Details for: CHRNA5

Gene ID: 1138

Symbol: CHRNA5

Ensembl ID: ENSG00000169684

Description: cholinergic receptor nicotinic alpha 5 subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 39.0883
    Cell Significance Index: -6.0800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.2754
    Cell Significance Index: -5.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 13.1198
    Cell Significance Index: -5.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.9556
    Cell Significance Index: -6.1100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.1508
    Cell Significance Index: 8.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1456
    Cell Significance Index: 113.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7874
    Cell Significance Index: 711.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7731
    Cell Significance Index: 46.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7676
    Cell Significance Index: 83.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6432
    Cell Significance Index: 104.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.4798
    Cell Significance Index: -1.0500
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.4457
    Cell Significance Index: 4.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3933
    Cell Significance Index: 20.4300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.3924
    Cell Significance Index: 4.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3906
    Cell Significance Index: 27.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3774
    Cell Significance Index: 21.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3748
    Cell Significance Index: 13.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3544
    Cell Significance Index: 8.8600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.3200
    Cell Significance Index: 8.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3145
    Cell Significance Index: 9.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3124
    Cell Significance Index: 6.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2473
    Cell Significance Index: 5.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2227
    Cell Significance Index: 42.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2146
    Cell Significance Index: 4.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1809
    Cell Significance Index: 3.9200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1640
    Cell Significance Index: 4.0900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1585
    Cell Significance Index: 2.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1406
    Cell Significance Index: 27.9000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.1377
    Cell Significance Index: 1.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1372
    Cell Significance Index: 6.2200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1305
    Cell Significance Index: 1.7800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1297
    Cell Significance Index: 1.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1108
    Cell Significance Index: 2.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1084
    Cell Significance Index: 3.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0801
    Cell Significance Index: 14.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0684
    Cell Significance Index: 37.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0607
    Cell Significance Index: 1.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0448
    Cell Significance Index: 8.9900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0402
    Cell Significance Index: 0.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0357
    Cell Significance Index: 1.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0350
    Cell Significance Index: 15.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0310
    Cell Significance Index: 3.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0243
    Cell Significance Index: 8.7100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0152
    Cell Significance Index: 0.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0130
    Cell Significance Index: 0.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0105
    Cell Significance Index: 0.2700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.0066
    Cell Significance Index: 0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0043
    Cell Significance Index: 8.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0028
    Cell Significance Index: 1.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0013
    Cell Significance Index: 0.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0013
    Cell Significance Index: 0.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0023
    Cell Significance Index: -4.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0026
    Cell Significance Index: -4.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0037
    Cell Significance Index: -0.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0044
    Cell Significance Index: -6.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0051
    Cell Significance Index: -1.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0064
    Cell Significance Index: -4.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0067
    Cell Significance Index: -3.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0071
    Cell Significance Index: -0.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0074
    Cell Significance Index: -5.5700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0089
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0098
    Cell Significance Index: -6.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0105
    Cell Significance Index: -1.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0136
    Cell Significance Index: -0.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0148
    Cell Significance Index: -1.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0149
    Cell Significance Index: -2.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0157
    Cell Significance Index: -0.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0218
    Cell Significance Index: -2.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0232
    Cell Significance Index: -0.6200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0238
    Cell Significance Index: -0.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0247
    Cell Significance Index: -1.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0248
    Cell Significance Index: -3.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0320
    Cell Significance Index: -6.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0322
    Cell Significance Index: -3.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0325
    Cell Significance Index: -4.2000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0354
    Cell Significance Index: -0.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0408
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0499
    Cell Significance Index: -5.7200
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: -0.0506
    Cell Significance Index: -0.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0508
    Cell Significance Index: -0.8500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0538
    Cell Significance Index: -0.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0555
    Cell Significance Index: -5.7800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0557
    Cell Significance Index: -0.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0626
    Cell Significance Index: -2.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0635
    Cell Significance Index: -4.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0655
    Cell Significance Index: -1.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0708
    Cell Significance Index: -5.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0728
    Cell Significance Index: -3.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0740
    Cell Significance Index: -5.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0854
    Cell Significance Index: -5.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0970
    Cell Significance Index: -2.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0987
    Cell Significance Index: -5.1800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1035
    Cell Significance Index: -1.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1051
    Cell Significance Index: -4.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1299
    Cell Significance Index: -4.9200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1311
    Cell Significance Index: -1.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1317
    Cell Significance Index: -3.7800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1343
    Cell Significance Index: -3.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1448
    Cell Significance Index: -4.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit structure:** The CHRNA5 gene encodes for the alpha 5 subunit of the nAChR, which is one of the five subunits that form the functional receptor complex. The alpha 5 subunit is unique in its ability to bind to the endogenous ligand acetylcholine, as well as to nicotine, the primary psychoactive compound in tobacco. 2. **Ion channel activity:** The CHRNA5 receptor is a ligand-gated ion channel that allows the flow of cations, primarily calcium and sodium, into the neuron upon activation by acetylcholine or nicotine. 3. **Anatomical distribution:** The CHRNA5 gene is highly expressed in the cerebral cortex, hippocampus, and other regions of the brain, where it is involved in regulating cognitive function, learning, and memory. 4. **Cell-type specificity:** The CHRNA5 receptor is predominantly expressed in GABAergic interneurons, radial glial cells, and epithelial cells, suggesting a role in modulating synaptic transmission and cellular communication. **Pathways and Functions:** 1. **Acetylcholine-gated channel complex:** The CHRNA5 receptor is part of the acetylcholine-gated channel complex, which regulates the release of neurotransmitters, including acetylcholine, and modulates synaptic transmission. 2. **Nicotine signaling pathway:** The CHRNA5 receptor is also involved in the nicotine signaling pathway, which is critical for the development of nicotine addiction and the regulation of cognitive function. 3. **Synaptic transmission:** The CHRNA5 receptor plays a key role in regulating synaptic transmission, particularly in the hippocampus and cerebral cortex, where it modulates the release of neurotransmitters and the strength of synaptic connections. 4. **Neuroprotection and neurodegeneration:** The CHRNA5 receptor has been implicated in neuroprotection and neurodegeneration, with evidence suggesting that it may play a role in the pathogenesis of Alzheimer's disease and other neurodegenerative disorders. **Clinical Significance:** 1. **Nicotine addiction:** The CHRNA5 receptor is a primary target for nicotine addiction, with evidence suggesting that genetic variations in the CHRNA5 gene may contribute to the development of nicotine dependence. 2. **Cognitive function:** The CHRNA5 receptor is involved in regulating cognitive function, particularly in the hippocampus and cerebral cortex, where it modulates the release of neurotransmitters and the strength of synaptic connections. 3. **Neurodegenerative disorders:** The CHRNA5 receptor has been implicated in the pathogenesis of Alzheimer's disease and other neurodegenerative disorders, where it may play a role in modulating synaptic transmission and regulating neurotransmitter release. 4. **Therapeutic applications:** The CHRNA5 receptor has been targeted as a potential therapeutic target for the treatment of nicotine addiction and other neurological disorders, with several small-molecule ligands and vaccines currently in development. In conclusion, the CHRNA5 gene encodes for the alpha 5 subunit of the nicotinic acetylcholine receptor, a crucial component of the cholinergic system that plays a pivotal role in various physiological and pathological processes. Further research is needed to fully elucidate the complexities of the CHRNA5 receptor and its role in regulating cognitive function, addiction, and neurological disorders.

Genular Protein ID: 2245861410

Symbol: ACHA5_HUMAN

Name: Neuronal acetylcholine receptor subunit alpha-5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1542648

Title: Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines.

PubMed ID: 1542648

DOI: 10.1073/pnas.89.5.1572

PubMed ID: 8906617

Title: Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.

PubMed ID: 8906617

DOI: 10.1007/bf02736842

PubMed ID: 9009220

Title: Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32.

PubMed ID: 9009220

DOI: 10.1016/s0014-5793(96)01383-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18385720

Title: Genomics: when the smoke clears.

PubMed ID: 18385720

DOI: 10.1038/452537a

PubMed ID: 18385738

Title: A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.

PubMed ID: 18385738

DOI: 10.1038/nature06885

PubMed ID: 18385676

Title: Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.

PubMed ID: 18385676

DOI: 10.1038/ng.109

PubMed ID: 27344019

Title: Functional interaction between Lypd6 and nicotinic acetylcholine receptors.

PubMed ID: 27344019

DOI: 10.1111/jnc.13718

Sequence Information:

  • Length: 468
  • Mass: 53054
  • Checksum: 7FE91A2E362289C0
  • Sequence:
  • MAARGSGPRA LRLLLLVQLV AGRCGLAGAA GGAQRGLSEP SSIAKHEDSL LKDLFQDYER 
    WVRPVEHLND KIKIKFGLAI SQLVDVDEKN QLMTTNVWLK QEWIDVKLRW NPDDYGGIKV 
    IRVPSDSVWT PDIVLFDNAD GRFEGTSTKT VIRYNGTVTW TPPANYKSSC TIDVTFFPFD 
    LQNCSMKFGS WTYDGSQVDI ILEDQDVDKR DFFDNGEWEI VSATGSKGNR TDSCCWYPYV 
    TYSFVIKRLP LFYTLFLIIP CIGLSFLTVL VFYLPSNEGE KICLCTSVLV SLTVFLLVIE 
    EIIPSSSKVI PLIGEYLVFT MIFVTLSIMV TVFAINIHHR SSSTHNAMAP LVRKIFLHTL 
    PKLLCMRSHV DRYFTQKEET ESGSGPKSSR NTLEAALDSI RYITRHIMKE NDVREVVEDW 
    KFIAQVLDRM FLWTFLFVSI VGSLGLFVPV IYKWANILIP VHIGNANK

Genular Protein ID: 3198071467

Symbol: H0YM98_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

Sequence Information:

  • Length: 160
  • Mass: 17810
  • Checksum: FA1F0090AFCFAA38
  • Sequence:
  • MAARGSGPRA LRLLLLVQLV AGRCGLAGAA GGAQRGLSEP SSIAKHEDSL LKDLFQDYER 
    WVRPVEHLND KIKIKFGLAI SQLVDVDEKN QLMTTNVWLK QEWIDVKLRW NPDDYGGIKV 
    IRVPSDSVWT PDIVLFDNAD GRFEGTSTKT VIRLLKIGNS

Genular Protein ID: 2229739451

Symbol: Q6EWN4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15716100

Title: In vivo RNA-RNA duplexes from human alpha3 and alpha5 nicotinic receptor subunit mRNAs.

PubMed ID: 15716100

DOI: 10.1016/j.gene.2004.12.005

Sequence Information:

  • Length: 57
  • Mass: 6619
  • Checksum: 36E995660FD2C213
  • Sequence:
  • DVREVVEDWK FIAQVLDRMF LWTFLFVSIV GSLGLFVPVI YKWANILIPV HIGNANK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.