Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 0.13
Marker Score: 37 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.13
Marker Score: 118 - Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.13
Marker Score: 143 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.12
Marker Score: 40 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.12
Marker Score: 207 - Cell Name: epithelial cell of thymus (CL0002293)
Fold Change: 0.12
Marker Score: 39
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3668001480
Symbol: ACHA4_HUMAN
Name: Neuronal acetylcholine receptor subunit alpha-4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7721089
Title: Cloning and transient expression of genes encoding the human alpha-4 and beta-2 neuronal nicotinic acetylcholine receptor (nAChR) subunits.
PubMed ID: 7721089
PubMed ID: 8833159
Title: Exon-intron structure of the human neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4).
PubMed ID: 8833159
PubMed ID: 8906617
Title: Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.
PubMed ID: 8906617
DOI: 10.1007/bf02736842
PubMed ID: 9009220
Title: Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32.
PubMed ID: 9009220
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16120769
Title: RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells.
PubMed ID: 16120769
PubMed ID: 27344019
Title: Functional interaction between Lypd6 and nicotinic acetylcholine receptors.
PubMed ID: 27344019
DOI: 10.1111/jnc.13718
PubMed ID: 22361591
Title: NMR structures of the transmembrane domains of the alpha4beta2 nAChR.
PubMed ID: 22361591
PubMed ID: 7550350
Title: A missense mutation in the neuronal nicotinic acetylcholine receptor alpha-4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy.
PubMed ID: 7550350
DOI: 10.1038/ng1095-201
PubMed ID: 10563623
Title: A novel mutation of CHRNA4 responsible for autosomal dominant nocturnal frontal lobe epilepsy.
PubMed ID: 10563623
PubMed ID: 14623738
Title: A Korean kindred with autosomal dominant nocturnal frontal lobe epilepsy and mental retardation.
PubMed ID: 14623738
Sequence Information:
- Length: 627
- Mass: 69957
- Checksum: B3A0C0151E5A2AA8
- Sequence:
MELGGPGAPR LLPPLLLLLG TGLLRASSHV ETRAHAEERL LKKLFSGYNK WSRPVANISD VVLVRFGLSI AQLIDVDEKN QMMTTNVWVK QEWHDYKLRW DPADYENVTS IRIPSELIWR PDIVLYNNAD GDFAVTHLTK AHLFHDGRVQ WTPPAIYKSS CSIDVTFFPF DQQNCTMKFG SWTYDKAKID LVNMHSRVDQ LDFWESGEWV IVDAVGTYNT RKYECCAEIY PDITYAFVIR RLPLFYTINL IIPCLLISCL TVLVFYLPSE CGEKITLCIS VLLSLTVFLL LITEIIPSTS LVIPLIGEYL LFTMIFVTLS IVITVFVLNV HHRSPRTHTM PTWVRRVFLD IVPRLLLMKR PSVVKDNCRR LIESMHKMAS APRFWPEPEG EPPATSGTQS LHPPSPSFCV PLDVPAEPGP SCKSPSDQLP PQQPLEAEKA SPHPSPGPCR PPHGTQAPGL AKARSLSVQH MSSPGEAVEG GVRCRSRSIQ YCVPRDDAAP EADGQAAGAL ASRNTHSAEL PPPDQPSPCK CTCKKEPSSV SPSATVKTRS TKAPPPHLPL SPALTRAVEG VQYIADHLKA EDTDFSVKED WKYVAMVIDR IFLWMFIIVC LLGTVGLFLP PWLAGMI
Genular Protein ID: 209298424
Symbol: Q59FV0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 533
- Mass: 58869
- Checksum: 1939A02DBF569C5A
- Sequence:
APEPGEAPRL DRAHPGCACA ELSLLWLCCC TFTSADGDFA VTHLTKAHLF HDGRVQWTPP AIYKSSCSID VTFFPFDQQN CTMKFGSWTY DKAKIDLVNM HSRVDQLDFW ESGEWVIVDA VGTYNTRKYE CCAEIYPDIT YAFVIRRLPL FYTINLIIPC LLISCLTVLV FYLPSECGEK ITLCISVLLS LTVFLLLITE IIPSTSLVIP LIGEYLLFTM IFVTLSIVIT VFVLNVHHRS PRTHTMPTWV RRVFLDIVPR LLLMKRPSVV KDNCRRLIES MHKMASAPRF WPEPEGEPPA TSGTQSLHPP SPSFCVPLDV PAEPGPSCKS PSDQLPPQQP LEAEKASPHP SPGPCRPPHG TQAPGLAKAR SLSVQHMSSP GEAVEGGVRC RSRSIQYCVP RDDAAPEADG QAAGALASRN THSAELPPPD QPSPCKCTCK KEPSSVSPSA TVKTRSTKAP PPHLPLSPAL TRAVEGVQYI ADHLKAEDTD FSVKEDWKYV AMVIDRIFLW MFIIVCLLGT VGLFLPPWLA GMI
Genular Protein ID: 1212308056
Symbol: B4DK78_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 216
- Mass: 22757
- Checksum: 388663C659882EED
- Sequence:
MHMQEGALFG VPECHGQDPQ HQSTAPAPAP VAGPDPGGGG RPVHCRPPEG RRHRLLGEGG LEVRGHGHRP HLPLDVHHRL PAGDGGPLPA ALAGWHDLGR DREPAWPGAA VHGASIHAAG LGPGWLLPGL CGATRLPNFP SCSVSAVRRP WTGTRPLGRP SVELLPVGLW PQEAVAWSRG GGRRLLPAGL GLSPVQESPE LPCRWNSLLP VSQQIW
Genular Protein ID: 4102445759
Symbol: Q4VAQ3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 451
- Mass: 49872
- Checksum: 43355984FB7B5383
- Sequence:
MKFGSWTYDK AKIDLVNMHS RVDQLDFWES GEWVIVDAVG TYNTRKYECC AEIYPDITYA FVIRRLPLFY TINLIIPCLL ISCLTVLVFY LPSECGEKIT LCISVLLSLT VFLLLITEII PSTSLVIPLI GEYLLFTMIF VTLSIVITVF VLNVHHRSPR THTMPTWVRR VFLDIVPRLL LMKRPSVVKD NCRRLIESMH KMASAPRFWP EPEGEPPATS GTQSLHPPSP SFCVPLDVPA EPGPSCKSPS DQLPPQQPLE AEKASPHPSP GPCRPPHGTQ APGLAKARSL SVQHMSSPGE AVEGGVRCRS RSIQYCVPRD DAAPEADGQA AGALASRNTH SAELPPPDQP SPCKCTCKKE PSSVSPSATV KTRSTKAPPP HLPLSPALTR AVEGVQYIAD HLKAEDTDFS VKEDWKYVAM VIDRIFLWMF IIVCLLGTVG LFLPPWLAGM I
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.