Details for: CHRNA5

Gene ID: 1138

Symbol: CHRNA5

Ensembl ID: ENSG00000169684

Description: cholinergic receptor nicotinic alpha 5 subunit

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5256
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 697
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.73
    Marker Score: 480
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.7
    Marker Score: 1229
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.7
    Marker Score: 536.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2925.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.69
    Marker Score: 200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.69
    Marker Score: 277
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.66
    Marker Score: 1365.5
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.63
    Marker Score: 227
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 341.5
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.47
    Marker Score: 296
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.45
    Marker Score: 213
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.4
    Marker Score: 138
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.4
    Marker Score: 497
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.39
    Marker Score: 6029
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.38
    Marker Score: 132
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.36
    Marker Score: 115
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.35
    Marker Score: 397
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.35
    Marker Score: 332
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.35
    Marker Score: 208
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.35
    Marker Score: 155
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.34
    Marker Score: 801
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.33
    Marker Score: 4364
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.33
    Marker Score: 558
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.33
    Marker Score: 394
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.32
    Marker Score: 653.5
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.31
    Marker Score: 119
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.31
    Marker Score: 327
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.3
    Marker Score: 1248
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.28
    Marker Score: 538
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.28
    Marker Score: 1148
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.28
    Marker Score: 87
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.27
    Marker Score: 260
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.26
    Marker Score: 107
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.24
    Marker Score: 344
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.23
    Marker Score: 569
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.21
    Marker Score: 99
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.2
    Marker Score: 132
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.2
    Marker Score: 116
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.2
    Marker Score: 104
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.19
    Marker Score: 719
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.19
    Marker Score: 190
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.19
    Marker Score: 64
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.19
    Marker Score: 65
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.18
    Marker Score: 125
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.18
    Marker Score: 418
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.18
    Marker Score: 72
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.17
    Marker Score: 82
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.17
    Marker Score: 46
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.17
    Marker Score: 101
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.17
    Marker Score: 92
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.17
    Marker Score: 207
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.17
    Marker Score: 93
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.16
    Marker Score: 43.5
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.16
    Marker Score: 389
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.16
    Marker Score: 780
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.16
    Marker Score: 245
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.16
    Marker Score: 146
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.15
    Marker Score: 191
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.15
    Marker Score: 38
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.15
    Marker Score: 87
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.15
    Marker Score: 59
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.15
    Marker Score: 234
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.14
    Marker Score: 127
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.14
    Marker Score: 1446
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.14
    Marker Score: 4780
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.14
    Marker Score: 119
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.14
    Marker Score: 201
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.13
    Marker Score: 117
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.13
    Marker Score: 42
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.13
    Marker Score: 32
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.13
    Marker Score: 251.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.13
    Marker Score: 143
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.13
    Marker Score: 113
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.13
    Marker Score: 37
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.13
    Marker Score: 265
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.12
    Marker Score: 479
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.12
    Marker Score: 64
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.12
    Marker Score: 60
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.12
    Marker Score: 24
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.12
    Marker Score: 47
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.12
    Marker Score: 71
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.12
    Marker Score: 267

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * The CHRNA5 gene is a single-exon gene that is expressed in all tissues of the body. * The protein encoded by the CHRNA5 gene is a transmembrane protein that is composed of 140 amino acids. * The protein is a ligand-gated monoatomic ion channel, which means that it opens when a ligand binds to it. * The protein is expressed in a variety of cell types, including neurons, astrocytes, and oligodendrocytes. * The protein is involved in a variety of cellular processes, including neurotransmission, synaptic plasticity, and learning and memory. **Pathways and functions:** * The CHRNA5 gene is involved in the regulation of acetylcholine signaling. * Acetylcholine is a neurotransmitter that is involved in a variety of physiological and behavioral functions, including cognition, memory, and muscle contraction. * The CHRNA5 gene is a key regulator of acetylcholine signaling in the central nervous system. * The protein encoded by the CHRNA5 gene is a key component of the nicotinic acetylcholine receptor complex. * The complex is responsible for the binding of acetylcholine to its receptors and the subsequent activation of downstream events. **Clinical significance:** * Mutations in the CHRNA5 gene have been linked to a number of neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. * The CHRNA5 gene is also involved in the treatment of epilepsy and muscle spasms. * Drugs that target the CHRNA5 receptor have been shown to be effective in treating these disorders. **Additional information:** * The CHRNA5 gene is a member of the nicotinic acetylcholine receptor family of genes. * The nicotinic acetylcholine receptors are a large family of ion channels that are involved in a variety of cellular processes, including neurotransmission, synaptic plasticity, and learning and memory. * The CHRNA5 gene is a highly conserved gene, with a similar gene found in mice and rats.

Genular Protein ID: 2245861410

Symbol: ACHA5_HUMAN

Name: Neuronal acetylcholine receptor subunit alpha-5

UniProtKB Accession Codes:

P30532 Q15824 Q99554

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 3 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 10 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1542648

Title: Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines.

PubMed ID: 1542648

DOI: 10.1073/pnas.89.5.1572

PubMed ID: 8906617

Title: Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.

PubMed ID: 8906617

DOI: 10.1007/bf02736842

PubMed ID: 9009220

Title: Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32.

PubMed ID: 9009220

DOI: 10.1016/s0014-5793(96)01383-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18385720

Title: Genomics: when the smoke clears.

PubMed ID: 18385720

DOI: 10.1038/452537a

PubMed ID: 18385738

Title: A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.

PubMed ID: 18385738

DOI: 10.1038/nature06885

PubMed ID: 18385676

Title: Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.

PubMed ID: 18385676

DOI: 10.1038/ng.109

PubMed ID: 27344019

Title: Functional interaction between Lypd6 and nicotinic acetylcholine receptors.

PubMed ID: 27344019

DOI: 10.1111/jnc.13718

Sequence Information:

  • Length: 468
  • Mass: 53054
  • Checksum: 7FE91A2E362289C0
  • Sequence:
    • MAARGSGPRA LRLLLLVQLV AGRCGLAGAA GGAQRGLSEP SSIAKHEDSL LKDLFQDYER 
WVRPVEHLND KIKIKFGLAI SQLVDVDEKN QLMTTNVWLK QEWIDVKLRW NPDDYGGIKV 
IRVPSDSVWT PDIVLFDNAD GRFEGTSTKT VIRYNGTVTW TPPANYKSSC TIDVTFFPFD 
LQNCSMKFGS WTYDGSQVDI ILEDQDVDKR DFFDNGEWEI VSATGSKGNR TDSCCWYPYV 
TYSFVIKRLP LFYTLFLIIP CIGLSFLTVL VFYLPSNEGE KICLCTSVLV SLTVFLLVIE 
EIIPSSSKVI PLIGEYLVFT MIFVTLSIMV TVFAINIHHR SSSTHNAMAP LVRKIFLHTL 
PKLLCMRSHV DRYFTQKEET ESGSGPKSSR NTLEAALDSI RYITRHIMKE NDVREVVEDW 
KFIAQVLDRM FLWTFLFVSI VGSLGLFVPV IYKWANILIP VHIGNANK

Genular Protein ID: 3198071467

Symbol: H0YM98_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YM98

Database IDs:

ARBA 13 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 3 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

Sequence Information:

  • Length: 160
  • Mass: 17810
  • Checksum: FA1F0090AFCFAA38
  • Sequence:
    • MAARGSGPRA LRLLLLVQLV AGRCGLAGAA GGAQRGLSEP SSIAKHEDSL LKDLFQDYER 
WVRPVEHLND KIKIKFGLAI SQLVDVDEKN QLMTTNVWLK QEWIDVKLRW NPDDYGGIKV 
IRVPSDSVWT PDIVLFDNAD GRFEGTSTKT VIRLLKIGNS

Genular Protein ID: 2229739451

Symbol: Q6EWN4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6EWN4

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 3 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 RefSeq 2 SAM 1 SUPFAM 1

Citations:

PubMed ID: 15716100

Title: In vivo RNA-RNA duplexes from human alpha3 and alpha5 nicotinic receptor subunit mRNAs.

PubMed ID: 15716100

DOI: 10.1016/j.gene.2004.12.005

Sequence Information:

  • Length: 57
  • Mass: 6619
  • Checksum: 36E995660FD2C213
  • Sequence:
    • DVREVVEDWK FIAQVLDRMF LWTFLFVSIV GSLGLFVPVI YKWANILIPV HIGNANK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.